• 동력기계공학회지
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• 제20권2호
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• pp.51-57
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• 2016

Non-esterified biodiesel fuel is cheaper than esterified that because of a simple manufacturing process that only consists of filtering. Applicability of this on diesel engine with electronic control system was accomplished, then optimization adopting a fractional factorial design and response surface methodology was carried out at 25% and 50% of engine load in this study. Pressure of common rail and injection timing mainly effected on responses as specific fuel oil consumption and nitrogen oxides regardless of engine load. Estimations were 310.3 g/kWh of specific fuel oil consumption and 237 ppm of nitrogen oxides at 25% load, and 233.2 g/kWh of specific fuel oil consumption and 730 ppm of nitrogen oxides at 50% load. Tests to verify these estimations were accomplished and as the results, specific fuel oil consumption was 300.4 g/kWh and NOx was 277 ppm at 25% load and 236.8 g/kWh and 573 ppm at 50% load.

• Toxicological Research
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• 제13권4호
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• pp.409-415
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• 1997

The influences of dietary supplement of citron tea on the hepatocellular chemical carcinogenesis have been studied by examining placental glutathione S-transferase(GST-P) positive foci area in a liver tissue, contents of total cytochrome P450, thiobarbituric acid reactive substances(TBARS) and glucose 6-phosphatase(G6Pase) in hepatic microsome and glutathione S-transferase(GST) activity. Weaning Sprague-Dawley male rats were fed AIN76 diet with or without citron tea supplement. Rats of CTR and CTR+ groups were fed diet without citron tea supplement while CDI and CDI+ groups were fed diet with citron tea supplement for the entire experimental period(13 weeks). Rats of CDP and CDP+ groups were fed diet without citron tea supplement for the first 7 weeks and swiched to citron tea containing diet for the last 6 weeks of experimental period. CTR+, CDI+ and CDP+ groups were carcinogen treated group. Diethylnitrosamine(DEN) was used as a carcinogen initiator and injected to the rats of carcinogen treated groups as a single dose of 200 mg/kg body weight intraperitoneally after 4 weeks of feeding. 2-Acethylaminofiuorene(AAF) was used as a carcinogen promoter and supplied in the diets of carcinogen treated rats as 0.02% content for the last 6 weeks starting from 2 weeks after DEN injection. Rats were sacrificed after 13 weeks of feeding. Liver/body weight ratio and GST activities were increased by carcinogen treatment. However, they were not changed by citron tea supplement. Total cytochrome P450 contents were not changed by carcinogen treatment or citron tea supplement. TBARS contents of carcinogen treated rats showed tendency to decrease by citron tea supplement. G6Pase activity decreased by carcinogen treatment and citron tea supplement. The area of GST-P positive foci detected in carcinogen treated rats were decreased by citron tea supplement and not affected by the timing and the duration of citron tea supplement. These results suggest that citron tea has suppressive effects on hepatocellular chemical carcinogenesis probably through antioxidant compounds by decreasing TBARS contents.

• 한국정보통신학회논문지
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• 제16권11호
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• pp.2446-2452
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• 2012

국내외의 배출가스 규제 강화에 부합하기위하여, 사용자 의도에 따른 연료 분사시기와 분사량 조절이 가능한 커먼레일 ECU를 제어할 수 있는 알고리즘 개발의 필요에 따라서 본 논문에서는 커먼레일 엔진 전용 ECU에 적용할 수 있는 노킹 판별 및 엔진 밸런스 보정이 가능한 노킹 진단 알고리즘을 구현하여 시뮬레이터로 개발하였다. 또한 운전자가 직접 차량을 진단하는 운전자 중심의 진단 서비스를 제공하고자 시뮬레이터의 결과를 OBD-II 표준에 의거하는 차량 위주의 진단기로 개발하고자 한다. 이를 위해 자동차 고장진단 신호 및 센서 출력 신호를 송수신하는 유선 시스템과 무선 시스템인 블루투스 모듈을 이용하여 실시간 통신이 제공될 수 있는 OBD-II 진단기 S/W 설계방안을 제안함으로써 차량의 연비향상 및 유해가스 저감을 통한 엔진의 효율성 향상을 실현하도록 한다.

• Clinical and Experimental Reproductive Medicine
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• 제20권1호
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• pp.31-36
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• 1993

The effects of freezing and 1,2-propanediol on early and late pronucleate stage mouse ova were investigated in terms of survival after thawing and development in vitro. The samples were divided into two groups according to different age in pronucleate ova: ova in(1) early pronuclear stage with two distant pronuclei at 18h after hCG injection, and (2) late pronuclear stage with adjacent pronuclei at 30h. Zygotes in the late pronuclear stage have been proven to be more resistant to 1,2-propanediol, showing a significantly higher developmental rate than zygotes in early stage (80.3 versus 66.3%, <0.05), but survival rate was similar in the two groups (91.0 versus 93.5%). After freezing and thawing, survival and developmental rates were decreased in both groups when compared to the control group (54.3 versus 92.3%, 47.7 versus 73.3%. respectively). And developmental rate in the late pronuclear stage zygotes showed significantly higher than in early (55.4 versus 40.0%) after thawing. In conclusion, early pronucleate mouse ova have a lower developmental capacity in vitro and a lower survival rate after freezing and thawing than late ova. These findings suggest that the timing of freezing could be important for survival and further development in vitro in cryopreservation of human pronucleate ova.

• The Korean Journal of Pain
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• 제35권1호
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• pp.14-21
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• 2022

The coronavirus disease 2019 (COVID-19) pandemic, which has been rampant since the end of 2019, has evidently affected pain management in clinical practice. Fortunately, a COVID-19 vaccination program is currently in progress worldwide. There is an ongoing discussion that pain management using steroid injections can decrease COVID-19 vaccine efficacy, although currently there is no direct evidence to support this statement. As such, the feeling of pain in patients is doubled in addition to the co-existing ill-effects of social isolation associated with the pandemic. Thus, in the COVID-19 era, it has become necessary that physicians be able to provide high quality pain management without negatively impacting COVID-19 vaccine efficacy. Steroids can alter the entire process involved in the generation of adaptive immunity after vaccination. The period of hypophysis-pituitary-adrenal axis suppression is known to be 1 to 4 weeks after steroid injection, and although the exact timing for peak efficacy of COVID-19 vaccines is slightly different for each vaccine, the average is approximately 2 weeks. It is suggested to avoid steroid injections for a total of 4 weeks (1 week before and after the two vaccine doses) for the double-shot vaccines, and for 2 weeks in total (1 week before and after vaccination) for a single-shot vaccine. This review focuses on the basic concepts of the various COVID-19 vaccines, the effect of steroid injections on vaccine efficacy, and suggestions regarding an appropriate interval between the administration of steroid injections and the COVID-19 vaccine.

• 한국수산과학회지
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• 제56권3호
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• pp.309-314
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• 2023

Shark populations are constantly decreasing owing to environmental destruction and overfishing; thus, sharks are now at risk of extinction, with 30.5% of species classified as endangered on the International Union for Conservation of Nature's Red List. Sharks are apex predators and keystone species in balancing the marine food chain; their extinction would create an imbalance in the entire marine ecosystem. Assisted reproductive technology is a last resort for protecting animals facing extinction. Here, as a proactive effort toward building a hormone-induced artificial insemination protocol for endangered wild sharks, we identified the possibility of germ cell maturation by administration of GnRH, a commercially produced synthetic salmon gonadotropin-releasing hormone, and calculated its optimum dosage and injection timing. The experiment was conducted on one shark species, Chiloscyllium plagiosum. Injections were administered in 24 h intervals to C. plagiosum females, and 0.2 mL/kg+0.2 mL/kg were the optimal doses. These doses effectively induced maturation and, and ovulation, and oocyte release. Our results confirm that GnRH is a suitable tool for shark hormone-induced artificial insemination and indicate that this method may facilitate the conservation of endangered shark species.

• Investigative Magnetic Resonance Imaging
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• 제22권1호
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• pp.1-9
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• 2018

Purpose: This study was designed to optimize the flip angle (FA) and scan timing of the hepatobiliary phase (HBP) using the 3D T1-weighted, gradient-echo (GRE) imaging with controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) technique on gadoxetic acid-enhanced 3T liver MR imaging. Materials and Methods: Sixty-two patients who underwent gadoxetic acid-enhanced 3T liver MR imaging were included in this study. Four 3D T1-weighted GRE imaging studies using the CAIPIRINHA technique and FAs of $9^{\circ}$ and $13^{\circ}$ were acquired during HBP at 15 and 20 min after intravenous injection of gadoxetic acid. Two abdominal radiologists, who were blinded to the FA and the timing of image acquisition, assessed the sharpness of liver edge, hepatic vessel clarity, lesion conspicuity, artifact severity, and overall image quality using a five-point scale. Quantitative analysis was performed by another radiologist to estimate the relative liver enhancement (RLE) and the signal-to-noise ratio (SNR). Statistical analyses were performed using the Wilcoxon signed rank test and one-way analysis of variance. Results: The scores of the HBP with an FA of $13^{\circ}$ during the same delayed time were significantly higher than those of the HBP with an FA of $9^{\circ}$ in all the assessment items (P < 0.01). In terms of the delay time, images at the same FA obtained with a 20-min-HBP showed better quality than those obtained with a 15-min-HBP. There was no significant difference in qualitative scores between the 20-min-HBP and the 15-min-HBP images in the non-liver cirrhosis (LC) group except for the hepatic vessel clarity score with $9^{\circ}$ FA. In the quantitative analysis, a statistically significant difference was found in the degree of RLE in the four HBP images (P = 0.012). However, in the subgroup analysis, no significant difference in RLE was found in the four HBP images in either the LC or the non-LC groups. The SNR did not differ significantly in the four HBP images. In the subgroup analysis, 20-min-HBP imaging with a $13^{\circ}$ FA showed the highest SNR value in the LC-group, whereas 15-min-HBP imaging with a $13^{\circ}$ FA showed the best value of SNR in the non-LC group. Conclusion: The use of a moderately high FA improves the image quality and lesion conspicuity on 3D, T1-weighted GRE imaging using the CAIPIRINHA technique on gadoxetic acid, 3T liver MR imaging. In patients with normal liver function, the 15-min-HBP with a $13^{\circ}$ FA represents a feasible option without a significant decrease in image quality.

• Clinical and Experimental Reproductive Medicine
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• 제21권2호
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• pp.165-176
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• 1994

This study was carried out to investigate the effect of the timing and dose of human chorionic gonadotropin(hCG) on oocyte recovery, in vitro fertilization, and preimplantation development in superovulation of mouse. F1 hybrid($C57BL{\times}CBA$) mice were obtained and superovulation was induced in female mice by sequential intraperitoneal injection of PMSG and hCG. In the first series of experiments, mice received 5 IU of PMSG given intraperitoneally, and 48 hours later were injected 1 IU, 5 IU, or 10 IU of hCG respectively. In the second series of experiments, mice received 5 IU of PMSG given intraperitoneally and were injected 5IU of hCG 36, 48, or 60 hours later respectively. 1. When the mice received 5 IU of PMSG given intraperitoneally and 48 hours later were injected 1 ItT, 5 IU, or 10 IU of hCG respectively, there were no differences in the total number of the oocytes obtained from the three experimental groups. When the cultures were examined 48 hrs after the termination of insemination the proportion of unfragmented oocytes which had developed over two-cell stage was observer to be lowest in 10 IU hCG group. When the cultrues were examined 120 hour after termination of insemination the proportion of embryos which had developed to the blastocyst stage was observed to be significantly higher in 10IU hCG group than 5IU hCG group(p<0.05), but there was no difference between 10 IU hCG group and 1IU hCG group. 2. When the mice received 5 IU of PMSG and were injected 5 IU of hCG 36, 48, or 60 hours later respectively, there were no differences in the total number of oocytes obtained from the three experimental groups. When cultures were examined 48 hour after the termination of insemination the proportion of unfragmented oocytes which had developed over two-cell stage was observed to be significantly lower in 36 hour interval group than 48 hour interval and 60 hour interval group(p<0.05). When the cultures were examined 120 hour after termination of insemination the proportion of embryos which had developed to the blastocyst stage was found to be higher in 60 hour interval group than 36 interval or 48 hour interval group (P<0.05), and the proportion of hatching blastocyst was found to be higher in 60 hour interval group as well. In this study, it was concluded that the administration of adequate dose of hCG, and long (60 hour) PMSG-hCG interval were necessary in superovulation of mice($C57BL{\times}CBA$) in order to get a large number of oocytes which had an early oocytes which had an early embryonic developmental capability when fertilized in vitro, and especially it had better have been avoided to administer a large dose of hCG.

• 대한기계학회논문집B
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• 제34권11호
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• pp.1005-1013
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• 2010

본 연구는 HCCI 엔진의 운전조건을 고려한 혼합연료의 감압비등 분무제어방법을 평가하기 위하여 수행하였다. 2상영역이 존재하는 혼합연료는 고비점성분의 증발촉진과 함께 연료분무의 급격한 증발을 유도할 수 있는 감압비등분무를 이용함으로써 저온 및 저밀도장에서 혼합기형성과정의 제어가 가능하다. HCCI 엔진은 이러한 분위기조건에서 연료를 조기분사하기 때문에 착화성이 높은 경유와 휘발성이 높은 가솔린성분으로 함유한 혼합연료의 감압비등현상을 이용함으로써 액체연료의 분열, 미립화와 같은 물리적 제어 및 착화연소에 의한 화학적 제어를 실현할 수 있다. 본 연구는 혼합연료의 성분과 몰분율을 주요변수로 설정하여 정적용기 내에 분사된 연료분무의 감압비등현상을 슐리렌 화상 및 Mie 산란광을 촬영한 후, 화상처리과정을 통하여 이루어졌다. 그 결과로 감압비등현상은 비교적 저온 및 저밀도장에서 분무구조가 크게 변화함을 알 수 있었으며, 조기 연료분사시기에서 감압비등분무를 이용한 혼합기형성을 제어함으로써 HCCI 연소에 적용이 가능할 것으로 분석하였다.

• Nuclear Engineering and Technology
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• 제28권2호
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• pp.137-149
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• 1996

본 연구는 불란서 CEA에서 수행한 부분충수 운전 중 잔열제거계통 기능 상실사고 실험인 BETHSY 실험 6.9c를 CATHARE2 코드를 이용하여 분석하였다. BETHSY 6.9c 실험은 잔열제거 계통 기능상 실시 가압기와 중기발생기 출구공동의 Manway를 통해 노심에서 발생한 증기를 제거하여 계통의 가압 정도를 시험한 것이다. 연구의 주요목적은 사고발생시 예상되는 주요 물리적 현상의 이해와 과도기에 영향을 미치는 민감 변수를 확인하고 CATHARE2 코드의 예측능력을 평가하여, 실제원전의 유사사고 해석에 대한 신뢰성을 확보하는 것이다. 연구결과 CATHARE2 코드는 실험을 통해 관측된 주요 물리적 현상들을 타당하게 예측하였으나, 가압기와 밀림관의 DP를 과대 예측하여 원자로 상부공동의 최대압력을 실험보다 약 7kPa 높게 예측하였다. 노심 노출시간도 노심에서 기포율 분포를 비현실적으로 예측하여 실험보다 약 500초 지연되었다. 실험과 코드의 모의결과를 통하여 노심 노출은 중력주입에 의한 냉각수 보충만으로 충분히 회복될 수 있음을 확인하였다. CATHARE2 코드는 비록 상세한 현상들에 대해 다소 불화실성을 내포하였으나, 전반적인 거동분석에는 타당한 것으로 판단된다.