• Korean Journal of Clinical Pharmacy
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• v.9 no.1
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• pp.49-54
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• 1999

This study was carried out to compare the bioavailability of Hanmi clarithromycin (250 mg/tablet) with that of $Klaricid^{(R)}$ The bioavailability was examined on 20 volunteers who received a single dose (500 mg) of each drug in the fasting state in a randomized balanced 2-way crossover design. After dosing, blood samples were collected for a period of 12 hours. Plasma samples were analyzed for clarithromycin and roxithromycin(internal standard) by HPLC/Coulometric BCD. The pharmaco-kinetic parameters ($AUC_{0-l2hr}$, Cmax, Tmax, $AUC_{inf}$, Ka, Kel, $t_{1/2}$, Vd/F and Cl/F) were calculated from the plasma clarithromycin concentration-time data of each volunteer. The computer program 'WinNonlin' was used for compartmental analysis. One compartment model with first-order input, from order output with lag time, weighting factor $l/y^2$ was chosen as the appropriate pharmacokinetic model. The major pharmacokinetic parameters ($AUC_{0-l2hr},\;AUC_{inf}$, Cmax and Tmax) of Hanmi clarithromycin were $10.7\pm0.5\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;12.7\pm0.7\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;1.7\pm0.1\;{\mu}g/ml\;and\;2.0\pm0.2\;hr$, respectively, and those of $Klaricid^{(R)}\;were\;9.8\pm0.5\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;11.7\pm0.6\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;1.6\pm0.1\;{\mu}g/ml\;and\;2.1\pm0.1\;hr$, respectively. The differences in mean values of $AUC_{0-l2hr},\;AUC_{inf}$ and Cmax between two products were $9.88\%,\;8.94%\;and\;6.59\%$, respectively. The least significant differences at $\alpha=0.05$ for $AUC_{0-l2hr},\;AUC_{inf}$ and Cmax were $16.08\%,\;17.81\%\;and\;18.94\%$, respectively. Though the plasma clarithromycin concentrations of Hanmi clarithromycin were higher than those of $Klaricid^{(R)}$ at all observed times, the bioavailability of Hanmi clarithromycin appeared to be bioequivalent with that of $Klaricid^{(R)}$. The Ka, Kel, $t_{1/2}$, Vd/F and Cl/F of the Hanmi clarithromycin were $2.69\pm0.53\;hr^{-1},\;0.18\pm0.01 hr^{-1},\;3.9\;hr,\;248.8\pm11.4\;L\;and\;43.7\pm2.6\;L/hr$, respectively, and those of $Klaricid^{(R)} were 2.19\pm0.51\;hr^{-1},\;0.18\pm0.02\;hr^{-1},\;3.7\;hr,\;266.7\pm22.4\;L\;and\;45.3\pm2.8L/hr$, respectively. There were no statistically significant differences between two drugs in all pharmacokinetic parameters.

• Korean Journal of Comparative Education
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• v.26 no.4
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• pp.173-198
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• 2016

The purpose of this study is to analyze the characteristics of Educational Reforms Policy in lately Japan and to evaluate it. Especially focus on the activities of the [MEXT; Ministry of Education, Culture, Sports, Science and Technology] and [CCE;The Central Council for Education] This article composed of five chapters; Implication and problem situation, History of the Japanese educational reforms, the characteristics in the site of process of educational reforms policy, evaluation on the main policies, and Conclusion(contain the suggestion for Korea). The method of study composed of the literature search and interview. The System Analysis[input-process-output-feedback] is used as a model of the analyze the characteristics of educational reforms policy. By the new Basic Act on Education, the principles of educational administration is changed. Education administration shall be carried out in a fair and proper manner through appropriate role sharing and cooperation between the national and local governments(Article 16). As a conclusion, The initiative in the establishment of educational reform plans has gone over to the cabinet side from MEXT. And evaluate the five policies. That is Japan's Basic Plan for the Promotion of Education, The new Basic Act on Education(enacted on 2006), Provincial Governor's (Tokyo & Oska) Educational Reform Plan, Reform plan of the Boards of Education, and Improvement Policy of the Quality of Teachers.

• Korean Journal of Comparative Education
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• v.27 no.1
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• pp.247-284
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• 2017

The purpose of this study is to analyze firm's motivation of participating and investing in apprenticeship in Germany and Korea, and to investigate institutional factors influencing firm's motivation. By comparing institutional factors of the two countries, it aims to drawing out policy implications for improving Korean apprenticeship. The main method for data collection was comprehensive literature review on international organizations, each countries' government and research institutes' policy materials, statistical data, research outputs and media resources related to each countries' apprenticeship. Considering whether firm's motivation for participating and investing in apprenticeship is production-oriented or investment-oriented, Germany is more inclined to investment motivation with firm's covering net cost during apprenticeship period. On the other hand, Korea is more inclined toward production orientation with firm's expectation of gaining net profit during the training period. Why is firm's training motivation different in these two countries? The author tried to find the reason from the difference of institutional factors of the countries by dividing institutional factors into 4 categories: context(tripartite relations, legal framework), input (flexibility of the system, government incentive), process(training contents, training duration, quality assurance), and output(completion/retention rate, apprentice's productivity). The key implication from the comparative analysis of institutional factors is that it is necessary to enforce companies to have "accountability" on the minimum critical elements, but also to ensure them to have "autonomy" on the rest of the elements.

• Korean Journal of Comparative Education
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• v.27 no.1
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• pp.29-49
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• 2017

The purpose of this study is to analyze the characteristics and implications of the quality management policy through teachers' entire life in Japan case study. This article composed of four chapters; Implication and problem situation, Backgrounds and streams of the japanese teacher reform policy, Characteristics of the main policies about managing the teacher's quality through their life, and Conclusion(Japanese characteristics and the suggestion for Korea). The main quality management policy means the various teacher recruitment and selection system, Merit system of personnel management, Effective management of a system for teachers performing unsatisfactorily, Professional development for teachers with new and 10 years' experience, and Teacher Certificate Renewal System every ten years. The method of study composed of the literature search and interview. The System Analysis[input-process-output-feedback] is used as a model of the analyze the policy process[backgrounds & T.O-quality management system-japanese teacher's reaction & implications to korea] The Central Council for Education(CCE;2012.8.28) has released "An Outline of Measures for Comprehensively Improving the Quality and Ability of Teachers throughout their career". This report can be regarded as a blueprint for the teacher reform policy in japan. As a conclusion, Ten lessons is proposed for the Korea policy improving the quality and ability of teachers(training, employment, and development).

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.10
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• pp.159-168
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• 2019

This study draws on goal orientation theory and proposes the team learning goal orientation as an antecedent of team creativity. In addition, an Input-Process-Output (IPO) model was adopted, in which the team reflexivity, team efficacy, and positive group affective tone (PGAT) are linking mechanisms in the relationship between team learning goal orientation and team creativity. Using 57 teams from three lectures of the college, hierarchical regression analysis was conducted at the team level. The results showed that the team learning goal orientation had positive associations with team creativity, team reflexivity, and team efficacy. In addition, team reflexivity and team efficacy positively predicted the team creativity. Furthermore, the relationship between team learning goal orientation and team creativity was mediated by the team reflexivity and team efficacy. In contrast to predictions, PGAT did not show significant relations with both team learning goal orientation and team creativity. In conclusion, this study integrated the team-learning goal orientation and team creativity literature and contributes to the understanding of team reflexivity as a cognitive process and team efficacy as a motivational process between the team property and team creativity. These results have practical implications for managing teams.

• Journal of Korea Port Economic Association
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• v.30 no.1
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• pp.23-55
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• 2014

The purpose of this paper is to show the clustering trend and to choose the clustering ports for 3 Korean ports(Busan, Incheon and Gwangyang Ports) by using the self organizing maps based on neural network(SOM) and Tier models for 38 Asian ports during 11 years(2001-2011) with 4 input variables(birth length, depth, total area, and number of crane) and 1 output variable(container TEU). The main empirical results of this paper are as follows. First, clustering results by using SOM show that 3 Korean ports[Busan(26.5%), Incheon(13.05%), and Gwangyang(22.95%) each]can increase the efficiency. Second, according to Tier model, Busan(Hongkong, Sanghai, Manila, and Singapore), Incheon(Aden, Ningbo, Dabao, and Bangkog), and Gwangyang(Aden, Ningbo, Bangkog, Hipa, Dubai, and Guangzhou) should be clustered with those ports in parentheses. Third, when both SOM and Tier models are mixed, (1) efficiency improvement of Busan Port is greater than those of Incheon and Gwangyang ports. (2) Incheon port has shown the slow improvement during 2001-2007, but after 2008, improvement speed was high. (3) improvement level of Gwangyang port was high during 2001-2003, but after 2004, improvement level was constantly decreased. The policy implication of this paper is that Korean port policy planner should introduce the SOM, and Tier models with the mixed two models when clustering among the Asian ports for enhancing the efficiency of inputs and outputs.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.6
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• pp.25-32
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• 2021

In this study, it proposes a mode converter that is relatively easy to implement and can shorten the transmission line length of the final combining port and it was fabricated and tested by applying it to an 8-way spatial combiner. The proposed mode converter converts the signal converted from the doorknob-shaped circular disk connected to the ground into the TM₀₁ mode by opening it in the circular waveguide. The 8-way waveguide spatial combiner is designed and implemented so that 8 signals input from the H-plane are combined in a circular waveguide at the center, and the final combining mode is TM₀₁. The test results confirmed excellent performance with an insertion loss of less than 0.4dB and a combining efficiency of 95% or more. In addition, it was confirmed that it is suitable for high output by calculating the breakdown voltage and discharge threshold power of the new mode conversion structure through electric field analysis. The results confirmed through this study are expected to be applicable to high-power, high-efficiency SSPA in various fields in the future.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.31 no.5
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• pp.875-888
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• 2021

In this paper, we search integral distinguishers of lightweight block cipher PIPO and propose a key recovery attack on 8-round PIPO-64/128 with the obtained 6-round distinguishers. The lightweight block cipher PIPO proposed in ICISC 2020 is designed to provide the efficient implementation of high-order masking for side-channel attack resistance. In the proposal, various attacks such as differential and linear cryptanalyses were applied to show the sufficient security strength. However, the designers leave integral attack to be conducted and only show that it is unlikely for PIPO to have integral distinguishers longer than 5-round PIPO without further analysis on Division Property. In this paper, we search integral distinguishers of PIPO using a MILP-aided Division Property search method. Our search can show that there exist 6-round integral distinguishers, which is different from what the designers insist. We also consider linear operation on input and output of distinguisher, respectively, and manage to obtain totally 136 6-round integral distinguishers. Finally, we present an 8-round PIPO-64/128 key recovery attack with time complexity 2^124.5849 and memory complexity of 2⁹³ with four 6-round integral distinguishers among the entire obtained distinguishers.

• Journal of Korea Port Economic Association
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• v.37 no.1
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• pp.19-30
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• 2021

The 21st Century Maritime Silk Road (MSR) is an important part of Belt and Road Initiative(BRI). As an economic and trade corridor for dozens of countries in Asia, Europe and Africa, and the port as an important link node, the efficiency of port operation directly affects the implementation of BRI's strategy. On the basis of combining BRI and related evaluation methods of port efficiency, this paper uses DEA-BCC model to select port production berth number and production berth length as input index container throughput and cargo throughput as output index to analyze the port efficiency of 14 ports in China. The results show that: (1) The overall efficiency level of the ports along the MSR is relatively low. Most of the ports have not reached the DEA efficiency and there are different degrees of problems in scale investment and technological improvement. However, this situation is accompanied by the implementation of China's maritime cooperation strategy and becoming better year by year. (2) The low operating efficiency of ports along China's MSR is mainly due to the lack of coordination between scale efficiency and technical efficiency, which is caused by insufficient scale investment in the port itself, weak economic linkage between the hinterland and the port, (3) Whether a port has a strong comprehensive strength does not entirely depend on the cargo throughput or scale but also includes the port's operating efficiency.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.6
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• pp.169-180
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• 2018

White light-emitting diodes (LEDs) are more economical than fluorescent lights, and provide high brightness, a high lifetime expectancy, and greater durability. As LEDs are closely connected with people's daily lives, dimming control of LED is an important component in providing energy savings and improving quality of life. In visible light communications systems using these LEDs, multiple input multiple output (MIMO) technology has attracted a lot of attention, in that it can attain the channel capacity in proportion to the number of antennas. This paper analyzes the power performance of three kinds of modulation in visible light communications (VLC) systems applied space-time block code (STBC) techniques. The modulation schemes are return-to-zero on-off keying (RZ-OOK), variable pulse position modulation (VPPM), and overlapping pulse position modulation (OPPM), and dimming control was applied. The power requirements and power consumption were used as metrics to compare the power efficiency in $2{\times}2$ STBC-VLC environments under the three kinds of modulation. We confirm that dimming control affects the communications performance of each modulation scheme. VPPM showed greater consumption among the three modulations, and OPPM showed energy savings comparable to VPPM.