• BMB Reports
• /
• 제49권12호
• /
• pp.653-654
• /
• 2016

The human reference genome, maintained by the Genome Reference Consortium, is conceivably the most complete genome assembly ever, since its first construction. It has continually been improved by incorporating corrections made to the previous assemblies, thanks to various technological advances. Many currently-ongoing population sequencing projects have been based on this reference genome, heightening hopes of the development of useful medical applications of genomic information, thanks to the recent maturation of high-throughput sequencing technologies. However, just one reference genome does not fit all the populations across the globe, because of the large diversity in genomic structures and technical limitations inherent to short read sequencing methods. The recent success in de novo construction of the highly contiguous Asian diploid genome AK1, by combining single molecule technologies with routine sequencing data without resorting to traditional clone-by-clone sequencing and physical mapping, reveals the nature of genomic structure variation by detecting thousands of novel structural variations and by finally filling in some of the prior gaps which had persistently remained in the current human reference genome. Now it is expected that the AK1 genome, soon to be paired with more upcoming de novo assembled genomes, will provide a chance to explore what it is really like to use ancestry-specific reference genomes instead of hg19/hg38 for population genomics. This is a major step towards the furthering of genetically-based precision medicine.

• 전자공학회논문지C
• /
• 제36C권7호
• /
• pp.27-35
• /
• 1999

필기서술의 인식과 관련된 연구는 인식대상 영상이 바르게 분리된 인식단위를 포함한다는 전제로 진행되어 왔다. 그러나 실제적인 필기인식 시스템의 설계에 있어서, 다양한 필기방식으로 인해, 인식단위로의 분리가 선결되어야 할 문제이다. 본 논문에서는 제한없이 쓰여진 필기 문자열로부터 인식의 도움없이 독립된 단어를 분리하는 방법을 제안한다. 구성요소간 물리적인 거리에 의존하는 종래의 방법과 달리, 필기서술 자체로부터 필기자의 띄어쓰기와 관련된 특징들을 적극적으로 추출하고 이를 신경회로망을 사용하여 해석한다. 띄어쓰기와 관련된 정보는 문자 분리과정을 통해 분리된 문자 세그먼트의 높이와 세그먼트 중심선 사이의 간격들을 정규화하여 구한다. 연결요소간의 거리에 기반한 방법들과의 비교실험을 통해 제한한 방법의 유용성을 입증하였다.

• 정보과학회 논문지
• /
• 제42권3호
• /
• pp.361-366
• /
• 2015

틈(Gap) 파싱은 완전하지 않고 틈이 있는 입력 스트링에 대한 구문 분석을 수행한다. 이런 틈 파싱에 관한 기존 연구로서 임의의 문법에 대한 단일 틈 파싱 알고리즘과 LL(1) 문법에 대한 단일 틈 파싱 알고리즘이 제안되었으며, 이들의 시간복잡도는 각각 $O(n^3)$와 $O(n^2)$이다. 본 논문에서는 확장된 PLR(1) 문법에 대한 단일 틈 파싱 알고리즘을 제안한다. 확장된 PLR(1) 문법은 LR(1) 문법의 부분 클래스이지만 LL(1) 문법보다는 휠씬 넒은 범위의 문법 클래스이다. 이 문법 클래스에 대한 단일 틈 파싱 알고리즘이 LL(1) 문법에 대한 기존에 알려진 단일 틈 파싱 알고리즘의 복잡도와 동일한 $O(n^2)$임을 보인다.

• 한국경영과학회지
• /
• 제23권2호
• /
• pp.187-200
• /
• 1998

This paper presents an original approach for solving short-term power scheduling in extended power system with two fuels in a unit and a limited fuel using Lagrangian relaxations. The underlying model incorporates the full set of costs and constraints including setup, production, ramping, and operational status, and takes the form of a mixed integer nonlinear control problem. Moreover, the mathematical model developed includes two fuels in a unit and a limited fuel, regulation reserve requirements of prespecified group of units. Lagrangian relaxation is used to disaggregate the model by generator into separate subproblems which are then solved with a nested dynamic program including empirical knowledges. The strength of the methodology lies partially in its ability to construct good feasible solutions from information provided by the dual. Thus, the need for branch-and-bound is eliminated. In addition, the inclusion of two fuels in a unit and a limited fuel provides new insight into the limitations of current techniques. Computational experience with the proposed algorithm indicates that Problems containing up to 23 units including 8 unit used two fuels and 24 time periods can be readily solved in reasonable times. Duality gaps of less than 4％ were achieved.

• 산업공학
• /
• 제17권1호
• /
• pp.93-103
• /
• 2004

Service importance has been growing increasingly as competition element of enterprises according to going on rapid softness, information and knowledge of industrial infrastructure recently. Quality management system that implemented in manufacturing sector have been spreading rapidly to service company, but the company performing pure engineering service only in construction fields performed mainly the evaluation on the operational aspect such as degree of implementation of the established system because it is difficult to objective evaluation on the activity of the established quality management system or quality assurance system. This study would like to make on offer the improvement points based on the evaluation of service quality and the itself evaluation result through the questionnaire on the service offerers and customers using the pre-qualified SERVQUAL model in establishment of the improvement goal of the company. According to the result of this study, it is analyzed a gap and required to establish a counter-plan to correct many gaps discovered between the real offered level and the expect level of custom.

• The Plant Pathology Journal
• /
• 제33권6호
• /
• pp.529-542
• /
• 2017

Control of plant diseases is largely dependent on use of agrochemicals. However, there are widening gaps between our knowledge on plant diseases gained from genetic/mechanistic studies and rapid translation of the knowledge into target-oriented development of effective agrochemicals. Here we propose that the time is ripe for computer-aided drug discovery/design (CADD) in molecular plant pathology. CADD has played a pivotal role in development of medically important molecules over the last three decades. Now, explosive increase in information on genome sequences and three dimensional structures of biological molecules, in combination with advances in computational and informational technologies, opens up exciting possibilities for application of CADD in discovery and development of agrochemicals. In this review, we outline two categories of the drug discovery strategies: structure- and ligand-based CADD, and relevant computational approaches that are being employed in modern drug discovery. In order to help readers to dive into CADD, we explain concepts of homology modelling, molecular docking, virtual screening, and de novo ligand design in structure-based CADD, and pharmacophore modelling, ligand-based virtual screening, quantitative structure activity relationship modelling and de novo ligand design for ligand-based CADD. We also provide the important resources available to carry out CADD. Finally, we present a case study showing how CADD approach can be implemented in reality for identification of potent chemical compounds against the important plant pathogens, Pseudomonas syringae and Colletotrichum gloeosporioides.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권6호
• /
• pp.2429-2435
• /
• 2012

Methyl isocyanate may have a role in cancer etiology, although the link is unclear. There is evidence in the literature that it can induce cancer in animals but the carcinogenic potency is weak. Pheochromocytoma of adrenal medulla and acinar cell tumors of pancreas have been observed in methyl isocyanate exposed animals. Conversely, emerging data from population-based epidemiological studies are contradictory since there is no evidence of such cancers in methyl isocyanate exposed humans. Recently, we reported a high prevalence of breast and lung cancers in such a population in Bhopal. In vitro findings appearing in the latest scientific literature suggest that genomic instability is caused by methyl isocyanate analogs in lung, colon, kidney, ovary epithelial cells, and that hepatocytes may undergo oncogenic transformation, have obvious implications. The conflicting information prompted us to present this update over the last three decades on methyl isocyanate-induced cancers after an extensive literature search using PubMed. While the pertinent literature remains limited, with a scarcity of strong laboratory analyses and field-epidemiological investigations, our succinct review of animal and human epidemiological data including in vitro evidences, should hopefully provide more insight to researchers, toxicologists, and public health professionals concerned with validation of the carcinogenicity of methyl isocyanate in humans.

• 한국IT서비스학회지
• /
• 제12권3호
• /
• pp.111-126
• /
• 2013

As the gaps become narrower in interconnection fee and volume rate, the MNOs began to introduce flat pricing for unlimited voice traffic competitively in Korea wireless telecommunication market : 'unlimited talks within intra-network' by the 1st operator, followed by the 3rd operator's 'unlimited talks over all networks'. As a result, subscribers tip in toward the third ranked operator and could bring a substantial change to steadfast market structure over the last decade in Korea. This paper aims to develop a simple economic model to analyze competition with flat pricing for unlimited voice traffic, and to check whether the pricing can be appropriate for the MNOs. The results show that MNOs already step in the necessary conditions to launch flat pricing for voice traffic. It also predicts that the MNOs compete with unlimited talk over all networks and set a single fee in an equilibrium. At present, the MNOs run virtually identical pricing for unlimited talk over all networks, considering their differentiation with respect to service quality, coverage and brand preference.

• 산경연구논집
• /
• 제9권12호
• /
• pp.7-14
• /
• 2018

Purpose - The core objective of the research is to explore the quality of services provided by the Nigerian health care sector that lead to know the satisfaction levels of the consumers. Research design, data, and methodology - After a meticulous literature review, the researchers administered a two part questionnaire to know the service gaps and satisfaction levels of the customers. The research carried out with a sample of 400 respondents but received only 150 responses from the residents around Adamawa state. The collected data was edited, coded, and analyzed with the SPSS latest version with the descriptive and inferential statistical tools. Results - Majority of the respondents expressed their discontentment over the responsiveness of the service providers when compared to tangibility and reliability quality variables. There is no relationship between the quality variable tangibility and overall satisfaction. Related to the overall satisfaction, 42 percent of respondents have neutral perspective indicated that they are either satisfied or dissatisfied as against the 43.3 percent of dissatisfied customers. Conclusions - This research proffers invaluable information to the entire Nigerian health-care sector to review their existing delivery of services to improve patient satisfaction. This research is first of its kind concentrated to know the quality of health-care services and customers overall satisfaction in Nigeria.

• 간호행정학회지
• /
• 제19권1호
• /
• pp.108-117
• /
• 2013

Purpose: To analyze trends in salaries for registered nurses when compared with salaries for elementary school teachers from 2002 to 2009 and identify salary gaps of nurses according to workplace size and geographic location. Methods: Data were obtained from the Occupational Employment Statistics collected by the Korea Employment Information Services each year from 2002 to 2009. The study sample consisted of 2,281 registered nurses and 2,578 elementary school teachers. Linear multiple regression analyses were conducted to analyze salary trends and differences. Results: Elementary school teachers had higher monthly salaries than nurses with a baccalaureate degree after adjusting for years of work. Salary differences increased significantly by 40,000 won every year (p<.001). Nurses working in large facilities in Seoul had the highest salaries, whereas those in small/medium, non-Seoul facilities had the lowest salaries consistently over time. Salary differences between the two groups increased by 47,000 won every year (p=.001); salary differences between nurses in large, non-Seoul facilities and those in small/medium, non-Seoul facilities also increased by 40,000 won annually (p=.001). Conclusion: Geographical imbalances in the nurse workforce and nurse shortages in small/medium, non-capital facilities could be reduced by increasing the salary of nurses working in those facilities.