• Journal of Pharmaceutical Investigation
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• v.23 no.1
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• pp.27-32
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• 1993

Pharmacokinetic drug interaction between phenytoin and diltiazem was investigated following i.v. administration concomitantly to rabbits. Diltiazem was coadministered at doses of 1, 2 and 3 mg/kg, respectively, with phenytoin (5 mg/kg) to rabbits. Plasma concentration and AUC of phenytoin were increased significantly, but volume of distribution and total body clearance were decreased significantly (p<0.05) at doses of 2 mg and 3 mg/kg of diltiazem. From the results of this experiment, it is desirable that dosage regimen of phenytoin should be adjusted and that therapeutic drug monitoring should be practiced for reduction of side or toxic effect when phenytoin should be administered with diltiazem in clinical practice.

• Bulletin of the Korean Chemical Society
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• v.2 no.4
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• pp.132-138
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• 1981

Ab initio molecular orbital calculations have been performed in an effort to determine which types of chemical interactions play essential roles for the system, , $H_2O+CH_2SH^+$, and $H_2O+ CH_2S$. The most important contribution to the interaction energy in controlling reaction path is the exchange repulsion energy, EX, which is largely responsible for the shape of the total interaction energy curve. In the ion-molecule reaction, prior protonation of thioformaldehyde or prior deprotonation of water leads to formation of the corresponding ionic adducts ($H_2O+CH_2SH$ and $HOCH_2S^-$), with no barrier to reaction, simulating specific acid and base catalysis, respectively, as in the case of formaldehyde. Otherwise, approach of water to thioformaldehyde gives rise to a completely repulsive interaction.

• Ocean Systems Engineering
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• v.9 no.3
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• pp.241-259
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• 2019

This paper presents a fully three-dimensional numerical approach for analyzing deepwater drilling riser-conductor system vortex-induced vibrations (VIV) including nonlinear soil-structure interactions (SSI). The drilling riser-conductor system is modeled as a tensioned beam with linearly distributed tension and is solved by a fully implicit discretization scheme. The fluid field around the riser-conductor system is obtained by Finite-Analytic Navier-Stokes (FANS) code, which numerically solves the unsteady Navier-Stokes equations. The SSI is considered by modeling the lateral soil resistance force according to nonlinear p-y curves. Overset grid method is adopted to mesh the fluid domain. A partitioned fluid-structure interaction (FSI) method is achieved by communication between the fluid solver and riser motion solver. A riser-conductor system VIV simulation without SSI is firstly presented and served as a benchmark case for the subsequent simulations. Two SSI models based on a nonlinear p-y curve are then applied to the VIV simulations. Also, the effects of two key soil properties on the VIV simulations of riser-conductor systems are studied.

• Journal of the Korea institute for structural maintenance and inspection
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• v.7 no.1
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• pp.181-190
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• 2003

The convergence-confinement method is an attempt to evaluate tunnel stability conditions by means of a mathematical model and a ground response curve. In this study, the convergence-confinement method by numerical model was examined. This method don't need the basic assumptions for a mathematical model. Also This is applicable to general tunnel. According to the results of this study, the change of shotcrete stiffness and the load-distribution ratio used for 2-Dimension numerical analysis are not signficant factors. The ground response curve and the support reaction curve are mutually dependent. Especially the support reaction curve depends upon the ground response curve. The mechanism of tunnel must be analyzed by the interaction between support and ground. Consequently the stability of tunnel must be qualitatively investigated by a ground response curve and quantitatively adjudged by a numerical analysis for the reasonable design of tunnel.

• Journal of the Korean Geotechnical Society
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• v.18 no.3
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• pp.126-126
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• 2002

In dynamic analyses such as seismic ground response and soil-structure interaction problems, it is very crucial to obtain accurate dynamic shear modulus of soil deposit. In this study, an extensive data base of available experimental data is compiled and reanalyzed to establish a simple empirical formula for the dynamic shear modulus reduction curve to cover wide range of strain for sandy soils. The proposed empirical equation is to represent the dynamic shear modulus degradation with strain in terms of low-amplitude dynamic shear modulus and effective mean confining Pressure, since those factors have the most significant effect on the Position and shape of the shear modulus reduction curve for nonelastic soils. If low-amplitude shear modulus is measured, degraded modulus at any shear strain amplitude can be calculated using the proposed equation.

• Journal of the Korean Geotechnical Society
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• v.18 no.3
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• pp.127-138
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• 2002

In dynamic analyses such as seismic ground response and soil-structure interaction problems, it is very crucial to obtain accurate dynamic shear modulus of soil deposit. In this study, an extensive data base of available experimental data is compiled and reanalyzed to establish a simple empirical formula for the dynamic shear modulus reduction curve to cover wide range of strain for sandy soils. The proposed empirical equation is to represent the dynamic shear modulus degradation with strain in terms of low-amplitude dynamic shear modulus and effective mean confining Pressure, since those factors have the most significant effect on the Position and shape of the shear modulus reduction curve for nonelastic soils. If low-amplitude shear modulus is measured, degraded modulus at any shear strain amplitude can be calculated using the proposed equation.

• Journal of Korean Society of Rural Planning
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• v.16 no.2
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• pp.57-64
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• 2010

This study aims to understand the degree of inequality of surveyed amenity resources and identify which resource and region have the highest concentration by estimating Lorenz Curve and the Gini's Coefficient. The Lorenz Curve and Gini's Coefficient derived from economics are introduced as tools for investigating and quantifying regional variability of amenity resources concentration. This study describes the concepts underlying the application of the Gini's coefficient to measure the concentration of amenity resources in 11 regions, Chungbuk Province, Korea. The Lorenz Curve presents a graphical view of the cumulative distribution of amenity resources and the Gini's Coefficient provides a single-parameter measure of the distributional concentration of amenity resources. Also the Gini's Coefficient is compared to the number of amenity resource for understanding distributional difference between concentration and quantitative distribution of amenity resources. The results demonstrate significantly different regional variation according to the amenity variables: almost intact nature, interaction between nature and man, man-made.

• Journal of Korean Society of Steel Construction
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• v.19 no.3
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• pp.335-344
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• 2007

The steel-concrete composite column (i.e., the SC composite column) supports large-gravity loads and simplifies the installation and removal of the work in pouring the concrete. The column takes advantage of the in-plant prefabrication of steel, the speed of erection of a steel structure, and the fire resistance of steel. This paper presents the results of a parametric study using heat transfer analysis and a P-M interaction curve, and compares these results with the experimental results to check the accuracy of the proposed parametric studies. The parametric studies, such as the study of the concrete ratio of an area and the fire protection thickness, provide information on the fire resistance of SC composite columns.

• Journal of the Korean GEO-environmental Society
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• v.13 no.6
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• pp.73-81
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• 2012

Safety issue for offshore wind-turbine foundation becomes a crucial factor as offshore wind turbines have been scaled up. Correspondingly, there is a demand to understand the effect of soil-structure interaction on to system behavior in geotechnical engineering point of view. The p-y curve method researched in past few decades is one of the most appropriate methodology to analyze the problem. In this study, recently proposed p-y curve models for various rocks are calibrated to analyze the engineering characteristics of seabed of Jeju Island where it is known to be most suitable area for offshore wind energy farm. Step by step calibration process for p-y models is presented. Analysis results show that subgrade reaction generally increases as closer to seabed. It is also shown that the behavioral characteristics of foundation reflect well rock properties in terms of resultant moment, shear force, etc.

• Journal of the Korean Geotechnical Society
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• v.27 no.10
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• pp.55-67
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• 2011

The shear load distribution and deformation of offshore friction piles are investigated using experimental tests and a numerical analysis. Special attention is given to the soil-pile interaction of axially loaded pile. A framework for determining the f-w curve is proposed based on both theoretical analysis and experimental load test data base. A numerical analysis that takes into account the proposed f-w curves was performed for major parameters on pile-soil interaction such as the pile diameter, the pile length, and the soil condition. Based on the analysis, it is shown that the proposed f-w method is capable of predicting the behavior of a friction pile in deep soft clay. Through comparisons with case histories and finite element results, it is found that the proposed f-w curves are more appropriate and realistic m representing the pile-soil interaction of axially loaded piles in deep soft clay than that of existing f-w method.