• Asian Pacific Journal of Cancer Prevention
• /
• 제14권6호
• /
• pp.3837-3841
• /
• 2013

Objectives: To analyse HPV integration prevalence and genotype distributions in cervical intraepithelial neoplasia (CIN) in east part of China, furthermore to assess preferential sites for common HPV integrations and provide baseline information for cervical abnormality screening and prevention. Methods: Integration of HPV in 113 paraffin-embedded cervical intraepithelial neoplasia samples was assessed using Gencap technology in Key Laboratory of Biotechnologies in BGI-Shenzhen. Results: 64 samples were HPV-integrated and as the cervical lesions increased, the integration rate became higher significantly (P=0.002). Fifteen different HPV genotypes were detected, 14 high-risk (16, 18, 31, 33, 51, 52, 56, 58, 66, 68) and 1 low-risk (11). The most common genotypes were HPV-16, 58, 33, 52, 66, and 56. Thirteen patients had co-integration involving mainly HPV-16 and 58. The frequency of HPV gene disruption was higher in L1 and E1 genes than in other regions of the viral genomes. Conclusion: Some 56.6% of CIN lesions in Qingdao had HPV integrations, and 67.2% of HPV-integrated patients were HPV-16 and 58, more prone to be integrated in younger patients below 45 years old. There exist preferential sites for HPV-16 and HPV-58 integration, and they are more likely to be disrupted in the L1 and E1 loci.

• 인터넷정보학회논문지
• /
• 제22권6호
• /
• pp.59-69
• /
• 2021

의료기기의 오작동이나 고장은 인명 피해나 큰 상해가 발생할 수 있으므로 안전성 확보가 필수적인 분야이다. 이를 위해 국제표준을 제정하고 준수하도록 하고 있지만 이들 표준은 상호의존적이고 특히, 안전성 분석 활동의 경우 시간, 노력, 비용이 많이 소요되어 표준 활동을 통합하고 커스터마이징할 필요가 있다. 따라서 본 논문에서는 의료기기 소프트웨어 개발 단계별 수행 활동과 안전성 프로세스의 활동을 통합하였다. 통합된 프로세스를 통해 하나의 프로세스로 체계적인 관리가 가능하며, STPA 기법을 기반으로 하는 프로세스 단계별로 가이드가 제공되어 안전성 활동을 효과적으로 수행할 수 있다.

• 한국정보기술응용학회:학술대회논문집
• /
• 한국정보기술응용학회 2005년도 6th 2005 International Conference on Computers, Communications and System
• /
• pp.173-176
• /
• 2005

This paper proposes a fuzzy correction algorithm that can correct the distorted medical image caused by the scanning nonlinear velocity of the Digital X-ray Scanner System (DX-Scanner) using the Multichannel Ionization Chamber (MIC). In the DX-Scanner, the scanned medical image is distorted for reasons of unsuitable integration time at the nonlinear acceleration period of the AC servo motor during the inspection of patients. The proposed algorithm finds the nonlinear motor velocity modeling through fuzzy system by clustering and reconstructs the normal medical image lines by calculating the suitable moving distance with the velocity of the motor using the modeling, acceleration time and integration time. In addition, several image processing is included in the algorithm. This algorithm analyzes exact pixel lines by comparing the distance of the acceleration period with the distance of the uniform velocity period in every integration time and is able to compensate for the velocity of the acceleration period. By applying the proposed algorithm to the test pattern for checking the image resolution, the effectiveness of this algorithm is verified. The corrected image obtained from distorted image is similar to the normal and better image for a doctor's diagnosis.

• 대한디지털의료영상학회논문지
• /
• 제5권1호
• /
• pp.86-92
• /
• 2002

Information concerning a patient visit is to be sent from the OCS(Order Communication System) to the PACS(Picture archiving and Communication System) and when the image acquisition is completed, information regarding the procedures also actually preformed should be sent back to the OCS. It should be possible to present related medical information from the OCS at the same image workstation in a coherent way with the images in the PACS, Examples of the related medical information are: the report of a diagnostic image procedure, data on medication, laboratory results, admission and discharge letters, and surgery reports, because we could maximize the efficiency of Radiological Work, like decrease examination time and human mistakes, though the integration of PACS and OCS, Therefore, We research some hospitals to find integral lists of PACS and OCS but there are no sufficient ingredients. Further, the percentage of Integral lists of PACS and OCS is different in all hospitals because there is no such standard yet like HL7(Healthcare Level 7) and DICOM(Digital Imaging and Communications in Medicine). Accordingly, if all hospital would follow national standard like HL7 and DICOM, the integration of OCS and PACS would be efficient but in this situation radiological technician should take part in construction integration system of PACS and OCS positively, so we could improve efficiency of radiological work and our status.

• Journal of Audiology & Otology
• /
• 제24권4호
• /
• pp.174-179
• /
• 2020

Background and Objectives: The integration of auditory-visual speech information improves speech perception; however, if the auditory system input is disrupted due to hearing loss, auditory and visual inputs cannot be fully integrated. Additionally, temporal coincidence of auditory and visual input is a significantly important factor in integrating the input of these two senses. Time delayed acoustic pathway caused by the signal passing through digital signal processing. Therefore, this study aimed to investigate the effects of hearing loss and hearing aid digital delay circuit on sound-induced flash illusion. Subjects and Methods: A total of 13 adults with normal hearing, 13 with mild to moderate hearing loss, and 13 with moderate to severe hearing loss were enrolled in this study. Subsequently, the sound-induced flash illusion test was conducted, and the results were analyzed. Results: The results showed that hearing aid digital delay and hearing loss had no detrimental effect on sound-induced flash illusion. Conclusions: Transmission velocity and neural transduction rate of the auditory inputs decreased in patients with hearing loss. Hence, the integrating auditory and visual sensory cannot be combined completely. Although the transmission rate of the auditory sense input was approximately normal when the hearing aid was prescribed. Thus, it can be concluded that the processing delay in the hearing aid circuit is insufficient to disrupt the integration of auditory and visual information.

• 대한의용생체공학회:의공학회지
• /
• 제26권6호
• /
• pp.399-406
• /
• 2005

In these days, HIS(Hospital Information System) raise the quality of medical services by effective management of medical records. As computing environment was developed, it is possible to search information quickly. But, standard medical data exchange is not completed between medical clinic and another organ so far. In case of patient transfer, past medical record was not efficiently transmitted. It be feasible treatment delay or medical accident. It is trouble that medical records is transferred by a person and communicate with each other. Extensible Markup Language (XML) is a simple, very flexible text format derived from SGML. Originally designed to meet the challenges of large-scale electronic publishing, XML is also playing an increasingly important role in the exchange of a wide variety of data on the Web and elsewhere. Form in system of company product, relative organs that handle bio-signal data is each other dissimilar and integration and to transmit to supplement bottleneck this research uses XML. In this study, it is discussed about sharing of medical data using XML web technology to standard medical record between hospital and relative organization The data structure model was designed to manage bio-signal data and patient record. We experimented about data transmission and all-in-one between different systems (one make use of MS-SQL database system and the other manage existent bio-signal data in itself form in file in this research). In order to search and refer medical record, the web-based system was implemented. The system that can be shared medical data was tested to estimate the merits of XML. Implemented XML schema confirms data transmission between different data system and integration result.

• 한국콘텐츠학회논문지
• /
• 제8권12호
• /
• pp.20-27
• /
• 2008

현재 병원에서는 병원관리시스템(HIS), 의료영상시스템(PACS), 처방전달시스템(OCS), 전자의무기록(EMR), 전사적 자원관리(ERP) 등 각 과별 업무별로 독립적인 시스템을 사용하고 있으며, 각 시스템에 종속적인 각각의 DB를 운용하고 있다. 이에 따라 정보의 원내 통합이 불가능하며, 데이터의 투명성과 일관성을 유지하기 어려운 상황이다. 본 연구는 기존의 타 시스템과의 유연한 연계처리를 통한 데이터 통합환경을 제공하고, 이를 통해 고객이 원하는 최적의 서비스를 최적의 타이밍에 제공할 수 있는 의료 CRM 프레임을 설계하였다. 고객관리 프로세스 표준화에 의해 고객관리, 홍보/마케팅, 서비스관리, 통계/분석의 4가지 의료 CRM 프레임을 설계하였고 개인화된 의료정보 서비스 제공을 위한 모바일 의료 콘텐츠를 확보하여 고객 데이터를 바탕으로 고객의 특성과 건강 상황에 따라 맞춤형 모바일 콘텐츠를 제공할 수 있도록 설계하였다.

• 한국컴퓨터정보학회논문지
• /
• 제10권4호
• /
• pp.37-46
• /
• 2005

인간의 건강한 삶을 위해 의료정보 서비스에 대한 수요가 급증함에 따라 웹 환경에서 상호작용적으로 작동할 수 있는 의료정보 서비스를 위한 밀티미디어 콘텐츠저작 시스템이 필요하다. 본 논문에서는 웹 기반 밀티미디어 지원 언어인 SMIL(Synchronized Multimedia Integration Language)을 이용하여 사용자 친화적 인터페이스 기능을 갖는 SMIL 기반 의료정보 서비스를 위한 멀티미디어 콘텐츠 저작시스템을 개발하였다. 본 논문에서 개발된 저작도구는 부분적으로 작성된 결과를 편집 즉시 재생하고 확인 수정할 수 있으며, 멀티미디어 객체를 간편하게 삽입할 수 있어 다양한 형태의 의료정보 요소를 포함한 멀티미디어 콘텐츠를 쉽게 저작할 수 있다. 또한 사용자의 편리성을 증대시켜 효과적으로 다양한 의료정보 서비스가 제공 가능한 멀티미디어 콘텐츠를 실현할 수 있다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제17권4호
• /
• pp.1216-1233
• /
• 2023

Conventional occupational therapy (OT) is conducted under the observation of an occupational therapist, and there are limitations in measuring and analyzing details such as degree of hand tremor and movement tendency, so this important information may be lost. It is therefore difficult to identify quantitative performance indicators, and the presence of observers during performance sometimes makes the subjects feel that they have to achieve good results. In this study, by using the Unity3D and artificial intelligence (AI) speaker, we propose a system that allows the subjects to steadily use it by themselves and helps the occupational therapist objectively evaluate through quantitative data. This system is based on the OT of the sensory integration approach. And the purpose of this system is to improve children's activities of daily living by providing various feedback to induce sensory integration, which allows them to develop the ability to effectively use their bodies. A dynamic OT cognitive assessment tool for children used in clinical practice was implemented in Unity3D to create an OT environment of virtual space. The Leap Motion Controller allows users to track and record hand motion data in real time. Occupational therapists can control the user's performance environment remotely by connecting Unity3D and AI speaker. The experiment with the conventional OT tool and the system we proposed was conducted. As a result, it was found that when the system was performed without an observer, users can perform spontaneously and several times feeling ease and active mind.

• 한국통신학회:학술대회논문집
• /
• 한국통신학회 2004년도 추계종합학술대회 논문 초록집
• /
• pp.325-325
• /
• 2004