• 제목/요약/키워드: Individual Giving

검색결과 180건 처리시간 0.021초

Systems-level mechanisms of action of Panax ginseng: a network pharmacological approach

  • Park, Sa-Yoon;Park, Ji-Hun;Kim, Hyo-Su;Lee, Choong-Yeol;Lee, Hae-Jeung;Kang, Ki Sung;Kim, Chang-Eop
    • Journal of Ginseng Research
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    • 제42권1호
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    • pp.98-106
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    • 2018
  • Panax ginseng has been used since ancient times based on the traditional Asian medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies concerning P. ginseng have focused on specific mechanisms of action of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases. In order to decipher the systems-level mechanism of multiple ingredients of P. ginseng, a novel approach is needed beyond conventional reductive analysis. We aim to review the systems-level mechanism of P. ginseng by adopting novel analytical framework-network pharmacology. Here, we constructed a compound-target network of P. ginseng using experimentally validated and machine learning-based prediction results. The targets of the network were analyzed in terms of related biological process, pathways, and diseases. The majority of targets were found to be related with primary metabolic process, signal transduction, nitrogen compound metabolic process, blood circulation, immune system process, cell-cell signaling, biosynthetic process, and neurological system process. In pathway enrichment analysis of targets, mainly the terms related with neural activity showed significant enrichment and formed a cluster. Finally, relative degrees analysis for the target-disease association of P. ginseng revealed several categories of related diseases, including respiratory, psychiatric, and cardiovascular diseases.

여성 척수장애인의 체험에 대한 현상학적 연구 (Phenomenology on the Lived Experience of Korean Women with Spinal Cord Injuries)

  • 황혜민;이명선;박은영;권은진
    • 대한간호학회지
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    • 제42권4호
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    • pp.508-516
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    • 2012
  • Purpose: The purpose of the study was to understand and explain the essences and structures of the experience of Korean women who have had a spinal cord injury. Methods: The data were collected in 2010 through individual in-depth interviews using open-ended questions. A total of 9 women with spinal cord injuries participated in the study. Each interview lasted about 2 hours. Verbatim transcripts were analyzed using phenomenological analysis. Results: Five theme clusters emerged from the analysis using Colaizzi's method: frozen mind with rigid body; shame due to restrictions of physical function and dependency; struggle to go back to the previous normal body; disabilities that are noticeable in everyday family life; rebirth by discarding the obsessions of the past. These theme clusters illustrate that although most participants faced very strange and unbearable situations in most aspects of life after the injury, they were empowered finally by finding their hope and by giving new meanings to the current existence. Conclusion: This study provides deep understanding of women with spinal cord injuries who are relatively alienated from society. Based on the results of the study, health professionals could develop effective nursing interventions to improve quality of life of these women.

수학일지 쓰기 활동이 초등학생의 수학적 성향과 수학적 의사소통 수준에 미치는 영향: 3학년 수와연산 영역을 중심으로 (A study on the mathematical disposition and communication level in process of applying mathematical journal writing to the 3rd graders in a mathematics classroom)

  • 양현수;김민경
    • 한국수학교육학회지시리즈A:수학교육
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    • 제57권3호
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    • pp.247-270
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    • 2018
  • The purpose of this study is to investigate the mathematical disposition and mathematical communication level of elementary school students in the process of applying mathematical journal writing activities. For this study, 21 third grade students in elementary school were observed when they participated in mathematical journal writing activities while studying number and operation area. According to the Mathematical disposition pre-test and post-test results, mathematical confidence, mathematical flexibility, mathematical will, and mathematical reflection increased and it was statistically proved. Expression and explanation level of the mathematical communication writing area also increased as the mathematical journal writing activity continued. Thus, mathematical journal writing activities can help to enhance the core competencies of the 2015 revised mathematics curriculum while make students 'to develop and transform mathematical expressions' and 'to express oneself'. Also, it provides implications of including active writing activities such as mathematical journal writing activities into mathematics classroom. Furthermore, the change in mathematical communication level according to mathematical disposition level was not statistically significant. Therefore, when providing active writing activities including mathematical journal writing activities into classroom, it is necessary to understand students' individual characteristics and to encourage communication to be active rather than giving feedback based on one's mathematical disposition level.

초유에 함유된 성장인자와 기능: 총설 (Growth Factors and Their Function in Colostrum: A Review)

  • 렌친핸드;손지윤;남명수
    • Journal of Dairy Science and Biotechnology
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    • 제34권1호
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    • pp.1-7
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    • 2016
  • 젖소 초유에는 성장인자가 풍부하게 함유되어 있는데, 상처 치유에 중요한 역할을 하고, 초유의 생리활성 기능을 담당하고 있다. Tyrosine kinase receptor의 활성을 유도하는 성장인자가 특이적으로 관여하여 세포의 분화, 면역기능, 신경기능 등 세포간 상호작용에 관여하는 EGFR(상피증식인자 수용체)와 FGFR(섬유아세포 증식인자)가 있다. 또한 VEGFR (혈관내피 증식인자)와 PDGF(혈소판유래 증식인자)도 존재한다. 조직회복을 위한 각질세포 분화와 세포의 이행에 성장인자가 상승효과를 나타내었고, 초유 또는 초유에 포함된 성장인자 peptide들은 장관질환 치료에 효과가 있으므로 치료제로 이용 가능성을 보여주었다.

고등학교 가정과"가족" 영역에서의 양성평등 수업지도안 개발 (Development of Gender Equity Instruction in Home Economics for the domain of Family Life in High School.)

  • 왕석순
    • 한국가정과교육학회지
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    • 제12권3호
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    • pp.77-91
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    • 2000
  • This study was conducted with three objectives. First of all we tired to find a momentum to boost the value of home economics education as a fixture of the curriculum by analyzing the relation between gender equity education and Home Economics Education. On the other hand it suggests the need of gender equity education in Home Economics Education the related measures and some applicable course of study. And For the purpose of exemplification this study was developed gender equity instruction in Home Economics Education. The results are as follows: First the recent gender equity education in our education system can be interpreted as giving equal education opportunity and equal education objective. Therefore this kind of theory results in the education of Home Economics for both the male and female students. This results can be valued as boosting the availability of Home Economics Education and providing a stepping stone for Home Economics Education Development. Second the ultimate objective of Gender Equity Education is to cultivate a person to be equipped with Gender Equity concept and to implement the concept. Therefore Home Economics Education (Ministry of Education 1995) which has the ultimate objective of improving the quality of the individual and family life can be the most important curriculum for understanding the abstract concept of Gender Equity and providing various practical contents. Third the Gender Equity Education in Home Economics can be realized through the following measures:(1) The efforts to positively restructure the education contents after analysing and evaluating the education contents in terms of the Gender Equity concept. For the purpose of exemplification, this study was developed ‘Gender Equity Instruction in Home Economics Education. (2) The development and application of an interesting course of study for both the male an female students (3) Providing the proper teachers for the male students who want to choose Home Economics.

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루이스 칸 건축의 외부화된 내부에 관한 연구 - 연결공간의 체험과 표현을 중심으로 - (A Study on the Exteriority of Interior in the Louis I. Kahn's Architecture - Focused on the Study of Character of Connecting Elements -)

  • 우영선;신범식
    • 건축역사연구
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    • 제14권4호
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    • pp.117-135
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    • 2005
  • This paper is a study of the possibility of experience and expression in the architecture of Louis I. Kahn by focusing on the characters of entrance, court and window/wall of his public buildings. In the course of composition, Kahn defined the entrance, court and window/wall as an connecting elements and elements of boundary. The characters revealed by these elements or rooms give the clue to insight Kahn's thought of relation of interior and exterior space or inner and outer space. Following are the characters of these elements. First, a entrance reveals the fact that inner space separates from outer space by connecting these two space and giving the value to inner space as the entity and totality like outer space. The entrance gives its ontological being to human subjects not by vision but experience and expression which is the essence of commonness, that is, Silence. Kahn made the possibility of activity amplify in this common and silent space. Second, this entrance is connected with wide and huge central space not individual spaces of interior space. This extreme procedure of entering makes human subject feel sublime of intoner space. And the central spaces becomes another exterior or another world in the inner world of architecture by the lights from above and by having the boundary wall which shows same pattern of exterior wall. Third, Kahn regarded a window as the giver of lights not as the medium of vision connecting inner space with outer. He tried to connect interior with exterior through the being and character of the light expressed in the interior. And in his buildings, interior space is connected with exterior by expressing the purpose of building, composition of inner space, structural truth and construction facts through the Form, a pattern of wall, details and ornamental joints. By practicing this thoughts in the real buildings, Kahn tried to gave aura to both the interior space and entity of architecture which is regarded as micro universe like flowers, rocks and human beings.

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얼치기완두(콩과) 집단의 교배계와 내교잡 압력 (Mating Systems and Inbreeding Pressure in Populations of Wild Lentil Tare, Vicia tetrasperm (Leguminosae))

  • 허만규
    • 생명과학회지
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    • 제17권11호
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    • pp.1477-1481
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    • 2007
  • 한국 내 얼치기완두(Vicia tetrasperm) 집단의 교배계를 알로자임 분석으로 실시하였다. 그 결과 얼치기완두는 타가수분 또는 혼합 교배 타가수분을 영위하고 있었다. 집단 수준에서 열 개 집단에 대한 내교배 계수는 0.131에서 0.176까지로 나타나며 평균은 0.154였다. 다대립좌위에서 타가수분 계수(tm)는 열 개 집단에 대해 0.269와 0.423사이에 있으며 평균은 0.333이었다. 다대립좌위와 단일좌위에서 타가수분 계수 차이는 상당히 높게 나타났으며 양친과의 근친교배가 유의하게 일어나고 있었다. 일부 집단에서 낮은 타가수분율은 광범위한 근친교배와 성숙한 개체간 격리에 기인한다. 비록 한 집단에서 이형접합체 과다가 기록되었지만 대부분 집단은 이형접합체의 결핍이 관찰되었다. 따라서 동형접합체에 대한 자연선택이 생활사를 통한 지손집단에 작용하고 있었다.

'Healthy Japan 21' : A New Perspective on Health Promotion Policy for Japan in the 21st Century

  • Hasegawa, Toshihiko
    • 보건교육건강증진학회지
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    • 제22권3호
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    • pp.135-155
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    • 2005
  • 'Healthy Japan 21' is a new health policy that has been proposed for the 21st century: it embodies a totally new concept for its viewpoints and methods. To start with, for its goal, the focus is placed on the 'quality of life' or a life that is free of diseases, rather than mere prolongation of life. For its doctrine, the emphasis has shifted dramatically from improving the health of the entire population(the traditional approach for health improvement) to 'achieving an ideal health status for each individual. The ultimate aged society that arrives first in Japan is a society in its ultimate form for human being. Why did Japan become westernized, giving up her traditional culture? Why did she go through industrialization, sacrificing her nature? And why does she try so hard to industrialize the developing countries? These efforts are all preparation for the arrival of a ultimate aged society. During the 20th century, we believed in unlimited possibilities and expanded our social frontier. In the 21st century, on the other hand, a super-aged society(the ultimate society), a glimpse of which we have witnessed from time to time, will descend on us sooner or later. It is expected to arrive first in Japan. 'Healthy Japan 21' is intended to prepare for the arrival of the hitherto unheard of super-aged society by building the physiological basis of people. This policy is social experimentation on an immense social scale, in which questions are posed on the understanding of health, the relationship between individuals and society, the relationship between administration and citizens, the manner by which central and local governments operate, and the new relationship between prevention and therapy, 'Healthy Japan 21' may be summarized as an experiment on a huge scale directed to the ultimate form of human society, in which Japan and each of her citizens play a role and set an example for the rest of the world. Even just by considering various approaches newly suggested for this venture, one may be convinced that it is a policy with features suitable for a country that has already achieved the world's highest longevity.

Contemporary Issues Surrounding Folic Acid Fortification Initiatives

  • Choi, Jeong-Hwa;Yates, Zoe;Veysey, Martin;Heo, Young-Ran;Lucock, Mark
    • Preventive Nutrition and Food Science
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    • 제19권4호
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    • pp.247-260
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    • 2014
  • The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification therefore has been implemented in multiple countries, resulting in a reduction in the occurrence of neural tube defects. However, emerging evidence suggests increased folate intake may also be associated with unexpected adverse effects. This literature review focuses on contemporary issues of concern, and possible underlying mechanisms as well as giving consideration the future direction of mandatory folic acid fortification. Folate fortification has been associated with the presence of unmetabolized folic acid (PteGlu) in blood, masking of vitamin $B_{12}$ deficiency, increased dosage for anti-cancer medication, photo-catalysis of PteGlu leading to potential genotoxicity, and a role in the pathoaetiology of colorectal cancer. Increased folate intake has also been associated with twin birth and insulin resistance in offspring, and altered epigenetic mechanisms of inheritance. Although limited data exists to elucidate potential mechanisms underlying these issues, elevated blood folate level due to the excess use of PteGlu without consideration of an individual's specific phenotypic traits (e.g. genetic background and undiagnosed disease) may be relevant. Additionally, the accumulation of unmetabolized PteGlu may lead to inhibition of dihydrofolate reductase and other enzymes. Concerns notwithstanding, folic acid fortification has achieved enormous advances in public health. It therefore seems prudent to target and carefully monitor high risk groups, and to conduct well focused further research to better understand and to minimize any risk of mandatory folic acid fortification.

구강보건인력의 예방치과진료에 대한 인식 및 교육요구도 (Awareness and educational needs on preventive dental treatment among oral health workers)

  • 정재연;한수진
    • 한국치위생학회지
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    • 제17권5호
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    • pp.875-887
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    • 2017
  • Objectives: The objective of this study is to provide basic data needed in developing an educational program designed to upgrade capacity and awareness of preventive dental treatment among oral health workers, by analyzing levels of awareness of preventive dental treatment and educational needs among dentists and dental hygienists. Methods: The collected data was analyzed with SPSS program ver. 19.0. The data was under t-test. Results: The frequency level of giving preventive dental treatment to patients among dentists and dental hygienists is below mid-point, 3 on the 5-point Likert scale. In terms of frequency level per item, scaling & polishing was ranked the highest, followed by periodontal maintenance, tooth-brushing instruction, and prescription and instruction of oral care product in descending order. On the questions asking how important preventive dental care they perceive to be, both dentists and dental hygienists perceived it to be highly important. When they were asked to rank those items by the importance of education, they considered periodontal maintenance as the most important one, followed by individual education of oral health, incremental oral health care, scaling& polishing, toothbrushing instruction, and prescription and instruction of oral care product. Respondents pointed out problems in running a preventive dental treatment program as follows: overwork, lack of dedicated workforce, un-fixed costs, and lack of necessary equipment. When they were asked to point out items needed to run such a program, the largest number of respondents indicated dedicated workforce placement, followed by improving awareness of the customer, and improving awareness of the dental workers. Conclusions: In order to effectively run a preventive dental treatment program, it is necessary for oral health workers to clearly understand the concept of it. It is also necessary to develop and operate an education program on preventive dental treatment targeting oral health professionals.