• IMMUNE NETWORK
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• v.20 no.6
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• pp.49.1-49.15
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• 2020

C-C chemokine receptor type 5 (CCR5) regulates the trafficking of various immune cells to sites of infection. In this study, we showed that expression of CCR5 and its ligands was rapidly increased in the kidney after systemic Candida albicans infection, and infected CCR5^-/- mice exhibited increased mortality and morbidity, indicating that CCR5 contributes to an effective defense mechanism against systemic C. albicans infection. The susceptibility of CCR5^-/- mice to C. albicans infection was due to impaired fungal clearance, which in turn resulted in exacerbated renal inflammation and damage. CCR5-mediated recruitment of NK cells to the kidney in response to C. albicans infection was necessary for the anti-microbial activity of neutrophils, the main fungicidal effector cells. Mechanistically, C. albicans induced expression of IL-23 by CD11c⁺ dendritic cells (DCs). IL-23 in turn augmented the fungicidal activity of neutrophils through GM-CSF production by NK cells. As GM-CSF potentiated production of IL-23 in response to C. albicans, a positive feedback loop formed between NK cells and DCs seemed to function as an amplification point for host defense. Taken together, our results suggest that CCR5-mediated recruitment of NK cells to the site of fungal infection is an important step that underlies innate resistance to systemic C. albicans infection.

• The Journal of Korean Academic Society of Nursing Education
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• v.18 no.2
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• pp.293-302
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• 2012

Purpose: The purpose of this study was to investigate nursing students' awareness and performance on standard precautions and to provide meaningful information for nursing students' education regarding hospital infection control. Method: Four hundred forty seven nursing students at 6 universities in D-city participated in this study. Data collection was conducted from March to April 2011. Students' awareness and performance on standard precautions of infection control in hospitals were measured using the modified 2007 CDC standard precautions guidelines. Data analysis was performed using the SPSS WIN 18.0 program, descriptive statistics, t-test, and ANOVA. Results: The level of students' awareness in the standard precautions was higher than performance. The higher levels of students' awareness and performance on standard precautions included patient care equipment, safe injection practices, and worker safety. The lower levels of students' awareness and performance on standard precautions included hand hygiene and personal protective equipment. There was no difference in the students' awareness and performance of standard precautions according to their characteristics. Conclusions: Based on the findings of this study, hand hygiene and personal protective equipment need to be stressed more within the program to improve nursing students' infection control techniques.

• The Journal of Korean Society for School & Community Health Education
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• v.15 no.3
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• pp.17-30
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• 2014

Objectives: The purpose of this study was to investigate the status of exposure to blood and body fluid and factors affecting on blood and body fluid exposure of nursing students including knowledge, performance regarding standard precautions. Methods: 280 nursing students in D-city and S-city participated in this study. Data collection was conducted from January to March 2012. Students' knowledge and performance on standard precautions of infection control in hospitals were measured using the measurement developed by Hong(2010). Data analysis was performed using descriptive statistics, t-test, one way-ANOVA, ${\chi}^2-test$, Pearson correlation coeficient, logistic regression by the SPSS WIN 18.0 program. Results: 58.6 percent of subjects experienced a exposure to blood and body fluid. The level of nursing students' knowledge level regarding standard precautions was $22.44{\pm}2.11$ and performance level was $4.31{\pm}0.50$. The factors affecting on blood and body fluid exposure of nursing students were knowledge level and education type about infection control. Conclusions: Based on the findings of this study, to decrease the exposure to blood and body fluid of nursing students, a proper education need to be stressed to improve nursing students' infection control knowledge and awareness.

• Journal of the Korea Convergence Society
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• v.12 no.11
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• pp.155-160
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• 2021

This study analyzed the awareness and performance of physical therapists' infection control using IPA. The four areas were divided into handwashing, personal management, Treatment room environment management, and infection control education, and a survey was conducted on awareness and practice. General characteristics were analyzed for frequency, and recognition and performance were analyzed through paired t-test and Pearson's correlation. Handwashing was both high and infection, control education had high performance, but low awareness. The performance of Treatment room environment was high, but the awareness was low, and personal management was both low. Therefore, based on this study, there is a need for a strategy to improve the awareness of infection control education, a strategy to improve performance in the treatment room environment, and a strategy to improve both performance and awareness in Personal management.

• The Korean Journal of Rehabilitation Nursing
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• v.19 no.1
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• pp.64-70
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• 2016

Purpose: The purpose of this study was to identify awareness and knowledge about hepatitis B virus (HBV) infection among North Korean immigrants who had resided in South Korea. Methods: This was a cross-sectional, community based study. Data were collected from a convenience sample of 198 North Korean immigrants aged 18 years old through 65 years old among those who had attended community centers, local churches, and gathering places in four cities. The questionnaire included 15 items about participants' knowledge on HBV infection and its consequences, mode of transmission, and preventive measures. Results: The mean score of HBV knowledge was $6.3{\pm}3.8$ (range 0~15). The items that over 60% of the respondents checked correct answer regarding knowledge about HBV were 'There is blood screening for hepatitis B infection', 'Hepatitis B can be transmitted through sharing needles with infected person'. Multivariate analysis showed that received education for the prevention of HBV infection and disease morbidity were significantly associated with the knowledge of HBV infection. Overall, approximately 11% of total variability in the knowledge of HBV infection could be explained by the 2 variables in this model ($R^2=.109$, p<.001). Conclusion: The results showed that North Korean immigrants need more education on HBV infection and prevention to improve their knowledge about HBV.

• Korean Journal of Health Education and Promotion
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• v.27 no.1
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• pp.1-8
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• 2010

Objectives: Human papillomavirus (HPV) infection is highly associated with cervical cancer. So, the modification of the risk factors of HPV infection is essential for prevention of cervical cancer. This study was performed to evaluate the risk factors of HPV infection. Methods: HPV test of 12,337 study population conducted using Hybrid-Capture II assay(HC-II) and self-administered questionnaires were collected. The study population was people who visited hospital-based medical screening center from January to December 2007 and all were female employees or employees' partner. Results: In logistic regression analysis, smoking and alcohol drinking were significant factors, with odds ratios of 1.328 (95% CI 1.010~1.746) and 1.644 (95% CI 1.309~2.066), respectively. Nutritional supplements was also significant factor, which odds ratio was 1.161 (95% CI 1.004~1.343). Oral contraceptives was positive association with HPV infection (odds ratio 2.108; 95% CI 1.217~3.652), whereas condom was negative association (odds ratio 0.851; 95% CI 0.740~0.979). Conclusion: HPV Prevalence of 12,377 study population was 11.4%. Smoking, alcohol drinking, nutritional supplements and oral contraceptives were possible risk factors of HPV infection, and condom had possible preventive effect on HPV infection. Further prospective and comprehensive studies about HPV risk factors are required.

• Journal of the Korean Society of Radiology
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• v.9 no.6
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• pp.409-416
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• 2015

This study is to examine the infection management cognition and to practice of dental hygienists about their general characteristics, type of workplace. 354 dental hygienists in Daegu and Kyungbuk cities. The questionnaire survey was performed from April to May, 2015. These showed that factors of dental infection management according to workplace depended existence and nonexistence that chief of station and program of infection management, education of infection control(p<.001). Also cognition of dental infection control according to workplace drawed the protection individual(p<.05), asepsis procedure(p<.01), control of dental equipment(p<.001), control of infectious waste(p<.01) and laundry(p<.001), to practice of dental infection control according to workplace drawed the protection individual and asepsis procedure(p<.001), methods of disinfected and sterilized(p<.05), control of dental equipment and laundry(p<.001), control of infectious waste(p<.05). As above results, in order to minimize the infection prevention in the dental clinic, the regular infection control education for infection control of dental hygienists required, infection control guidelines place at the dental office.

• The Journal of Korean society of community based occupational therapy
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• v.6 no.2
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• pp.39-49
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• 2016

Objective : The aim of this study was to investigate the status of infection for infectious diseases and infection control in occupational therapy. Methods : This study was implemented through the survey composed of the status of infection for infectious disease and the infection control and awareness of the infection control. The duration of survey was a month, June, 2016. 111 occupational therapists in 23 room of occupational therapy completed a survey. Results : 34.8% of occupational therapy room experienced the infectious diseases. This study showed the occupational therapists have high performance in almost items of infection control. But the occupational therapist showed the low performance in the items including 'Washing hands over than 15 seconds', 'Washing hands before and after wearing gloves', 'Wearing mask during treatment', 'Throwing away mask after using' and 'Washing your uniform separate from other cloths'. Almost occupational therapists think infection control is important and the education for infection control is needed in occupational therapy. But most of the education is implemented in only medical institution. Conclusion : To improve performance in infection control, individual effort of occupational therapists and institutional strategies are needed. This study will use as basic data for the education about infection control aimed at the occupational therapists.

• The Journal of Korean Academy of Prosthodontics
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• v.52 no.4
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• pp.287-297
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• 2014

Purpose: The purpose of this study is to examine the impacts of infection control education on dental hygienists' perceptions for hepatitis B and their behaviors. Materials and methods: Study participants were chosen by random selection among dental hygienists working in Seoul, Korea. A total of 150 questionnaires were sent out for the survey from April 2013 to May 2013, of which 140-excluding incomplete responses-were used for the study. Chi-square tests and t-tests were used (SPSS 19.0), and post-hoc analysis was performed as well. The maximum significance level was 0.05. Results: Average 1.53 times infection control education was taken, but dental hygienists' perceptions for hepatitis B and their behaviors did not show statistical differences whether the education was done or not. Practices to prevent infection showed differences depending on categories, especially disinfection and sterilization were well performed by educated group. The most common reasons for not taking the education and noncompliance with infection prevention guidelines are lack of time and opportunity due to busy schedule. Conclusion: 1. The more highly educated, the greater number of patients per day, and the greater size of hospitals, the better infection control education was conducted. 2. Although hepatitis B is one of the most common chronic liver diseases in Korea, no significant correlation between perceptions of hepatitis B and infection control education was found. 3. Dental hygienists who received infection control education performed more efficient practices for protection against infections than those who did not.

• Journal of Korean society of Dental Hygiene
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• v.9 no.1
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• pp.45-58
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• 2009

The purpose of this study was to examine the recognition level related to the infection prevention in dental medical institute in dental hygienists and to offer basic data of enhancing the knowledge education in dental hygienists on the infection prevention according to it. As a result of collecting and analyzing data by using the self-administered questionnaire on April 27, 2008 targeting 230 dental hygienists who are working at hospitals and clinics in P,K region, the following conclusions were obtained. 1. Dental hygienists' recognition on hospital-virus treatment method was indicated to be averagely 1.20 out of 3-point perfection. 2. The recognition on infection was indicated to be averagely 2.64 out of 4-point perfection. The statistically significant difference was shown with the appearance of periodical health examination(t=-2.42, p<.05) and by infection-education experience(t=2.28, p<0.05). 3. The recognition on an infection disease was indicated to be averagely 4.38 out of 8-point perfection. The significant difference(t=3.52, p<0.05) was shown depending on task in charge. 4. The recognition on the infection prevention in dental treatment institute was indicated to be averagely 4.89 out of 7-point perfection. The recognition on the infection prevention of dental treatment institute in dental hygienists, who work for general hospital, was indicated to be the highest. Accordingly, it was considered to be required an effort for dental hygienists, other dental-medical practitioners, and patients to be able to treated safely by enhancing the recognition level on infection prevention in dental hygienists and by maximally reducing exposure to infection in dental medical institute.