• Toxicological Research
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• v.11 no.2
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• pp.315-327
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• 1995

Diverse neurotoxic insults result in proliferation and hypertrophy of astrocytes, a subtype of glia in central nervous system. The hallmark of this response, often terms "reactive gliosis", is the enhanced expression of the major intermediate filament protein of castrocytes, glial fibrillary acidic protein (GFAP). These changes in the astrocytes suggest that GFAP may be a useful biochemical indicator of neurotoxicity. To investigate this possibility, we administered intra-peritoneally prototype nerotoxicants, metharnphetamine (MAP, 5 mg/kg), cocaine (30 mg/kg), N-buthyl benzenesulfonamide (NBBS, 300 mg/kg) and trimethytin (TMT, 8 mg/kg) to Wistar Rats and then assessed the effects of these agents on content of GFAP, which were determined by Sandwish ELISA and evaluated with neurotoxic symptoms, and quantitative changes of imrnunoreactivity of GFAP by light microscopic image analysis in specific regions. We found that assay of GFAP revealed time- and region-dependant patterns of neurotoxicity. The GFAP immunoreactivity of rat brain was increased in substantia nigra and hippocampus by MAP, NBBS and TMT; in roedial septal nucleus and nucleus accurnbens, it was also increased by RrBBS. Sandwich ELISA showed that GFAP levels of cerebrum in all groups on days 3 and 7 and that of brainstem(including cerebellum) in MAP, NBBS groups on day 1 and 3 were increased. A review of the background, design and results of these experiments are presented in this paper. Our findings indicate that GFAP is a sensitive and specific biomarker of neurotoxicity.otoxicity.

• International Journal of Highway Engineering
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• v.16 no.6
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• pp.137-147
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• 2014

PURPOSES : Daejeon is basically divided into an old downtown and a new downtown, and the recent relocation of the Chungcheongnam-do Provincial Government of Republic of Korea from the old downtown and the opening of governmental buildings in the new downtown as well have made this new downtown only densely populated with industrial and business facilities. Such changes in the downtowns have promoted the conditions of the new downtown while, consequently, dragging down the old downtown. Out of concern for those unbalanced developments of the two downtowns, Daejeon is now carrying out several city projects to revive the old downtown. In the light of that, as a part of the project to promote the old downtown, this study aims to conduct an evaluation on landscape of the culture and arts street in Daeheungdong which was built upon those ideas of a theme street project by Daejeon. METHODS : Based on the findings from the questionnaire not only on the components that would design the streetscape of the culture and arts street but also on the public satisfaction with the streetscape, the study defined how those changes in the components affect emotional factors of the pedestrians. In order to achieve the research goal, the study made changes in D/H ratio of the street structural components as well as the roadside trees. In terms of the questionnaire method, the study used the SD scale, and proceeded with its investigation through the frequency analysis, the principal component analysis (the factor analysis) and the structural equation model. RESULTS : According to the results from the factor analysis and the regression analysis, of those three factors, such as the openness, the comfortable sensation and the safety, the openness followed by the comfortable sensation and the safety was determined to have the most positive influence on the total satisfaction. The structural model analysis reported that the D/H and the structural components of the roadside trees and planting have a positive effect on the emotional image, and this emotional image also appeared to be positively related to the total satisfaction. CONCLUSIONS : This study looked into how the changes in the street structural components of the culture and arts street in Daeheungdong would affect the satisfaction with the streetscape, and finally confirmed that the D/H and the planting are what would have a positive effect on this satisfaction. What has been learned from this study will be the basic data to figure out how to promote and improve the culture and arts street in Daeheung-dong as this data will also help designing and developing of those specialized streets in other regions.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4409-4419
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• 2015

The Bhopal gas tragedy involving methyl isocyanate (MIC) is one of the most horrific industrial accidents in recent decades. We investigated the genotoxic effects of MIC in long-term survivors and their offspring born after the 1984 occurrence. There are a few cytogenetic reports showing genetic damage in the MIC-exposed survivors, but there is no information about the associated cancer risk. The same is true about offspring. For the first time, we here assessed the micronucleus (MN) frequency using cytokinesis-blocked micronucleus (CBMN) assay to predict cancer risk in the MIC-affected population of Bhopal. A total of 92 healthy volunteers (46 MIC-affected and 46 controls) from Bhopal and various regions of India were studied taking gender and age into consideration. Binucleated lymphocytes with micronuclei (BNMN), total number of micronuclei in lymphocytes (MNL), and nuclear division index (NDI) frequencies and their relationship to age, gender and several lifestyle variabilities (smoking, alcohol consumption and tobacco-chewing) were investigated. Our observations showed relatively higher BNMN and MNL (P<0.05) in the MIC-affected than in the controls. Exposed females (EF) exhibited significantly higher BNMN and MNL (P<0.01) than their unexposed counterparts. Similarly, female offspring of the exposed (FOE) also suffered higher BNMN and MNL (P<0.05) than in controls. A significant reduction in NDI (P<0.05) was found only in EF. The affected group of non-smokers and non-alcoholics featured a higher frequency of BNMN and MNL than the control group of non-smokers and non-alcoholics (P<0.01). Similarly, the affected group of tobacco chewers showed significantly higher BNMN and MNL (P<0.001) than the non-chewers. Amongst the affected, smoking and alcohol consumption were not associated with statistically significant differences in BNMN, MNL and NDI. Nevertheless, tobacco-chewing had a preponderant effect with respect to MNL. A reasonable correlation between MNL and lifestyle habits (smoking, alcohol consumption and tobacco-chewing) was observed only in the controls. Our results suggest that EF and FOE are more susceptible to cancer development, as compared to EM and MOE. The genotoxic outcome detected in FOE reflects their parental exposure to MIC. Briefly, the observed cytogenetic damage to the MIC-affected could contribute to cancer risk, especially in the EF and FOE.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.11 no.2
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• pp.115-121
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• 1978

Early developmental stages of Mactra chinensis were bioassayied to determin the water quality of the costal waters of Busan. The water samples were obtained at 12 stations from July 12 to July 17, 1977. Water quality evaluation was made in terms of the rates of normal development to abnormal development in three indicatory states, i. e. fertilization membrane formation, morula and trochophore larvae. The pollution degree of the waters brought from five swimming beaches was found to be highest at Haewundae followed by Songdo, Kwang-anri, Songjeong and Dadaepo with decreasing order. The highest value of the water at Haewundae was mainly due to the accidental oil spill from an oil tanker which happened on July 7, 1977. At Dongsamdong the rate of total abnormal development was $47.17\%$. This result is apparently attributable to fish byproducts discarded from a number of restaurants. At Chungmudong where a large fish-market is located, the rate of total abnormal development was $61.14\%$. At Suyeng Bay and Yongho Bay the rates of total abnormal development were $73.82\%$ and $72.90\%$ respectively. At these bays the drainage presumably contains a large amount of chemical pollutants from the industrial areas. This result shows that no organisms can normally breed in these regions.

• Journal of Cadastre & Land InformatiX
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• v.47 no.2
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• pp.79-90
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• 2017

Urban environment represent one of the most dynamic regions on earth. As in other countries, forests, green areas, agricultural lands are rapidly changing into residential or industrial areas in South Korea. Monitoring such rapid changes in land use requires rapid data acquisition, and satellite imagery can be an effective method to this demand. In general, SAR(Synthetic Aperture Radar) satellites acquire images with an active system, so the brightness of the image is determined by the surface roughness. Therefore, the water areas appears dark due to low reflection intensity, In the residential area where the artificial structures are distributed, the brightness value is higher than other areas due to the strong reflection intensity. If we use these characteristics of SAR images, settlement areas can be extracted efficiently. In this study, extraction of settlement areas was performed using TerraSAR-X of German high-resolution X-band SAR satellite and KOMPSAT-5 of South Korea, and object-oriented image classification method using the image segmentation technique is applied for extraction. In addition, to improve the accuracy of image segmentation, the speckle divergence was first calculated to adjust the reflection intensity of settlement areas. In order to evaluate the accuracy of the two satellite images, settlement areas are classified by applying a pixel-based K-means image classification method. As a result, in the case of TerraSAR-X, the accuracy of the object-oriented image classification technique was 88.5%, that of the pixel-based image classification was 75.9%, and that of KOMPSAT-5 was 87.3% and 74.4%, respectively.

• Korean Journal of Microbiology
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• v.30 no.1
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• pp.53-59
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• 1992

Four bacterial strains capable of catabolizing 4-chlorobiphen!;l (4CB) were isolated from the industrial waste waters. The bacterial isolates designated as PO$. P20, P27, and P1242. respectively, were examined for their catabolic activities. And in order to examine molecular homology of the 4CB catabolizing genes of these bacterial isolates. Southern hybridization was conducted with bphABC genes of P. p.srudoalculigrnrs KF707 as a DNA probe. The metabolites of 2-hydroxy-6-0x0-6-(4'-chlorophenyl)hexa-2 .4-dienoic acid and Cchlorobenzoate were detected to be produced by the isolatc:~ in the MM2 liquid cultures. But Cchlorobenzoate was further catabolized to produce 4.-hydroxybenzoate by DJ-12, P08. and P27. but not by P20 and P1242. As results of hybridization, homologous regions were commonly observed in Xhol fragments of 2.2 and 1.8 kb and in EcoRl fragment of 11 kb in the DJ- 12. P08, and P27 isolates. But in any restriction enzyme digests ot the P20 and PI242 isolates. homologous region was not detected. The cbp genes of the bactcria capable of catabolizing 4CB in nature could be divided into two groups by divergence<

• The Journal of Industrial Distribution & Business
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• v.9 no.6
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• pp.57-64
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• 2018

Purpose - With the rapid economic development, great changes have happened in the Chinese beer market. The scale of imported beer is increasing. However, the sales of native Chinese beer decrease in recent years. It is because more Chinese customers prefer beer with unique attributes than those with lower prices. In order to take an advantage in this market, practitioners should develop new products to satisfy Chinese customers. Scholars have also focused on beer characteristics to estimate consumers' behavior for improving the development of beer industry. However, most studies are theoretically centered on marketing strategy management or general understanding of the market. It is not enough for us to explain customers' consumption patterns. Some empirical research did attempt to find out beer attributes that may influence their choice behavior. However, they failed to verify what can increase customers' utility through a new product. More importantly, few evidences can be found in the literature. Therefore this study explores the major characteristics of imported beer which may associate with customers' preferences. Research design, data, and methodology - With the results of literature review and focus group interview, we found out four main imported beer attributes and the levels of each factor. A pre-test is constructed to check the problems in the questionnaire protocol. With the results of pre-test, the revised questionnaire is processed among customers who have purchased and had imported beer in China regions such as Beijing, Shanghai, Jiangsu, Guangdong and so on. The choice-based conjoint analysis is applied to analyze the useful data of 205. Results - Results indicate that choice-based conjoint analysis is the effective method to estimate customers' choice behavior. Results also indicate that country of origin, price, taste, and package affect customers' preference and the importances of imported beer attributes are significantly different. Conclusions - Country of origin, price, taste, and package are important for customers to make an imported beer choice decision. Marketers should consider these determinants and their importance to develop new products. Moreover, choice-based conjoint analysis should be the useful method for practitioners to develop a new product of imported beer for sustainable business in the competitive industry.

• Journal of Technology Innovation
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• v.27 no.3
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• pp.27-52
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• 2019

This research studied the determinants of private R&D investment by examining the innovation strategies of 481 small and medium enterprises (SMEs, their employee size is 5 or more and less than 300) in Busan, South Korea. The data is derived from the Technology Survey of Small and Medium Enterprises in 2001 and 2003. Three explanatory variables for the innovation strategies are the R&D portfolio, the organization (personnel) for R&D, and the strategic role of CEO for innovation. The technological levels of industries are controlled in the linear regression model. The dependent variable is the total private R&D investment of a firm in the given fiscal year. The empirical results indicate that the private R&D investment positively correlates with the complexity of the R&D portfolio, the formal organization for R&D team, and the increase of R&D personnel. The formal organization for R&D team and the number of R&D personnel are correlated with the increase of private R&D investment across the four groups in the manufacturing sector but not in the service sector. These findings suggest that the innovation policy needs to target firms who have complex R&D portfolios, the formal organization of R&D teams, and sufficient R&D personnel in order to increase the private R&D investment of SMEs in regions, with consideration of industrial characteristics.

• Membrane Journal
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• v.18 no.3
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• pp.206-213
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• 2008

Poly(vinylidene fluoride) (PVDF) membrane surfaces were modified using surface modifying macromolecules (SMMs). The Zonyl BA-L as SMM was used and the various PVDF membranes containing 0 to 2 wt% SMM were prepared. The resulting membranes were characterized through SEM, contact angle measurements and pervaporation separation of water-ethanol system. SMM layers were created in the surface regions of PVDF membranes by SEM images and the contact angles were increased more than untreated PVDF membranes. The pervaporation was carried out at 50, 60 and $70^{\circ}C$, and the PVDF membranes containing 1 and 2 wt% SMM were used for 10, 20, 50 wt% water in the binary water/ethanol mixtures and pure water. PVDF/2 wt% Zrlnyl BA-L membrane showed the permeability 5.3 $g/m^2hr$ and separation factor 287 at $50^{\circ}C$ for water : ethanol = 10 : 50 solution.

• Journal of Preventive Medicine and Public Health
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• v.27 no.2 s.46
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• pp.230-241
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• 1994

Though people occupationally exposed to machineries and automation in the industrialized society desire work involving decreased strength, due to the continuous and repetitive activities, a new industrial stress is present. Studies on prevalence of musculoskeletal disease and their related risk factors have evolved. In this study in relation to work tasks, we investigated the differences in musculoskeletal symptoms occurring In each body region. The results of the survey were as follows. 1. When comparing age, level of education, work duration, job satisfaction and leisure time activities according to work task, age in control group was $38.83{\pm}5.5$, in comparison to the other 2 groups was smaller(p<0.05), and level of education in control group was higher (p<0.05). Work duration in the cutting department was $8.04{\pm}4.99$ years longer than the other 2 groups (p<0.05), but there was no difference in the job satisfaction and leisure time activities. 2. The mean of symptom scores of each work task was 1.54 in the cutting department, 1.57 in the press department and 1.59 in the control group, and there was no significant differnce in the 3 groups. The mean of symptom scores for upper extremities in the control group was low but no statistically significant diffrence was shown. 3. When comparing the mean of symptom score according to work task in the each body region, in the shoulder region, the symptom score in the press department which desired strength was higher than the other 2 groups but no significant difference was shown. In the wrist region the cutting department scored 1.01 and in comparison to the other 2 groups was significantly increased (p<0.05). 4. The results of the univariate regression analysis on the major individual risk factors associated with musculoskeletal symptom relating work showed that previous symptom complaints in the same body region was significant risk factor(p<0.001) in the whole body Besides wrist, hip, and knee, psychological problem was shown to be a significant factor(p<0.05). And the body regions which work task was significant risk factor were wrist and neck region (p<0.05). 5. The results of the multiple regression analysis involving significant factors of each body region from the univariate regression analysis showed that previous symptom complaint in whole body region(p<0.001) and psychological problem in the shoulder, elbow and lumbar region (p<0.05) were significant factors, and work task was significant factor in the wrist (p<0.05).