• Journal of Life Science
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• v.34 no.2
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• pp.128-137
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• 2024

This review discusses the pivotal role of vascular endothelial growth factors (VEGF) in angiogenesis and lymphangiogenesis, vital processes influencing vascular permeability, endothelial cell recruitment, and the maintenance of tumor-associated blood and lymphatic vessels. VEGF exerts its effects through tyrosine-kinase receptors, VEGFR-1, VEGFR-2, and VEGFR-3. This VEGF-VEGFR system is central not only to cancer but also to diseases arising from abnormal blood vessel and lymphatic vessel formation. In the context of cancer, VEGF and its receptors are essential for the development of tumor-associated vessels, making them attractive targets for therapeutic intervention. Various approaches, such as anti-VEGF antibodies, receptor antagonists, and VEGF receptor function inhibitors, are being explored to interfere with tumor growth. However, the clinical efficacy of anti-angiogenic agents remains uncertain and necessitates further refinement. The article also highlights the physiological role of VEGFs, emphasizing their involvement in endothelial cell functions, survival, and vascular permeability. The identification of five distinct VEGFs in humans (VEGF-A, VEGF-B, VEGF-C, VEGF-D, and PLGF) is discussed, along with the classification of VEGFRs as typical receptor tyrosine kinases with distinct signaling systems. The family includes VEGFR-1 and VEGFR-2, crucial in tumor biology and angiogenesis, and VEGFR-3, specifically involved in lymphangiogenesis. Overall, this review has provided a comprehensive overview of VEGF and VEGFR, detailing their roles in various diseases, including cancer. This is expected to further facilitate the utilization of VEGF and VEGFR as therapeutic targets.

• The Journal of the Convergence on Culture Technology
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• v.10 no.1
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• pp.183-192
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• 2024

The purpose of this study is to empirically analyze the determining factors (economy, security, domestic politics, administration, and international politics) that affect the ROK-US defense cost sharing decision. Through this, we will gain a deeper understanding of the defense cost sharing decision process and improve the efficiency of defense cost sharing calculation and execution. The scope of the study is ROK-US defense cost sharing from 1991 to 2021. The data used in the empirical analysis were various secondary data such as Ministry of National Defense, government statistical data, SIPRI, and media reports. As an empirical analysis method, multiple regression analysis using time series was used and the data was analyzed using an autoregressive model. As a result of empirical research through multiple regression analysis, we derived the following results. It was analyzed that the size of Korea's economy, that is, GDP, the previous year's defense cost share, and the number of U.S. troops stationed in Korea had a positive influence on the decision on defense cost sharing. This indicates that Korea's economic growth is a major factor influencing the increase in defense cost sharing, and that the gradual increase in the budget and the negotiation method of the Special Agreement (SMA) for cost sharing of stationing US troops in Korea play an important role. On the other hand, the political tendencies of the ruling party, North Korea's military threats, and China's defense budget were found to have no statistically significant influence on the decision to share defense costs.

• Earthquakes and Structures
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• v.26 no.6
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• pp.417-431
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• 2024

The fundamental period of vibration is one of the most critical parameters in the analysis and design of structures, as it depends on the distribution of stiffness and mass within the structure. Therefore, building codes propose empirical equations based on the observed periods of actual buildings during seismic events and ambient vibration tests. However, despite the fact that infill walls increase the stiffness and mass of the structure, causing significant changes in the fundamental period, most of these equations do not account for the presence of infills walls in the structure. Typically, these equations are dependent on both the structural system type and building height. The different values between the empirical and analytical periods are due to the elimination of non-structural effects in the analytical methods. Therefore, the presence of non-structural elements, such as infill panels, should be carefully considered. Another critical factor influencing the fundamental period is the effect of Soil-Structure Interaction (SSI). Most seismic building design codes generally consider SSI to be beneficial to the structural system under seismic loading, as it increases the fundamental period and leads to higher damping of the system. Recent case studies and postseismic observations suggest that SSI can have detrimental effects, and neglecting its impact could lead to unsafe design, especially for structures located on soft soil. The current research focuses on investigating the effect of infill panels on the fundamental period of moment-resisting and eccentrically braced steel frames while considering the influence of soil-structure interaction. To achieve this, the effects of building height, infill wall stiffness, infill openings and soil structure interactions were studied using 3, 6, 9, 12, 15 and 18-story 3-D frames. These frames were modeled and analyzed using SeismoStruct software. The calculated values of the fundamental period were then compared with those obtained from the proposed equation in the seismic code. The results indicate that changing the number of stories and the soil type significantly affects the fundamental period of structures. Moreover, as the percentage of infill openings increases, the fundamental period of the structure increases almost linearly. Additionally, soil-structure interaction strongly affects the fundamental periods of structures, especially for more flexible soils. This effect is more pronounced when the infill wall stiffness is higher. In conclusion, new equations are proposed for predicting the fundamental periods of Moment Resisting Frame (MRF) and Eccentrically Braced Frame (EBF) buildings. These equations are functions of various parameters, including building height, modulus of elasticity, infill wall thickness, infill wall percentage, and soil types.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.44 no.2
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• pp.191-201
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• 2024

In this study, three-dimensional finite element analysis was used to analyze the behavior of existing and reinforcing piles according to the pile support conditions for vertical extension remodeling. Cap support conditions (group pile, piled raft foundation) and pile tip conditions (rock, soil embedment) were considered as factors influencing existing and reinforcing piles behavior. For the quantitative analysis of existing and reinforcing piles, the displacement, load distribution ratio, and axial force by depth according to the analysis stage were analyzed. As a result of the analysis, it was confirmed that the largest settlement occurred in the reinforcing pile due to the pre-loading method. In particular, a large amount of settlement occurred in group piles regardless of the embedment conditions. In the piled raft foundation, it was confirmed that the displacement and load distribution ratio of existing piles and reinforcing piles were reduced due to the influence of the raft. The axial force by depth showed a difference between group pile and piled raft foundation, which appears to be a major factor affecting displacement and load distribution ratio. Based on the numerical analysis results, it was confirmed that cap support conditions and pile tip embedment conditions should be considered in the design of pile foundations for vertical extension remodeling.

• Journal of the Society of Naval Architects of Korea
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• v.61 no.4
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• pp.267-277
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• 2024

The Sortie Generation Rate (SGR) is a critical performance indicator for carrier-based aircraft and is a key factor for the carrier design process. This study aims to analyze the factors that affect SGR and establish a representative Sortie Generation Process (SGP) along with simulation results to calculate SGR for a naval ship equipped to carry aircraft. Detailed SGR factors are identified from the perspectives of the aircraft, aviation personnel, and aircraft carrier during the flight preparation stage, and the SGP is established accordingly. As a representative, Korean Navy's CVX basic design is chosen for detailed analysis. The physical dimension and spots for the deck design with time and probabilistic data of SGP are considered to develop a queueing network model for SGR calculation. To consider the specific probabilistic features, the model was solved with discrete event simulation tools(SimPy and AnyLogic) where the results show great agreement. Such findings on SGR factors and calculation are expected to be incorporated in the future development of SGR calculation algorithms and also present guidelines for proper design of aircraft carrier based on concrete operation concept.

• Journal of Microbiology and Biotechnology
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• v.34 no.7
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• pp.1484-1490
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• 2024

The gut microbiota is a key factor significantly impacting host health by influencing metabolism and immune function. Its composition can be altered by genetic factors, as well as environmental factors such as the host's surroundings, diet, and antibiotic usage. This study aims to examine how the characteristics of the gut microbiota in pigs, used as source animals for xenotransplantation, vary depending on their rearing environment. We compared the diversity and composition of gut microbiota in fecal samples from pigs raised in specific pathogen-free (SPF) and conventional (non-SPF) facilities. The 16S RNA metagenome sequencing results revealed that pigs raised in non-SPF facilities exhibited greater gut microbiota diversity compared to those in SPF facilities. Genera such as Streptococcus and Ruminococcus were more abundant in SPF pigs compared to non-SPF pigs, while Blautia, Bacteroides, and Roseburia were only observed in SPF pigs. Conversely, Prevotella was exclusively present in non-SPF pigs. It was predicted that SPF pigs would show higher levels of processes related to carbohydrate and nucleotide metabolism, and environmental information processing. On the other hand, energy and lipid metabolism, as well as processes associated with genetic information, cell communication, and diseases, were predicted to be more active in the gut microbiota of non-SPF pigs. This study provides insights into how the presence or absence of microorganisms, including pathogens, in pig-rearing facilities affects the composition and function of the pigs' gut microbiota. Furthermore, this serves as a reference for tracing whether xenotransplantation source pigs were maintained in a pathogen-controlled environment.

• Korean Journal of Environment and Ecology
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• v.38 no.4
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• pp.354-366
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• 2024

Hibiscus hamabo, the northernmost semi-mangrove species in East Asia, presents an important case study for examining climate change's impact on temperate ecosystems and shifts in Korea's subtropical vegetation. This study investigates vegetation characteristics of H. hamabo and evaluates environmental factors influencing their distribution. H. hamabo communities are classified by regional and coastal types. Group I is found in depressed areas within deep bays, cohabiting with herbaceous halophytes. Group II develops along coasts with exposed bedrock or on gravelly coasts, cohabiting with tide tolerance vine shrubs. Group III in Japan encompasses a broader range of coastal environments compared to Korea. A monospecific population with over 100 individuals appeared in this group. this study reveals that precipitation of warmest quarter is the most important environmental factor affecting the distribution of H. hamabo communities. This research analyzes the influence of climatic variables in the distribution of semi-mangrove species, contributing to our understanding of ecological responses to climate change.

• The Journal of the Convergence on Culture Technology
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• v.10 no.5
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• pp.41-52
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• 2024

This study was conducted to verify the impact of department and major satisfaction, as well as teacher efficacy, on the career aspiration of pre-service early childhood teachers. Data from 118 students majoring in a three-year early childhood education in Gyeonggi-do were collected and analyzed. Regression analysis was performed to assess the impact of department and major satisfaction and teacher efficacy on career aspiration, along with an analysis of the mediating effect of teacher efficacy. The results showed that department and major satisfaction had a positive effect on career aspiration, with general satisfaction among the sub-variables identified as a significant factor influencing career aspiration. Additionally, both teacher efficacy and its sub-variables, general teaching efficacy and personal teaching efficacy, were found to positively influence career aspiration. Furthermore, teacher efficacy was found to significantly mediate the relationship between department and major satisfaction and career aspiration, indicating it as an important variable in career education for pre-service early childhood teachers. The results of this study provide basic data for career education of pre-service early childhood teachers and suggest alternative methods for improving department and major satisfaction as well as teacher efficacy.

• Asia pacific journal of information systems
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• v.23 no.4
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• pp.53-84
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• 2013

With rapid development of ICT (Information and Communications Technology), new services by the convergence of mobile network and application technology began to appear. Today, smart phone with new ICT convergence network capabilities is exceedingly popular and very useful as a new tool for the development of business opportunities. Previous studies based on Technology Acceptance Model (TAM) suggested critical factors, which should be considered for acquiring new customers and maintaining existing users in smart phone market. However, they had a limitation to focus on technology acceptance, not value based approach. Prior studies on customer's adoption of electronic utilities like smart phone product showed that the antecedents such as the perceived benefit and the perceived sacrifice could explain the causality between what is perceived and what is acquired over diverse contexts. So, this research conceptualizes perceived value as a trade-off between perceived benefit and perceived sacrifice, and we need to research the perceived value to grasp user's continuous intention to use of smart phone. The purpose of this study is to investigate the structured relationship between benefit (quality, usefulness, playfulness) and sacrifice (technicality, cost, security risk) of smart phone users, perceived value, and continuous intention to use. In addition, this study intends to analyze the differences between two subgroups of smart phone users by the degree of personal innovativeness. Personal innovativeness could help us to understand the moderating effect between how perceptions are formed and continuous intention to use smart phone. This study conducted survey through e-mail, direct mail, and interview with smart phone users. Empirical analysis based on 330 respondents was conducted in order to test the hypotheses. First, the result of hypotheses testing showed that perceived usefulness among three factors of perceived benefit has the highest positive impact on perceived value, and then followed by perceived playfulness and perceived quality. Second, the result of hypotheses testing showed that perceived cost among three factors of perceived sacrifice has significantly negative impact on perceived value, however, technicality and security risk have no significant impact on perceived value. Also, the result of hypotheses testing showed that perceived value has significant direct impact on continuous intention to use of smart phone. In this regard, marketing managers of smart phone company should pay more attention to improve task efficiency and performance of smart phone, including rate systems of smart phone. Additionally, to test the moderating effect of personal innovativeness, this research conducted multi-group analysis by the degree of personal innovativeness of smart phone users. In a group with high level of innovativeness, perceived usefulness has the highest positive influence on perceived value than other factors. Instead, the analysis for a group with low level of innovativeness showed that perceived playfulness was the highest positive factor to influence perceived value than others. This result of the group with high level of innovativeness explains that innovators and early adopters are able to cope with higher level of cost and risk, and they expect to develop more positive intentions toward higher performance through the use of an innovation. Also, hedonic behavior in the case of the group with low level of innovativeness aims to provide self-fulfilling value to the users, in contrast to utilitarian perspective, which aims to provide instrumental value to the users. However, with regard to perceived sacrifice, both groups in general showed negative impact on perceived value. Also, the group with high level of innovativeness had less overall negative impact on perceived value compared to the group with low level of innovativeness across all factors. In both group with high level of innovativeness and with low level of innovativeness, perceived cost has the highest negative influence on perceived value than other factors. Instead, the analysis for a group with high level of innovativeness showed that perceived technicality was the positive factor to influence perceived value than others. However, the analysis for a group with low level of innovativeness showed that perceived security risk was the second high negative factor to influence perceived value than others. Unlike previous studies, this study focuses on influencing factors on continuous intention to use of smart phone, rather than considering initial purchase and adoption of smart phone. First, perceived value, which was used to identify user's adoption behavior, has a mediating effect among perceived benefit, perceived sacrifice, and continuous intention to use smart phone. Second, perceived usefulness has the highest positive influence on perceived value, while perceived cost has significant negative influence on perceived value. Third, perceived value, like prior studies, has high level of positive influence on continuous intention to use smart phone. Fourth, in multi-group analysis by the degree of personal innovativeness of smart phone users, perceived usefulness, in a group with high level of innovativeness, has the highest positive influence on perceived value than other factors. Instead, perceived playfulness, in a group with low level of innovativeness, has the highest positive factor to influence perceived value than others. This result shows that early adopters intend to adopt smart phone as a tool to make their job useful, instead market followers intend to adopt smart phone as a tool to make their time enjoyable. In terms of marketing strategy for smart phone company, marketing managers should pay more attention to identify their customers' lifetime value by the phase of smart phone adoption, as well as to understand their behavior intention to accept the risk and uncertainty positively. The academic contribution of this study primarily is to employ the VAM (Value-based Adoption Model) as a conceptual foundation, compared to TAM (Technology Acceptance Model) used widely by previous studies. VAM is useful for understanding continuous intention to use smart phone in comparison with TAM as a new IT utility by individual adoption. Perceived value dominantly influences continuous intention to use smart phone. The results of this study justify our research model adoption on each antecedent of perceived value as a benefit and a sacrifice component. While TAM could be widely used in user acceptance of new technology, it has a limitation to explain the new IT adoption like smart phone, because of customer behavior intention to choose the value of the object. In terms of theoretical approach, this study provides theoretical contribution to the development, design, and marketing of smart phone. The practical contribution of this study is to suggest useful decision alternatives concerned to marketing strategy formulation for acquiring and retaining long-term customers related to smart phone business. Since potential customers are interested in both benefit and sacrifice when evaluating the value of smart phone, marketing managers in smart phone company has to put more effort into creating customer's value of low sacrifice and high benefit so that customers will continuously have higher adoption on smart phone. Especially, this study shows that innovators and early adopters with high level of innovativeness have higher adoption than market followers with low level of innovativeness, in terms of perceived usefulness and perceived cost. To formulate marketing strategy for smart phone diffusion, marketing managers have to pay more attention to identify not only their customers' benefit and sacrifice components but also their customers' lifetime value to adopt smart phone.

• Journal of Life Science
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• v.23 no.6
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• pp.812-824
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• 2013

Reserpine, an anti-hypertensive drug, is able to positively modulate several phenotypes associated with $A{\beta}$ toxicity in a Caenorhabditis elegans model of Alzheimer's disease (AD). We investigated into the therapeutic effects of reserpine on mammalian neurodegenerative disorders, and found that significant alteration of the key factors influencing AD was detected in Tg2576 mice after reserpine treatment for 30 days. The aggressive behavior of Tg2576 mice was significantly improved upon reserpine treatment, whereas their social contact was consistently maintained. Furthermore, the levels of $A{\beta}$-42 peptide in the hippocampus of the brain and blood serum were lower in the reserpine-treated group than in the vehicle-treated group. Among g-secretase components, the expression levels of PS-2, Pen-2, and APH-1 were slightly lower in reserpine-treated Tg2576 mice, although a significant change in nicastrin (NCT) expression was not detected. Furthermore, the serum level of nerve growth factor (NGF) increased in reserpine-treated Tg2576 mice compared with vehicle-treated mice. Among down-stream effectors of the NGF receptor TrkA signaling pathway, reserpine treatment induced elevation of TrkA phosphorylation and reduction of ERK phosphorylation. In addition, in the NGF receptor $p75^{NTR}$ signaling pathway, the expression levels of $p75^{NTR}$ and Bcl-2 were enhanced in reserpine-treated Tg2576 mice compared with vehicle-treated mice, whereas the expression level of RhoA declined. Overall, these results suggest that reserpine can help relieve AD pathogenesis in Tg2576 mice through downregulation of $A{\beta}$-42 deposition, alteration of ${\gamma}$-secretase components, and regulation of NGF metabolism.