• Title/Summary/Keyword: Initiative

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Nafamostat mesilate promotes endothelium-dependent vasorelaxation via the Akt-eNOS dependent pathway

  • Choi, Sujeong;Kwon, Hyon-Jo;Song, Hee-Jung;Choi, Si Wan;Nagar, Harsha;Piao, Shuyu;Jung, Saet-byel;Jeon, Byeong Hwa;Kim, Dong Woon;Kim, Cuk-Seong
    • The Korean Journal of Physiology and Pharmacology
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    • v.20 no.5
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    • pp.539-545
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    • 2016

  • Nafamostat mesilate (NM), a synthetic serine protease inhibitor, has anticoagulant and anti-inflammatory properties. The intracellular mediator and external anti-inflammatory external signal in the vascular wall have been reported to protect endothelial cells, in part due to nitric oxide (NO) production. This study was designed to examine whether NM exhibit endothelium dependent vascular relaxation through Akt/endothelial nitric oxide synthase (eNOS) activation and generation of NO. NM enhanced Akt/eNOS phosphorylation and NO production in a dose- and time-dependent manner in human umbilical vein endothelial cells (HUVECs) and aorta tissues obtained from rats treated with various concentrations of NM. NM concomitantly decreased arginase activity, which could increase the available arginine substrate for NO production. Moreover, we investigated whether NM increased NO bioavailability and decreased aortic relaxation response to an eNOS inhibitor in the aorta. These results suggest that NM increases NO generation via the Akt/eNOS signaling pathway, leading to endothelium-dependent vascular relaxation. Therefore, the vasorelaxing action of NM may contribute to the regulation of cardiovascular function.

  • https://doi.org/10.4196/kjpp.2016.20.5.539 인용 PDF KSCI

Eurasia Initiative and East Sea Rim Maritime Community (유라시아 이니셔티브와 환동해권 전략)

  • Kang, Tae-Ho
    • Strategy21
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    • s.37
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    • pp.144-176
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    • 2015

  • In September 2013, President Park Geun-hye announced her controversial "Look North" policy, of which the most salient aspect is the "Eurasia Initiative". This comprises various proposals designed to overcome existing constraints by developing new markets and creating new economic partners in continental areas from which South Korea has been alienated since the end of World War II, and this dovetails nicely with China's One Belt, One Road Initiative. The concepts of the "Silk Road Rail Express (SRX)" and the "East Sea Rim Maritime Community (ESRMC)" have also been discussed. SRX is at present a purely symbolic railroad project intended to encourage individual, cultural, trade and diplomatic exchanges. ESRMC is a model for establishing an ad hoc community to promote regional economic cooperation around the East Sea. President Park's Eurasia Initiative will provide South Korean investment for the Northeast to complement Russian plans, like the "Northern Energy Road" being built by Gazprom, and Chinese plans, like the Chang-Ji-Tu Development Plan for the North Korean port of Rajin. China's trade, as well as its energy and food supplies, pass through the Strait of Malacca and the Indian Ocean, and are thus vulnerable to interdiction by India or the US. China is therefore trying to reduce its exposure geopolitical risk by establishing a network of corridors between the Belt and the Road to provide alternative paths. The "China-Pakistan Economic Corridor" and the "China-Myanmar Economic Corridor" provide such connections, and South Korea hopes that SRX and ESRMC can become part of a "China-South Korea Economic Corridor". This concept could do much to revitalize the underdeveloped northern provinces of China and Russia's Far East, not to mention North Korea. By linking up the Trans-Siberian Railway, the Trans-China Railway, the Trans-Mongolian Railway and the Trans-Korean Railway all these Asian countries will be connected to one another, and ultimately to Europe. An interim connection between China and South Korea using a rail-ferry has also been proposed.

  • https://doi.org/10.22803/strategy21.2015.s37.144 인용 PDF

Difference Analysis between Social Workers and Community Members about Perception of Citizen-Initiative (주민주도성에 대한 사회복지사와 주민간 인식 차이에 관한 연구)

  • Jang, Yeon-Jin;Kang, Kyu-Tae;Ha, Eun-Sol
    • Journal of Digital Convergence
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    • v.17 no.9
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    • pp.451-469
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    • 2019

  • The purpose of this study is to find developing way of community welfare aimed community-initiative by analyzing differential perception of citizen-initiative between social workers and community members. For this purpose, this study did a difference analysis on self-rating result of importance and difficulty in 59 statements about the citizen-initiative. Participants were 10 social workers in charge of community center over 2 years and 10 community members joined in community group over 2 years. The results are as follows. Differential perception between social workers and community members appeared both importance and difficulty. Especially, differential perception in difficulty was bigger. The statements that social workers as well as community members answered high level of difficulty were related with securing budget and external financial support. As the analysis of categorized statements, the differential perception in 'Goal and responsibility' and 'Democratic system' in procedural aspects were statistically significant. Based on these results, this study presented practical suggestions to make consensus about citizen-initiative in community organization.

  • https://doi.org/10.14400/JDC.2019.17.9.451 인용 PDF KSCI