• 한국발생생물학회지:발생과생식
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• 제20권4호
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• pp.367-377
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• 2016

Red spotted grouper, Epinephelus akaara, is a popular aquaculture species and a protogynous hermaphrodite. Induction of artificial sex change at the time of primary sex differentiation is of interest but has not been successful due to the lack of necessary basic information. To find out the potential neuroendocrine influence on the primary sex differentiation, the expression of key genes in the brain was investigated during the formation of ovarian cavity. Expression of cyp19a1b, esr1, gnrhr1, fsh, lh and cga in the brain was positively associated with the formation of ovarian cavity, showing gradual increase as the formation proceeds. However, the expression of gnrh1 was suppressed during the early part of the ovarian cavity formation, signifying potential hypothalamic influence on the primary sex differentiation in this species.

• Toxicological Research
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• 제29권4호
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• pp.221-227
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• 2013

Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid bodies (EBs). In earlier study, embryonic stem cell test (EST) was established for assessment of the embryotoxic potential of compounds. Using EBs indicating the onset of differentiation of mouse ES cells, many toxicologists have refined the developmental toxicity of a variety of compounds. However, due to some limitation of the EST method resulting from species-specific differences between humans and mouse, it is an incomplete approach. In this regard, we examined the effects of several developmental toxic chemicals on formation of EBs using human ES cells. Although human ES cells are fastidious in culture and differentiation, we concluded that the relevancy of our experimental method is more accurate than that of EST using mouse ES cells. These types of studies could extend our understanding of how human ES cells could be used for monitoring developmental toxicity and its relevance in relation to its differentiation progress. In addition, this concept will be used as a model system for screening for developmental toxicity of various chemicals. This article might update new information about the usage of embryonic stem cells in the context of their possible ability in the toxicological fields.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권11호
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• pp.2636-2656
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• 2013

To improve the cooperative efficiency of node cooperation and multiple access performance for multihop wireless networks, a priority-differentiated cooperative medium access control protocol with contention resolution (CRP-CMAC) is proposed. In the protocol, the helper selection process is divided into the priority differentiation phase and the contention resolution phase for the helpers with the same priority. A higher priority helper can choose an earlier minislot in the priority differentiation phase to send a busy tone. As a result, the protocol promptly selects all the highest priority helpers. The contention resolution phase of the same priority helpers consists of k round contention resolution procedures. The helpers that had sent the first busy tone and are now sending the longest busy tone can continue to the next round, and then the other helpers that sense the busy tone withdraw from the contention. Therefore, it can select the unique best helper from the highest priority helpers with high probability. A packet piggyback mechanism is also adopted to make the high data rate helper with packet to send transmit its data packets to its recipient without reservation. It can significantly decrease the reservation overhead and effectively improve the cooperation efficiency and channel utilization. Simulation results show that the maximum throughput of CRP-CMAC is 74%, 36.1% and 15% higher than those of the 802.11 DCF, CoopMACA and 2rcMAC protocols in a wireless local area network (WLAN) environment, and 82.6%, 37.6% and 46.3% higher in an ad hoc network environment, respectively.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권10호
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• pp.5179-5196
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• 2019

To explore an effective non-invasion medical imaging diagnostics approach for hepatocellular carcinoma (HCC), we propose a method based on adopting the multiple technologies with the multi-parametric data fusion, transfer learning, and multi-scale deep feature extraction. Firstly, to make full use of complementary and enhancing the contribution of different modalities viz. multi-parametric MRI images in the lesion diagnosis, we propose a data-level fusion strategy. Secondly, based on the fusion data as the input, the multi-scale residual neural network with SPP (Spatial Pyramid Pooling) is utilized for the discriminative feature representation learning. Thirdly, to mitigate the impact of the lack of training samples, we do the pre-training of the proposed multi-scale residual neural network model on the natural image dataset and the fine-tuning with the chosen multi-parametric MRI images as complementary data. The comparative experiment results on the dataset from the clinical cases show that our proposed approach by employing the multiple strategies achieves the highest accuracy of 0.847±0.023 in the classification problem on the HCC differentiation. In the problem of discriminating the HCC lesion from the non-tumor area, we achieve a good performance with accuracy, sensitivity, specificity and AUC (area under the ROC curve) being 0.981±0.002, 0.981±0.002, 0.991±0.007 and 0.999±0.0008, respectively.

• 디지털산업정보학회논문지
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• 제15권2호
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• pp.29-42
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• 2019

As online services become more and more popular due to the development of IT, non-face-to-face transactions are continuously increasing rather than face-to-face transactions. The personal identity proofing service(PIPS) based on the alternative method of the resident registration number is used for the purpose of confirming the identity of the other party on the Internet. However, in the case of the current PIPS, the personal information of the PIPS user is excessively provided to the online service provider. As a result, privacy problems of online users, shortage of choice of information providing options, and lack of differentiation of authentication methods are becoming problems. Therefore, this paper proposes a method to improve the PIPS based on the current resident registration number alternative method and to provide a method to differentiate the provision of excessive personal information. In the proposed method, we analyze trends and current status of overseas online PIPS in order to provide a method of providing differentiation of personal information and proposes an effective improvement method applicable to domestic.

• 한국통신학회:학술대회논문집
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• 한국통신학회 2006년도 하계종합학술발표회 논문 초록집
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• pp.310-310
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• 2006

• 한국정보통신학회논문지
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• 제16권9호
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• pp.1906-1914
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• 2012

본 논문은 우회경로를 적용하는 JET 스위칭 방식의 광 버스트 스위치 네트워크에서 클래스간 비율적 서비스 차별화 방안을 제안한다. 제안하는 방식은 동적파장할당, 선취권, 그리고 우회경로 방식을 적용한다. 동적파장할당은 주기적인 측정을 통해 클래스간 손실 비율의 조정이 요구되는 경우에 높은 클래스에 할당된 파장의 수를 동적으로 증가시킴으로서 높은 클래스의 손실률도 낮추면서 동시에 상대적 손실 비율도 유지한다. 가용한 파장이 모두 사용된 경우에는 낮은 클래스의 트래픽이 사용하던 파장을 높은 클래스의 트래픽에 이양하는 선취권 방식을 적용한다. 동시에 우회경로를 적용하여 높은 클래스나 낮은 클래스의 손실률을 낮춘다. 제안된 방식에 대한 큐잉 기반의 분석 모델이 도출되고, 도출된 모델을 기반으로 성능분석을 수행하여 제안모델이 비율적 서비스 차별화를 제공함을 입증한다.

• 한국통신학회논문지
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• 제27권12C호
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• pp.1197-1206
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• 2002

최근 파장 분할 다중화 기술을 이용한 광 인터넷 백본망 구성에 관한 연구가 활발히 진행되고 있다. 본 논문에서는 광 버스트 스위칭 (optical burst switching; OBS) 기술을 이용한 광 통신망에서 offset 시간을 이용한 서비스 차별화 기법을 제시한다. 제시된 기법은 서비스를 상위 클래스와 하위 클래스로 구분하여 각 서비스의 버스트 손실률 (burst loss rate; BLR)이 서비스 차등률 (service-differentiation ratio; SDR)에 의하여 유지될 수 있도록 상위 클래스의 offset 시간을 결정한다. 여기서 서비스 차등률은 OBS망 환경과 사용자의 요구에 의해서 다양하게 설정될 수 있으며, 서비스 차등률과 다중 클래스의 Conservation Law의 관계에 의해서 상위 클래스의 버스트 손실률이 요구 QoS로 결정된다. 제안된 기법은 상위 클래스의 QoS를 만족하는 offset 시간을 결정하는 하기 위하여 offset 시간 결정(offset time decision; OTD) 알고리즘을 이용한다. 제안된 기법을 단일 노드와 균등 트래픽 망 환경에서 시뮬레이션과 분석을 통하여 성능을 검증하며, 서비스간의 차별이 요구 SDR에 근거하여 유지됨을 보이고 offset에 의한 전송 지연이 감소함을 보인다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권1호
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• pp.178-202
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• 2012

In this paper, we first survey cross-layer architectures for Wireless Sensor Networks (WSNs) and Wireless Multimedia Sensor Networks (WMSNs). Afterwards, we propose a novel cross-layer architecture for QoS provisioning in clustered and multi-hop based WMSNs. The proposed architecture provides support for multiple network-based applications on a single sensor node. For supporting multiple applications on a single node, an area in memory is reserved where each application can store its network protocols settings. Furthermore, the proposed cross-layer architecture supports heterogeneous flows by classifying WMSN traffic into six traffic classes. The architecture incorporates a service differentiation module for QoS provisioning in WMSNs. The service differentiation module defines the forwarding behavior corresponding to each traffic class. The forwarding behavior is primarily determined by the priority of the traffic class, moreover the service differentiation module allocates bandwidth to each traffic class with goals to maximize network utilization and avoid starvation of low priority flows. The proposal incorporates the congestion detection and control algorithm. Upon detection of congestion, the congested node makes an estimate of the data rate that should be used by the node itself and its one-hop away upstream nodes. While estimating the data rate, the congested node considers the characteristics of different traffic classes along with their total bandwidth usage. The architecture uses a shared database to enable cross-layer interactions. Application's network protocol settings and the interaction with the shared database is done through a cross-layer optimization middleware.

• Journal of Animal Science and Technology
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• 제50권4호
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• pp.475-484
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• 2008

본 연구는 retinoic acid(RA)가 돼지지방전구세포의 분화와 유전자 발현에 미치는 영향을 구명하기 위해서 수행하였다. 지방전구세포는 갓난 돼지의 등지방에서 분리했으며 RA는 배양중인 세포에 4일 동안 처리하였다. 배양중인 세포에서 RNA를 추출한 후 14,688개의 유전자가 부착되어 있는 cDNA microarray와 혼성화 하여 유전자 발현 양상을 분석하였다. 지방전구세포의 분화는 GPDH의 활성도에 의해 측정했다. RA는 돼지지방전구세포의 분화를 78% 억제했다. Retinoic acid 처리에 의해 지질 대사에 관계된 유전자를 포함하여 특히 sphin- gomyelin phosphodiesterase, apolipoprotein R precursor, growth factor receptor-bound protein 14, retinoic receptor RXR gamma의 발현이 증가 되었다. 그리고 세포 성장에 중요 역할을 하는 vascular endothelial growth factor D precursor, growth hormone receptor precursor의 유전자의 발현이 감소되었다. 이러한 결과는, RA가 성장촉진인자 또는 성장호르몬 수용체의 조절을 통해서 돼지 지방전구세포의 분화를 억제함을 나타낸다.