• 대한기계학회논문집
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• 제12권5호
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• pp.952-958
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• 1988

본 연구에서는 폭방향 불균일 냉각에 따른 열응력이 판변형 및 잔류응력의 주 요원인이라는 고려하에 냉각중에 압연판의 온도분포 및 열응력을 예측할 수 있는 수치 해석 모델을 구성하였다. 온도와 응력 계산에 상변태 현상을 고려하였으며, 판변형 은 압축성분 열응력에 의한 좌굴현상으로 고려하여 해석하였다.

• 한국구조물진단유지관리공학회 논문집
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• 제16권2호
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• pp.75-86
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• 2012

본 논문에서는 FR-ECC의 수축특성과 균열도입 전후의 내동해성을 평가하였으며, FR-ECC를 활용한 다층복공구조의 지수성능과 박리박락저항성, 또한 FR-ECC로 단면복구 된 보부재의 휨성능을 평가하였다. 그 결과, FR-ECC는 소성수축에 의한 균열 및 건조수축에 의한 길이변화율이 기존의 보수모르터에 비해 크게 저감되었으며, 구속상태에서의 건조수축에 대한 균열저항성이 개선됨을 알 수 있었다. 또한, FR-ECC는 내동해성이 매우 우수하였으며, 균열도입 후에도 동결융해작용에 의한 인장성능의 저하는 확인되지 않았다. 한편, FR-ECC로 보수된 휨부재는 초기균열모멘트, 항복모멘트 및 극한모멘트 등의 휨성능이 증대되었으며, 멀티플크랙 특성에 의해 휨파괴시까지 균열폭을 안정적으로 제어할 수 있었다.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권3호
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• pp.127-141
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• 2015

Silver-based systems activated by low intensity direct current continue to be investigated as an alternative antimicrobial for infection prophylaxis and treatment. However there has been limited research on the quantitative characterization of the antimicrobial efficacy of such systems. The objective of this study was to develop a semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model providing the quantitative relationship between the critical system parameters and the degree of antimicrobial efficacy. First, time-kill curves were experimentally established for a strain of Staphylococcus aureus in a nutrientrich fluid environment over 48 hours. Based on these curves, a modified PK/PD model was developed with two components: a growing silver-susceptible bacterial population and a depreciating bactericidal process. The test of goodness-of-fit showed that the model was robust and had good predictability ($R^2>0.7$). The model demonstrated that the current intensity was positively correlated to the initial killing rate and the bactericidal fatigue rate of the system while the anode surface area was negatively correlated to the fatigue rate. The model also allowed the determination of the effective range of these two parameters within which the system has significant antimicrobial efficacy. In conclusion, the modified PK/PD model successfully described bacterial growth and killing kinetics when the bacteria were exposed to the electrically activated silver-titanium implant system. This modeling approach as well as the model itself can also potentially contribute to the development of optimal design strategies for other similar antimicrobial systems.

• 한국지진공학회논문집
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• 제25권3호
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• pp.103-110
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• 2021

A shake table test is conducted for the three-story reinforced concrete building structure using 0.28 g, 0.5 g, 0.75 g, and 1.0 g of seismic input motions based on the Gyeongju earthquake. Computational efforts are made in parallel to explore the mechanical details in the structure. For engineering practice, the elastic modulus of concrete and rebar in the dynamic analysis is reduced to 38% and 50%, respectively, to calibrate the structure's natural frequencies. The engineering approach to the reduced modulus of elasticity is believed to be due to the inability to specify the flexibility of the actual boundary conditions. This aspect may lead to disadvantages of nonlinear dynamic analysis that can distort local stress and strain relationships. The initial elastic modulus can be applied directly without the so-called engineering adjustment with infinite element models with spring and spring-dashpot boundary conditions. This has the advantage of imposing the system flexibility of the structure on the sub-boundary conditions of springs and damping devices to control its sensitivity in a serial arrangement. This can reflect the flexibility of realistic boundary conditions and the effects of system damping (such as the gap between a concrete footing and shake table, loosening of steel anchors, etc.) in scalar quantities. However, these spring and dashpot coefficients can only be coordinated based on experimental results, making it challenging to select the coefficients in-prior to perform an experimental test.

• 한국전산구조공학회논문집
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• 제31권6호
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• pp.283-291
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• 2018

본 연구는 지진에 저항하는 부재인 비보강 조적벽체로 구성된 건물의 내진성능평가에 활용되는 비선형 정적해석을 위한 비보강 조적벽체의 해석모델을 수립하고자 하였다. 본 연구의 해석모델은 비보강 조적벽체의 휨거동을 모사하기 위한 파이버 요소와 비보강 조적벽체의 전단에 대한 응답을 예측하기 위한 전단스프링 요소로 구성된다. 본 논문은 먼저 제안하고 있는 모델의 형상에 대해서 설명하고, 기존에 행해진 조적조 프리즘의 실험결과로부터 얻은 응력-변형률 곡선을 근거로 파이버와 전단스프링 요소의 물성치에 대한 결정 방법을 설명한다. 제시하고 있는 모델은 비선형 정적 해석결과와 다른 연구자들에 의해 수행된 실험결과를 비교하여 타당성을 검증한다. 해당 모델은 최대강도, 초기강성, 그리고 이들로부터 얻어지는 비보강 조적벽체의 하중-변위 곡선을 적절하게 모사하고 있다. 또한, 해석모델이 비보강 조적벽체의 파괴모드를 예측할 수 있는 것으로 나타난다.

• Journal of Microbiology and Biotechnology
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• 제29권6호
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• pp.933-943
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• 2019

Gamma-aminobutyric acid (GABA)-producing strains were isolated from four edible insects and subjected to 16S rRNA sequence analysis. Among the four GABA-producing bacteria, Enterococcus avium JS-N6B4 exhibited the highest GABA-production, while cultivation temperature, initial pH, aerobic condition, and mono-sodium glutamate (MSG) feeding were found to be the key factors affecting GABA production rate. The culture condition was optimized in terms of glucose, yeast extract, and MSG concentrations using response surface methodology (RSM). GABA production up to 16.64 g/l was obtained under the conditions of 7 g/l glucose, 45 g/l yeast extract, and 62 g/l MSG through the optimization of medium composition by RSM. Experimental GABA production was 13.68 g/l, which was close to the predicted value (16.64 g/l) calculated from the analysis of variance, and 2.79-fold higher than the production achieved with basic medium. Therefore, GABA-producing strains may help improve the GABA production in edible insects, and provide a new approach to the use of edible insects as effective food biomaterials.

• Structural Engineering and Mechanics
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• 제68권5호
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• pp.603-619
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• 2018

In this research, an effective computational technique is carried out for nonlinear and post-buckling analyses of cracked imperfect composite plates. The laminated plates are assumed to be moderately thick so that the analysis can be carried out based on the first-order shear deformation theory. Geometric non-linearity is introduced in the way of von-Karman assumptions for the strain-displacement equations. The Ritz technique is applied using Legendre polynomials for the primary variable approximations. The crack is modeled by partitioning the entire domain of the plates into several sub-plates and therefore the plate decomposition technique is implemented in this research. The penalty technique is used for imposing the interface continuity between the sub-plates. Different out-of-plane essential boundary conditions such as clamp, simply support or free conditions will be assumed in this research by defining the relevant displacement functions. For in-plane boundary conditions, lateral expansions of the unloaded edges are completely free while the loaded edges are assumed to move straight but restricted to move laterally. With the formulation presented here, the plates can be subjected to biaxial compressive loads, therefore a sensitivity analysis is performed with respect to the applied load direction, along the parallel or perpendicular to the crack axis. The integrals of potential energy are numerically computed using Gauss-Lobatto quadrature formulas to get adequate accuracy. Then, the obtained non-linear system of equations is solved by the Newton-Raphson method. Finally, the results are presented to show the influence of crack length, various locations of crack, load direction, boundary conditions and different values of initial imperfection on nonlinear and post-buckling behavior of laminates.

• Journal of Microbiology and Biotechnology
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• 제29권3호
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• pp.367-372
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• 2019

Deactivation of aminoglycosides by their modifying enzymes, including a number of aminoglycoside O-phosphotransferases, is the most ubiquitous resistance mechanism in aminoglycoside-resistant pathogens. Nonetheless, in a couple of biosynthetic pathways for gentamicins, fortimicins, and istamycins, phosphorylation of aminoglycosides seems to be a unique and initial step for the creation of a natural defensive structural feature such as a 3',4'-dideoxy scaffold. Our aim was to elucidate the biochemical details on the beginning of these C3',4'-dideoxygenation biosynthetic steps for aminoglycosides. The biosynthesis of istamycins must surely involve these 3',4'-didehydroxylation steps, but much less has been reported in terms of characterization of istamycin biosynthetic genes, especially about the phosphotransferase-encoding gene. In the disruption and complementation experiments pointing to a putative gene, istP, in the genome of wild-type Streptomyces tenjimariensis, the function of the istP gene was proved here to be a phosphotransferase. Next, an in-frame deletion of a known phosphotransferase-encoding gene forP from the genome of wild-type Micromonospora olivasterospora resulted in the appearance of a hitherto unidentified fortimicin shunt product, namely 3-O-methyl-FOR-KK1, whereas complementation of forP restored the natural fortimicin metabolite profiles. The bilateral complementation of an istP gene (or forP) in the ${\Delta}forP$ mutant (or ${\Delta}istP$ mutant strain) successfully restored the biosynthesis of 3',4'-dideoxy fortimicins and istamycins, thus clearly indicating that they are interchangeable launchers of the biosynthesis of 3',4'-dideoxy types of 1,4-diaminocyclitol antibiotics.

• 센서학회지
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• 제28권3호
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• pp.198-204
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• 2019

In this study, we propose a wearable force sensor using 3D printed mold and liquid metal. Liquid metal, such as Galinstan, is one of the promising functional materials in stretchable electronics known for its intrinsic mechanical and electronic properties. The proposed soft force sensor measures the external force by the resistance change caused by the cross-sectional area change. Fused deposition modeling-based 3D printing is a simple and cost-effective fabrication of resilient elastomers using liquid metal. Using a 3D printed microchannel mold, 3D multichannel Galinstan microchannels were fabricated with a serpentine structure for signal stability because it is important to maintain the sensitivity of the sensor even in various mechanical deformations. We performed various electro-mechanical tests for performance characterization and verified the signal stability while stretching and bending. The proposed sensor exhibited good signal stability under 100% longitudinal strain, and the resistance change ranged within 5% of the initial value. We attached the proposed sensor on the finger joint and evaluated the signal change during various finger movements and the application of external forces.

• Coupled systems mechanics
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• 제8권4호
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• pp.299-313
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• 2019

The paper represents computer modeling of the deformed state of physically nonlinear transversally isotropic bodies with hole. In order to describe the anisotropy of the mechanical properties of transversally-isotropic materials a structurally phenomenological model has been used. This model allows representing the initial material in the form of the coupled isotropic materials: the basic material (binder) considered from the positions of continuum mechanics and the fiber material oriented along the anisotropy direction of the original material. It is assumed that the fibers perceive only the axial tensile-compression forces and are deformed together with the base material. To solve the problems of the theory of plasticity, simplified theories of small elastoplastic deformation have been used for a transversely-isotropic body, developed by B.E. Pobedrya. A simplified theory allows applying the theory of small elastoplastic deformations to solve specific applied problems, since in this case the fibrous medium is replaced by an equivalent transversely isotropic medium with effective mechanical parameters. The essence of simplification is that with simple stretching of composite in direction of the transversal isotropy axis and in direction perpendicular to it, plastic deformations do not arise. As a result, the intensity of stresses and deformations both along the principal axis of the transversal isotropy and along the perpendicular plane of isotropy is determined separately. The representation of the fibrous composite in the form of a homogeneous anisotropic material with effective mechanical parameters allows for a sufficiently accurate calculation of stresses and strains. The calculation is carried out under different loading conditions, keeping in mind that both sizes characterizing the fibrous material fiber thickness and the gap between the fibers-are several orders smaller than the radius of the hole. Based on the simplified theory and the finite element method, a computer model of nonlinear deformation of fibrous composites is constructed. For carrying out computational experiments, a specialized software package was developed. The effect of hole configuration on the distribution of deformation and stress fields in the vicinity of concentrators was investigated.