• 대한본초학회지
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• 제21권4호
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• pp.123-131
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• 2006

Objectives : This research was investigated the effect of the Ginseng Radix plus Crataegi Fructus on the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. Methods : Observed a change of the injury of brain tissue and reduced the infarction area of hippocampus in the mice with Alzheimer's disease induced by ${\beta}A$. Results : 1. The Gin-CF extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. 2. The Gin-CF extract reduced the Tau protein, GFAP protein, and presenilin1/presenilin2 protein (immunohistochemistry) of hippocampus in the mice with Alzheimer's disease induced by ${\beta}A$. Conclusion : These results suggest that the Ginseng Radix plus Crataegi Fructus extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the Ginseng Radix plus Crataegi Fructus extract for Alzheimer's disease is suggested for future research.

• Molecular & Cellular Toxicology
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• 제3권3호
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• pp.151-158
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• 2007

The failure of injured axons to regenerate in the mature central nervous system (CNS) has devastating consequences for victims of spinal cord injury (SCI). Traditional strategies to treat spinal cord injured people by using drug therapy and assisting devices that can not help them to recover fully various vital functions of the spinal cord. Many researches have been focused on accomplishing re-growth and reconnection of the severed axons in the injured region. Using cell transplantation to promote neural survival or growth has had modest success in allowing injured neurons to re-grow through the area of the lesion. Strategies for successful regeneration will require tissue engineering approach. In order to persuade sufficient axons to regenerate across the lesion to bring back substantial neurological function, it is necessary to construct an efficient biocompatible bridge (cell-free or implanted with different cell lines as hybrid implant) through the injured area over which axons can grow. Therefore, in this paper, spinal cord and its injury, different strategies to help regeneration of an injured spinal cord are reviewed. In addition, different aspects of designing a biocompatible bridge and its applications and challenges surrounding these issues are also addressed. This knowledge is very important for the development and optimalization of therapies to repair the injured spinal cord.

• Archives of Reconstructive Microsurgery
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• 제19권2호
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• pp.88-92
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• 2010

The forefoot reconstruction is a challenging field for plastic surgeons. Weight bearing tolerability and stability are important factor of choosing reconstruction methods, but cosmetic aspect has to be considered. 51 year old man visited our clinic with extensive degloving injury on right forefoot by roller. The soft tissue defect started from metatarsal area to the toe tip including nails. We harvested the anterolateral thigh flap and transferred it to the forefoot defect area with nerve coaptation. The flap was successful without skin necrosis or other complications. Secondary flap debulking surgery was performed after ten months from initial operation. Patient was satisfied with functional and cosmetic outcomes. The patient was able to wear shoes and walk with adequate sensory recovery. As there is few report about reconstruction of forefoot soft tissue defects, we report a unique case of the anterolateral thigh innervated free flap reconstruction in degloving injury.

• Journal of Photoscience
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• 제9권2호
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• pp.518-520
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• 2002

Photodynamic therapy (PDT) is a treatment modality based on photochemical reaction and the resultant cytotoxic reactive oxygen species. The platelet thrombus formation leading to stasis observed in vivo during PDT is called vascular shut down (VSD) effect. To investigate the mechanism of the VSD effect, we observed Human Umblical Vein Endothelial Cell (HUVEC) injury induced by photochemical reaction. We observed cell retraction and blebbing after PDT. It seems that the injury was not fetal and only morphological change. Then, the cytoplasm was stained by Calcein-AM and subendothelial area was evaluated from fluorescence microscopy. The rate of subendothelial area after PDT increased significantly. Second, we investigated interaction between neutrophils and HUVEC. Human promyelocytic leukemia cells (HL-60) were differentiated into neutrophil by incubation with all-trans retinoic acid. Calcein-AM labeled neutrophil adhesion to HUVEC was evaluated from fluorescence microscopy. PDT-induced neutrophil adhesion to HUVEC depended more on the exposure of subendothlial area than on neutrophil activation. This result suggests that there is a certain interaction between neutrophil and HUVEC during PDT.

• Preventive Nutrition and Food Science
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• 제17권3호
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• pp.177-183
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• 2012

Interruption of blood flow through coronary arteries and its subsequent restoration triggers the generation of a burst of reactive oxygen species (ROS), leading to myocardial cell death. In this study, we determined whether a methanol extract of Cassia mimosoides var. nomame Makino could prevent myocardial ischemia-reperfusion injury. When radical scavenging activity of the extract was measured in vitro using its ${\alpha}$,${\alpha}$-diphenyl-${\beta}$-picrylhydrazyl (DPPH) radical quenching ability, the extract showed an activity slightly lower than that of ascorbic acid. Three days after oral administration of the extract (400 mg/kg/day) to rats, myocardial ischemia/reperfusion injury was generated by 30 min of ligation of the left anterior descending coronary artery (LAD), followed by 3 hr reperfusion. Compared with the vehicle-treated group, administration of the extract significantly reduced infarct size (IS) (ratio of infarct area to area at risk) in the extract-treated group by 28.3%. Reduction in the cellular injury was mediated by attenuation of Bax/Bcl-2 ratio by 33.3%, inhibition of caspase-3 activation from procaspase-3 by 40%, and subsequent reduction in the number of apoptotic cells by 66.3%. These results suggest that the extract attenuates myocardial injury in a rat model of ischemia-reperfusion by scavenging ROS, including free radicals, and consequently blocking apoptotic cascades. Therefore, intake of Cassia mimosoides var. nomame Makino might be beneficial for preventing ischemic myocardial injury.

• 국제물리치료학회지
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• 제9권4호
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• pp.1657-1662
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• 2018

This epidemiological study aims to determine the incidence, areas, severity, and time of occurrence of sports injuries in elite female rowing athletes who were training at the Jincheon National Training Center for a 1-year period from January 1st to December 31st, 2017. According to the daily injury reports form of the IOC, sport events, weight division, injured area, and cause of injury were recorded, and the following results were found. Upon comparing the incidence of sports injuries, there was a significant difference in weight of double scull athletes. In terms of sports, there was a significant difference between pair and athletes who played double skull. Injuries occurred most commonly in the lower extremity (40.5%), followed by the trunk (35.1%), upper extremity (24.3%). for all athletes in rowing. The knee and lumbar spine/lower back were the most common injury sites. More than 60% of all injuries were Level III, and injuries occurred most frequently during training, followed by weight training and then competition.

• 한국보건간호학회지
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• 제37권2호
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• pp.179-192
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• 2023

Purpose: This study aimed to examine the injury prevention behaviors of school-age children using the Theory of Planned Behavior (TPB) and sought to identify the associated factors. Methods: A sample of 199 students in Grades 3 to 6 and their parents participated in the study. Measures were used to assess injury prevention behaviors, intentions, and parental influence. The data were analyzed using logistic regression analysis. Results: The findings showed that a stronger intention toward injury prevention behavior, living in an urban area, and higher involvement of parent's to prevent injuries were significantly associated with higher levels of injury prevention behaviors among the children. Conclusion: This study highlights the importance of intention, parental influence, and urban residence in promoting injury prevention behaviors among school-age children. The findings suggest the need for tailored interventions targeting these factors to promote prevention of injuries among children. Further research is needed to develop comprehensive strategies to prevent injuries in this population.

• 한국운동역학회지
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• 제13권3호
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• pp.151-162
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• 2003

The purpose of this study was to investigate the frequency of sports injury among Korean junior elite golf players. The survey was made through the questionnaire which consist of eight categories and 280 valid answers were used to perform frequency analysis. The results indicated that 197 out of 280 participants experienced golf injuries (30%: during a game, 70%: during a practice) and 70% of them also experienced injuries within a year. The frequency analysis for the site of injury has shown that back was the most vulnerable area for all players(33%), followed by the right wrist, left shoulder and elbow for male players. Among female players, left wrist was the second weak site of injury, followed by the right wrist, right thoracic spine, and left shoulder. A few of them also have shown abnormal symptoms of ruptured lumbar disk, scoliosis, and lordosis and these injuries might be caused by the lack of flexibility and the fatigue due to over-practice. High frequency of wrist injury also demonstrated that excessive chopping or punching shot and poor environmental course conditions may cause this injury to be common. Overall, lack of warm up time, lack of strength and flexibility, and excessive amount of practice were the major reasons of injury for the junior elite golfers in Korea. The study also proved that these young Korean golfers actually had more chances to be faced with the injury than average. Thus, it is necessary to develop systematic and scientific methods of training, and prevention, treatment of these injuries with medical professionals.

• Journal of Trauma and Injury
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• 제22권2호
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• pp.154-160
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• 2009

Purpose: This study aimed to determine new criteria for detecting independent factors with high sensitivity in cases of cervical spine injury. We compared the sensitivity, the specificity, and the false negative predictive value (NPV) of plain radiographs with those of computed tomography for cervical spine injury in patients with minor head injury. Methods: We retrospectively reviewed the cases of 357 patients who underwent both cervical plain radiographs and computer tomography from January 2006, to September 2008. Patients were divided into two groups: the cervical spine injury group and the no cervical spine injury group. New criteria were organized based on variables that had significant differences in the logistic regression test. Results: Among the 357 patients, 78 patients had cervical spine injuries. The average age was $43.9{\pm}15.2$ yrs old, and the male-to-female ratio was 1.90. The most common mechanism of injury was motor vehicle accidents. There was a significant difference in loss of consciousness, Glasgow Coma Scale (GCS)=14, neurologic deficit, posterior neck tenderness, and abnormality of the cervical plain radiographs between the two groups on the logistic regression test. New criteria included the above five variables. If a patient has at least variable, the area under the ROC curve of the new criteria was 0.850, and the sensitivity and the false NPV were 87.2% and 5.2%, respectively. Conclusion: New criteria included loss of consciousness, GCS=14, neurologic deficit, posterior neck tenderness, and abnormality of the cervical plain radiographs. If the patient had at least 1 variable, he or she could have a of cervical spine injury with a sensitivity of 87.2% and a false NPV of 5.2%.

• 한국학교보건학회지
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• 제22권2호
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• pp.157-167
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• 2009

Purpose : The purpose of this study is to explore the students injuries by analyzing the data which has been inputted by the emergency center of the cooperated hospitals and the 119 rescue party through the injury surveillance system in Cheonan city. Method : Students were divided into the elementary, middle, high school students with the 776 cases of children and teenagers(7-19years old) of injury surveillance system in Cheonan area from january to june in 2009. Frequency analysis and $x^2$-test was done to recognize the features of students injuries among the groups. The program to be used for the statistical analysis is SPSS 17.0. Result : Out of the injury incidence rate, the elementary school students(52.1%) are first, the high school students (24.9%) are second, the middle school students appear to be 23.1%. Male is about two times higher than female by 66.6% in the injury incidence. In terms of the injury mechanism, the injury(22.2%) by hit is the first, the traffic accident(21.5%) is the second, the slippery(16.8%) is followed. The injuries were occurred most largely at 16:00-20:00(33.4%), and the 33.6% of injury by daily leisure activity occurs at 16:00-20:00 chiefly. Conclusion : Analysis using the data of the injury surveillance system has some advantages compared to the previous research such as reliability and specification. To prevent the students injuries, not the individual problem but the social dimension should be acknowledged so that we can secure and promote the safety from the risk. Therefore, we must organize the role assignment and the cooperative network in the school, home and community.