• Journal of Preventive Medicine and Public Health
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• v.17 no.1
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• pp.75-83
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• 1984

A retrospective study has been made of 170,026 cases of motor vehicle accidents which had been reported to the National Police Headquarters of Republic of Korea, 1983. Also a study has been made of 264 cases of road traffic casualties who were treated at the Eul-ji General Hospital from Jan. 1, 1983 to Dec. 31, 1983. This study was conducted to find out the nature and pattern of the traffic accidents from the clinical and epidemiological view points. In additions, the modes of injury from the road accidents were persued which might help to reduce the traffic accident rate. The results of the study were summarized as follows; 1. In this study, the highest incidence was in the age group between $21{\sim}30$ years (21.29%). And the age group of highest death rate was under 10 years (7.28%). 2. In the comparison of sexual differences, male was dominated in accidents number and death rate. (Casualty rate; 61.66%). 3. In the comparison of each hour differences, the accident was mostly occured during afternoon from 16:00 to 18:00(12.23%). 4. The most common day of week was Sunday (14.74%). 5. The most common season of year was Autumn (27.92%). 6. In the comparison of occupational differences, the high incidences were showed in labor men (31.06%) and business men (12.12%). 7. In the comparison of accidental vehicles, the most common vehicle were cars and the next were trucks and buses. 8. The most common mechanism of accidents was collision (57.41%). 9. In the comparison of clinical differences, orthopaedic and neurosurgical injuries were most common types of the hospitalized casualties. 10. In the comparison of anatomical fracture sites, the most common site was tibia (15.81%) and the next site was femur (12.56%).

• Journal of Preventive Medicine and Public Health
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• v.22 no.1 s.25
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• pp.102-115
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• 1989

The purpose of this study was to find out morbidity rate and utilization pattern of medical services of sailors on a voyage. The subjects of this study were 470 sailors who are sailors' trainee and safety-trainee for embarkation in a ship. Data were collected by means of personal survey conducted from September 5 to October 30, 1988. The subjects were sailed 12.6 months on the average. During the voyage, 49.4% of the sailors had sickness more than once, and 24.7% was unable to work more than a day because of illness. The average monthly morbidity rate was 85.7 per 1,000 and the monthly prevalence rate of disease that was unable to work more than a day was 21.2 per 1,000. The sailors of 40-49 years old had the highest morbidity rate of 103.6 per 1,000/month. The number of days activity restricted due to sickness was 93.4 days per 1,000 persons, and the average duration of illness was 11.2 days per sickness. The proportion of treatment days to sickness days was 48.8%. Considering morbidity unable to work more than a day, the number of those who had traumatic injury were 17.2%, which revealed the highest rate, influenza or cold were 15.5%, and the digestive disease 11.2%. Less than half(42.1%) of patients were treated with medicine kept in the cabin. However, 2.1% was transferred by helicopter and 29.5% was treated at hospitals or clinics in nearby port. In the cabin, 67.4% of patients was cured completely.

• Journal of Veterinary Clinics
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• v.4 no.2
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• pp.473-481
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• 1987

This experiment was performed in order to establish a proper method to determine the half life of indocyanine green(ICG T$\frac{1}{2}$) and its fractional clearance rate(KICG) and investigate the applicability of indocyanine green ( ICG ) excretion test in hepatotoxicity experiment in Korean black goats. The results were as follows : 1. Maximum absorbance of ICG in plasma was at 810 nm in this experiment. 2. The coefficient of correlation between the results obtained by standard method and potassium cyanide method was 0.99 and the regression equation between two methods was y=0.9996 x＋0.0065. 3. As the disappearance curve of ICG plotted in semi-log graph revealed linear pattern at least for 6 minutes after injection, the postinjection blood samples were decided to collect at 2 and 6 minutes after ICG injection. 4. ICG T$\frac{1}{2}$ and KICG values were not affected by dose level of ICG. 5. When 0.25 mg of ICG per kg body weight was administered the normal data of ICG T$\frac{1}{2}$ and KICG in Korean black goa were 1.468${\pm}$0.197 minutes(mean${\pm}$SD) and 0.482${\pm}$0.076/minutes respectively. 6. After administration of carbon tetracholride. the ICG T$\frac{1}{2}$ started to increase acutely from day 1, revealed the peak at day 3, and then returned almostly but not completely to preinjection level at day 14. The ICG T$\frac{1}{2}$ value was suggested to be a sensitive indicator of hepatic injury in Korean black goats.

• Molecular & Cellular Toxicology
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• v.1 no.4
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• pp.275-280
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• 2005

Carbon tetrachloride ($CCl_4$) is well known hepatotoxicant. Its overdose cause severe centrilobular hepatic necrosis in human and experimental animals. We administered $CCl_{4}$ at low (0.2 mL/kg p.o.) and high (2 mL/kg p.o.) doses to mice. Mice were sacrificed at 24 h after administration. We evaluated liver toxicity by serum AST and ALT level and by microscopic observation. Using cDNA chip, we conducted gene expression analysis in liver. Mean serum activities of the hepatocellular leakage enzymes, ALT and AST, were significantly increased compare to control, respectively, in the low and high dose groups. H&E evaluation of stained liver sections revealed $CCl_{4}-related$ histopathological findings in mice. Moderate centrilobular hepatocellular necrosis was present in all $CCl_{4}$ treated mice. We found that gene expression pattern was very similar between low and high dose group. However, some stress related genes were differently expressed. These results could be a molecular signature for the degree of liver injury. Our data suggest that the degree of severity could be figure out by gene expression profiling.

• Horticultural Science & Technology
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• v.32 no.5
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• pp.607-613
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• 2014

Calcium has been associated with improved cold tolerance in many crops. The aim of this study was to investigate the changes in leaf cell $Ca^{2+}$ distribution and cell organelle ultrastructure of loquat (Eriobotrya japonica Lindl.) plants in response to cold stress at $-3^{\circ}C$, using transmission electron microscopy (TEM). Two loquat accessions, Zaozhong 6 (a commercial cultivar) and oakleaf loquat (a wild relative) were used. Cold tolerance, as measured by leaf browning rate, was higher in oakleaf plants, and calcium treatment improved cold tolerance in both species. Cold stress first induced inward transport of $Ca^{2+}$ from the intracellular space. Then, the imported $Ca^{2+}$ was aggregated around the chloroplast membrane, finally entering the chloroplast. This pattern of $Ca^{2+}$ distribution in leaf cells occurred earlier in Zaozhong 6 than in the wild loquat. With increasing time of cold exposure, the chloroplast membranes of Zaozhong 6 leaves were damaged, blurred and even disappeared, while those of wild oakleaf loquat leaves maintained their structure longer. In Zaozhong 6, cold stress induced a clear cavity between poorly structured granal thylakoids and vesicles appearing inside the chloroplast, while in oakleaf leaves cold stress had little effect on the ultrastructure of chloroplasts (although chloroplast membranes looked blurred). Loquat leaves accumulated free calcium ions around chloroplasts in response to cold stress, with earlier calcium accumulation occurring in the cold-sensitive cultivar Zaozhong 6 than in wild oakleaf loquat. These results demonstrate that these two loquat species have differences in both cold tolerance and calcium accumulation dynamics.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.17 no.2
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• pp.41-48
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• 2011

Background: Patellofemoral pain syndrome is very common knee problem and altered hip rotation may play a role in patellofemoral pain. The purpose of this case study is to describe the manual therapy of and the therapeutic exercise for a patient with asymmetrical hip rotation and patellofemoral pain. Method: The patient was a 29 years old woman with an 3 month history of anterior right knee pain, without known trauma or injury. Prior to intervention, her score on the VAS was Max 6 to Min 4. Left hip internal rotation was less than right hip internal rotation, and manual muscle testing showed weakness of the left hip internal rotator and abductor muscles. The intervention consisted of manual therapy and therapeutic exercise for three times a weeks, two weeks for increasing right hip medial rotation, improving left hip muscle strength, and eliminating anterior right knee pain. Result: After intervention for 2weeks, passive left and right hip medial rotations were symmetrical, and her right hip internal rotator and abductor muscle grades were Good plus. Her VAS score was Max 2 to Min 0. Conclusion: Manual therapy and therapeutic exercise is effective in improving for patient had patellofemoral pain with pattern of asymmetrical hip rotation.

• Journal of the korean academy of Pediatric Dentistry
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• v.40 no.2
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• pp.120-126
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• 2013

Preserving the pulp is important in the treatment of carious pulp exposure in young permanent teeth. Pulpotomy is a vital pulp therapy in which a portion of the coronal pulp tissue is surgically removed, and the remaining radicular tissue is covered with suitable material that protects the pulp from further injury and permits and promotes healing. It is important to develop biocompatible treatment directed at maintaining pulp vitality and increasing tooth longevity. Platelet-rich fibrin (PRF) has been referred to as a second-generation platelet concentrate. Two clinical cases in which PRF was applied as a medicament after pulpotomy of an immature permanent tooth are presented. After isolation, caries removal and pulpotomy with PRF was performed. A layer of mineral trioxide aggregate (MTA) was placed over the PRF, and the final restoration was performed. Postoperatively, the patient had no pain or discomfort, and follow-up radiographs revealed normal periodontal ligament space and trabecular bone pattern.

• Journal of the Korea Society of Computer and Information
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• v.18 no.8
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• pp.113-119
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• 2013

The requirement of rehabilitation is increasing from the stroke, spinal cord injury. One of the most difficult part is the upper limb rehabilitation because of its nervous complexity. A rehabilitation has effectiveness when a professional therapist treats in work at facility, but it has problems of an accessibility, a constant availability, a self-participation and taking lots of cost and time. In this paper, we test and experiment the accuracy and execution time of the pattern recognition algorithms like PCA, ICA, LDA, SVM to show the recognition possibility of it on the upper limb function from the 3D trajectory information which is gathered from stereo vision sensor(Kinect). From the result, PCA, ICA have low accuracy, but LDA, SVM have good accuracy to use for physical rehabilitation on the upper limb function.

• BMB Reports
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• v.52 no.11
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• pp.665-670
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• 2019

Nucleotide-binding oligomerization domain protein 2 (NOD2), an intracellular pattern recognition receptor, plays important roles in inflammation and cell death. Previously, we have shown that NOD2 is expressed in vascular smooth muscle cells (VSMCs) and that NOD2 deficiency promotes VSMC proliferation, migration, and neointimal formation after vascular injury. However, its role in endoplasmic reticulum (ER) stress-induced cell death in VSMCs remains unclear. Thus, the objective of this study was to evaluate ER stress-induced viability of mouse primary VSMCs. NOD2 deficiency increased ER stress-induced cell death and expression levels of apoptosis mediators (cleaved caspase-3, Bax, and Bak) in VSMCs in the presence of tunicamycin (TM), an ER stress inducer. In contrast, ER stress-induced cell death and expression levels of apoptosis mediators (cleaved caspase-3, Bax, and Bak) were decreased in NOD2-overexpressed VSMCs. We found that the $IRE-1{\alpha}-XBP1$ pathway, one of unfolded protein response branches, was decreased in NOD2-deficient VSMCs and reversed in NOD2-overexpressed VSMCs in the presence of TM. Furthermore, NOD2 deficiency reduced the expression of XBP1 target genes such as GRP78, PDI-1, and Herpud1, thus improving cell survival. Taken together, these data suggest that the induction of ER stress through NOD2 expression can protect against TM-induced cell death in VSMCs. These results may contribute to a new paradigm in vascular homeostasis.

• Journal of Gastric Cancer
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• v.21 no.3
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• pp.279-297
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• 2021

Purpose: Various changes in nutrition, metabolism, immunity, and psychological status occur through multiple mechanisms after gastrectomy. The purpose of this study was to predict disease status after gastrectomy by analyzing diseases pattern that occur or change after gastrectomy. Materials and Methods: A retrospective cohort study was conducted using nationwide claims data. Patients with gastric cancer who underwent gastrectomy or endoscopic resection were included in the study. Eighteen target diseases were selected and categorized based on their underlying mechanism. The incidence of each target disease was compared by dividing the study sample into those who underwent gastrectomy (cases) and those who underwent endoscopic resection for early gastric cancer (controls). The cases were matched with controls using propensity score matching. Thereafter, Cox proportional hazard models were used to evaluate intergroup differences in disease incidence after gastrectomy. Results: A total of 97,634 patients who underwent gastrectomy (84,830) or endoscopic resection (12,804) were included. The incidence of cholecystitis (P<0.0001), pancreatitis (P=0.034), acute kidney injury (P=0.0083), anemia (P<0.0001), and inguinal hernia (P=0.0007) were higher after gastrectomy, while incidence of dyslipidemia (P<0.0001), vascular diseases (ischemic heart disease, stroke, and atherosclerosis; P<0.0001, P<0.0001, and P=0.0005), and Parkinson's disease (P=0.0093) were lower after gastrectomy. Conclusions: This study identifies diseases that may occur after gastrectomy in patients with gastric cancer.