• BMB Reports
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• 제38권4호
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• pp.486-490
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• 2005

Genetic factors are important in the pathogenesis of coronary artery disease (CAD). Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism is one of the genetic factor found to be related with CAD. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD. Threehundred and seven patients (187 males and 120 females, aged between 35-80, mean $54.3{\pm}9.8$ years) who underwent diagnostic coronary angiography were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. Of the 307, 176 had CAD. The most frequently observed genotype in all subjects was ID (47.9 %). However, in patients with CAD the frequency of II genotype was lower whereas DD genotype was higher compared to the controls (p < 0.05). The number of D allele carrying subjects were also higher (p < 0.05) in CAD patients. The logistic regression analysis indicated that the ACE D allele is an independent risk factor (odds ratio = 1.48, 95% CI = 1.01-2.18, p < 0.05). In conclusion, the I/D polymorphism of ACE gene (carrying D allele) is an independent risk factor for CAD in the studied Turkish population.

• 정보처리학회논문지A
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• 제9A권2호
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• pp.225-230
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• 2002

제한된 경쟁삭제 문제는 집합연산 문제의 간단한 형태의 하나로서, 경쟁삭제 문제에서 삽입연산을 제외한 것이다. 현재 경쟁삭제 문제에 대해서는 최적의 순차 알고리즘이 개발되어 있으며, 병렬 알고리즘의 경우 O(n/loglogn)개의 처리기를 사용하여 $O(log^2nloglogn)$에 수행되는 알고리즘이 개발되어 있다. 본 논문에서는 제한된 경우의 경쟁삭제 문제를 해결하기 위한 재구성 가능 메쉬 알고리즘을 제시한다. 제안된 알고리즘은 $n{\times}n$ 재구성 가능 메쉬에서 상수시간에 수행되며, 이 결과는 $AT^2$ 퇴적이다.

• 말소리와 음성과학
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• 제1권3호
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• pp.3-18
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• 2009

Do loanword properties emerge in the acquisition of a foreign language and if so, how? Classic studies in adult language learning assumed loanword properties that range from near-ceiling to near-chance level of appearance depending on speech proficiency. The present research argues that such variations reflect different phonological types, rather than speech proficiency. To investigate the difference between learner speech and loanword phonology, the current research analyzes the speech data from five different proficiency levels of 92 Korean speakers who read 19 pairs of English words and sentences that contained loanwords. The experimental method is primarily an acoustical one, by which the phonological cause in the loanwords (e.g., the insertion of [$\Box$] at the end of the word stamp) would be attested to appear in learner speech, in comparison with native speech from 11 English speakers and 11 Korean speakers. The data investigated for the research are of segment deletion, insertion, substitution, and alternation in both learner speech and the native speech. The results indicate that learner speech does not present the loanword properties in many cases, but depends on the types of phonological causes. The relatively easy acquisition of target pronunciation is evidenced in the cases of segment deletion, insertion, substitution, and alternation, except when the loanword property involves the successful command of the target phonology such as the de-aspiration of [p] in apple. Such a case of difficult learning draws a sharp distinction from the cases of easy learning in the development of learner speech, particularly beyond the intermediate level of proficiency. Overall, learner speech departs from loanword phonology and develops toward the native speech value, depending on phonological contrasts in the native and foreign languages.

• 한국공간정보시스템학회 논문지
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• 제7권3호
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• pp.55-65
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• 2005

본 논문은 이동체의 잦은 갱신에 의해 발생하는 색인 재구성에 대한 비용을 줄이기 위해 이동체의 지연 다량 삽입 기법을 제안한다. 기존 이동체 색인에 대한 연구는 주로 색인 구성 후에 발생하는 질의 처리 효율성에 초점을 두었다. 이들은 이동체 데이터의 갱신 연산에 의한 색인 재구성에 대한 디스크 접근 오버헤드를 거의 고려하지 않았다. 이러한 이동체 데이터의 갱신 연산에 대한 비용을 줄이기 위해 다량 삽입 기법과 여러 색인이 제안되었다. 하지만 제안된 기법들은 매우 가변적이고 대량인 데이터를 효율적으로 처리하는데 많은 디스크 I/O 비용을 필요로 한다. 본 논문에서는 빠른 데이터 생성 속도에 적합하도록 디스크 접근 오버헤드를 고려해서 R-트리를 관리할 수 있는 현재색인에 대한 다량 삽입 기법을 제안한다. 이 기법에서는 다차원 색인 구조에서의 다량 삽입 기법을 위한 버퍼링 기법을 사용한다. R-트리의 단말 노드 정보를 관리하는 보조 색인을 추가하여 노드의 분할과 합병을 예상한다. 또한 연산을 종류에 따라 분류하여 불필요한 삽입과 삭제 연산을 줄인다. 노드의 변환를 최소화하는 방향으로 이동 객체의 처리 순서를 정하여 데이터 갱신에 따른 노드의 분할과 합병을 최소화한다. 실험을 통해 제안한 기법을 이용한 다량 삽입 기법이 기존의 삽입 기법들보다 색인의 갱신 비용을 감소시키는 것을 알 수 있다.

• The Plant Pathology Journal
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• 제22권3호
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• pp.215-221
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• 2006

Gibberella zeae (anamorph: Fusarium graminearum) is an important pathogen of cereal crops. This fungus produces a broad range of secondary metabolites, including polyketides such as aurofusarin (a red pigment) and zearalenone (an estrogenic mycotoxin), which are important mycological characteristics of this species. A screen of G. zeae insertional mutants, generated using a restriction enzyme-mediated integration (REMI) procedure, led to the isolation of a mutant (Z43R606) that produced neither aurofusarin nor zearalenone yet showed normal female fertility and virulence on host plants. Outcrossing analysis confirmed that both the albino and zearalenone-deficient mutations are linked to the insertional vector in Z43R606. Molecular characterization of Z43R606 revealed a deletion of at least 220 kb of the genome at the vector insertion site, including the gene clusters required for the biosynthesis of aurofusarin and zearalenone, respectively. A re-creation of the insertional event of Z43R606 in the wild-type strain demonstrated that the 220-kb deletion is responsible for the phenotypic changes in Z43R606 and that a large region of genomic DNA can be efficiently deleted in G. zeae by double homologous recombination. The results showed that 52 putative genes located in the deleted genomic region are not essential for phenotypes other than the production of both aurofusarin and zearalenone. This is the first report of the molecular characterization of a large genomic deletion in G. zeae mediated by the REMI procedure.

• Animal cells and systems
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• 제3권4호
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• pp.393-397
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• 1999

Length variations in human mitochondrial DNA (mtDNA) offer useful markers in the study of female aspects of human population history. One such length variation is a 9-bp deletion in the small noncoding segment located between the COII and Iysine tRNA genes (COII/tRNA/$^{Lys}$ intergenic region) which usually contain two tandemly arranged copies of a 9-bp sequence (ccccctcta) in human mtDNA. The mtDNA 9-bp deletion and polymorphic variants of expanded 9-bp repeat motif in the intergenic COII/tRNA$^{Lys}$ region have been found at varying frequencies among different human ethnic groups. We have examined the length variation of the mtDNA COII/tRNA$^{Lys}$ intergenic region from a total of 813 individuals in east Asian populations. The occurrence of the 9-bp deletion was found to be relatively homogeneous in northeast Asian populations (Chinese, 14.2%; Japanese, 14.3%: Koreans, 15.5%), with the exception of Mongolians (5.1%). In contrast, Indonesians (25.0%) and Vietnamese (23.2%) of the southeast Asian populations appeared to have relatively high frequencies of the 9-bp deletion. We identified the existence of a new expanded 9-bp repeat motif which likely resulted from a slipped mispairing insertion of six more cytosines in the intergenic COII$^{Lys}$ region. It was present at low frequencies in the Korean (2/349) and Japanese populations (2/147). Based on the results of this study, the Korean population may reflect a close genetic affinity with the Japanese and Chinese populations than the others surveyed east Asian populations.

• 한국컴퓨터정보학회논문지
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• 제15권12호
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• pp.93-100
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• 2010

본 논문에서는 병렬 TCAM을 기반으로 한 IP 주소 검색 구조에서 프리픽스를 신속하게 삭제하는 기법을 제안한다. 기존의 삭제 기법들은, 프리픽스의 순서 유지와 가용 메모리 공간의 연속성 유지를 위해 한 차례 이상의 메모리 이동을 필요로 하고 있다. 본 기법에서는 삭제 시 TCAM에서 실제 메모리를 이동하지 않고, SRAM으로 구현된 스택을 사용하여 삭제된 프리픽스의 주소를 이 스택에 저장한다. SRAM은 TCAM에 비해 접근시간이 매우 짧기 때문에, 제안된 기법이 신속한 갱신을 수행할 수 있다. 그리고 실제 사용되는 포워딩 테이블과 갱신 내용을 적용한 실험을 통해, 프리픽스 삽입과 삭제에 따른 메모리 접근 시간의 관점에서 제안된 기법의 성능을 평가한다. 또한 상대적으로 매우 작은 크기의 스택을 사용해도 좋은 성능을 나타내고 있음을 실험 결과를 통해 제시한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5249-5252
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• 2014

Nogo protein, encoded by gene reticulon-4 (RTN4), includes three major isoforms by different splicing, named Nogo-A Nogo-B and Nogo-C. Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. RTN4 single nucleotide polymorphisms (SNPs) can influence the efficiency of transcription and translation thus being related with an individual's predisposition to cancer. The CAA insertion/deletion polymorphism (rs34917480) within RTN4 3'-UTR has been reported to be associated with many cancer types. In order to investigate the relationship between this polymorphism and susceptibility to non-small cell lung cancer (NSCLC) in the Chinese population, we conducted the present case-control study including 411 NSCLC patients and 471 unrelated healthy controls. The genotype distributions were significantly different between cases and controls (p=0.014). We found that the del allele could significantly increase NSCLC risk (ins/ins vs ins/del: p=0.007, OR 1.46, 95%CI=1.11-1.93; dominant model: p=0.004, OR 1.47, 95%CI=1.13-1.92 and allele model: p=0.008, OR 1.35, 95%CI=1.08-1.67). This association was stronger in participants over 60 years old, males and smokers. We therefore conclude that the CAA insertion/deletion polymorphism (rs34917480) contributes to non-small cell lung cancer risk in Chinese population. Age, sex and environmental exposure are also related to carcinogenic effects of rs34917480.

• 식물분류학회지
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• 제51권2호
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• pp.176-180
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• 2021

Arabidopsis thaliana (L.) Heynh. is a small plant species that serves as a model organism of plant biology and genetics. Here, we present the first complete mitochondrial genome of Korean A. thaliana natural isolate (named as 180404IB4), which is 368,875 bp long and contains 58 genes (33 protein-coding genes, 22 tRNAs, and three rRNAs), with a GC ratio of 44.8%. Sixty-four single-nucleotide polymorphisms and 11 insertion and deletion regions (1,089 bp in length) are identified against the Col-0 ecotype, showing one large insertion of 1,069 bp without structural variation. Phylogenetic trees constructed from 30 conserved genes indicate that the 180404IB4 mitochondrial genome is clustered with Col-0 and three East Asian ecotypes.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2007년도 Proceedings of ISRS 2007
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• pp.3-5
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• 2007

Many continuous queries are important to be process efficiently in a data stream environment. It is applied a query index technique that takes linear performance irrespective of the number and width of intervals for processing many continuous queries. Previous researches are not able to support the dynamic insertion and deletion to arrange intervals for constructing an index previously. It shows that the insertion and search performance is slowed by the number and width of interval inserted. Many intervals have to be inserted and searched linearly in a data stream environment. Therefore, we propose Hashed Multiple Lists in order to process continuous queries linearly. Proposed technique shows fast linear search performance. It can be utilized the systems applying a sensor network, and preprocessing technique of spatiotemporal data mining.