• Biomolecules & Therapeutics
• /
• v.30 no.1
• /
• pp.98-116
• /
• 2022

The small GTPase RhoA has been studied extensively for its role in actin dynamics. In this study, multiple bioinformatics tools were applied cooperatively to the microarray dataset GSE64714 to explore previously unidentified functions of RhoA. Comparative gene expression analysis revealed 545 differentially expressed genes in RhoA-null cells versus controls. Gene set enrichment analysis (GSEA) was conducted with three gene set collections: (1) the hallmark, (2) the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and (3) the Gene Ontology Biological Process. GSEA results showed that RhoA is related strongly to diverse pathways: cell cycle/growth, DNA repair, metabolism, keratinization, response to fungus, and vesicular transport. These functions were verified by heatmap analysis, KEGG pathway diagramming, and direct acyclic graphing. The use of multiple gene set collections restricted the leakage of information extracted. However, gene sets from individual collections are heterogenous in gene element composition, number, and the contextual meaning embraced in names. Indeed, there was a limit to deriving functions with high accuracy and reliability simply from gene set names. The comparison of multiple gene set collections showed that although the gene sets had similar names, the gene elements were extremely heterogeneous. Thus, the type of collection chosen and the analytical context influence the interpretation of GSEA results. Nonetheless, the analyses of multiple collections made it possible to derive robust and consistent function identifications. This study confirmed several well-described roles of RhoA and revealed less explored functions, suggesting future research directions.

• Journal of Radiation Protection and Research
• /
• v.39 no.3
• /
• pp.127-133
• /
• 2014

North Korea's uranium enrichment facility is a matter of international concern. It is of particular alarming to South Korea with regard to the security and safety of the country. This situation requires continuous monitoring of the DPRK and emergency preparedness on the part of the ROK. To assess the detectability of an undeclared uranium enrichment plant in North Korea, uranium concentrations in the air at both a short and a long distance from the enrichment facility were estimated. $UF_6$ source terms were determined by using existing information on North Korean facility and data from the operation experience of enrichment plants from other countries. Using the calculated source terms, two atmospheric dispersion models (Gaussian Plume Model and HYSPLIT models) and meteorological data were used to estimate the uranium particle concentrations from the Yongbyon enrichment facility. A maximum uranium concentration and its location are dependent upon the meteorological conditions and the height of the UF6 release point. This study showed that the maximum uranium concentration around the enrichment facility was about $1.0{\times}10^{-7}g{\cdot}m^{-3}$. The location of the maximum concentration was within about 0.4 km of the facility. It has been assumed that the uranium sample of about a few micrograms (${\mu}g$) could be obtained; and that few micrograms of uranium can be easily measured with current measurement instruments. On the contrary, a uranium concentration at a distance of more than 100 kilometers from the enrichment facility was estimated to be about $1.0{\times}10^{-13}{\sim}1.0{\times}10^{-15}g{\cdot}m^{-3}$, which is less than back-ground level. Therefore, based on the results of our paper, an air sample taken within the vicinity of the Yongbyon enrichment facility could be used to determine as to whether or not North Korea is carrying out an undeclared nuclear program. However, the air samples taken at a longer distance of a few hundred kilometers would prove difficult in detecting a clandestine nuclear activities.

• Language and Information
• /
• v.14 no.1
• /
• pp.165-196
• /
• 2010

The primary goal of this paper is to propose methods of enriching two heterogeneous ontologies: Sejong Semantic Classes (SJSC) and KorLexNoun 1.5 (KLN). In order to achieve this goal, this study introduces the pros and cons of two ontologies, and analyzes the error patterns found during the fine-grained manual mapping processes between them. Error patterns can be classified into four types: (1) structural defectives involved in node branching, (2) errors in assigning the semantic classes, (3) deficiency in providing linguistic information, and (4) lack of the lexical units representing specific concepts. According to these error patterns, we propose different solutions in order to correct the node branching defectives and the semantic class assignment, to complement the deficiency of linguistic information, and to increase the number of lexical units suitably allotted to their corresponding concepts. Using the results of this study, we can obtain more enriched ontologies by correcting the defects and errors in each ontology, which will lead to the enhancement of practicality for syntactic and semantic analysis.

• Journal of Internet of Things and Convergence
• /
• v.8 no.5
• /
• pp.1-9
• /
• 2022

As various services are linked to IoT(Internet of Things) and portable communication terminals, cyber attacks that exploit security vulnerabilities of the devices are rapidly increasing. In particular, cyber attacks targeting heterogeneous devices in large-scale network environments through advanced persistent threat (APT) attacks are on the rise. Therefore, in order to improve the effectiveness of the response system in the event of a breach, it is necessary to apply a data enrichment mechanism for the collected artifact data to improve threat analysis and detection performance. Therefore, in this study, by analyzing the data supplementation common elements performed in the existing incident management framework for the artifacts collected for the analysis of intrusion accidents, characteristic elements applicable to the actual system were derived, and based on this, an improved accident analysis framework The prototype structure was presented and the suitability of the derived data supplementary extension elements was verified. Through this, it is expected to improve the detection performance when analyzing cyber incidents targeting artifacts collected from heterogeneous devices.

• Nuclear Engineering and Technology
• /
• v.31 no.6
• /
• pp.23-38
• /
• 1999

This study addresses the reference spent fuel and its characteristics for developing a geological repository concept. As a disposal capacity of the reference repository system to be developed, spent fuel inventories were projected based on the basis of the Nuclear Energy Plan of the Long-term National Power Program. The reference spent fuel encompassing a variability in characteristics of all existing and future spent fuels of interest was defined. Key parameters in the reference fuel screening processes were the nuclear and mechanical design parameters and the burnup histories for existing spent fuels as of 1996 and for future spent fuels with the more extended burnup the initial enrichment and its expected turnup. The selected reference fuel was characterized in terms of initial enrichment, bumup, dimension, gross weight and age. Also the isotopic composition and the radiological properties are quantitatively identified. This information provided in this study could be used as input for repository system development and performance assessment and applied in fuel material balance evaluation for the various types of back-end fuel cycle studies.

• International Commerce and Information Review
• /
• v.10 no.3
• /
• pp.143-162
• /
• 2008

The Title 19 of the U.S. Code covers custom duties and is the heart of international trade regulation in the U.S.. Among the provisions in Title 19, is Chapter 4, the Tariff Act of 1930. Under U.S. Antidumping duty law, dumping occurs when `subject merchandise' is imported into the U.S. and sold at less than `fair value.' The administration of U.S. Antidumping duty law is shared between the Department of Commerce('Commerce') and International Trade Commission('USITC'). The U.S. Court of International Trade ("CIT") and the U.S. Court of Appeals for the Federal Circuit ("CAFC") decided the review of antidumping duty ("AD") determinations and administrative review results issued by the Commerce and the USITC, as well as the review of countervailing duty ("CVD") decisions. In Eurodif S.A. v. United States, the CAFC considered the important issue of whether the antidumping and countervailing duty laws apply to sales and purchases of services--in this case, the sale or purchase of enrichment services. Although the federal courts had considered the issue of whether a sale of enrichment services constitutes a sale of goods, the issue had never arisen in the context of the antidumping and countervailing duty laws. Also this is the first time that the Supreme Court has ever agreed to consider an antidumping case.

• Proceedings of the Korean Institute of Intelligent Systems Conference
• /
• 1998.06a
• /
• pp.552-555
• /
• 1998

In dealing with representing knowledge under uncertainty there is a sustain tendency to increase flexibility in order to avoid problems of inconsistency in the knowledge. Many knowledge systems(information retrieval systems, expert system) include hybrid representation models. Funny retrieval systems appear as a complement or as an enrichment of this models. In this paper, we describe dynamic rule modification through situation assessment for uncertainty management.

• Proceedings of the IEEK Conference
• /
• 2001.10a
• /
• pp.751-754
• /
• 2001

A possibility of using waste plastics as a source of secondary fuel in blast furnace has been of recent interest. The success of this process, however, will be critically dependent upon the optimization of operating systems. for instance, the supply of waste plastics must be reliable as well as economically attractive compared with conventional secondary fuels such as heavy oil, natural gas and pulverized coal. In this work, we put special importance on the improvement of the combustibility of waste plastics as a way to enhance energy efficiency in blast furnace. As experimental variables to approach this target, the effects of plastic particle size, blast temperature, and the level of oxygen enrichment were investigated using a custom-made blast model designed to simulate a real furnace. Lastly, the combustion efficiency of the mixture of waste plastics and pulverized coal was tested. The observations made from these experiments led us to the conclusion that with the increase of both blast temperature and the level of oxygen enrichment, and with the decrease of particle size, the combustibility of waste PE could be improved at a given distance from tuyere. Also it was found that the efficiency of coal combustion decreased with the addition of plastics; however, the combustion efficiency of mixture could be comparable at longer distance from tuyere.

• Genomics & Informatics
• /
• v.15 no.2
• /
• pp.56-64
• /
• 2017

We have previously reported that NS-398, a cyclooxygenase-2 (COX-2)-selective inhibitor, inhibited replicative cellular senescence in human dermal fibroblasts and skin aging in hairless mice. In contrast, celecoxib, another COX-2-selective inhibitor, and aspirin, a non-selective COX inhibitor, accelerated the senescence and aging. To figure out causal factors for the senescence-modulating effect of the inhibitors, we here performed cDNA microarray experiment and subsequent Gene Set Enrichment Analysis. The data showed that several senescence-related gene sets were regulated by the inhibitor treatment. NS-398 up-regulated gene sets involved in the tumor necrosis factor ${\beta}$ receptor pathway and the fructose and mannose metabolism, whereas it down-regulated a gene set involved in protein secretion. Celecoxib up-regulated gene sets involved in G2M checkpoint and E2F targets. Aspirin up-regulated the gene set involved in protein secretion, and down-regulated gene sets involved in RNA transcription. These results suggest that COX inhibitors modulate cellular senescence by different mechanisms and will provide useful information to understand senescence-modulating mechanisms of COX inhibitors.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.20 no.1
• /
• pp.111-118
• /
• 2022

The denuclearization of North Korea was unpredictable and resulted in radical changes. Despite the skepticism and disappointment surrounding denuclearization, it is important for certain verification technologies to establish what is technically possible or practically impossible, and how reliable these technical means are. This article presents the technical hurdles in nuclear verification by systematically categorizing them into issues of correctness and completeness. Moreover, it addresses the safety and security risks during the denuclearization process, including the radiological impact on humans, environmental effects, and the illegal transfer of material, information, and technologies.