• Korean Institute of Interior Design Journal
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• no.14
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• pp.63-73
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• 1998

The aim of this study is to understand and redefine the nature of architectural environment within the paradigm of natural science. The chaos theory non-equilibrium thermodynamics theory self-organization of modern physics offer new insights to explain not only natural phenomena but also to define creative and dynamic architectural environment. First natural laws in modern physics like the arrow of time but is related not only with certainty but also possibility so nature is understood as a constantly changing process of evolution. Second the new architectural environment is defined as a kind of fluid and irreducible organic biosytem that cannot be fully understood by modernist idea of architecture. It is conceived of as a fluid constantly changing self-oraganizing system that consists of different situations events movements and programs in uncertain and irreducible time frame. Third insights and implications of natural science offer new language and strategy for design and the two disciplines can be understood as interdependent and co-evolving

• Molecules and Cells
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• v.37 no.2
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• pp.95-99
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• 2014

Cancer is unique amongst human diseases in that its cellular manifestations arise and evolve through the acquisition of somatic alterations in the genome. In particular, instability in the number and structure of chromosomes is a near-universal feature of the genomic alterations associated with epithelial cancers, and is triggered by the inactivation of tumour suppressor mechanisms that preserve chromosome integrity in normal cells. The nature of these mechanisms, and how their inactivation promotes carcinogenesis, remains enigmatic. I will review recent work from our laboratory on the tumour suppressor BRCA2 that addresses these issues, focusing on new insights into cancer pathogenesis and therapy that are emerging from improved understanding of the molecular basis of chromosomal instability in BRCA2-deficient cancer cells.

• Journal of Contemporary Eastern Asia
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• v.15 no.1
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• pp.64-77
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• 2016

This case study takes a look at the hyperlink networks extracted from the websites of 367 international non-governmental organizations (NGOs) with datasets from 2010, 2012 and 2014. The first level of evaluation focuses on connections between the NGOs, identifying important nodes, groups and their relations. The second level takes into account the broad range of networked websites from the World Wide Web delivering insights into general networking patterns. The third level explores the underlying spatial configurations of the network which offers a great variety of geographic insights on information flows between and within continents, countries and cities. The most interesting findings of this study are a low level of interconnectedness between the NGOs and at the same time a strong spatial concentration of all embedded network actors.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1307-1313
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• 2015

Colangiocarcinoma (CCA) is a progressively fatal disease which generally occurs due to malignant transformation of hepatic biliary cholangiocytes. The incidence of CCA has been increasing worldwide and there is an urgent requirement for effective diagnosis and treatment strategies against this devastating disease. Different factors including liver-fluke infestation, viral hepatitis, exogenous nitrosamine-mediated DNA damage, and chronic inflammation have been linked to CCA genesis. However, the risk factors and underlying complex mechanisms leading to development of CCA are not sufficiently understood to devise an effective targeted treatment therapy. In this review, we summarize currently known epidemiological and pathological aspects of the disease and briefly describe various potential biomarkers and experimental anticancer phytochemicals related to CCA research. In addition, we also sum up recent findings that link chronic inflammation of hepatic biliary cholangiocytes with CCA. The collective information concisely presented in this article would provide useful insights into the current understanding of this cancer.

• The Journal of Information Systems
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• v.24 no.3
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• pp.115-131
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• 2015

Purpose The purpose of this study is to introduce U-CAAM(University-Competence Assessment & Accreditation Management) system which is designed to effectively manage extracurricular education programs in a university. Extracurricular education is known to be very important to increase core competences of students who have different levels of knowledge and skills as well as career plans. Design/methodology/approach In this study, U-CAAM system which is designed and developed to tackle the problems related to university extracurricular education is introduced. The case will give meaningful insights to those universities which consider to have similar environment. The survey is conducted to show the need to a systematic management environment to effectively manage the problems with operating extracurricular education programs. Findings The survey result shows that universities understand the need to manage extracurricular education programs effectively. Implementation of U-CAAM provides the practical insights related to this issue.

• Archives of Plastic Surgery
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• v.47 no.3
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• pp.203-208
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• 2020

Vascular anomalies are congenital localized abnormalities that result from improper development and maintenance of the vasculature. The lesions of vascular anomalies vary in location, type, and clinical severity of the phenotype, and the current treatment options are often unsatisfactory. Most vascular anomalies are sporadic, but patterns of inheritance have been noted in some cases, making genetic analysis relevant. Developments in the field of genomics, including next-generation sequencing, have provided novel insights into the genetic and molecular pathophysiological mechanisms underlying vascular anomalies. These insights may pave the way for new approaches to molecular diagnosis and potential disease-specific therapies. This article provides an introduction to genetic testing for vascular anomalies and presents a brief summary of the etiology and genetics of vascular anomalies.

• Proceedings of the Korean Nuclear Society Conference
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• 1998.05a
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• pp.862-868
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• 1998

Korean Next Generation Reactor(KNGR) is a standardized evolutionary Advanced Light Water Reactor design under development Korea Power Company(KEPCO). It incorporates design enhncements such as active and passive advanced design features(ADFs) to increase the plant safety. A Preliminary level 1 Probabilistic Safety Assessment(PSA) has been performed for KNGR to examine the effect of these safety features. The preliminary PSA result shows that it meets the KNGR safety goal on core damage frequency(CDF). The result of this safety assessment shows that the four-train safety systems, and the ADFs such as Passive Secondary Cooling System (PSCS) contributes greatly to the reduction the CDF. Furthermore, several design changes are made or proposed for detailed review based on the PSA insights.

• Korean System Dynamics Review
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• v.9 no.1
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• pp.33-56
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• 2008

With emphasis on the importance of systems thinking for the establishment of learning organization, Senge in his famous book "The Fifth Discipline", explains in depth four disciplines such as personal mastery, mental models, shared vision, team learning, which are all geared up to the implementation of learning organization. However, two critical pitfalls are found: First, a holistic picture is absent in his presentation of learning organization, which just seems like a puzzle with linking pieces missing between disciplines. Secondly, as is often the case too much details are discussed in expense of insights on each discipline. This paper thus attempts to draw core metaphysical insights underlying Senge's learning organization disciplines by reinterpreting them from oriental perspectives; and to identify mechanisms depicting how they are working together as a whole, which is enabled by exploiting causal loop diagrams as a tool of systems thinking. In addition some thoughts on the implications of systems thinking on each of the learning organization disciplines.

• Smart Structures and Systems
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• v.5 no.6
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• pp.591-612
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• 2009

New insights are presented in simplified modeling and analysis of free vibrations of piezoelectric - based smart structures and systems. These consist, first, in extending the wide used piezoelectric-thermal analogy (TA) simplified modeling approach in currently static actuation to piezoelectric free-vibrations under short-circuit (SC) and approximate open-circuit (OC) electric conditions; second, the popular piezoelectric strain induced - potential (IP) simplified modeling concept is revisited. It is shown that the IP resulting frequencies are insensitive to the electric SC/OC conditions; in particular, SC frequencies are found to be the same as those resulting from the newly proposed OC TA. Two-dimensional plane strain (PStrain) and plane stress (PStress) free-vibrations problems are then analyzed for above used SC and approximate OC electric conditions. It is shown theoretically and validated numerically that, for both SC and OC electric conditions, PStress frequencies are lower than PStrain ones, and that 3D frequencies are bounded from below by the former and from above by the latter. The same holds for the modal electro-mechanical coupling coefficient that is retained as a comparator of presented models and analyses.

• Clinical and Experimental Pediatrics
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• v.61 no.12
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• pp.375-380
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• 2018

With the increase in the prevalence of overweight and obesity worldwide, early adiposity rebound, which is known to have a strong association with obesity, has recently been a focus of research. Early adiposity rebound is conventionally known to have a close relationship with non-communicable diseases. However, novel insights into early adiposity rebound have implied an acceleration of growth and puberty, which is directly reflected in the trends in the timing of adiposity rebound, in the 21st century compared with in the past. Furthermore, the observation that lean mass changes rather than fat mass changes show a more similar pattern to body mass index trajectories is interesting. In this article, the later outcomes and risk factors of early adiposity rebound are briefly summarized, and the current trends in the timing of adiposity rebound and novel insights into its relationship with body composition are reviewed.