• 제목/요약/키워드: Initiation

검색결과 3,726건 처리시간 0.026초

미역의 섭취가 화학적으로 유도된 쥐의 대장암화 표지자인 Aberrant Crypt 형성 및 상피세포 분열에 미치는 영향에 관한 연구 (Effect of Fiber-Rich Sea Mustard Feeding on AOM-Induced Colon Aberrant Crypt Formation and Colonic Cell Proliferation in Sprague Dawley Rats)

  • 이은주;성미경
    • 한국식품영양과학회지
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    • 제30권3호
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    • pp.535-539
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    • 2001
  • The modulating effect of feeding sea mustard (Undarina pinnatifida), a fiber-rich seaweed, during initiation and post-initiation phases of colon carcinogenesis was investigated in Sprague Dawley rats. Four groups of animals were exposed to the two weekly injections of a chemical carcinogen, azoxymethane (AOM). Animals were placed on diet containing 15% sea mustard during initiation. post-initiation or initiation+post-initiation phase of carcinogenesis for 10 weeks, and colonic aberrant crypt formation and cell proliferation were compared to those of rats fed semi-synthetic control diet. Results showed that sea mustard feeding significantly reduced the numbers of both aberrant crypts and aberrant crypt foci. Also, labeling indices and proliferation zones were significantly reduced in the colon of the rats fed sea mustard diets. These results indicate that the diet containing sea mustard may decrease the risk of colon cancer development, and a part of such effect may be mediated through both the blocking of initiation and the suppression of cell proliferation in the colonic crypts, although precise mechanisms should be further examined.

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Age at Smoking Initiation and Subsequent Smoking Among Korean Adolescent Smokers

  • Hwang, Jun Hyun;Park, Soon-Woo
    • Journal of Preventive Medicine and Public Health
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    • 제47권5호
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    • pp.266-272
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    • 2014
  • Objectives: The aim of this study was to investigate the relationship between age at cigarette smoking initiation and smoking level among adolescent current smokers. Methods: In 2007, students from one or two classes of the 10th or 11th grade were randomly selected using the probability proportional to size sampling method. In total, 743 current smokers were included. Multiple logistic regression was used to determine the association between age at smoking initiation and smoking level as either frequent, daily, or heavy smokers. Results: The adjusted odds ratios for each smoking level were significantly higher for younger ages of smoking initiation than those for older ages of initiation were (p for trend <0.001). Compared with the students who started smoking in grades 10 to 11, the adjusted odds ratios for frequent, daily, and heavy smokers increased from 2.24 (95% confidence interval [CI], 1.30 to 3.87) to 3.90 (95% CI, 2.02 to 7.56), from 1.56 (95% CI, 0.92 to 2.62) to 3.17 (95% CI, 1.70 to 5.92), and from 2.56 (95% CI, 1.21 to 5.42) to 5.67 (95% CI, 2.61 to 12.30) with younger ages of smoking initiation. Conclusions: Smoking frequency and amount were closely associated with age at smoking initiation. Therefore, smoking prevention programs should be initiated from the young adolescent period.

Analytical solutions for crack initiation on floor-strata interface during mining

  • Zhao, Chongbin
    • Geomechanics and Engineering
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    • 제8권2호
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    • pp.237-255
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    • 2015
  • From the related engineering principles, analytical solutions for horizontal crack initiation and propagation on a coal panel floor-underlying strata interface due to coal panel excavation are derived in this paper. Two important concepts, namely the critical panel width of horizontal crack initiation on the panel floor-underlying strata interface and the critical panel width of vertical fracture (crack) initiation in the panel floor, have been presented. The resulting analytical solution indicates that: (1) the first criterion can be used to express the condition under which horizontal plane cracks (on the panel floor-underlying strata interface or in the panel floor because of delamination) due to the mining induced vertical stress will initiate and propagate; (2) the second criterion can be used to express the condition under which vertical plane cracks (in the panel floor) due to the mining induced horizontal stress will initiate and propagate; (3) this orthogonal set of horizontal and vertical plane cracks, once formed, will provide the necessary weak network for the flow of gas to inrush into the panel. Two characteristic equations are given to quantitatively estimate both the critical panel width of vertical fracture initiation in the panel floor and the critical panel width of horizontal crack initiation on the interface between the panel floor and its underlying strata. The significance of this study is to provide not only some theoretical bases for understanding the fundamental mechanism of a longwall floor gas inrush problem but also a benchmark solution for verifying any numerical methods that are used to deal with this kind of gas inrush problem.

탄소성 유한요소 해석을 통한 곡관 두께에 따른 파손 위치 및 균열 진전 방향 분석 (Analysis of the Elbow Thickness Effect on Crack Location and Propagation Direction via Elastic-Plastic Finite Element Analysis)

  • 김재윤;이종민;김윤재;김진원
    • 한국압력기기공학회 논문집
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    • 제18권1호
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    • pp.26-35
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    • 2022
  • When piping system in a nuclear power plant is subjected to a beyond design seismic condition, it is important to accurately determine possibility of crack initiation and, if initiation occurs, its location and time. From recent experimental works on elbow pipes, it was found that the crack initiation location and crack propagation direction of the SA403 WP316 stainless steel elbow pipe were affected by the pipe thickness. In this paper, the crack initiation location and crack propagation direction for SA403 WP316 stainless steel elbow pipes with different thickness were analyzed via elastic-plastic finite element analysis. Based on FE results, the effect of the pipe thickness on different crack initiation location and crack propagation direction was analyzed using ovality, stress and strain components. It was also confirmed that the presence of internal pressure had no effect on the crack initiation location and crack propagation direction.

기업의 배당개시결정에 관한 실증적 연구 (An Empirical Study on Dividend Initiation Decisions of Firms)

  • 신민식;송준협
    • 재무관리연구
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    • 제24권4호
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    • pp.135-161
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    • 2007
  • 본 연구는 1997년 1월 1일부터 2006년 12월 31일까지 한국증권선물거래소의 유가증권시장과 코스닥시장에 상장된 IPO 기업을 대상으로 배당개시결정의 3가지 측면, 즉, 배당개시 여부, 배당수준 및 배당개시시점의 결정요인을 실증분석 하였으며, 주요한 분석결과는 다음과 같다. 첫째, 주요 배당이론, 즉, 잔여배당이론, 배당신호이론, 대리인이론, 케이터링이론, 거래비용이론 등에서 제시된 배당결정요인들은 IPO 기업의 배당개시결정에도 유의한 영향을 미친다. 성장기회 변수인 M/B 비율과 R&D지출 비율이 낮을수록, 수익성 변수인 EBITDA 비율이 높을수록, 거래량회전율이 낮을수록, 그리고 배당프리미엄이 높을수록 배당개시확률은 높아진다. 둘째, 주요 배당이론에서 제시된 배당결정요인 중에서 성장기회 변수와 수익성 변수는 IPO 기업의 배당수준결정에도 유의한 영향을 미친다. 즉, 성장기회 변수인 R&D지출 비율이 낮을수록, 그리고 수익성 변수인 EBITDA 비율이 높을수록 배당수준이 증가한다. 셋째, 배당개시확률을 증가시키는 요인들은 배당개시시점을 단축시키는 요인으로 작용한다. 즉, 성장기회 변수인 R&D지출이 낮을수록, 수익성 변수인 EBITDA 비율이 높을수록, 그리고 거래량 회전율이 낮을수록, 배당개시확률은 증가하고 배당개시시점은 단축된다. 특히, 수익성 변수인 EBITDA 비율 및 거래량회전율은 배당개시시점과 배당지급/연기 결정에 모두 유의한 영향을 미친다. 즉, EBITDA 비율이 높을수록 배당개시시점이 단축되고, 거래량회전율이 높을수록 배당개시시점이 연기된다. 또한 배당개시기업의 대부분은 IPO 후 2년 이내에 배당개시 여부를 결정한다. 따라서 기업이 IPO 후 2년 이내에 배당개시를 하지 않으면 그 이후에는 배당개시를 하지 않을 가능성이 많다.

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임계평면법을 이용한 거친 표면의 구름접촉시 피로균열 시작수명 (The Fatigue Crack Initiation Life under the Rolling Contact of Rough Surfaces using Critical Plane Approach)

  • 설광조;김태완;조용주
    • Tribology and Lubricants
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    • 제19권1호
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    • pp.26-30
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    • 2003
  • The stresses of surface and substrate under the rough surface contact are irregular. Using rainflow counting method for irregular stresses, the fatigue surface crack initiation lift was calculated. With the surface generated by computer, this paper figures out the random load generated by contacting to the rough surface, analyzes the stress of its subsurface, and calculates the fatigue crack initiation life of the rough surface fatigue theory.

3차원 거친 접촉하에서의 피로균열 시작수명에 관한 연구 (Study on the Fatigue Crack Initiation Life uncle]r 3-Dimensional Rough Contact)

  • 김태완;구영필;조용주
    • Tribology and Lubricants
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    • 제18권2호
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    • pp.160-166
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    • 2002
  • In case of rough contact fatigue, the accurate calculation of surface tractions is essential to the prediction of crack initiation life. Accurate Surface tractions influencing shear stress amplitude can be obtained by contact analysis based on the morphology of contact surfaces. In this study, to simulate rough contact under sliding condition, gaussian rough surface generated numerically in the previous study was used and to calculate clack initiation life in the substrate, dislocation pileup theory was used.

3차원 거친 접촉하에서의 피로균열 시작수명에 관한 연구 (Study on the Fatigue Crack Initiation Life under 3-Dimensional Rough Contact)

  • 이문주;구영필;조용주
    • 한국윤활학회:학술대회논문집
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    • 한국윤활학회 2000년도 제32회 추계학술대회 정기총회
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    • pp.72-79
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    • 2000
  • In case of rough contact fatigue, the accurate calculation of surface tractions is essential to the prediction of crack initiation life. Accurate Surface tractions influencing shear stress amplitude can be obtained by contact analysis based on tile morphology of contact surfaces. In this study, to simulate rough contact under sliding condition, gaussian rough surface generated numerically in the previous study was used and to calculate crack initiation life in the substrate, dislocation pileup theory was used.

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Systematic Review of Smoking Initiation among Asian Adolescents, 2005-2015: Utilizing the Frameworks of Triadic Influence and Planned Behavior

  • Talip, Tajidah;Murang, Zaidah;Kifli, Nurolaini;Naing, Lin
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권7호
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    • pp.3341-3355
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    • 2016
  • Background: A recent WHO data report on mortality attributable to tobacco use including cigarette smoking indicated a very high burden of deaths in Asia and that people often initiate smoking as early as young adolescents. The objectives of this study were to systematically review peer-reviewed articles on cigarette smoking initiation among Asian adolescents and to develop a conceptual model of factors influencing smoking initiation by integrating all relevant factors based on existing data. Materials and Methods: Following a PRISMA guideline, a systematic review of articles published between 2005 and June 2015 was conducted using 5 databases on cigarette smoking initiation among adolescents (aged 10-19 years) living in Asia. We summarized the main findings of each study according to our research questions and data that emerged during the data extraction process. Analysis and categorization were based on the TTI and TPB models and classification of factors extracted from the study, were as follows: personal factors, social factors, broader environmental factors, mediators, and intention to initiate smoking and smoking behavior. Results: Of 1,227 identified studies, only 20 were included in this review. Our findings found that the mean age of cigarette smoking initiation ranged from 10 to 14 years and those who are more likely to initiate smoking are male, older adolescents, adolescents with low parental SES, individuals with low parental monitoring, low parental education level and having no discussion on smoking at home, those living in public housing and those exhibiting health-risk behavior. Our study also revealed that the risk of smoking initiation increased when they are exposed to smokers, influenced by peers, exposed to tobacco advertisements, receive pocket money, have lack of knowledge about smoking, have poor school performance, have a family conflict and have psychological problems. The conceptual model developed demonstrated complex networks of factors influencing initiation. Conclusions: This systematic review presents various factors influencing smoking initiation of the Asian adolescents and provides a conceptual framework to further analyze factors. Future studies should have a standard measure of smoking initiation, should analyze interactions and the intensity of relationships between different factors or variables in the conceptual model. This will in turn consolidate the understanding of the different factors affecting smoking initiation and will help to improve interventions in this area.

Characteristics of Corrosion Fatigue of High Strength Steel for Marine Weld Structure

  • Choi, Seong-Dae;Kubo, Takeo;Misawa, Hiroshi;Lee, Jong-Hyung;Song, Dug-Jung
    • 한국기계가공학회지
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    • 제2권4호
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    • pp.53-60
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    • 2003
  • Large sized marine structures are used under corrosion environment of seawater and applied by severe service loading such as an ocean current, a billow and a tempest. Marine structures are usually constructed by lots of thick wall steel pipes joining welded joints. The thickness of such as steel pipes is usually more than 40mm. The such as steels are called "Thermo-Mechanical Control Process steel (TMCP steel)" strengthened by a heat treatment in process of steel manufactures. The failure, especially crack initiation, of marine structures was starting at weld joints under service condition. Then they should be designed by basis of the fatigue strength under seawater corrosion environment of weld joints. To clarity the fatigue crack initiation behavior is important more than to clarify the crack propagation behavior on the strength design of marine structures, because it is very difficult to find out the crack initiation and propagation phenomena and then even if it will be able to find out, it is considered that the refit of the damaged parts of welded joints have a technical difficulty under the sea. Therefore, it is most important to clarify the corrosion fatigue crack initiation behavior under the seawater condition. But, there is one big difficulty to make a test for thick plate specimen, for example thicker than 40mm. Because, it is need large capacity loading apparatus to test such as thick plate specimen. In this research, the new configuration specimen for fatigue crack initiation tests was proposed. Using this new specimen, it is easy to carry out the fatigue clack initiation tests with relatively low cyclic loading and to observe a fatigue crack initiation behavior.

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