• Journal of Sasang Constitutional Medicine
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• v.14 no.2
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• pp.138-146
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• 2002

1. Background and Purpose 1 intented to be helpful to treat diabetes through a clinical study of lndongdeungjikolpitang effect of soyangm 2. Methods I studied 6 patients with middle diabetes who were diagnosed by Soyangin at department of Sasang constitutional Medicine in Dongeui Oriental Hospital during 1 year from August. 2001 to July. 2002. and then I investigated the clinical symptoms of the diabetics and analyzed level of examination after administration of lndongdeungjikolpitang 3. Results and Conclusion lndongdeungjikolpitang was administered to six diabetic patients, So-yang-in for 8 weeks. The symptoms such as frequent hunger(P<0.05), decrease of body weight(P<0.05) have improved after the treatment. As results, level of HbAlC(P<0.05), total protein(P<0.05) and blood pressure(P<0.05) significantly decreased after administration of Indongdeungjikolpitang.

• Journal of Sasang Constitutional Medicine
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• v.12 no.1
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• pp.186-200
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• 2000

The purpose of this research was to investigate the effects of Indongdeungjikolpitang water extract(IJTE) on the complication of diabetes. IJTE did not affect the level of blood glucose in alloxan- or streptozotocin-induced hyperglycemic mice, but inhibited the motility of gastrointestine. IJTE inhibited the writhing syndrome induced by acetic acid, the permeability of evans blue into peritoneal cavity induced by acetic acid, the paw edema induced by histamine, and the formation of cotton pellet granuloma. IJTE increased the cell viability of thymocytes and splenocytes. IJTE decreased the release of ${\gamma}-interferone$(${\gamma}-IFN$) and interleukin-2(IL-2), but did not affect the release of interleukin-4(IL-4) from murine thymocytes. IJTE increased the release of IL-4 and decreased the release of tumor necrosis $factor-{\alpha}$($TNF-{\alpha}$) and $interleukin-1{\beta}$($IL-1{\beta}$), but did not affect of ${\gamma}-IFN$ and IL-2 from murine splenocytes. IJTE decreased the release of $TNF-{\alpha}$ and $IL-1{\beta}$ from murine peritoneal macrophages. IJTE decreased the production of niric oxide(NO) from murine peritioneal macrophages and increased the phagocytic activity of murine peritoneal macrophages. These results suggest that IJTE has an anti-inflammatory action via the inhibition of $TNF-{\alpha}$, $IL-1{\beta}$ and NO production from immune cells.