• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.179-179
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• 1996

The involvement of the cyclic AMP (cAMP) effector system in the release of endogenous dopamine and acetylcholine from the rat neostriatum was assessed. Forskolin, an activator of adenylate cyclase, was used to enhance CAMP production, and the consequence of this enhancement on the spontaneous and potassium stimulated release of dopamine and acetylcholine was evaluated. Neostriatal slices were prepared from Fischer 344 rats and after a preincubation period the release of each endogenous neurotransmitter was measured from the same slice preparation. To measure acetylcholine release the slice acetylcholinesterase (AChE) activity was inhibited with physostigmine, but the release from slices with intact AChE activity was also determined (choline, instead of acetylcholine was detected in the medium). Under both conditions forskolin induced a significant dose-dependent increase in the potassium-evoked release of dopamine. In the same tissue preparations the release of neither acetylcholine (AChE inhibited) nor choline (AChE intact) was affected by forskolin. The results indicate that the cAMP second messenger system is involved ill neuronal mechanisms that enhance neuronal dopamine release, but stimulation of this second messenger by forskolin does not further enhance neostriatal acetylcholine release.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2005.05a
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• pp.74-77
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• 2005

Most of the loads in industrial power distribution systems are balanced and connected to three power systems. However, voltage unbalance is generated at the user's 3-phase 4-wire distribution systems with single & three phase. Voltage unbalance is mainly affected by load system rather than power system. Unbalanced voltage will draws a highly unbalanced current and results in the temperature rise and the low output characteristics at the machine. It is necessary to analyse correct voltage unbalance factor for reduction of side effects in the industrial sites. Voltage unbalance is usually defined by the maximum percent deviation of voltages from their average value, by the method of symmetrical components or by the expression in a more user-friendly form which requires only the three line voltage readings. If the neutral point is moved at the 3-phase 4-wire system by the unbalanced load, by the conventional analytical method, line and phase voltage unbalance leads to different results due to zero-sequence component. This paper presents a new analytical method for phase and line voltage unbalance factor in 4-wire systems. Two methods indicate exact results.

• Journal of Electrical Engineering and Technology
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• v.10 no.4
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• pp.1773-1779
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• 2015

Insulation coordination is a key problem in UHVDC systems in terms of safety and cost. Although high-voltage ±1100kV UHVDC projects are being planned in China, the characteristics and key points of high-voltage systems have not yet been analyzed. This study aims to improve the safe, effective operation of these high-voltage power transmission systems. First, we analyzed two typical insulation coordination schemes used in ±800kV UHVDC systems in China. Next, we used the two typical ±800kV insulation coordination schemes as a reference to analyze the ±1100kV UHVDC system. Finally, we compared these schemes and proposed an effective insulation coordination solution, as well as developing principles for ±1100kV UHVDC systems. Our findings indicate that the points enduring the highest voltage in the system should be protected separately by special arresters. Our analysis of the insulation coordination of ±800kV and ±1100kV UHVDC systems concluded that, in ±1100kV UHVDC systems, the main goal of insulation coordination is to lower the insulation level of points enduring the highest voltage. However, in a ±800kV UHVDC system, the main goal is to reduce the cost of manufacture for arresters, as well as the space occupation in the valve hall, with an acceptable insulation level.

• Journal of Advanced Marine Engineering and Technology
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• v.26 no.3
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• pp.313-319
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• 2002

Since the oil crisis in 1970, a great deal of effort has been made to develop automatic electric load sharing systems as a part of the efforts to save energy. A large scale electric generating system composes more than two generators whose characteristics may be different. When such a system is operated individually or in parallel, the lagrange multiplier's method has difficulty in achieving optimal load distribution because generators usually have the limitations of the operating range with inequality constraints. Therefore, a suitable operating mode of generators has to be decided according to the selection of the generators to meet electric power requirements at the minimum cost. In this study, a method which solves the optimal electric load distribution problem using the dynamic programming technique is proposed. This study also shows that the dynamic programming method has an advantage in dealing with the optimal load distribution problem under the limitations of the operating range with inequality constraints including generator operation mode. In this study, generator operating cost curve of second order equation by shop trial test results of diesel generators are used. The results indicate that the proposed method can be applied to the ship's electric generating system.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.42 no.3
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• pp.50-57
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• 2010

A mill trial was performed in a kraft paper mill in order to evaluate the possibility of utilizing dual polymer dry strength aids system consisting of cationic PVAm and anionic PAM. It was found that the cationic PVAm - anionic PAM dry strength additives can improve paper strength without significantly disturbing the stability of the kraft papermaking process when virgin UKP was used as a furnish. Tensile strength (25.3% in machine direction, 48.4% in cross machine direction), elongation of paper (31.6%, 15.6%) and tensile energy absorption (48%, 54%) were improved. Air permeability of the kraft paper was improved as well (22%). Tear strength was decreased with PVAm dry strength aids system, but it can be compensated with decreasing refining degree. In addition, the mill trial results indicate that highly air permeable kraft sack paper can be produced by the addition of PVAm dry strength agents at the stock with reduced freeness.

• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.295-301
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• 1997

Nitrendipine, a slightly soluble calcium channel blocking agent forms a solid dispersion system with $hydroxypropyl-{\beta}-cyclodextrin$, which exhibits better dissolution characteristics than the uncomplexed drug. The dissolution rate of nitrendipine was markedly increased in solid dispersion system in pharmacopeial disintegration media at pH 1.2 and pH 6.8. Four different dosage forms of nitrendipine were administered to rats: (a) nitrendipine in the solution of PEG 400; (b) nitrendipine solid dispersion system with $hydroxypropyl-{\beta}-cyclodextrin$ in a molar ratio of 1:2 by solvent evaporation method and administered in capsule form; (c) physical mixture of nitrendipine with $hydroxypropyl-{\beta}-cyclodextrin$ in a molar ratio of 1:2 and administered in capsule form; (d) nitrendipine alone administered in capsule form. Relative bioavailability after the oral administration of various dosage forms to rats with a dose of 10 mg/kg equivalent to nitrendipine was compared with that of nitrendipine in the solution of PEG 400. The AUC of solid dispersion was significantly bigger than that of nitrendipine powder. $T_{max}$ of solid dispersion was significantly shorter and $C_{max}$ was higher than that of nitrendipine powder. These results indicate that the bioavailability of nitrendipine could be improved markedly by inclusion complexation. An interesting correlation also appears to exist between the in vitro dissolution data and the area under the plasma concentration-time curves.

• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.55-65
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• 2007

This paper sought to investigate pupil size variability, pupil size parameters in terms of time domain and frequency domain, the autonomic activity change induced by posture change, degree of sleepiness and cognitive task (math task). With a specially designed pupil image acquisition system in the dark room, these three kinds of experiments were performed to induce a dominant state of sympathetic or parasympathetic activation. Electrocardiogram and pupil size were measured in all the experiments. Based on three experiments, we calculated heart rate variability. In the pupil size analysis, we calculated the mean and standard deviation of pupil size (in time domain), and proposed several frequency bands that exhibit different autonomic activation between different sessions. The results indicate that in terms of heart rate variability, posture change exhibited significant differences but not between sleepiness level, or between cognitive task. Pupil sizes differed only during the postures. And we found some frequency bands that correlated with autonomic activation in each experiment. While heart rate variability reflects posture change that need cardiac control, pupil size variability reflects not only posture induced autonomic activation but sleepiness and cognitive load, which is processed in the brain, in time and frequency domain parameter.

• Journal of Electrical Engineering and Technology
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• v.9 no.6
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• pp.1832-1842
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• 2014

A novel probabilistic small signal stability analysis (PSSSA) method considering load correlation is proposed in this paper. The superiority Latin hypercube sampling (LHS) technique combined with Monte Carlo simulation (MCS) is utilized to investigate the probabilistic small signal stability of power system in presence of load correlation. LHS helps to reduce the sampling size, meanwhile guarantees the accuracy and robustness of the solutions. The correlation coefficient matrix is adopted to represent the correlations between loads. Simulation results of the two-area, four-machine system prove that the proposed method is an efficient and robust sampling method. Simulation results of the 16-machine, 68-bus test system indicate that load correlation has a significant impact on the probabilistic analysis result of the critical oscillation mode under a certain degree of load uncertainty.

• Structural Engineering and Mechanics
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• v.76 no.2
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• pp.207-222
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• 2020

Due to the rugged terrain, metro lines in mountain city across numerous wide rivers and deep valleys, resulting in instability of high-pier bridge and insecurity of metro train subjected to fluctuating crosswind. To ensure the safe operation in metro lines in mountain cities, running safety of the metro train over the high-pier bridge under crosswind is analyzed in this paper. Firstly, the dynamic model of the wind-train-bridge (WTB) system is built, in which the speed-up effect of crosswind is fully considered. On the basis of time domain analysis, the basic characteristics of the WTB system with high-pier are analyzed. Afterwards, the dynamic responses varies with train speed and wind speed are calculated, and the safety zone of metro train over a high-pier bridge subjected to fluctuating crosswind in mountain city is determined. The results indicate that, fluctuating crosswind triggers drastic vibration to the metro train and high-pier bridges, which in turn causes running instability of the train. For this reason, the corresponding safety zone for metro train running on the high-pier is proposed, and the metro traffic on the high-pier bridge should be closed as the mean wind speed of standard height reaches 9 m/s (15.6 m/s for the train).

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.2
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• pp.161-168
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• 2016

Abnormal localization of tumor suppressor proteins is a common feature of renal cancer. Nuclear export of these tumor suppressor proteins is mediated by chromosome region maintenance-1 (CRM1). Here, we investigated the antitumor effects of a novel reversible inhibitor of CRM1 on renal cancer cells. We found that S109 inhibits the CRM1-mediated nuclear export of RanBP1 and reduces protein levels of CRM1. Furthermore, the inhibitory effects of S109 on CRM1 is reversible. Our data demonstrated that S109 significantly inhibits proliferation and colony formation of renal cancer cells. Cell cycle assay showed that S109 induced G1-phase arrest, followed by the reduction of Cyclin D1 and increased expression of p53 and p21. We also found that S109 induces nuclear accumulation of tumor suppressor proteins, Foxo1 and p27. Most importantly, mutation of CRM1 at Cys528 position abolished the effects of S109. Taken together, our results indicate that CRM1 is a therapeutic target in renal cancer and the novel reversible CRM1 inhibitor S109 can act as a promising candidate for renal cancer therapy.