• 한국화재소방학회논문지
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• 제31권3호
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• pp.144-150
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• 2017

국가 간 교류 확대와 기후변화 등으로 감염병의 국내유입도 증가하고 있는 추세이다. 또한 사회적 환경변화로 감염병 발생 가능성의 증가에 대한 국민적 관심과 불안은 크게 증가하고 있다. 이러한 감염병 발생은 경제에도 심각한 위협이 되고 있으므로 감염병 예방과 확산 방지를 위한 다각적인 노력이 필요하다. 현재 많은 의료 기관에서는 전염병이 발생했을 때, 질병관리본부 등 상급 기관으로의 신속한 보고가 매우 중요하며 또한 일반 환자와 감염된 의심환자를 공간적으로 나누는 시설이 여의치 않아 병원 내에서 감염이 확대될 위험성이 높은 편이다. 본 연구에서는 감사원의 중동증후군(MERS)의 감사 결과를 토대로 감염병 발생 보고, 감염자의 분리 방법 및 감염 확대를 막는 방법 등을 고찰하여 예방 및 확산 방지를 위한 개선방안에 대해서 연구하였다.

• Journal of Microbiology and Biotechnology
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• 제25권2호
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• pp.255-267
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• 2015

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic debilitating disease affecting ruminants worldwide. In the present study, we aimed to determine the major gene networks and pathways underlying the immune response to MAP infection using whole-blood cells, as well as provide the potential transcriptional markers for identifying the status of MAP infection. We analyzed the transcriptional profiles of whole-blood cells of cattle identified and grouped according to the presence of MAP-specific antibodies and the MAP shed by them. The grouping was based on the results obtained by ELISA and PCR analyses as follows: i) Test1 group: MAP-negative results obtained by ELISA and positive results obtained by PCR; ii) Test2 group: MAP-positive results obtained by ELISA and negative results obtained by PCR; iii) Test3 group: MAP-positive results obtained by ELISA and positive results obtained by PCR; iv) uninfected control: MAP-negative results obtained both by ELISA and PCR analysis. The results showed down-regulated production and metabolism of reactive oxygen species in the Test1 group, activation of pathways related to the host-defense response against MAP (LXR/RXR activation and complement system) in the Test2 and Test3 groups, and anti-inflammatory response (activation of IL-10 signaling pathway) only in the Test3 group. Our data indicate a balanced response that serves the immune-limiting mechanism while the host-defense responses are progressing.

• 한국콘텐츠학회논문지
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• 제21권12호
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• pp.250-263
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• 2021

본 연구는 항공사를 이용하는 고객들이 코로나19라는 감염병 인식과 감염병에 대한 지각된 위험이 위험감소행동과 관광지 전환의도에 미치는 영향관계를 분석하고자 실시하였다. 2021년 6월 2일부터 24일까지 일년 이내에 항공기를 이용한 여행 경험이 있는 소비자를 대상으로, 온라인을 통해 설문을 실시하였다. SPSS 20.0과 AMOS 23.0 통계 프로그램을 활용하였고, 유효한 250부의 설문으로 분석을 실시하였다. 연구의 결과는 첫째, 코로나19의 감염병 인식은 지각된 위험에 유의한 영향을 미치는 것으로 나타났다. 둘째, 코로나19의 감염병 인식은 위험감소행동에 유의한 영향을 미치는 것으로 나타났다. 셋째, 코로나19의 지각된 위험은 위험감소행동에는 유의한 영향을 미치는 것으로 나타났다. 넷째, 코로나19의 지각된 위험은 관광지 전환의도에는 영향을 미치지 못하는 것으로 나타났다. 다섯째, 위험감소행동은 관광지 전환의도에 유의한 영향을 미치는 것으로 나타났다. 본 연구를 통해 코로나19 감염병에 대한 항공사 고객들의 인식을 통해 감염병에 대한 위험과 위험감소행동과 관광지 전환의도에 대한 관계를 실증적으로 규명하고 분석하고자 하였다. 코로나19의 장기적인 위기 속에서 외부 변수에 취약한 관광산업이 이에 대한 대응방안을 모색해야 할 것이다.

• 지능정보연구
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• 제24권4호
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• pp.137-154
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• 2018

조류인플루엔자와 구제역 같은 동물감염병은 거의 매년 발생하며 국가에 막대한 경제적 사회적 손실을 일으키고 있다. 이를 예방하기 위해서 그간 방역당국은 다양한 인적, 물적 노력을 기울였지만 감염병은 지속적으로 발생해 왔다. 최근 빅데이터와 딥러닝 기술을 활용하여 감염병의 예측모델을 개발하고자 하는 시도가 시작되고 있지만, 실제로 활용가능한 모델구축 연구와 사례보고는 활발히 진행되고 있지 않은 실정이다. KT와 과학기술정보통신부는 2014년부터 국가 R&D사업의 일환으로 축산관련 차량의 이동경로를 분석하여 예측하는 빅데이터 사업을 수행하고 있다. 동물감염병 예방을 위하여 연구진은 최초에는 차량이동 데이터를 활용한 회귀분석모델을 기반으로 한 예측모델을 개발하였다. 이후에는 기계학습을 활용하여 좀 더 정확한 예측 모델을 구성하였다. 특히, 2017년 예측모델에서는 시설물에 대한 확산 위험도를 추가하였고 모델링의 하이퍼 파라미터를 다양하게 고려하여 모델의 성능을 높였다. 정오분류표와 ROC 커브를 확인한 결과, 기계 학습 모델보다 2017년 구성된 모형이 우수함을 확인 할 수 있었다. 또한 2017에는 결과에 대한 설명을 추가하여 방역당국의 의사결정을 돕고 이해관계자를 설득할 수 있는 근거를 확보하였다. 본 연구는 빅데이터를 활용하여 동물감염병예방시스템을 구축한 사례연구로 모델주요변수값, 이에따른 실제예측성능결과, 그리고 상세하게 기술된 시스템구축 프로세스는 향후 감염병예방 영역의 지속적인 빅데이터활용 및 분석 모델 개발에 기여할 수 있을 것이다. 또한 본 연구에서 구축한 시스템을 통해 보다 사전적이고 효과적인 방역을 할 수 있을 것으로 기대한다.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제28권2호
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• pp.17-29
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• 2022

Purpose: In terms of efficiency and safety, this study attempted to organize data on the operation methods and architectural planning of infectious diseases hospitals. Methods: The results obtained through on-site and interview surveys with hospital officials and medical staffs at four infectious diseases hospitals under construction were summarized based on those original business plans and facility guidelines. Results: First, the operational methods to secure safety and operational efficiency were summarized for each department which are major hospital functions of infectious disease hospitals. Second, as the architectural planning, the characteristics of space and circulation of each department are summarized. For safety of medical staff, negative pressure and non-negative pressure zone have to completely separated. In addition medical staff wears PPE and enters the negative pressure zone and returns in the order of admiral, shower, and gowning in the PPE undressing room after patient treatment. In case of operational efficiency, flexible operation is required in normal and crisis situations. For example, it is important for The Ward to gradually switch to negative pressure beds in times of crisis from normal situation and the outpatient department considers the composition of negative pressure and non-negative pressure outpatient spaces that can operate in parallel even in crisis situations. Implications: Infectious disease hospitals require flexible operation and appropriate facilities for normal and crisis situations.

• 한국간호교육학회지
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• 제28권4호
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• pp.421-432
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• 2022

Purpose: As coronavirus disease 2019 (COVID-19) and other emerging infectious diseases continue to threaten health security, a strategy is required to increase nursing students' care intention for patients with such diseases. This study aimed to identify factors influencing Korean nursing students' care intentions in regard to patients with emerging infectious diseases. Methods: The care intention, COVID-19 knowledge level, ethical sensitivity, beliefs, attitudes toward the care intention, subjective norms, and perceived behavioral control were investigated using the theory of planned behavior. An online survey was completed from December 2020 to January 2021 by 227 nursing students who had complete a clinical practicum. Descriptive statistics, correlation, and hierarchical regression analyses were conducted on the data. Results: The care intention was higher in men than in women nursing students and in junior than in senior students. Behavioral and normative beliefs, attitude toward the behavior, and perceived behavioral control significantly predicted care intention. Ethical sensitivity increased the predictability of nursing students' care intentions for emerging infectious disease patients. Conclusion: The theory of planned behavior predicted nursing students' care intentions for emerging infectious diseases. Therefore, an experience-based response program on emerging infectious diseases is required for nursing students.

• 대한수의학회지
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• 제30권1호
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• pp.79-84
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• 1990

A single inoculation of combined vaccines of Newcastle disease and avian infectious bronchitis of chicken, in a form of gel-oil emulsion type (gel-OEV) was tested their immunogenecity in chickens. The results were summerized as follows: 1. Average minimum and maximum ELISA antibody titers of ND were recorded 2407 and 13144 respectively. In the case of IB, 1824 and 4496 were recorded as minimum and maximum titers. 2. The distribution of average proportional groups, in the lowest and the highest, were 1.6 and 7.0 in ND ELISA and 1.4 and 2.8 in IB ELISA antibody titers. 3. ND ELISA antibody titers were significantly increased upto 7th week after the vaccination. On the other hand, IB ELISA antibody titers were raised upto 4th week after the vaccination.

• Journal of Preventive Medicine and Public Health
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• 제43권2호
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• pp.105-108
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• 2010

Objectives: To evaluate the policies on 2009 influenza pandemic in Korea at the end of first wave. Methods: The main policies and the estimation of these were described according to the progress of 2009 influenza pandemic. Results: The public health measures for containment were estimated to be successful in the early stage. The preparedness of antiviral agents and vaccines before the pandemic, risk-communication on pandemic influenza and policies of government including vaccines, and the education of health care worker and support of health care institutions was not enough to respond to the pandemic. Conclusions: The additional evaluation should be performed at the end of the pandemic in various aspects including health and socioeconomic effects.

• Journal of Microbiology
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• 제44권1호
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• pp.98-105
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• 2006

Yersinia enterocolitica induces a broad range of gastrointestinal syndromes, including acute enteritis. We previously reported that the clinical isolate, Y. enterocolitica KU14, which lacks pYV, was still capable of causing clinical infection. The present study demonstrated that KU14 did not trigger the death of macrophages in vitro, unlike WA-314 (ATCC51871, which harbors the pYV virulence plasmid). However, the intracellular growth of KU14 in the macrophages was greater than that of WA-C (ATCC51872, a non-plasmid harboring the derivative pYV plasmid). Treatment with a cholesterol-binding drug $(\beta-cyclodextrin)$ that affected lipid rafts resulted in a dramatic reduction in the inracellular growth of KU14. These data clearly indicate that the enhanced inracellular growth of KU14 is related to lipid raft-mediated infection.

• Journal of Preventive Medicine and Public Health
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• 제38권4호
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• pp.373-378
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• 2005

Influenza virus has a unique characteristics of annual epidemics of acute respiratory disease with attack rate of 10%-30% of the population. It is also the classical emerging infectious disease causing global pandemics when new antigenic shift occur. This antigenic shift is the key to its ability to evoke periodic pandemics, and it has caused at least 3 pandemics in 20th century. I reviewed these 3 pandemics in their natural courses and the epidemiology of the recent emerging influenza A viruses, especially the H5 and H7 subtypes. I descr ibed the epidemics of these vi ruses in human population and why we should be prepared to these viruses.