• 한국발생생물학회지:발생과생식
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• 제25권4호
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• pp.279-291
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• 2021

Hair loss is one of the most common chronic diseases, with a detrimental effect on a patient's psychosocial life. Hair loss results from damage to the hair follicle (HF) and/or hair regeneration cycle. Various damaging factors, such as hereditary, inflammation, and aging, impair hair regeneration by inhibiting the activation of hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs). Formyl peptide receptor 2 (FPR2) regulates the inflammatory response and the activity of various types of stem cells, and has recently been reported to have a protective effect on hair loss. Given that stem cell activity is the driving force for hair regeneration, we hypothesized that FPR2 influences hair regeneration by mediating HFSC activity. To prove this hypothesis, we investigated the role of FPR2 in hair regeneration using Fpr2 knockout (KO) mice. Fpr2 KO mice were found to have excessive hair loss and abnormal HF structures and skin layer construction compared to wild-type (WT) mice. The levels of Sonic hedgehog (Shh) and β-catenin, which promote HF regeneration, were significantly decreased, and the expression of bone morphogenetic protein (Bmp)2/4, an inhibitor of the anagen phase, was significantly increased in Fpr2 KO mice compared to WT mice. The proliferation of HFSCs and DPCs was significantly lower in Fpr2 KO mice than in WT mice. These findings demonstrate that FPR2 impacts signaling molecules that regulate HF regeneration, and is involved in the proliferation of HFSCs and DPCs, exerting a protective effect on hair loss.

• 대한건축학회논문집:계획계
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• 제34권12호
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• pp.55-64
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• 2018

The purpose of this study is to examine the status and limitations of the activation plan as a result of the change in urban regeneration paradigm. In particular, the change in housing life was considered following the guidelines of the New Deal project. Specifically, the three types - General Neighborhood, Housing Support, and DongneSaligi - were analyzed from the perspective of organization, space and program. In addition, the master plan and unit project, the organization and progress, and the budget plan were reviewed. As a result, the New Deal project for urban regeneration is importance on economic regeneration, which, unlike the integrated and continuous guide proposed by the government, could limit the individual progress of transitional organizations, 2-dimensional planing and various programs. Thus, first, in order to supplement the organization's verticality and inefficiency in progress, the annual business assessment should be discouraged and the permit and progress of the project should be determined at the local government level. Second, integrated and multidimensional planning is necessary to produce synergy effects in the physical environment. Finally, the link between program unit projects and the economic effects can be considered.

• 토지주택연구
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• 제15권1호
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• pp.99-115
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• 2024

본 연구의 목적은 마르세유의 유로메디테라네의 사업 현황과 특성을 살펴보고, 국내 도시재생사업의 활성화를 위한 정책적 시사점을 도출하는 것이다. 연구결과를 요약하면 다음과 같다. 첫째, 유로메디테라네는 마르세유의 도시재생사업으로, 중앙정부와 지방정부가 공동으로 출자･협력한 거버넌스형 사업추진기구인 EPAEM을 통해 사업을 수행하여, 유로메디테라네가 마르세유의 활성화와 삶의 질 개선에 의미 있는 성과를 보임을 확인할 수 있다. 둘째, 도시재생사업으로서 유로메디테라네의 특성으로는 전면 재개발과 수복재개발 방식을 결합한 복합적 접근방법의 활용, 하드웨어적인 물리적 재생과 소프트웨어적인 경제･문화･환경적 재생을 결합한 통합적 재생의 활용, 거버넌스형 도시재생 사업구조의 활용을 들 수 있다. 마지막으로, 국내 도시재생사업의 활성화를 위한 정책적 시사점으로 도시재생사업 단위의 복합화 및 대형화, 국가차원의 거버넌스형 추진기구의 활용, 적절한 민관 파트너십의 활용을 제안하였다.

• 대한건축학회논문집:계획계
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• 제34권6호
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• pp.47-56
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• 2018

This study aims to reconsider public architecture as effective resources for the local regeneration and draws a couple of issues based on analysis of planning status and cases from the perspectives of local regeneration. Through the analysis, this study suggests following as ways of improvement of public architecture planning: first, in order to secure systematic management of local regeneration, it is necessary to build up a dedicated organization or collaboration system that organically links and manages public facilities. Also related criteria that include the feasibility study, preliminary examination system, conduct review of investment and review standards need to be supplemented. Second, it is necessary to establish an integrated plan including the periphery of public architecture in the aspect of integrated urban planning, and to set up a selection of location standard that supports public architecture be a local center. Lastly, to activate local communities, the study proposes diversification of ways of combining programs and a process for participation and operating funds.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.693-694
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• 2015

While urban regeneration projects are currently under active execution in several old cities in Korea, there are few projects to improve the quality of life of rural communities. Considering the decline of the SOC system, deterioration of housing, and degeneration of economic feasibility, the purpose of this study is to provide solutions to realize an improved economic and social environment of rural communities through an integrated management system for traffic safety and water management systems. Therefore, this research used an Entity-Relationship Diagram to construct an integrated system for traffic safety and water management systems for Chungcheong rural communities. The ERD is prepared by depicting 7 relationships for 13 entities, including traffic accidents and agricultural products, and 26 attributes, including soil moisture and underflow storage. Consequently, it will be possible to set up a decision-making support system that can analyze and evaluate the regeneration index, technology, and management of the systems for Chungcheong rural communities, based on supplier and user perspectives

• 도시과학
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• 제11권1호
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• pp.59-68
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• 2022

This study, the meaning of historical and cultural content utilization in urban regeneration was examined and in the process, the causal relationship between each variable was verified through path analysis among physical, cultural, social, and economic factors. The purpose of this study is to find the main variables of historical and cultural content urban regeneration projects in which the moderating effect of economic factors and demographic characteristics, which are mediating effects, have a significant effect on resident participation and life satisfaction of local residents. Furthermore, by presenting a more integrated and effective urban regeneration policy plan, it is intended to ultimately contribute to the vitalization and direction of urban regeneration.

• 농촌계획
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• 제16권4호
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• pp.131-138
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• 2010

The purpose of this paper is to identify the determinants of spillover effects of regional regeneration projects. This finds that the effects are positively determined by population sizes of regions and degree of industrial specialization of regeneration related industries. In particular, the improvement of accessibility through the development of transportation infrastructure facilities can contribute to increases of economic impacts of regeneration projects of high-income regions on the lagged regions. Microeconomic approaches and dynamic modelling need to be integrated for this impact analysis as further research fields.

• 건축사
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• 통권557호
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• pp.86-87
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• 2015

• 한국산학기술학회논문지
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• 제16권7호
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• pp.4984-4991
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• 2015

성장에 중점을 둔 도시정책은 도시 내 쇠퇴지역을 발생시켰고, 지속가능한 성장을 위한 도시재생의 중요성은 증대되고 있다. 이에 따라 도시쇠퇴 실태의 정확한 진단과 현재 진행되고 있는 도시재생사업의 측면별 평가를 통해 도시재생 전략과 사업의 문제점 수정, 보완의 근거를 제시하는 것이 필요하다. 본 연구는 도시 내 쇠퇴지역을 유형별로 도출하고, 쇠퇴지역에서 시행되고 있는 도시재생사업을 물리적, 경제적, 사회적 측면의 지속가능한 도시재생 계획요소로 평가하여 지역의 유형별 쇠퇴양상에 적합한 도시재생사업이 시행되고 있는지를 평가하는 것을 목적으로 하고 있다. 대전시의 19개 쇠퇴지역 모두 지속가능한 도시재생 계획요소 적용 정도가 '보통' 이하로 나타나, 도시재생사업이 적극적으로 시행되고 있지 않는 것으로 나타났다. 또한 회덕동을 제외한 모든 지역이 쇠퇴유형에 대응하는 도시재생사업을 시행하고 있지 못한 것으로 평가되었으며, 물리적 도시재생사업에 치우쳐 있는 것으로 나타나 쇠퇴유형에 대응할 수 있는 사회적, 경제적 도시재생사업의 발굴과 통합적, 지속적 도시재생 노력이 필요하다.

• 한국산학기술학회논문지
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• 제13권2호
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• pp.893-899
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• 2012

본 논문은 경인선 백운역 및 백운역세권을 대상으로 철도에 의해 양분된 지역생활권의 단절 해소 및 철도시설 연변부지의 효율적 토지이용을 통한 입체적인 철도 환승시스템을 제안함과 동시에 철도 이용객의 편의를 도모하며 기존의 단절된 녹지축을 활성화하여 친환경적이며 안전하고, 편리한 주거환경의 개선을 통해 지역주민들의 삶을 한층 풍요롭게 하고 나아가 지역 생활권의 활성화 방안을 모색하는 것에 있다.