• Journal of Pharmaceutical Investigation
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• 제22권3호spc1호
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• pp.35-47
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• 1992

Hydrogel coated ring shaped ocular inserts (containing the antibiotic, tylosin tartrate) were used in an evaluation of the effectiveness of polymeric ocular drug release devices for treating infectious bovine keratoconjunctivitis. The in vivo experiments represent the first experiments using hydrogel ocular inserts containing an antibiotic for treating infectious bovine keratoconjunctivitis. In the infection tests, ten calves. were challenged with $2.4{\times}10^8{\sim}1.6{\times}10^9$ Moraxella bovis (a bacterium) colonies per eye following two ten minute ultraviolet radiation eye preconditioning exposures. Ninety five percent of the eyes (19 of 20 eyes) were successfully infected by this method. All infected eyes were monitored for the presence of the bacteria quantitiatively, and clinical observations were made for 14 days. The test was performed by three consecutive steps: 1) inoculation with 2 ultraviolet (UV) radiations, 2) growth of bacterial colonies and 3) treatment with medicated ring-shaped devices. The first. bacteriological measurements after 2 UV exposures were performed at day 3 of the tests. At day 7 after inoculation of both eyes of a calf with M. bovis, a medicated or a non-medicated ring-shaped device was inserted into each eye of a calf. The eye receiving the non-medicated ring was taken as a control for comparison with the eye that received a medicated ring. During the next 7 day period following a medicated ring insertion, the number of bacteria in the treated eyes dropped dramatically to negligible levels (0 to 30 colony forming units/swab), while the control eyes which received a non-medicated ring still exhibited a relatively high number of bacteria ($10^3\;to\;10^6$ colony forming units/swab). The number of bacteria was significantly reduced by the antibiotic released from the medicated ocular insert.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2009년도 추계학술대회 논문집
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• pp.119-123
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• 2009

In this paper, effects of major design parameters of cold forging dies on die mechanics are quantitatively investigated with emphasis on shrink fit using a thermoelastic finite element method. A ball-stud cold forging process found in a cold forging company is selected as a test process and the effects of die insert material, shrink fit, dimension of ring, partition of die inert and clamping force on effective stress and circumferential stress are analyzed.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2001년도 추계학술대회 논문집
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• pp.170-173
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• 2001

The design for cold extrusion dies is very important because the die insert is subjected to very high radial and hoop stresses. The design of cold extrusion dies has many constrained conditions. In this paper, two assumptions were proposed. First assumption was selected by yielding strength dependent on the to hoop stress of each ring in dies. Second assumption is that the maximum inner pressure is determined when yielding occurs in one ring of dies. To obtain the maximum inner pressure the flexible tolerance method was applied. A comparison of design values between the proposed method and the conventional method has been discussed.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2003년도 춘계학술대회논문집
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• pp.19-22
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• 2003

In this study, the design of prestressed die for spur gear forging have been investigated. The stress concentration at notch of the die insert is very important in the design of die for the forging of spur gear such as non-axisymmetric geometry. In the previous study, the flexible tolerance method was used in order to search the optimal value of design variables considering the constrain conditions. In the design process, it was also involved the safety factor to the yield strength of each ring by considering allowable tensile or compressive hoop stress in each ring. Using this technique, the die deign for spur gear forging has been successfully performed without yielding of the die after shrink fitting and during forging.

• Clinical and Experimental Pediatrics
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• 제45권2호
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• pp.261-266
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• 2002

저자들은 출생 후 호흡기 증상이 지속되어 오던 여아가 respiratory syncytial virus와 b형 헤모필루스 인플루엔자균에 의한 하기도 감염에 이환되면서 생후 4개월에 혈관륜으로 진단된 1예를 보고하는 바이다. 환아는 출생 후 협착음과 천명음 등의 잦은 호흡기 증상을 보였고, 3개월에 호흡 곤란을 주소로 입원하였으며 respiratory syncytial virus에 의한 세기관지염으로 치료받고 호전되었다. 퇴원 후 증상이 다시 악화되어 재입원 하였으며 b형 헤모필루스 인플루엔자균에 의한 기관염 및 폐렴이 확인되었고, 치료를 위해 기관내 튜브에 도관 삽입을 시도하였을 때 하부 기도에서 저항감이 감지되어 기도 부위의 해부학적 기형을 의심하게 되었다. 3차원 흉부 단층 촬영에서 이중 대동맥궁으로 인한 혈관륜이 확인되었고, 교정 수술을 시행한 후 좋은 경과를 보이고 있다.

• 한국산학기술학회논문지
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• 제14권12호
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• pp.6060-6065
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• 2013

유효 전단면의 크기를 최대가 되도록 하기 위해서는 다이 롤 높이의 최소화가 매우 중요하다. 본 연구에서는 V-링 압입량의 변화와 클리어런스의 변화에 대한 다이 롤 변화를 연구하였다. V-링 거리를 2mm로 고정하고 클리어런스가 다른 다이인서트를 적용할 수 있는 파인블랭킹 금형을 제작하여 전단해석과 실험을 진행하였다. 각 실험으로부터 시편을 채취하여 다이 롤 높이를 분석한 결과 V-링의 압력이 재료의 유동을 효과적으로 억제하고 펀치와 다이 사이의 클리어런스가 재료 두께에 대하여 1%의 경우가 다이 롤 높이가 낮게 됨을 알 수 있었다.

• 한국생산제조학회지
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• 제19권1호
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• pp.33-41
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• 2010

This study was aimed at the design of the dies for the unified pipe joint of the intermediate shaft using the computer simulation to shorten the period of production, on the basis of the process planning which was designed by the field experts. In the computer simulation, 'Deform-3d' and 'eesy-DieOpt' have been used, which are the commercial process analysis and die design program. Through the process analysis, we could know the propriety of the forming process, the inner pressure of the die and the suitable fitting pressure between the insert and the sleeve which was not showing any positive tangential stresses in the insert. Through the simulation of die design, we could know the number of the stress ring, the diameter ratios, the stresses of the die, the shrink fitting tolerance and temperature in the condition of the already determined maximum outer die diameter of the multi-stage former. The validity of the die design using the computer simulation was analyzed by the experiments and the results were satisfactory. As the results of this study, the new and easy die design system for multi-forging has been developed.

• 한국생산제조학회지
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• 제21권2호
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• pp.331-336
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• 2012

This study was aimed at the design of the dies for the guide valve for the fuel pressure regulator using the computer simulation to shorten the period of production, on the basis of the process planning which was designed by the field experts. In the computer simulation, 'Deform-3d' and 'Eesy-DieOpt' have been used, which are the commercial process analysis and die design program. Through the process analysis, we could know the propriety of the forming process, the inner pressure of the die and the suitable fitting pressure between the insert and the sleeve which was not showing any positive tangential stresses in the insert. Through the simulation of die design, we could know the number of the stress ring, the diameter ratios, the stresses of the die, the shrink fitting tolerance and temperature in the condition of the already determined maximum outer die diameter of the multi-stage former. The validity of the die design using the computer simulation was analyzed by the experiments and the results were satisfactory. As the results of this study, the new and easy die design system for multi-forging has been developed.

• 소성∙가공
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• 제14권8호통권80호
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• pp.675-680
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• 2005

This study was aimed at the design of the dies for the automobile part for the engine oil leakage prevention using the computer simulation to shorten the period of production, on the basis of the process planning which was designed by the field experts. In the computer simulation,'eesy-2-form' of 2D FEM simulation package and 'eesy-DieOpt' have been used, which are the commercial process analysis and die design program. Through the simulation of 'eesy-2-form', we could know the propriety of the forming process, the inner pressure of the die and the suitable fitting pressure between the insert and the sleeve which was not showing any positive tangential stresses in the insert. Through the simulation of 'eesy-DieOpt', we could know the number of the stress ring, the diameter ratios, the stresses of the die, the shrink fitting tolerance and temperature in the condition of the already determined maximum outer die diameter of the multi-stage former. The validity of the die design using the computer simulation was analyzed by the experiments and the results were satisfactory. As the results of this study, the new and easy die design system for cold forging has been developed.

• 한국정밀공학회지
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• 제16권2호통권95호
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• pp.87-94
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• 1999

The automated die design program is developed for cold forging of axisymmetric parts which are mainly produced by forward extrusion, backward extrusion, composite extrusion and upsetting. For this study, firstly classification of forged parts and investigation of die construction type usually employed in forging industry are carried out and the most proper type from several kinds of die construction is proposed as a standardized one. Based on the die design rules summarized in the references such as handbooks, technical papers, monthly journals, etc. the automated die design program was made using AutoLISP language available in AutoCAD software of personal computer. This program interactively runs for only input data, for example, forging process, shape of forged parts, type of punch, split of die insert and design of shrinkage rings and then displays details of drawings necessary to make a forging die. When a variety of forging processes and forged parts are tested to examine the validity of this program, it was confirmed to give good results applicable to the forging die design in press shop.