• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4549-4553
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• 2014

Background: Infection is a serious cause of mortality in febrile neutropenia of pediatric cancer patients. Recently, monotherapy has replaced the combination therapy in empirical treatment of febrile neutropenia. Since there has been no reported trial comparing the efficacy of meropenem and piperacillin-tazobactam (PIP/TAZ) monotherapies, the present retrospective study was conducted to compare safety and efficacy in febrile neutropenic children with cancer. Materials and Methods: Charts of febrile, neutropenic children hospitalized at our center between March 2008 and April 2011 for hemato-oncological malignancies were reviewed. Patients received PIP/TAZ 360 mg/kg/day or meropenem 60 mg/kg/day intravenously in three divided doses. Duration of fever and neutropenia, absolute neutrophil count, modification, and success rate were compared between the two groups. Resolution of fever without antibiotic change was defined as success and resolution of fever with antibiotic change or death of a patient was defined as failure. Modification was defined as changing the empirical antimicrobial agent during a febrile episode. Results: Two hundred eighty four febrile neutropenic episodes were documented in 136 patients with a median age of 5 years. In 198 episodes meropenem and in 86 episodes PIP/TAZ were used. Duration of fever and neutropenia, neutrophil count, sex, and primary disease were not different between two groups. Success rates and modification rate between two groups showed no significant differences (p>0.05). Overall success rate in the meropenem and PIP/TAZ groups were 92.4% and 91.9% respectively. No serious adverse effects occurred in either of the groups. Conclusions: Meropenem and PIP/TAZ monotherapy are equally safe and effective in the initial treatment of febrile neutropenia in children with cancer.

• Archives of Reconstructive Microsurgery
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• 제18권2호
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• pp.41-48
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• 2009

There are several advantages for groin flap, but its small and unpredictable vessels of pedicle have made it to lose its initial popularity. Although it would be ideal flap when it is focused on its useful advantages such as relative larger size, low donor site morbidity and possible bone graft, there have been few studies for prognostic factors for successful groin flap. Authors intended to determine prognostic factors which are relative with success of free groin flap. From January 1985 to December 2007, 107 patients who underwent groin flap for reconstruction of extremities were selected consecutively. Univariate and multivariate analysis were performed to determine prognostic factors which were related with success of groin flap. Eighty of 107 (74.8%) flaps survived. There was significant difference in success rate according to the recipient site. Nineteen of 20 cases (95%) survived in upper extremities, but 61 of 87 cases (70.1%) survived in lower extremities, which was statistically significant (p=0.022). Univariate analysis showed that mean diameter of donor veins was significantly larger in success group (p=0.021). Groin flap is recommended for reconstruction of upper extremities than lower extremities. It is thought to be critical that surgeons try to match vessel diameters between donor and recipient site.

• 한국간담췌외과학회지
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• 제26권4호
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• pp.318-324
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• 2022

Backgrounds/Aims: Gallstone disease is a recognized complication of bariatric surgery. Subsequent management of choledocholithiasis may be challenging due to altered anatomy which may include Roux-en-Y gastric bypass (RYGB). We conducted a retrospective service evaluation study to assess the safety and efficacy of endoscopic ultrasound-directed transgastric endoscopic retrograde cholangiopancreatography (EDGE) in patients with RYGB anatomy. Methods: All the patients who underwent EDGE for endoscopic retrograde cholangiopancreatography after RYGB at two tertiary care centers in the United Kingdom between January 2020 and October 2021 were included in the study. Clinical and demographic details were recorded for all patients. The primary outcome measures were technical and clinical success. Adverse events were recorded. Hot Axios lumen apposing metal stents measuring 20 mm in diameter and 10 mm in length were used in all the patients for creation of a gastro-gastric or gastro-jejunal fistula. Results: A total of 14 patients underwent EDGE during the study period. The majority of the patients were female (85.7%) and the mean age of patients was 65.8 ± 9.8 years. Technical success was achieved in all but one patient at the first attempt (92.8%) and clinical success was achieved in 100% of the patients. Complications arose in 3 patients with 1 patient experiencing persistent fistula and weight gain. Conclusions: In patients with RYGB anatomy, EDGE facilitated biliary access has a high rate of clinical success with an acceptable safety profile. Adverse events are uncommon and can be managed endoscopically.

• 벤처창업연구
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• 제16권3호
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• pp.145-158
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• 2021

이 연구의 목적은 비상장기업의 소유구조가 코스닥 상장에 미치는 영향을 살펴보는 것이다. 소유구조를 중심으로 상장 성공의 특성을 분석한 선행연구가 거의 없어 상장을 목표로 스타트업을 성장시키는 경영진들이 창업 초기부터 상장의 가능성을 높일 수 있는 소유구조를 갖추어 가는데 참고할 만한 자료가 부족한 실정이다. 따라서 본 연구에서는 코스닥 시장에 상장 예비 심사 청구 기업 중 상장(IPO) 성공기업과 실패기업 대상비교를 통해, 선행연구에서 충분히 고려하지 않았던 기업의 소유구조가 상장 성공에 미치는 영향을 분석하였다. 주요 결과를 요약하면 다음과 같다. (1)벤처캐피탈의 투자 및 지분율은 코스닥 상장 성공에 긍정적인 영향을 미쳤다. 이는 벤처캐피탈의 투자가 정보 비대칭 문제를 완화하며, 벤처캐피탈의 투자는 시장참여자에게 유의한 신호가 된다는 것을 뜻한다. 이러한 결과는 벤처캐피탈이 코스닥 시장에 상장하려는 기업에게 중요한 역할을 한다는 것을 보여준다. (2)최대주주 지분율과 기업의 상장 성공 간에는 약한 역U자 관계가 존재하는 것으로 나타났다. 즉, 최대주주 지분율이 증가함에 따라 도덕적 해이가 완화되어 상장 성공 가능성이 높아진다. 그러나 최대주주지분율이 일정 수준보다 높아지면, 최대주주의 사익추구에 대한 우려로 상장 성공 가능성이 낮아진다. 이러한 비선형 관계는 기존 실증연구와 일치하는 결과로, 최대주주의 주식 소유가 대리인 비용을 줄이는데 기여한다는 것을 의미한다. 이 연구는 신호이론과 대리인 이론을 활용하여 기업의 소유구조가 상장 성공에 미치는 영향을 분석함으로써 학문적으로 기여하였다. 본 연구 결과는 기업공개를 준비하는 기업에 실무적 시사점을 제공하고 있다.

• Nuclear Medicine and Molecular Imaging
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• 제42권sup1호
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• pp.137-139
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• 2008

Wilms Tumor is a great therapeutic success story within pediatric oncology. Therefore, accurate initial staging is needed to assess tumor spread and to assign patients appropriately to the different risk branches. However, it is recognized that FDG-PET can provide useful information about tumor and has better accuracy than CT and MRI for staging, but its role in Wilms tumor is unclear. According to clinical research data, FDG PET may be useful for the management of selected patients with Wilms tumors.

• 기술사
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• 제41권2호
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• pp.64-67
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• 2008

According to grow maritime activities in coastal zone, a threat increase to the marine environment from oil spill. The success or failure of initial effort depends on the adequacy of the plan and the ability of immediate execution. Successful response to oil spills requires critical information in real time topics, including spill data, environmental conditions, ecological factors. Diverse simulation provides tactical decision-makers with the information on the movement of pollutant.

• 한국컴퓨터정보학회논문지
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• 제9권3호
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• pp.143-148
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• 2004

게임 개발 프로세스의 초기단계에서는 창의적인 아이디어 발상이 요구되는 단계로 게임의 성공과 실패 여부를 조기에 판가름 할 정도로 중요한 일이다. 이를 위해 개발된 웹 기반 창의적 발상 시스템(Creative Group Thinking System)은 이와 같은 컨셉디자인 단계에서 아이디어 발상을 지원하기 위해 개발된 것이다. 따라서 본 연구는 아이디어 발상에서 발상의 전환과 시너지 효과를 주는 Tips를 이용한 효과를 알아보고 이를 토대로 개발 초기에 컨셉의 완성도를 높일 수 있는 방법을 찾아 게임 개발 프로세스를 개선하는데 목적을 둔다.

• 정보보호학회논문지
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• 제16권2호
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• pp.25-32
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• 2006

본 논문에서는 shrinking 생성기와 self-shrinking 생성기에 대한 향상된 고속 상관 공격을 제안한다. 본 논문에서 제안하는 공격은 Zhang 등이 CT-RSA 2005에서 제안한 shrinking 생성기에 대한 고속 상관 공격을 개선한 것으로 shrinking 생성기에서 길이가 61인 생성 LFSR의 초기 상태값을 $2^{15.43}$ 키스트림 비트와 $2^{56.3314}$의 계산 복잡도로 성공 확률 99.9%로 복구할 수 있다. 또한 245.89 키스트림 비트와 $2^{112.424}$ 계산 복잡도로 self-shrinking 생성기에서 길이가 $2^{40}$인 LFSR의 초기 상태값을 성공 확률 99.9%로 복구할 수 있다.

• 한국해양공학회지
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• 제36권3호
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• pp.181-193
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• 2022

This study presents a mission management technique that is a key component of underwater docking system used to expand the operating range of autonomous underwater vehicle (AUV). We analyzed the docking scenario and AUV operating environment, defining the feasible initial area (FIA) level, event level, and global path (GP) command to improve the rate of docking success and AUV safety. Non-holonomic constraints, mounted sensor characteristic, AUV and mission state, and AUV behavior were considered. Using AUV and docking station, we conducted experiments on land and at sea. The first test was conducted on land to prevent loss and damage of the AUV and verify stability and interconnection with other algorithms; it performed well in normal and abnormal situations. Subsequently, we attempted to dock under the sea and verified its performance; it also worked well in a sea environment. In this study, we presented the mission management technique and showed its performance. We demonstrated AUV docking with this algorithm and verified that the rate of docking success was higher compared to those obtained in other studies.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제49권5호
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• pp.278-286
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• 2023

Objectives: This review assessed the performance of implant-supported fixed hybrid prostheses in 21 patients who received a total of 137 implants between 2003 and 2010. The implants were evaluated for marginal bone resorption, complications, success rate, and survival rate based on their vertical angularity, type of bone graft, and measured implant stability. Materials and Methods: One-way ANOVA and chi-square tests were used to analyze the relationships among long-term evaluation factors and these variables. The mean initial bone resorption in the implant group with a vertical angle of more than 20° was 0.33 mm and mean final bone resorption was 0.76 mm. In contrast, the mean initial bone resorption in the implant group with a vertical angle of less than 10° was 1.19 mm and mean final bone resorption was 2.17 mm. Results: The results showed that mean bone resorption decreased with an increase in the vertical placement angle of the implants used in fixed hybrid prostheses, as well as in the group without additional bone grafts and those with high implant stability. The success rate of implants placed after bone grafting was found to be higher than those placed simultaneously. Conclusion: These results suggest that implant-supported fixed hybrid prostheses may be an effective treatment option for edentulous patients, and intentionally placing implants with high angularity may improve outcomes.