• Proceedings of the PSK Conference
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• 2003.04a
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• pp.130.3-131
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• 2003

The biological effects of NADPH-dependent isocitrate dehydrogenase (IDPc) inhibitor. DA-11004, was examined in obese zucker rats or streptozotocin-induced diabetic SD rats. Diabetes was induced by injection of streptozotocin (50mg/kg) dissolved in citrate buffer (pH 4.8) into the tail vein and induction of diabetes was confirmed by the measurement of the tail blood glucose level at 48h. DA-11004 (30mg/kg, po) was injected for successive 7days and significantly reduced the plasma glucose in streptozotocin-induced diabetic rats (P<0.05). (omitted)

• Journal of the Korean Institute of Telematics and Electronics
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• v.27 no.10
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• pp.89-95
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• 1990

A model for bipolar-CMOS buffer design is presented which offers a guideline for determining device sizes based on speed and capacitive load. Closed-form solutions for area optimization are obtained assuming high level injection and channel velocity limitation. The solutions and circuit simulations show that the areas of BICMOS buffers are optimized by scaling the emitter length and the channel width approximately in proportion with capacitive load.

• Korean Journal of Pharmacognosy
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• v.40 no.3
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• pp.213-217
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• 2009

This study was done to investigate the antioxidative effect of polygoni radix in Streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45 mg/kg dissolved in citrate buffer. The ethanol extract of Polygoni radix was orally administrated once a day for 7 days. The contents of Total cholesterol, triglyceride (TG) were significantly decreased in Polygoni radix treated STZ-sample group compared with to the those of STZ-control group. The hepatic cytosolic activities of glutathione-s-transferase (GST), superoxide dismutase (SOD) were significantly increased, Also the content of glutathione (GSH) was incresaed in Polygoni radix treated STZ-sample group compared with to the those of STZ-control group. but the content of malondialdehyde (MDA) and the hepatic cytosolic activity of Catalase (CAT) were decreaed but not statistical significant. These results indicated that ethanol extract of polygoni radix was effective for the antidxidative in the STZ-induced diabetic rats.

• YAKHAK HOEJI
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• v.34 no.5
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• pp.334-340
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• 1990

The bioequivalence of Mandol and Mancef (cefamondole nafate injection preparation) was investigated for 8 healthy human volunteers. Cefamandole nafate hydrolysis to cefamandole base in the blood and shows antibacterial activity. As the rate of the hydrolysis can be varied according to the buffer used in the preparation, the bioequivalence of cefamandole nafate I.V. was studied. A new HPLC method, the column switching technique, was developed and used for the simultaneous determination of cefamandole and cefamandole nafate in the plasma and in the urine. There were no statistically significant difference in between Mandol and Mancef for the parameters of AUC and Cp 0.25 hr even through the power of the test was not enough.

• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.5
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• pp.908-913
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• 1997

The purpose of this study was to investigate phospholipase $A_{2}$ activity and lipid peroxidation I streptozotocin induced diabetic rats. Sprague-Dawley male rats weighting-Dawley male rats weighting 300$\pm$10gm were randomly assigned to normal and STZ-induced diabetic group. Diabetes was induced by intravenous injection of 55mg/kg of STZ in sodium citrate buffer(pH 4.3). Animals were sacrificed at the 6th day of diabetic states. Body weight gains were lower in DM group. Phosphatidylcholine hydrolysis in liver was not significantly different between two groups, whereas phosphatidylethanolamine hydrolysis in liver was increased by 69% in DM group comparing with that of normal group. Liver microsomal phospholipase $A_{2}$ activity and level of TBARS was increased by 91%, 109% in DM group compared with that of normal group, respectively. The present results indicate that phospholipase $A_{2}$ activity is specific to PE hydrolysis, leading to lipid peroxidation process in STZ induced diabetic rats.

• Journal of the Korean Applied Science and Technology
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• v.25 no.3
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• pp.347-354
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• 2008

This study was done to investigate the antidiabetic effect of polygoni radix in Streptozotocin(STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45mg/kg dissolved in citrate buffer. The ethanol extract of polygoni radix was orally administrated once a day for 7 days. The content of serum glucose, triglyceride(TG), total cholesterol were significantly decreased in polygoni radix treated STZ-sample group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-6-phosphate dehydrogenase(Glucose-6-PDH), glucokinase were significantly increased, but activity of glucose-6-phoshatase was decreased in polygoni radix treated STZ-sample group compared to the those of STZ-control group. These results indicated that ethanol extract of polygoni radix would have antidiabetic effect in STZ-induced diabetic rats.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.126-126
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• 1995

본 연구는 중금속에 의한 생체내 독성기전을 연구하고자 흰쥐간의 상층액에서 카드뮴과 잘 결합하는 HMWP들을 분리, 정재하고 나아가 생화학적 특성을 밝히고 이단백질이 카드뮴에 의해 생성되는 것인지 아니면 간의 기존 단백질인지를 밝히고자 함을 연구의 목적으로 하였다. CdCl %2 (3mg/kg body wt.)을 3일간 ip injection시킨 후 흰쥐의 간을 적출하고 균질화하여 원심분리한 crude extract를 직접 Sephacryl S-100에 흡착시켜 10mM phosphate buffer(pH 7.0)으로 용출시켰다. 용출된 fraction tube를 UV spectrometer로 흡광도를 측정하고 atomic absorption spectrophotometer로 카드뮴량을 측정하여 카드뮴량이 높은 분획을 모아서 ion exchange column chromatography(DEAE-Sepharose)에 흡착시켜 염농도 구배로 chromatography를 실시하고, 음이온 교환수지에서 흡착되지 않고 용출된 분획을 ultrafiltration으로 농축시킨 후 S-Sepharose에 흡착시켜 염농도 구배로 chromatography를 실시한 결과 두 종류의 카드뮴 결합 단백질(Cd-BP)를 분리, 정제하였다.

• Journal of the Korean Applied Science and Technology
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• v.27 no.4
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• pp.494-500
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• 2010

This study was carried to investigate the antidiabetic and lipid metabolism of water extract paecilomyces japonica(PJ) in Streptozotocin (STZ) induced diabetic rats. Diabetes were induced by intravenous injection of STZ at a dose of 42mg/kg dissolved in citrate buffer. The water extract of paecilomyces japonica were orally administrated once a day for 7 days at a dose of 500mg/kg or 1,000mg/kg. The contents of serum glucose, triglyceride(TG), total cholesterol were significantly decreased in PJ treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-6-phosphate dehydrogenase(G-6-PDH), glucokinase(GK) were significantly increased, but activity of glucose-6-phoshatase(G-6-Pase) was significantly decreased in PJ treated group compared to the those of STZ-control group. These results indicated that water extract of paecilomyces japonica would have antidiabetic and lipid metabolism effect in STZ-induced diabetic rats.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.791-793
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• 2009

We have developed novel small molecular materials for solution phosphorescent OLEDs having multilayered device structures. These novel materials are applied as an interlayer which is between a buffer layer (or hole injection layer) and an emitting layer to improve the luminance efficiency of solution green phosphorescent OLEDs. In order to form stable double layers by spincoating process, we take the advantage of solubility differences of interlayer materials and emitting materials. Using CIM3 as an interlayer, we have attained the best luminance efficiency, 36 cd/A at a given constant of 2000cd/$m^2$ in the structure of ITO/PEDOT:PSS/CIM3/CIM6:Ir(mppy)$_3$/BAlq/Alq$_3$/LiF/Al.

• Proceedings of the KIEE Conference
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• 2004.11a
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• pp.86-88
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• 2004

정공주입 버퍼층(PTFE)두께에 변화에 따른 유기발광소자 전압-전류-휘도 효율을 측정한 결과 ITO/PTFE/Al 구조에서 두께가 증가하면 전류 밀도 및 전압이 증가하며, 두께가 0.7 (nm)일 때 부성 저항 영역이 나타났었고, ITO/PTFE/NPB/$Alq_3$/Al 구조에서 두께가 1.0 [nm]에서는 가장 좋은 휘도와 효율을 나타났었다. 두께가 증가하면 이것은 PTFE 내의 정공의 이동을 어렵게 하기 때문에 효율이 감소하는 것으로 판단된다. 그래서 적당한 PTFE 두께만이 가장 좋은 휘도와 효율을 얻을 수가 있다.