• Journal of Preventive Medicine and Public Health
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• 제31권3호
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• pp.540-563
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• 1998

This Study has been carried out to make a recommendation for the next amendment of the Infectious Disease Prevention Act with a specific focus on the kind of notifyable disease. Korean, Japanese, German, U.S, English and French acts on infectious diseases prevention were reviewed, compared with and analized in regards of numbers and kinds of notifyable infectious diseases and their tendency of amendments. An criteria was designed to assess the level of validity of diseases to be designated in the act. Four items, the fatality (greater than 10% or not), the possibility to make a big epidemic, the availability of efficient vaccination and the usefulness of isolation, are used in the assessment. This index is applied to the diseases in Korean and other countries' Infectious Disease Prevention Acts. Results are as follows: 1. The Korean Infectious Disease Preventon Act has a unique way of classifying the notifyable infectious disease, that is, the first, the second and the third class. But the author cannot find the basis of classification. No other countries reviewed have the similar classification. 2. The ten diseases, cholera, plague, yellow fever, diphtheria, typhoid fever, poliomyelitis, rabies, tetanus, malaria, and meningococcal meningitis are designated as the notifyable diseases not only in Korea but also in Japan, Germany, United States, England and france. 3. Thirty seven diseases including small pox, Lassa fever, anthrax, influenza, German measles, Legionellosis, infection with E. coli O157:H7, Q-fever, brucellosis, Lyme disease are designated as legal disease at least one of the above mentioned countries. 4. The Korea has been coped with the change of the infectious disease occurrence for last fifty years in amendment of the Infectious Disease Prevention Act. 5. Japan has a special infectious surveillance system composed of 3,880 clinics throughout the whole country. 6. Germany has classified infectious diseases in five categories which are based on seriousness of disease. Any confirmed death, cases and suspected cases in class I should be reported within 24 hours. But only confirmed death and cases in class II, but not suspected cases, are reportable in Germarny. 7. Plague, bacillary dysentery, pertussis, mumps, Japanese encephaltis and Korean hemorrhagic fevers are diseases with high credits validity index among Korean legal disease. 8. German measles, anthrax, E. coli O157 : H7 infection, Lassa fever, Q-fever, brucellosis are high in validity index among those which are not designated in Korea but designated in other countries. In conclusion, the Korean Infectious Disease Prevention Act has well been coped with the changes of infectious disease occurrence for last fifty years, but the classification basis and the validity of diseases to be designated as legal diseases is worth reevaluating.

• Infection and chemotherapy
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• 제50권4호
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• pp.357-361
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• 2018

While carbapenems are the drug of choice to treat extended-spectrum-${\beta}$-lactamase (ESBL)-producing strains, some alternative carbapenem-sparing regimens are suggested for antibiotic stewardship. We experienced a case of ciprofloxacin treatment failure for acute pyelonephritis caused by an apparently susceptible Escherichia coli. A 71-year-old woman presented the emergency department with fever for 7 days and bilateral flank pain for 2 days. The laboratory results and abdominopelvic computed tomography finding were compatible with acute pyelonephritis. During 3-day ciprofloxacin therapy, the patient remained febrile with persistent bacteremia. After the change in antibiotics to ertapenem, the patient's clinical course started to improve. ESBL-producing E. coli isolates were identified in all three consecutive blood samples. Pulsed-field gel electrophoresis (PFGE) patterns, serotypes, and sequence types showed the three isolates were derived from the identical strain. The isolates produced CTX-M-14 type ESBL belonging to the ST69 clonal group. Despite in vitro susceptibility, the failure was attributed to a gyrA point mutation encoding Ser83Leu within quinolone resistance-determining regions. This case suggests that ciprofloxacin should be used cautiously in the treatment of serious infections caused by ciprofloxacin-susceptible, ESBL-producing E. coli, even in acute pyelonephritis because in-vitro susceptibility tests could fail to detect certain genetic mutations.

• 한국안전학회지
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• 제37권2호
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• pp.88-96
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• 2022

Widespread infectious diseases are a concern for workers working in confined spaces. However, there is no risk assessment index for the risk of infectious disease in the workplace. Therefore, we propose a simple but effective index model to assess the risk of infectious diseases in the workplace. The proposed model identifies the risk of each workplace through an evaluation sheet comprising the frequency and intensity of the infectious disease. The intensity of an infectious disease is generally governed by the density of workers, whereas frequency is the sum of physical-e nvironmental and human management factors. By multiplying intensity and frequency, the risk of the workplace is derived. Through the proposed model, we evaluate the risks of workers at 15 different work sites. The proposed model clearly reveals what should be improved to keep workers safe from infectious diseases and will be helpful in assessing the risk of contagious disease at the work place.

• Bulletin of the Korean Chemical Society
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• 제27권8호
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• pp.1149-1153
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• 2006

LPC analogues including natural and unnatural LPC, 3-L-2-PC, acetylated LPC and ethylene glycol derivative are prepared from D-mannitol using in convenient procedures by only changing the synthetic sequences, and their protective activities against cecal ligation and puncture (CLP)-induced severe sepsis are compared. The chirality at C2 position in LPC is found to be required as (S)-configuration for sepsis inhibition, comparing from the protection activity between LPC 6 and unnatural LPC 8. The hydroxyl functionality is also very important and required at C2 or C3 position as shown in the protection activities of ethylene glycol analogue 11 and 3-L-2-PC 9.

• 한국학교ㆍ지역보건교육학회지
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• 제22권2호
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• pp.41-52
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• 2021

Background & Objectives: The purpose of this study is to present infectious diseases control and crisis response plans for International students by investigating the management of International students and prevention of infectious diseases targeting International students infectious disease control managers at universities in Busan in a situation where the risk of infectious diseases increases due to the spread of COVID-19. Methods: The data were collected from 14 International students infectious disease control managers at universities in Busan. Statistical analysis was done by using SPSS 22.0. Results: There were differences in the importance and performance of COVID-19 infectious disease control and support work by university. Conclusions: It is necessary to integrate management of support and roles of infectious diseases control for foreign students. Furthermore, strengthening the competence of experts and communication tools with international students are needed.

• 산업융합연구
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• 제18권3호
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• pp.109-116
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• 2020

본 연구의 목적은 미래감염병 발생 시 적합하고 신속한 위기관리체계를 수행으로 인한 피해경감을 최소화할 수 있는 정부의 보건의료정책을 마련하기 위한 감염병 감시체계 방안의 모색하는 것이다. 연구의 방법으로는 국내외 감염병 발생과 관리현황을 분석하고, 재난피해 지역에 대한 감염병 감시체계방안을 제시하기 위한 기술적 연구를 하는 것이다. 본 연구를 통해 과거 미래감염병의 사회적 확산에 대해서 원인과 그 대응정책의 시행착오 등에 대해 보다 명확한 관리체계를 확인할 수 있었다. 이에 대유행하고 있는 코로나바이러스감염증-19 확산사태를 지켜보면서 국내 재난대응체계에서는 재난 발생시 참여하게 되는 여러 기관의 역할과 관련된 감염병 예방을 위한 교육 및 훈련과 홍보가 매우 중요할 것으로 본다.

• 지역연구
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• 제38권3호
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• pp.41-49
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• 2022

본 논문의 목적은 감염병 조건이 도시열섬현상 저감을 위해 시행한 옥상녹화 사업에 대한 서울시민들의 지불의사금액에 미치는 영향을 파악하는 것이다. 이를 위해 감염병 조건과 비감염병 조건 하에서 옥상녹화 사업에 대한 지불의사액을 조건부가치추정법을 통해 산정 및 비교분석하였다. 그 결과 감염병 조건에 따른 지불의사액이 통계적으로 유의미한 차이가 있게 나타났고, 감염병 조건의 지불의사액이 비감염병조건보다 낮음을 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제23권1호
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• pp.85-87
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• 2013

An outbreak of Staphylococcus aureus infections occurred in a university with an enrollment of 80 students in the city of Daejon, Republic of Korea. All nine S. aureus isolates from patients (n = 7), staff members (n = 1), and the fried chicken served as the lunch (n = 1) harbored the enterotoxin A gene and showed an identical antibioticresistant profile, PFGE banding pattern (STAS16.001), and sequence type, ST 6. These results suggested that the outbreak was associated with eating the fried chicken that had been handled by an infected staff member. This case report demonstrated a practical approach to identifying the source and transmission of an infection.

• 월간양계
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• 제6권8호통권58호
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• pp.73-76
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• 1974

• Journal of Microbiology and Biotechnology
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• 제31권12호
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• pp.1716-1721
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• 2021

Chikungunya fever is an arboviral disease caused by the Chikungunya virus (CHIKV). The disease has similar clinical manifestations with other acute febrile illnesses which complicates differential diagnosis in low-resource settings. We aimed to develop a rapid test for CHIKV detection based on the nucleic acid lateral flow immunoassay technology. The system consists of a primer set that recognizes the E1 region of the CHIKV genome and test strips in an enclosed cassette which are used to detect amplicons labeled with FITC/biotin. Amplification of the viral genome was done using open-source PCR, a low-cost open-source thermal cycler. Assay performance was evaluated using a panel of RNA isolated from patients' blood with confirmed CHIKV (n = 8) and dengue virus (n = 20) infection. The open-source PCR-NALFIA platform had a limit of detection of 10 RNA copies/ml. The assay had a sensitivity and specificity of 100% (95% CI: 67.56% - 100%) and 100% (95% CI: 83.89% - 100%), respectively, compared to reference standards of any positive virus culture on C6/36 cell lines and/or qRT-PCR. Further evaluation of its performance using a larger sample size may provide important data to extend its usefulness, especially its utilization in the peripheral healthcare facilities with scarce resources and outbreak situations.