• 한국융합학회논문지
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• 제12권5호
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• pp.313-326
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• 2021

본 연구는 EMA 연구방법을 소개하고 연구에 적용하는 방법을 보여주는 것을 목적으로 한다. 노년 활력 증강을 측정하는 지속개발을 위한 사전연구로, 노인의 종단자료를 이용하여 성장모형을 성립하고 분석방법으로써 다층모형의 적합성을 설명하였다. 절편만 존재하는 모형을 통해 종속변수의 총분산을 확인한 결과, 전체분산 중 약 47%는 개인 차이에 의해 발생하였고 53%는 측정 시점 차이에 의해 발생하였다. 두 번째는 일차항을 고정효과로 추가한 모형으로, 시간을 집단평균 중심화하여 노년 활력 지수에 미치는 영향을 개인마다 다르게 확인하였다. 그 결과, 시간에 대한 효과는 유의하지 않았다. 이는 본 연구가 처치를 투입하지 않은 사전연구이기 때문이며, EMA 자료 수집 과정에서 외부개입 없이 변화가 크지 않은 자료를 보임을 의미한다. 세 번째는 성별을 독립변수로 추가한 모형으로, 변화는 시간과 성별 모두에서 유의하지 않은 결과를 보였다. 마지막으로 각 모형에 대한 PRD를 비교해본 결과, 성별변수를 투입하지 않는 모형이 더 효과적으로 자료에 적합함을 보였다. 이는 EMA 연구에서 응답자의 시간과 맥락을 고려하여 개인의 특성을 측정할 수 있는 다층모형을 이용해야 함을 시사한다.

• 환경영향평가
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• 제28권4호
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• pp.413-426
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• 2019

주거지 내 위치하거나 매우 인접한 곳에 무분별하게 난립된 개별입지 공장들은 궁극적으로는 준 산업단지 또는 새로운 계획입지로의 조정이 필요하다. 본 연구에서는 김포시 환경을 예로 김포시 전역에 난립된 개별입지 공장들을 새로운 지역으로 군집시킴에 따른 대기 $SO_2$ 오염도의 변화를 AERMOD 모형을 이용하여 평가하였다. 평가결과 개별입지 공장들의 공간 재배치를 통해 김포시 자체 배출원에 의한 오염도를 개선할 수 있는 가능성을 확인하였다. 재배치와 더불어 배출 굴뚝의 높이 조정과 같은 배출규제가 병행되는 경우 김포시 자체 배출원에 의한 오염도를 김포시 전체적으로 볼 때 약 70% 감소 가능하며 행정 구역별로는 최대 약 87% 감소 가능함을 정량적으로 확인하였다. 단, 군집지역으로 선정된 해당 행정구역은 김포시 전체 오염도의 변화 폭과 비교했을 때 상대적으로 큰 오염도 증가가 나타날 수 있다.

• Nuclear Engineering and Technology
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• 제37권3호
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• pp.245-258
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• 2005

This paper addresses two types of uncertainty: stochastic uncertainty and subjective uncertainty in probabilistic accident consequence assessments. The off-site consequence assessment code OSCAAR has been applied to uncertainty and sensitivity analyses on the individual risks of early fatality and latent cancer fatality in the population outside the plant boundary due to a severe accident. A new stratified meteorological sampling scheme was successfully implemented into the trajectory model for atmospheric dispersion and the statistical variability of the probability distributions of the consequence was examined. A total of 65 uncertain input parameters was considered and 128 runs of OSCAAR with 144 meteorological sequences were performed in the parameter uncertainty analysis. The study provided the range of uncertainty for the expected values of individual risks of early and latent cancer fatality close to the site. In the sensitivity analyses, the correlation/regression measures were useful for identifying those input parameters whose uncertainty makes an important contribution to the overall uncertainty for the consequence. This could provide valuable insights into areas for further research aiming at reducing the uncertainties.

• 환경영향평가
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• 제18권2호
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• pp.89-97
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• 2009

Korean society is faced with various new problems arising from the development projects of new towns, industrial cities, large-scale residential complexes, etc. started from the 1970s. Particularly with the construction of residential and industrial complexes by the roadsides, they are openly exposed to road traffic noise and vibration. Thus, the objective of this study is to examine using noise maps how increasing traffic volume affects road traffic noise and what problems it causes in areas where new towns or complexes are constructed by development projects. According to the results of this study, in areas around the sites of development projects, the noise level increased by road traffic noise compared to that before development and was 1.16~6.92 times higher than the environmental noise standard, but measures to reduce road traffic noise was lukewarm. In addition, areas with soundproof facilities showed a noise level 1~3 step lower than other areas, and in individual buildings, the noise level on the side facing the road was 1~2 step higher than that on the rear side.

• 보건행정학회지
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• 제19권1호
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• pp.49-61
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• 2009

Background: The appropriate management of diabetes mellitus(DM) can help reduce its relapse and economic burden, but the level of management of DM in Korea is reported to be insufficient. This study aims to identify the management level of DM by figuring out the HbA1c examination performance rate of the diabetics and analyzing the variation according to the characteristic of a diabetic. Methods: This study used the Korean National Health Insurance Database which includes E10-14(ICD-10 code) as a primary or secondary disease as of 2006. Study population is 1,892,062 diabetics excluding 393,784 patients with the first attack of DM in 2006, 33,440 diabetics who died in 2006, and 21,299 patients with DM having no record of ambulatory care among the 2,340,585 DM patients in total. Results: The HbA1c examination performance rate of all DM patients in our country is estimated to be 41.5% as of 2006 and shows variation according to the characteristic of individual DM patients. The highest performance odds was shown by the patients who were below 19 of age, insured for health insurance, attended more than 3 ambulatory care providers, made ambulatory care visits more than 10 times annually, attended a specialized general hospital as their main attending medical institution, had a record of hospitalization or had co-morbidity. Conclusion: This study propose that is necessary to make politic preparations for the appropriate management of diabetes at a national level, and particularly, the patients with advanced age, the ones dependent on Medical Aid, and the ones using hospitals or clinics, whose appropriate management seems vulnerable, demand a careful management.

• Preventive Nutrition and Food Science
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• 제9권3호
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• pp.276-282
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• 2004

Marginal Zn deficiency is prevalent through the world and yet human zinc status has not been properly assessed due to the lack of a reliable diagnostic indicator. One potential possibility for zinc status assessment using Zn-binding protein, metallothionein (MT)-mRNA, has been proposed. The purpose of the present study was aimed to show whether measurement of mononuclear cell (MNC) MT mRNA, using a competitive-reverse transcriptase-polymerase chain reaction (competitive-RT-PCR) assay, could indicate zinc status in human subjects. In this study, MNC MT-mRNA expression was measured using a competitive-RT-PCR to compare before and after 14 days of zinc supplementation (50 mg Zn/das zinc gluconate). RT-PCR oligonucleotide primers which were designed to amplify both a 278 bp segment of the human MT-2A cDNA and a 198 bp mutant competitor cDNA template from MNCs, were prepared. MT-2A mRNA was normalized by reference to the housekeeping gene, $\beta$-actin, mRNA for which was also measured by competitive-RT-PCR. There was considerable inter-individual variation in MT-mRNA concentration and yet, the mean MT-2A mRNA level increased 4.7-fold after Zn supplementation, as compared to before Zn supplementation. This MT-2A mRNA level was shown as the same pattern and, even more sensitive assay, compared to the conventional plasma and red blood cells (RBCs) Zn assessment in which plasma and RBCs zinc levels increased 2.3- and 1.2-fold, respectively (p<0.05). We suggest that MT competitive-RT-PCR can be a useful assessment tool for evaluating human zinc status.

• 한국방사선학회논문지
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• 제8권2호
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• pp.81-88
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• 2014

진단영상의학에서 일반영상촬영의 경우 각각의 부위를 연속(series)촬영으로 검사하는 경우가 대부분이다. 그러나 환자선량권고량(DRL)의 경우 각 부위의 전후(AP)방향과 측면(lateral)자세의 촬영 측정값만이 설정되어있는 것이 현실이다. 병원에서는 환자의 연속 촬영에 의해 누적 선량이 발생되며, 이는 환자선량권고량(DRL)과 누적된 피폭선량을 비교할 수 없거나, 과소평가할 수 있다. 본 연구에서 각 부위별 연속촬영의 누적선량을 측정한 결과, 조사야에 포함된 경우 입사표면선량(ESD)을 유효선량으로 변환하면 공중의 선량한도(Individual dose)의 최대 38.06%에서 최소 0.23%까지 측정되었다. 그리고 조사야에 포함되지 않은 각 부위의 입사표면선량(ESD)을 유효선량(Effective dose)으로 변환한 경우 공중의 선량한도(Individual dose)의 최대 5%에서 최소 0.04%까지 측정되었다. 연구결과 각 부위별 연속촬영에서 입사표면선량(ESD)이 많이 증가하는 것을 알 수 있다. 따라서 병원에서는 환자선량권고량(DRL)을 구체적으로 설정할 필요가 있으며, 불필요한 검사를 줄이기 위해 환자 촬영 order의 세분화가 필요하다고 판단된다. 또한, 여러 부위의 검사에서는 정확한 조사야의 필요성이 강조된다.

• 정보보호학회논문지
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• 제22권4호
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• pp.901-911
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• 2012

개발단계에서의 보안취약점 제거는 운영단계에서 실행하는 것보다 훨씬 더 효율적이고 효과적으로 적용될 수 있다. 소프트웨어에 내재된 보안취약점이 사이버 침해사고의 주요 원인이 되고 있어서 소스코드 수준에서의 보안취약점을 최소화하기 위한 일환으로 시큐어코딩이 주목받고 있다. 소프트웨어 개발과정에서 보안취약점을 제거하는 것이 보다 효과적이면서도 근본적인 해결책이 될 수 있다. 본 논문에서는 개인 단체 조직에서 모바일 시큐어코딩 적용에 따른 보안수준을 평가하기 위한 모바일 시큐어코딩 자가평가(Mobile-Secure Coding Self Assessment) 방법을 연구 제안한다.

• Toxicological Research
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• 제24권4호
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• pp.235-243
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• 2008

While in some instances, loss of diversity results from acute toxicity (e.g. major pollution incidents), in most cases it results from long-term sub-lethal effects that alter the relative competitive ability and fitness of certain organisms. In such cases the sub-lethal effects will cause a physiological response in the organism that ultimately leads to community level changes. Very sensitive tools are now available to study sub-lethal responses at the molecular level. However, relating such laboratory measurements to ecological effects represents a substantial challenge that can only be met by investigation at all scales (molecular, individual organism and community level) with an appropriate group of organisms. Among the various in vertebrates which can be used as model organisms in such a way, the soil nematode, Caenorhabditis elegans appear to be a promising biological model to diagnose environmental quality. This paper reviews the current status of multilevel biomarkers in environmental toxicology, and C. elegans as promising organisms for this approach.

• 한국환경과학회지
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• 제22권2호
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• pp.151-161
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• 2013

The assessment of personal exposure is a critical component in population-based epidemiologic studies of air pollution. This study was conducted to apply and compare the four exposure estimation methods of individual-level to air pollution concentration in a cohort including 2,283 subjects in Gwangyang, Korea. Individual-level exposure of air pollution were estimated using multiple approaches, including average across all monitors, nearest monitor, and spatial interpolation by inverse distance weighting and kriging. The mean concentrations of $PM_{10}$, $NO_2$, $SO_2$, CO, $O_3$ by four exposure estimation methods were slightly different but not significantly different from each other. Cross-validation showed that kriging was more accurate than other exposure estimation methods because kriging has probably predicted individual exposure levels equivalent to residential locations after estimating the parameters of a model according to the spatial surface of air pollution concentration. These data support that spatial interpolation methods may provide better estimates than selecting the value from the nearest monitor and averaging across values from all monitors by reflecting spatial attributes of air pollution on personal level.