• BMB Reports
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• v.32 no.6
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• pp.547-553
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• 1999

Aminoacyl-tRNA synthetases are essential enzymes catalyzing the attachment of specific amino acids to cognate tRNAs. In the present work, the substrate analogue L-methionine hydroxamate was used to identify functional residues located in the active site of the E. coli methionyl-tRNA synthetase (MetRS). This compound inhibited bacteria, yeast, and human MetRS activities to a similar degree, suggesting a conserved active site structure and mechanism between MetRSs of different phylogenetic domains. Mutants of the E. coli MetRS resistant to methionine hydroxamate were also isolated. These mutants contained a substitution either at T10, Y15, or Y94. These residues are highly conserved among the different MetRSs and the mutants showed decreased aminoacylation activity, suggesting their functional and structural significances. The putative roles of these residues are discussed on a structural basis.

• The Korean Journal of Community Living Science
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• v.25 no.1
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• pp.51-64
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• 2014

With a shift in the rural development process toward a bottom-up approach, the need to enhance the endogenous capacity of communities has become the core of rural development. In this regard, scholars have paid close attention to social capital to identify ways to facilitate endogenous rural development but focused mainly on relationships between social capital and local environment. That is, few studies have investigated the relationships between social capital and its various dimensions in the context of rural development initiatives. This study examines the effects of social capital on the problem-solving ability of community residents'rural development initiatives and assesses the types of social capital associated with such initiatives to propose optimal path for improving this ability. To distinguish between major dimensions of social capital, a questionnaire was developed by considering various stages of the rural development process. The survey considered a sample of 59 employees from public rural development institutions. According to the results, four paths were significant at the 5% level. Among these four paths, three set common goals. The effective channel was the path [common goals${\Rightarrow}$network${\Rightarrow}$cooperation${\Rightarrow}$problem-solving ability]. The key factor in improving problem-solving skills, the endogenous ability of community residents to facilitate rural development initiatives. The results suggest that governments should strengthen education and training programs to help residents set their common goals.

• Journal of the Korean Society of Food Culture
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• v.38 no.4
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• pp.239-245
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• 2023

The objective of this study was to explore how different types of rewards affect customers' inclinations to engage in environmental activities promoted through restaurant social media platforms. In addition, we investigated the potential moderating role of customer level of participation within the social media community. A total of 202 valid responses obtained by distributing a self-administered survey among restaurant patrons were subjected to hierarchical regression analysis to examine relationships between variables. The findings underscored the significant influence of economic and social rewards on shaping customer intent to participate in environmental initiatives promoted within restaurant social media communities. Furthermore, the study revealed that the extent of customer participation within the social media community moderated the relationship between rewards and their likelihood to partake in environmentally conscious behaviors. These results have meaningful implications for restaurant managers seeking to promote environmental initiatives effectively through social media platforms and within their establishments.

• The Korean Journal of Franchise Management
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• v.14 no.4
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• pp.51-65
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• 2023

Purpose: As social interest in environmental issues increases, pro-environmental initiatives are becoming more active in many industry sectors. This study explores how a firm's perceived green brand image affects consumer loyalty through brand trust and attachment. Research design, data, and methodology: The data of 363 respondents aged 20 to 59 who purchased the franchise lunchbox in the last three months were analyzed using SPSS 25.0 and SmartPLS 4.0. Result: Green brand image affects consumer loyalty through cognitive trust, affective trust, and brand attachment. Regarding serial mediations, cognitive trust affects brand attachment only through affective trust and, in turn, consumer loyalty. Conclusions: This study employs the hierarchy of effects theory to explore the role of the perceived green image of the franchise lunchbox brand in prompting consumer loyalty through brand trust and attachment. The eco-friendly initiatives are imperative in establishing a green brand image, given their critical roles in generating consumer brand trust and attachment as well as consumer loyalty in the franchise lunchbox industry. The franchise lunchbox firms should implement environmental initiatives and effectively communicate and actively inform these initiatives to raise perceptions of green brand image and build cognitive brand trust.

• Journal of Information Display
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• v.2 no.3
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• pp.48-53
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• 2001

Carbon nanotube emitters, prepared by screen printing, have demonstrated a great potential towards low-cost, largearea field emission displays. Carbon nanotube paste, essential to the screen printing technology, was formulated to exhibit low threshold electric fields as well as an emission uniformity over a large area. Two different types of triode structures, normal gate and undergate, have been investigated, leading us to the optimal structure designing. These carbon nanotube FEDs demonstrated color separation and high brightness over 300 $cd/m^2$ at a video-speed operation of moving images. Our recent developments are discussed in details.

• Journal of Science and Technology Studies
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• v.14 no.1
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• pp.117-137
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• 2014

In recent years, there has been a gradual increase in the number of R&D projects for solving societal problems. However, government-funded research institutes(GRIs) are going through many trials and errors due to the lack of R&D systems suitable for solving societal problems. In this regard, this study attempted to discuss the improvement directions for evaluation systems of GRIs, which serves as a major influencing factor in performing R&D initiatives for solving societal problems. Towards this end, a study of R&D initiatives for solving societal problems was conducted first, and improvement directions for effective promotion were presented after deriving limits in terms of R&D initiatives for solving societal problems, along with the current status of evaluation systems by GRIs. Lastly, implications and limitations of this study were discussed. This study has its significance in that it is the first research to propose evaluation indicators in terms of solving societal problems at the level of GRIs and is expected to be a foundation for future research of related fields.

• The Journal of Information Systems
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• v.27 no.2
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• pp.197-219
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• 2018

Purpose The purpose of this study is to examine what motivates users to adopt one of the emerging applications for collaborative consumption of sharing economy. Using the self-determination theory, motivation theory and TAM(Technology Acceptance Model) as the theoretical framework, this study illustrates important factors that influence adoption of collaborative consumption service. We develops the ICTs(Information and Communications Technologies) initiatives and motivation model to collaborative consumption. Design/methodology/approach This paper makes use of a quantitative methodology using survey questionnaire that allows for the measurement of the eight constructs(System Availability, Contents Quality, Design & Personalization, Security & Privacy, Emotional & Social Value, Economic Value, Attitude, Adoption & Consumption) contained in the hypothesized theoretical model on the basis of the prior literatures. Data collected from a sample of 227 respondents who have used the collaborative consumption services and provided the foundation for the examination of the proposed relationships in the model. Findings This study has the following implications for the users and providers of CC platforms and services. The ICTs initiatives (System Availability, Contents Quality, Design & Personalization, Security & Privacy) are the influential factors that motivate the emotional and social value to CC. On the other hand, The ICTs initiatives (System Availability, Contents Quality) are not very significant factors of economic value to CC. The empirical analysis result indicate that there are significant causal effect among emotional & social value, economic value, and adoption to CC. This study provides important theoretical implications for innovation adoption research through an empirical examination of the relationship between ICTs initiatives, motivation factors to collaborative consumption in the sharing economy.

• Molecules and Cells
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• v.41 no.10
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• pp.900-908
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• 2018

Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) ${\gamma}$. Although TZDs are synthetic ligands for $PPAR{\gamma}$, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective.

• Asia Marketing Journal
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• v.8 no.1
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• pp.19-47
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• 2006

This study explores the effect of the properties of digital infra on customer participation to explain how customers' initiatives impact the marketing process in the digital environment. Also the effect of the accumulated information through customers' information sharing on their initiatives in the marketing activities can be discovered. These effects can be better understood by developing comprehensive model and employing large sample empirical test. Study1 identifies the properties of digital infra which overcomes the limitations of off-line environment in customers' participation - Information openness, connectedness, community interaction and structure clarity - and how these properties activate customers' participation in the marketing process. Study2 shows the process structure of reverse marketing activities in the digital environment. These findings deliver the fact that customers' initiatives in the marketing activities will be accepted generally under the digital environment. Consequently, this study suggests some managerial implications for completely different marketing strategies in response to customers' initiatives in the marketing activities under the digital environment.

• Journal of Information Technology Applications and Management
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• v.15 no.4
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• pp.189-203
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• 2008

Technology plays an important role in e-Government with people and policies to make e-Government more efficient. And much attention and investment has been given to the technological development, so called informatization, of electronic government (e-Government) in Korea. But the measures of quality and efficiency for the e-Government initiatives have not been verified well. For this reason, a great deal of effort has been devoted to develop the measurement of e-Government system; however, a measurement model to support such effort has not been developed enough yet. In this empirical study, we proposed a comprehensive theoretical model for measuring performance of e-Government initiatives and analyzed such model through 112 collected questionnaires from people in charge of informatization in central government administrations.