• Title/Summary/Keyword: Insights

Search Result 4,105, Processing Time 0.029 seconds

Using Mean Residual Life Functions for Unique Insights into Strengths of Materials Data

  • Guess Frank M.;Zhang Xin;Young Timothy M.;Leon Ramon V.
    • International Journal of Reliability and Applications
    • /
    • v.6 no.2
    • /
    • pp.79-85
    • /
    • 2005
  • We show how comparative mean residual life functions (MRL) can be used to give unique insights into strengths of materials data. Recall that Weibull's original reliability function was developed studying and fitting strengths for various materials. This creative comparing of MRL functions approach can be used for regular life data or any time to response data. We apply graphical MRL's to real data from tests of tensile strength of high quality engineered wood.

  • PDF

Identification of Differentially Expressed Genes in the Dicer 1 Knock-down Mouse Embryos using Microarray

  • Lee, Jae-Dal;Cui, Xiang-Shun
    • Reproductive and Developmental Biology
    • /
    • v.32 no.4
    • /
    • pp.229-235
    • /
    • 2008
  • Silencing of Dicer1 by siRNA did not inhibit development up to the blastocyst stage, but decreased expression of selected transcription factors, including Oct-4, Sox2 and Nanog, suggesting that Dicer1 gene expression is associated with differentiation processes at the blastocyst stage (Cui et al., 2007). In order to get insights into genes which may be linked with microRNA system, we compared gene expression profiles in Gapdh and Dicer1 siRNA-microinjected blastocysts using the Applied Biosystem microarray technology. Our data showed that 397 and 737 out of 16354 genes were up- and down-regulated, respectively, following siRNA microinjection (p<0.05), including 24 up- and 28 down-regulated transcription factors. Identification of genes that are preferentially expressed at particular Dicer1 knock down embryos provides insights into the complex gene regulatory networks that drive differentiation processes in embryos at blastocyst stage.

Silver ICT Trends and Policy Implications (실버ICT 동향과 정책적 시사점)

  • Han, Hyun-Soo
    • Journal of Information Technology Applications and Management
    • /
    • v.21 no.4_spc
    • /
    • pp.501-516
    • /
    • 2014
  • Rapidly shifting to aging population is a global trend, and one of the challenging issue for the government, business and welfare perspective. In this paper, we focus on application potentials of information and communication technologies, to capture the insights for effectively coping with population aging issue. As the research for silver ICT field is rather limited, we adopt case study research method to extract policy implications and related foundation research agenda. As such, we first investigated comprehensive up-to-date trends, cases for innovative ICT applications, and policy initiatives mainly from the works of OECD nations. With reference to the review findings, we propose policy implications and guidelines for ICT innovations which contributes better quality of life and continuing job opportunities for silver population. The results provides insights for government policy initiative and further research in silver ICT area.

Assembled and Annotated Genome of Plasmodiophora brassicae with Insights into Developmental Stage-Specific

  • Schwelm, Arne
    • 한국균학회소식:학술대회논문집
    • /
    • 2015.05a
    • /
    • pp.23-23
    • /
    • 2015
  • Plasmodiophora brassicae is a major disease threat for Brassica oil and vegetable crop production worldwide. The causal agent is a Plasmodiophorid, which are obligate biotrophic plant-pathogenic protists in the Rhizarian kingdom. Although the Plasmodiophorids include other important agricultural pathogens such as Polymyxa betae, Spongospora subterranea, their biology remains poorly understood due to their intracellular biotrophic life style. I will present the assembled and annotated genome of P. brassicae, with insights into developmental stage-specific. We provide the first genomic data for pathogenic Rhizaria. The exploitation of the life stage specific transcripts will shed light in the understanding of the life cycle at a molecular basis, which will in the long run help to understand and control club root disease. Our data also fill an important gap for the understanding of the eukaryotic tree of life, since this is only the third genome of the eukaryotic kingdom of Rhizaria.

  • PDF

Protein Interaction Databases and Its Application (단백질 상호작용 데이터베이스 현황 및 활용 방안)

  • Kim, Min Kyung;Park, Hyun Seok
    • IMMUNE NETWORK
    • /
    • v.2 no.3
    • /
    • pp.125-132
    • /
    • 2002
  • In the past, bioinformatics was often regarded as a difficult and rather remote field, practiced only by computer scientists and not a practical tool available to biologists. However, the various on-going genome projects have had a serious impact on biological sciences in various ways and now there is little doubt that bioinformatics is an essential part of the research environment, with a wealth of biological information to analyze and predict. Fully sequenced genomes made us to have additional insights into the functional properties of the encoded proteins and made it possible to develop new tools and schemes for functional biology on a proteomic scale. Among those are the yeast two-hybrid system, mass spectrometry and microarray: the technology of choice to detect protein-protein interactions. These functional insights emerge as networks of interacting proteins, also known as "pathway informatics" or "interactomics". Without exception it is no longer possible to make advances in the signaling/regulatory pathway studies without integrating information technologies with experimental technologies. In this paper, we will introduce the databases of protein interaction worldwide and discuss several challenging issues regarding the actual implementation of databases.

From Gas Phase Clusters to Nanomaterials: An Overview of Theoretical Insights

  • Kim, Kwang-S.
    • Bulletin of the Korean Chemical Society
    • /
    • v.24 no.6
    • /
    • pp.757-762
    • /
    • 2003
  • Since theoretical investigations of gas phase clusters enable the evaluation of intrinsic molecular properties and intermolecular interactions, one can predict the macroscopic properties of bulk matter, from a microscopic determination of the properties of individual atoms, molecules, or clusters. Based on the insights obtained from theoretical investigations of the properties of a large number of cluster systems (ranging from simple water clusters to large π-systems), we have investigated the properties of various novel molecular systems including endo/exohedral fullerenes, nanotori, nonlinear optical materials, ionophores/receptors, polypeptides, enzymes, organic nanotubes, nanowires, and electronic and nano-mechanical molecular devices. The present minireview highlights some of the interesting results obtained in the course of our extensive theoretical investigations of clusters and nanomaterials.