In Vivo Characterization of Phosphotransferase-Encoding Genes istP and forP as Interchangeable Launchers of the C3',4'-Dideoxygenation Biosynthetic Pathway of 1,4-Diaminocyclitol Antibiotics |
Nguyen, Lan Huong
(Department of Biotechnology Convergent Pharmaceutical Engineering, SunMoon University)
Lee, Na Joon (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) Hwang, Hyun Ha (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) Son, Hye Bin (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) Kim, Hye Ji (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) Seo, Eun Gyo (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) Nguyen, Huu Hoang (Department of Biotechnology Convergent Pharmaceutical Engineering, SunMoon University) Park, Je Won (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) |
1 | Park SR, Park JW, Ban YH, Sohng JK, Yoon YJ. 2013. 2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways. Nat. Prod. Rep. 30: 11-20. DOI |
2 | Pokrovskaya V, Nudelman I, Kandasamy J, Baasov T. 2010. Aminoglycosides redesign strategies for improved antibiotics and compounds for treatment of human genetic diseases. Methods Enzymol. 478: 437-462. DOI |
3 | Park JW, Nam SJ, Yoon YJ. 2017. Enabling techniques in the search for new antibiotics: combinatorial biosynthesis of sugar-containing antibiotics. Biochem. Pharmacol. 134: 56-73. DOI |
4 | Yamamoto M, Okachi R, Kawamoto I, Nara T. 1977. Fortimicin A production by Micromonospora olivoasterospora in a chemically defined medium, J. Antibiot. (Tokyo) 30: 1064-1072. DOI |
5 | Ikeda D, Miyasaka T, Yoshida M, Horiuchi Y, Kondo S, Umezawa H. 1979. Synthesis of istamycin A. J. Antibiot. (Tokyo) 32: 1365-1366. DOI |
6 | Matsuhashi Y, Yoshida T, Hara T, Kazuno Y, Inouye S. 1985. In vitro and in vivo antibacterial activities of dactimicin, a novel pseudodisaccharide aminoglycoside, compared with those of other aminoglycoside antibiotics, Antimicrob. Agents Chemother. 27: 589-594. DOI |
7 | Ramirez MS, Tolmasky ME. 2010. Aminoglycoside modifying enzymes. Drug Resist. Updat. 13: 151-171. DOI |
8 | Park JW, Ban YH, Nam SJ, Cha SS, Yoon YJ. 2017. Biosynthetic pathways of aminoglycosides and their engineering. Curr. Opin. Biotechnol. 48: 33-41. DOI |
9 | Dairi T, Ohta T, Hashimoto E, Hasegawa M. 1992. Organization and nature of fortimicin A (astromicin) biosynthetic genes studied using a cosmid library of Micromonospora olivasterospora DNA. Mol. Gen. Genet. 236: 39-48. DOI |
10 | Shao L, Chen J, Wang C, Li JA, Tang Y, Chen D, Liu W. 2013. Characterization of a key aminoglycoside phosphotransferase in gentamicin biosynthesis. Bioorg. Med. Chem. Lett. 23: 1438-1441. DOI |
11 | Li S, Guo J, Reva A, Huang F, Xiong B, Liu Y, et al. 2018. Methyltransferases of gentamicin biosynthesis. Proc. Natl. Acad. Sci. USA 115: 1340-1345. DOI |
12 | MacNeil DJ, Gewain KM, Ruby CL, Dezeny G, Gibbons PH, MacNeil T. 1992. Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. Gene 111: 61-68. DOI |
13 | Huong NL, Hoang NH, Hong SY, Sohng JK, Yoon YJ, Park JW. 2016. Characterization of fortimicin aminoglycoside profiles produced from Micromonospora olivasterospora DSM 43868 by high-performance liquid chromatography-electrospray ionization-ion trap-mass spectrometry. Anal. Bioanal. Chem. 408: 1667-1678. DOI |
14 | Hoang NH, Huong NL, Kim B, Sohng JK, Yoon YJ, Park JW. 2016. Istamycin aminoglycosides profiling and their characterization in Streptomyces tenjimariensis ATCC 31603 culture using high-performance liquid chromatography with tandem mass spectrometry. J. Sep. Sci. 39: 4712-4722. DOI |
15 | Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, et al. 2011. Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation, Nat. Chem. Biol. 7: 843-852. DOI |
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