• 제목/요약/키워드: Indoles

검색결과 50건 처리시간 0.025초

Synthesis and Biological Activities of New Substituted Indoles

  • Hishmat, Orchidee H.;Nakkady, Sally S.;El Shabrawy, Osama A.;Mahmoud, Sawsan S.
    • Archives of Pharmacal Research
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    • 제15권1호
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    • pp.104-108
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    • 1992
  • 2, 3-Diphenyl-6-formyl-5-methoxyindole reacts with ethyl cyano acetate to yield the arylidene derivative which forms with urea and thiourea the corresponding pyrimidine derivatives. The arylidene derivatives react with hydrazines and with active methylenes to form the respective pyrazole derivatives and the $\alpha, \;\beta$-disubstituted acrylonitriles. Seven new compounds were tested for their effects on the arterial blood pressure of rats and analgesic activity.

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Effect of horseradish, mushroom waste and almond hull on the concentrations of odorous compounds in swine manure for spreading on grassland in spring

  • Hwang, Ok-Hwa;Han, Deug-Woo;Lee, Sang-Ryoung;Kwag, Jeong-Hoon;Lim, Joung-Soo;Cho, Sung-Back
    • 농업과학연구
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    • 제43권4호
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    • pp.589-594
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    • 2016
  • The objective of the current study was to investigate the effect of odor reducing agents on the levels of pH, total carbon, total nitrogen, and odorous compounds [phenols, indoles, short chain fatty acid (SCFA), branched-chain fatty acid (BCFA), and ammonium nitrogen] of swine manure during the spring season (temperature around $20^{\circ}C$). Odor reducing agents included horseradish powder, mushroom waste powder, and almond hull powder. A manure sample (15 L) was taken from the pit under the pens of a swine feeding operation and incubated with 0.03% horseradish powder, 1% mushroom waste powder, and 1% almond hull powder, respectively, in acryl chambers for 14 days. Addition of almond hull powder showed the lowest pH (p < 0.05) and the highest level of total carbon (p < 0.05) among treatments of odor reducing agents. Although addition of odor reducing agents increased the level of phenols (p < 0.05), addition of almond hull powder decreased the level of indoles (p < 0.05). Levels of SCFA and BCFA were higher in almond hull powder than those in control (p < 0.05). Taken together, the results from our current study showed that odor reducing agents can be used for reducing the odor of swine manure by providing fermentable carbohydrates. At $20^{\circ}C$, however, the function of odor reducing agents might be decreased due to lower microbial activity.

갈대의 Indole 화합물(化合物) 연구(硏究) -II. 갈대유아(幼芽)의 생장과정중(生長過程中)의 Indole 화합물(化合物)의 변화(變化)- (Studies on the Indoles in the Common Reed -II. Changes of Indole Compounds During the Growth of Sprouts-)

  • 이춘영;김용화
    • Applied Biological Chemistry
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    • 제19권2호
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    • pp.65-69
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    • 1976
  • 갈대(Phragmites communis Trin) 유아(幼芽)를 $27^{\circ}C$의 암소에서 110시간 동안 사경(砂耕) 배양(培養)하였다. 유아(幼芽)가 자라는 동안 일정(一定)한 시간마다 시료(試料)를 채취하여 methanol로 처리(處理)하여 그 추출물(抽出物)에 대하여 thin layer chromatography를 실시(實施)하였다. 그 결과 배양(培養)하지 않은 유아(幼芽)에서는 indole화합물(化合物) 중에서 serotonin, tryptophan, tryptamine이 다량(多量)으로 나타났으나, 배양(培養) 과정(過程) 중에 이들 화합물(化合物)의 감소(減少)와 더불어 다른 여러 가지 indoleamine류(類)의 생합성(生合成)이 현저(顯著)하였다. 즉 배양(培養) 과정(過程) 중에 tryptophan의 양(量)에는 큰 변화(變化)가 없으나, serotonin 및 tryptamine이 감소하면서, 이들의 methyl화(化) 유도체들이 증가(增加) 하였다. 그 증감(增感)의 상호관계(相互關係)를 관찰하여 본 결과, bufotenine은 tryptophan에서 tryptamine을 거쳐 serotonin, N-methylserotonin의 경로(經路)로 합성(合成)될 것임을 시사하였다.

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The Synthesis and Light Absorption Behaviour of Novel Coumarin Chromophores

  • An, Kyoung Lyong;Shin, Seung Rim;Jun, Kun;Park, Soo Youl
    • 대한화학회지
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    • 제58권3호
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    • pp.297-302
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    • 2014
  • The synthetic route to coumarin systems is well established and one approach of particular interest leads to the intermediate 7-diethylamino-3-formylcoumarin. A combination of the N,N-diethylamino-coumarin donor with a wide range of acceptor groups of varying electron withdrawing strength should permit the synthesis of a series of extended coumarin dyes with absorption maxima range from 500 to 600 nm, or even beyond. In this communication, a novel efficient synthesis of indoles, benzothiazole and benzoxazole based on coumarin chromophores were achieved and the coloristic and fluorophoric properties of these chromophores were studied.

Analytical Characterization of Aza-Indole Alkaloids in the Biosynthesis of Catharanthus Roseus

  • Lee, Hyang-Yeol
    • 한국응용과학기술학회지
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    • 제29권2호
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    • pp.248-256
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    • 2012
  • Aza-indoles are important pharmacophores that have similar size and biological properties of indole. Here we have synthesized 4- and 7-azaindole tryptamines and showed that they are successfully incorporated in the biosynthesis of monoterepene indole alkaloids (MIAs) to form novel azaindole alkaloids by enzymatic reactions of strictosidine synthase(STR) and strictosidine glucosidase(SDG) monitored by UPLC/MS. By using HPLC equipped with a HPLC photo diode array(PDA) detector, each of the UV spectra of azaindole alkaloids was obtained and characterized. When hydrophilicity of azaindole alkaloids was compared, 4-azaindole alkaloids were more hydrophilic than 7-azaindole alkaloids.

The Synthesis and Evaluation of Squarylium Dyes Based On the NIR Spectra Region

  • Park, Soo-Youl;Shin, Seung-Rim;Shin, Joung-Il;An, Kyoung-Lyong;Jun, Kun
    • 한국염색가공학회:학술대회논문집
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    • 한국염색가공학회 2008년도 제39차 학술발표회
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    • pp.131-132
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    • 2008
  • Several squarylium dyes, derived from benzothiazole and indoles, were synthesized as a potential NIR dyes with absorption in the 700-900 nm region. These chromophores were induced much more bathochromic shift in the absorption maximum of the compound relative to the neutral parent squarylium dyes which we were described before. The squaryliums offer a convenient way of linking the dye to functional substrates and may be an advantage to be potential chromophores for NIR-absorbing, NIR-Cut-off filter, PDT(Photo Dynamic Therapy) materials.

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Indium(III) Chloride Mediated Michael Addition of Indoles to Ketene S,S-Acetals: Synthesis of Bis- and Tris-indolylketones

  • Singh, Thokchom Prasanta;Khan, Ruhima;Noh, Young Ri;Lee, Sang-Gyeong;Singh, Okram Mukherjee
    • Bulletin of the Korean Chemical Society
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    • 제35권10호
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    • pp.2950-2954
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    • 2014
  • A series of bis and tris-indolylketones and meridianin alkaloids are prepared by one pot Michael reaction of indole and ketene S,S-acetals under solvent-free condition using mild Lewis acid $InCl_3$.

채소류의 기능성 (Bioactive Compounds in Vegetables: Their Role in the Prevention of Disease)

  • 이영은
    • 한국식품조리과학회지
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    • 제21권3호
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    • pp.380-398
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    • 2005
  • There are various bioactive compounds in vegetables which are called 'phytochemicals' They are extranutritional constituents that typically occur in small quantities. They are being intensively studied to evaluate their effects on health. These biologically active compounds vary widely in chemical structure and function and are grouped accordingly, carotenoids, flavonoids, isothiocyanates, allyl compounds, indoles, isoflavones and saponins, etc. Traditionally used vegetables are defined, and their trivial names, biological functions and traditional and oriental medicinal effects are investigated in this study. Much scientific research needs to be conducted before we can begin to make science-based dietary recommendations. Despite this, there is sufficient evidence to recommend consuming vegetables rich in bioactive compounds, especially for the prevention of cancer.

HPLC-ECD에 의한 흰쥐 뇌 부위별 Catecholamine 및 대사산물의 신속정량법 (Determination of Catecholamines and Their Metabolites in Rat Brain by High Performance Liquid Chromatography with Electrochemical Detector)

  • 노일협
    • 약학회지
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    • 제32권1호
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    • pp.50-54
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    • 1988
  • A simple and sensitive method was studied for the simultaneous determination of catecholamine, indoleamine and their related metabolites by high performance liquid chromatography with electrochemical detector. Norepinephrine, dopamine, serotonin and their metabolites of 3,4-dihydroxyphenylacetic acid, homovanillic acid, 5-indoleacetic acid were resolved from rat brain tissue homogenates by separation on reversed phase $C_{18}$ column with mobile phase consisting of monochloroacetate buffer (pH2.47), 1.42mM sodium octyl sulfonate and 7% acetonitrile. Both catechols and indoles can be eluted in 15min. The sensitivities of this method are sufficient for determination of at least 100 pg of neurochemical amines in brain samples, for example, frontal cortex, olfactory bulb, striatum, septum, hippocampus, thalamus, hypothalamus, medulla & pons and cerebellum. The highest level of dopamine was observed in striatum whereas norepinephrine and serotonin were in hypothalamus.

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한국(韓國), 일본(日本), 중국(中國) 삼개국(三個國) 참기름의 이화학적(理化學的) 특성(特性) 및 궁능적(宮能的) 특성(特性) (Physicochemical and Sensory Characteristics of Sesame Oils Manufactured in Korea, Japan and China)

  • 김현위;이민정;김기홍
    • 동아시아식생활학회:학술대회논문집
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    • 동아시아식생활학회 2004년도 참깨과학 국제학술대회 발표 논문집
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    • pp.107-129
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    • 2004
  • 참기름은 특유의 풍미와 건강 기능적 특성으로 한국에서 널리 이용되고 있으며, 제조방법에 따라 휘발성 향기성분과 항산화성이 달라지기 때문에 이에 대한 연구가 많이 행해져 왔다. 이에 한국, 일본, 중국 참기름의 품질특성과 기호특성을 알아보기 위해 시판 한국, 일본, 중국 참기름을 대상으로 이화학적 특성, 휘발성 향기성분, 항산화성, 이들간의 상관성 및 관능평가를 조사하였다. 지방산 조성은 올레산, 리놀산이 거의 80%이상이고, P/S 비는 4.99${\sim}$5.73 이었으며, 토코페롤은 ${\gamma}$체가 대부분으로 23.14${\sim}$34.85 mg/100g 범위이었다. 리그난 함량에 있어서는 세사민(322.91${\sim}$689.39ppm), 세사몰린(62.19${\sim}$289.82ppm)이 대부분이었고, 세사몰은 8.52${\sim}$51.21ppm 로 제조국간의차이가 뚜렷하여 한국>중국>일본의 순으로 많았다. 산화안정성의 지표가 되는 유도기간은 한국>중국>일본 순이었고, Lovibond 색가에서는 제품간의 차이는 있지만 대체로 한국${\geq}$중국>일본제품의 순서로 red 값과 yellow 값이 큼을 알 수 있었다. 향기성분의 주요 구성은 pyrazines>phenols>aldehydes> furans 이었고, 이외에 pyrroles, thiazoles, indoles 을 소량 포함하고 있었다. 향기성분 총량은 한국>중국>일본 제품의 순서로 많았고, 한국제품에 pyrazines 이 총향기성분 함량의 35%으로 월등히 많았으며, 중국 참기름의 경우는 phenols이 많았다. good flavor(pyrazines, pyroles, thiazoles, furans)/off flavor(phenols, aldehydes, Indoles)은 대체로 한국>일본${\fallingdotseq}$중국이었다. 또한, Pyrazines, sesamol, b 값(yellowness), 유도기간 간에는 양의 상관이 있음을 알았다. 한국, 일본, 중국 참기름에 대한 기호특성을 조사한 결과에서는 한국인들은 고소한 향의 강도, 고소한 향의 기호도, 전체적인 맛에서 한국참기름>일본참기름>중국참기름의 순서로 일본인들은 전체적인 맛에서는 한국인들과 비슷한 기호성을 보였으나, 고소한 향의 기호도에서는 한국참기름과 일본참기름을 동일하게 평가한 반면, 중국인들은 고소한 향의 강도, 고소한 향의 기호도, 전체적인 맛에서 뚜렷하게 일본참기름을 우수하게 평가하였다.

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