• Title/Summary/Keyword: Initiative

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The role of lipid binding for the targeting of synaptic proteins into synaptic vesicles

  • Jang, Deok-Jin;Park, Soo-Won;Kaang, Bong-Kiun
    • BMB Reports
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    • v.42 no.1
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    • pp.1-5
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    • 2009
  • Synaptic vesicles (SVs) are key structures for synaptic transmission in neurons. Numerous membrane-associated proteins are sorted from the Golgi complex to the axon and the presynaptic terminal. Protein-protein and protein-lipid interactions are involved with SV targeting in neurons. Interestingly, many SV proteins have lipid binding capability, primarily with either cholesterol or phosphoinositides (PIs). As examples, the major SV protein synaptophysin can bind to cholesterol, a major lipid component in SVs, while several other SV proteins, including synaptotagmin, can bind to PIs. Thus, lipid-protein binding plays a key role for the SV targeting of synaptic proteins. In addition, numerous SV proteins can be palmitoylated. Palmitoylation is thought to be another synaptic targeting signal. Here, we briefly describe the relationship between lipid binding and SV targeting.

Mixed-state Hall angle Hg-based superconducting thin films

  • Kim, Wan-Seon;Lee, Sung-Ik;Kang, Won-Nam
    • 한국초전도학회:학술대회논문집
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    • v.10
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    • pp.41-44
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    • 2000
  • The mixed-state Hall angle has been measured in Hg-based superconducting thin films as functions of magnetic fields (H) up to 18 T. The temperature dependence of the Hall angle shows a peak (T$^{\ast}$) at low temperature, which is consistent with a crossover point from the thermally activated flux flow (TAFF) to a critical region (CR). At low fields below 10 T, T$^{\ast}$ shifts to low temperature with increasing fields. Interestingly, however, we found that T$^{\ast}$ is independent of fields above 10 T, suggesting unusual vortex state. A physical implication of H - T$^{\ast}$ line will be discussed.

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Mixed-state Hall Angle in Hg-based Superconducting Thin Films

  • Kang, Won-Nam;Kim, Wan-Seon;Lee, Sung-Ik
    • Progress in Superconductivity
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    • v.2 no.1
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    • pp.39-42
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    • 2000
  • The mixed-state Hall angle has been measured in Hg-based superconducting thin films as functions of magnetic fields (H) up to 18 T. The temperature dependence of the Hall angle shows a peak (T*) at low temperature, which is consistent with a crossover point from the thermally activated flux flow (TAFF) to a critical region (CR). At low fields below 10 T, T* shifts to low temperature with increasing fields. Interestingly, however, we found that T* is independent of fields above 10 T, suggesting unusual vortex state. A physical implication of H-T* line will be discussed.

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Development of the Innovation Leadership Scale (혁신 리더십 척도 개발 및 효과성 검증)

  • Tak, Jinkook;Kim, Chan Mo;Cho, Eunhyun
    • Knowledge Management Research
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    • v.9 no.1
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    • pp.1-21
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    • 2008
  • The present study investigatesthe reliability and validity of the innovation leadership scale. Originally the seven factors with 25 items were developed through literature review. With a sample of 177 employees in a large company, the results of factor analyses showed that the five-factor model with 14 items had a better fit to the data than the seven-factor model. These five factors were innovativeness pursue, problem solving, vision presentation, risk-taking, and showing initiative. All of these factors were significantly related to various criteria such as identification with the group, attachment to the group, organizational commitment, and supervisor satisfaction, confirming criterion-related validity of the scale. Results of multiple regression analyses showedthat risk taking and showing initiative were more important predictors in explaining criteria. Finally, implications and limitations were discussed. The findings suggest that the key factors of innovation leadership were initiative and risk-taking.

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3-DIMENSIONAL TILING TECHNIQUE TO PROCESS HUGE SIZE HIGH RESOLUTION SATELLITE IMAGE SEAMLESSLY AND RAPIDLY

  • Jung, Chan-Gyu;Kim, Jun-Chul;Hwang, Hyun-Deok
    • Proceedings of the KSRS Conference
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    • 2007.10a
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    • pp.85-89
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    • 2007
  • This paper presents the method to provide a fast service for user in image manipulation such as zooming and panning of huge size high resolution satellite image (e.g. Giga bytes per scene). The proposed technique is based on the hierarchical structure that has 3D-Tiling in horizontal and vertical direction to provide the image service more effectively than 2D-Tiling technique in the past does. The essence of the proposed technique is to create tiles that have optimum level of horizontal as well as vertical direction on the basis of current displaying area which changes as user manipulates huge image. So this technique provides seamless service, and will be very powerful and useful for manipulation of images of huge size without data conversion.

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Reverse-optimization Alignment Algorithm using Zernike Sensitivity

  • Kim Eugene D.;Choi Young-Wan;Kang Myung-Seok;Choi Se Chol
    • Journal of the Optical Society of Korea
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    • v.9 no.2
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    • pp.68-73
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    • 2005
  • When aligning catoptric or catadioptric telescopes for space cameras, it is difficult to align precisely if the field of view is large or there are several reflective surfaces. The quantitative knowledge of mirror misalignments greatly helps align a misaligned telescope precisely, and also reduce the alignment time. This paper describes a generalized reverse-optimization alignment solution algorithm using Zernike sensitivity, and proposes the minimum number of fields to take interferograms. This method was successfully applied on a Cassegrain telescope design for Earth observation from space with arbitrary misalignments and a model including some primary mirror deformation.

A proteomic approach to identify yeast proteins responding to accumulation of misfolded proteins inside the cells

  • Shin, Yong-Seung;Seo, Eun-Joo;Kim, Joon;Yu, Myeong-Hee
    • Proceedings of the Korean Biophysical Society Conference
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    • 2003.06a
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    • pp.57-57
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    • 2003
  • In growing number of diseases it has been shown that aggregation of specific proteins has an important role in pathogenesis of the disorder. This has been demonstrated in structural details with the liver cirrhosis of ${\alpha}$$_1$-antitrypsin deficiency, and it is now believed that similar protein aggregation underlies many neurodegenerative disorders such as autosomal dominant Parkinson disease, prion diseases, Alzheimer disease, and Huntington disease. ${\alpha}$$_1$-Antieypsin, a member of serine pretense inhibitor (serpin) family, functions as an inhibitor of neutrophil elastase.

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