• Development and Reproduction
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• v.25 no.4
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• pp.279-291
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• 2021

Hair loss is one of the most common chronic diseases, with a detrimental effect on a patient's psychosocial life. Hair loss results from damage to the hair follicle (HF) and/or hair regeneration cycle. Various damaging factors, such as hereditary, inflammation, and aging, impair hair regeneration by inhibiting the activation of hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs). Formyl peptide receptor 2 (FPR2) regulates the inflammatory response and the activity of various types of stem cells, and has recently been reported to have a protective effect on hair loss. Given that stem cell activity is the driving force for hair regeneration, we hypothesized that FPR2 influences hair regeneration by mediating HFSC activity. To prove this hypothesis, we investigated the role of FPR2 in hair regeneration using Fpr2 knockout (KO) mice. Fpr2 KO mice were found to have excessive hair loss and abnormal HF structures and skin layer construction compared to wild-type (WT) mice. The levels of Sonic hedgehog (Shh) and β-catenin, which promote HF regeneration, were significantly decreased, and the expression of bone morphogenetic protein (Bmp)2/4, an inhibitor of the anagen phase, was significantly increased in Fpr2 KO mice compared to WT mice. The proliferation of HFSCs and DPCs was significantly lower in Fpr2 KO mice than in WT mice. These findings demonstrate that FPR2 impacts signaling molecules that regulate HF regeneration, and is involved in the proliferation of HFSCs and DPCs, exerting a protective effect on hair loss.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.12
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• pp.55-64
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• 2018

The purpose of this study is to examine the status and limitations of the activation plan as a result of the change in urban regeneration paradigm. In particular, the change in housing life was considered following the guidelines of the New Deal project. Specifically, the three types - General Neighborhood, Housing Support, and DongneSaligi - were analyzed from the perspective of organization, space and program. In addition, the master plan and unit project, the organization and progress, and the budget plan were reviewed. As a result, the New Deal project for urban regeneration is importance on economic regeneration, which, unlike the integrated and continuous guide proposed by the government, could limit the individual progress of transitional organizations, 2-dimensional planing and various programs. Thus, first, in order to supplement the organization's verticality and inefficiency in progress, the annual business assessment should be discouraged and the permit and progress of the project should be determined at the local government level. Second, integrated and multidimensional planning is necessary to produce synergy effects in the physical environment. Finally, the link between program unit projects and the economic effects can be considered.

• Land and Housing Review
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• v.15 no.1
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• pp.99-115
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• 2024

This study aims to investigate Marseille's Euromméditerranée project and provide policy implications for revitalizing domestic urban regeneration projects. First, we identify Euroméditerranée as a pivotal urban regeneration effort, executed by EPAEM-an organization fostering governance-driven project advancement through collaboration and investment from both central and local governments. This endeavor has significantly contributed to revitalizing Marseille, enriching the quality of life for its residents. Second, this urban regeneration project has the following notable features: consolidated approach with combination of full redevelopment and rehabilitation, integrated regeneration covering hardware-like physical regeneration and software-like economic, cultural, and environmental regeneration; government-type urban regeneration project structure. Finally, we suggest that policymakers should consider the economic scale in urban regeneration projects, national-level government organizations, and efficient public-private partnerships.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.6
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• pp.47-56
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• 2018

This study aims to reconsider public architecture as effective resources for the local regeneration and draws a couple of issues based on analysis of planning status and cases from the perspectives of local regeneration. Through the analysis, this study suggests following as ways of improvement of public architecture planning: first, in order to secure systematic management of local regeneration, it is necessary to build up a dedicated organization or collaboration system that organically links and manages public facilities. Also related criteria that include the feasibility study, preliminary examination system, conduct review of investment and review standards need to be supplemented. Second, it is necessary to establish an integrated plan including the periphery of public architecture in the aspect of integrated urban planning, and to set up a selection of location standard that supports public architecture be a local center. Lastly, to activate local communities, the study proposes diversification of ways of combining programs and a process for participation and operating funds.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.693-694
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• 2015

While urban regeneration projects are currently under active execution in several old cities in Korea, there are few projects to improve the quality of life of rural communities. Considering the decline of the SOC system, deterioration of housing, and degeneration of economic feasibility, the purpose of this study is to provide solutions to realize an improved economic and social environment of rural communities through an integrated management system for traffic safety and water management systems. Therefore, this research used an Entity-Relationship Diagram to construct an integrated system for traffic safety and water management systems for Chungcheong rural communities. The ERD is prepared by depicting 7 relationships for 13 entities, including traffic accidents and agricultural products, and 26 attributes, including soil moisture and underflow storage. Consequently, it will be possible to set up a decision-making support system that can analyze and evaluate the regeneration index, technology, and management of the systems for Chungcheong rural communities, based on supplier and user perspectives

• Journal of Urban Science
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• v.11 no.1
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• pp.59-68
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• 2022

This study, the meaning of historical and cultural content utilization in urban regeneration was examined and in the process, the causal relationship between each variable was verified through path analysis among physical, cultural, social, and economic factors. The purpose of this study is to find the main variables of historical and cultural content urban regeneration projects in which the moderating effect of economic factors and demographic characteristics, which are mediating effects, have a significant effect on resident participation and life satisfaction of local residents. Furthermore, by presenting a more integrated and effective urban regeneration policy plan, it is intended to ultimately contribute to the vitalization and direction of urban regeneration.

• Journal of Korean Society of Rural Planning
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• v.16 no.4
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• pp.131-138
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• 2010

The purpose of this paper is to identify the determinants of spillover effects of regional regeneration projects. This finds that the effects are positively determined by population sizes of regions and degree of industrial specialization of regeneration related industries. In particular, the improvement of accessibility through the development of transportation infrastructure facilities can contribute to increases of economic impacts of regeneration projects of high-income regions on the lagged regions. Microeconomic approaches and dynamic modelling need to be integrated for this impact analysis as further research fields.

• Korean Architects
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• s.557
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• pp.86-87
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• 2015

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.7
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• pp.4984-4991
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• 2015

This study derives the city's declining area by the type, and evaluates urban regeneration projects to sustainable urban regeneration planning factors. And assess whether urban regeneration projects are suitable for declining aspect of area. Application of sustainable urban regeneration plan factors of 19 declining areas is found to be less than 'normal'. This showed that urban regeneration projects not being actively enforced. All areas except hoedeokdong have been estimated that urban regeneration projects did not enforce the corresponding type on the decline, it still showed that concentrated on the physical regeneration projects. Excavation of social, economic regeneration projects that can respond to the type of decline and integrated, ongoing urban regeneration efforts are needed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.2
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• pp.893-899
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• 2012

This paper suggests some strategies for the regional regeneration of Baegun Railway station and surrounding area. One is the reduction of the regional unbalance in those divided into two parts, the other is multi-dimentional plan through the efficient land-use on the side area of railway. For these regional regeneration, providing integrated transit system for the passenger's convenience, connecting existing green axis and creating green zone covering the railway, modifying and improvement of residential environment are suggested.