• 한국산림과학회지
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• 제86권2호
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• pp.158-166
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• 1997

본 연구에서는 임분구조의 다양성 또는 동질성을 계량화시키는 방법을 제시하였다. 우선 인접목과의 직경비율에 의해 임분구조를 파악할 수 있는 Gadow의 직경차이율을 소개하였고, 직경급별 본수비율과 단면적 또는 재적비율에 의해 형성되는 Lorenz곡선형태로 부터 임분구조의 다양성지수를 유도하는 새로운 방법을 제시하였다. 본 연구에서 제시한 Lorenz곡선원리에 의한 횡적 임분구조지수는 Gadow의 직경차이율과 마찬가지로 0에서 1사이의 값을 가지며, 임분구조가 다양할수록 1에 접근하는 특정을 지니고 있다. 이러한 Lorenz곡선원리에 의한 횡적 임분구조지수를 Gadow의 직경차이율과 비교한 결과, 본 연구에서 제시한 새로운 형적 임분구조지수는 Gadow의 직경차이율과 비슷하게 임분구조를 설명하는 것으로 나타났다.

• Clinical and Experimental Reproductive Medicine
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• 제19권2호
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• pp.175-179
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• 1992

The factors involved in the initial neoplastic transformation and subsquent growth of uterine fibroid are poorly understood. The reduction in uterine fibroid volume associated with the chronic administration of the mechanisms mediating the decrease in fibroid volume in GnRH-a treated patients are poorly defined. The purpose of this study was to determine the proliferating cell nuclear antigen(PCNA) in fibroid from-women pretreated with GnRH analogue(GnRH-a) compared with controls. Tissue was obtained from 16 premenopausal women with uterine fibroid who received GnRH-a(D-Trp6-GnRH) intramusculary every 28 days for four injections. The mean proliferating index(PI) in patients with uterine fibroids was $2.25{\pm}0.9$, and in controls was $8.82{\pm}1.8$(P<0.001). The proliferating index was not corrleated with the reduction of fibroid volume. In this clinical study, although hypoestrogenism may be the main factor that reduce the volume of fibroid, other factors are also considered to be involved in that process. And the regrowth of uterine fibroid may be affected by increased production of PCNA after stopping GnRH-a.

• 한국임상약학회지
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• 제12권1호
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• pp.7-12
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• 2002

Pharmacokinetic parameters and dosage of aminoglycosides (AGs) were studied retrospectively in 36 patients with neutropenic fever after stem cell transplantation in Seoul National University Hospital from July 1996 to June 2001. AGs pharmacokinetic parameters were calculated with steady-state peak and trough serum drug concentrations by the method of Sawchuk and Zaske et at. The calculated aminoglycosides volume of distribution and clearance were greater than population value $(0.36\pm0.06\;L/kg,\;116\pm32\;ml/min/1.73\;m^2,\;respectively)$. The average dosage of aminoglycosides required to maintain optimal serum AGs concentration was also greater than recommended dose in insert paper. The average dosage of amikacin was $11\pm2.1$ mg/kg every 12 hours (In case of tobramycin, $2.09\pm0.37$ mg/kg every 8 hours or $2.59\pm0.20$ mg/kg every 12 hours). The relationship between AGs volume of distribution and sex, serum albumin (g/dl), body mass index $(kg/m^2)$, body weight change $(\%)$, the amount of fluid inpu (ml/kg/day), the degree of hematocrit decrease $(\%)$ were studied respectively. Univariate anlysis revealed that body mass index $(kg/m^2)$, the amount of fluid input (ml/kg/day) and the degree of hematocrit decrease $(\%)$ had significant correlation with aminoglycosides volume of distribution. But sex, serum albumin, body weight change $(\%)$ had no significant correlation with aminoglycosides volume of distribution.

• Journal of Gastric Cancer
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• 제17권3호
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• pp.204-211
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• 2017

Purpose: Recently, a nomogram predicting overall survival after gastric resection was developed and externally validated in Korea and Japan. However, this gastric cancer nomogram is derived from large-volume centers, and the applicability of the nomogram in smaller centers must be proven. The purpose of this study is to externally validate the gastric cancer nomogram using a dataset from a medium-volume center in Korea. Materials and Methods: We retrospectively analyzed 610 patients who underwent radical gastrectomy for gastric cancer from August 1, 2005 to December 31, 2011. Age, sex, number of metastatic lymph nodes (LNs), number of examined LNs, depth of invasion, and location of the tumor were investigated as variables for validation of the nomogram. Both discrimination and calibration of the nomogram were evaluated. Results: The discrimination was evaluated using Harrell's C-index. The Harrell's C-index was 0.83 and the discrimination of the gastric cancer nomogram was appropriate. Regarding calibration, the 95% confidence interval of predicted survival appeared to be on the ideal reference line except in the poorest survival group. However, we observed a tendency for actual survival to be constantly higher than predicted survival in this cohort. Conclusions: Although the discrimination power was good, actual survival was slightly higher than that predicted by the nomogram. This phenomenon might be explained by elongated life span in the recent patient cohort due to advances in adjuvant chemotherapy and improved nutritional status. Future gastric cancer nomograms should consider elongated life span with the passage of time.

• 대한기계학회논문집A
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• 제40권6호
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• pp.547-555
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• 2016

철도차량의 휠의 마모는 주로 곡선 주행 시 발생한다. 휠의 형상 변화는 차량 동적 안정성에 중요한 영향을 미친다. 본 연구에서는 곡선 주행 시 휠 마모 특성 분석을 위해 곡선 반경 크기와 속도를 변경시키면서 휠 마모량을 계산하였다. 다물체 동역학 해석에 기초한 차량 동역학 해석결과로부터 마모인자를 계산하고 BRR(British Rail Research)에서 제시한 마모 모델을 이용하여 휠의 마모량을 계산하였다. 반경 300m에서의 마모량이 다른 반경과 비교하여 매우 큰 것으로 나타났다. 곡선 선로에 윤활유를 도유하는 경우 마모 특성 변화를 분석하기 위해 휠의 답면과 플랜지 부위의 마찰계수를 다르게 하여 휠 마모량을 계산하였다. 도유 시 휠 마모의 개선 효과를 여러 반경에서 계산하고 실제 도시철도구간에서 마모 개선 효과를 확인하였다.

• Radiation Oncology Journal
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• 제31권4호
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• pp.247-251
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• 2013

Purpose: This study aimed to investigate efficient approaches for determining internal target volume (ITV) from four-dimensional computed tomography (4D CT) images used in stereotactic body radiotherapy (SBRT) for patients with early-stage non-small cell lung cancer (NSCLC). Materials and Methods: 4D CT images were analyzed for 15 patients who received SBRT for stage I NSCLC. Three different ITVs were determined as follows: combining clinical target volume (CTV) from all 10 respiratory phases ($ITV_{10Phases}$); combining CTV from four respiratory phases, including two extreme phases (0% and 50%) plus two intermediate phases (20% and 70%) ($ITV_{4Phases}$); and combining CTV from two extreme phases ($ITV_{2Phases}$). The matching index (MI) of $ITV_{4Phases}$ and $ITV_{2Phases}$ was defined as the ratio of $ITV_{4Phases}$ and $ITV_{2Phases}$, respectively, to the $ITV_{10Phases}$. The tumor motion index (TMI) was defined as the ratio of $ITV_{10Phases}$ to $CTV_{mean}$, which was the mean of 10 CTVs delineated on 10 respiratory phases. Results: The ITVs were significantly different in the order of $ITV_{10Phases}$, $ITV_{4Phases}$, and $ITV_{2Phases}$ (all p < 0.05). The MI of $ITV_{4Phases}$ was significantly higher than that of $ITV_{2Phases}$ (p < 0.001). The MI of $ITV_{4Phases}$ was inversely related to TMI (r = -0.569, p = 0.034). In a subgroup with low TMI (n = 7), $ITV_{4Phases}$ was not statistically different from $ITV_{10Phases}$ (p = 0.192) and its MI was significantly higher than that of $ITV_{2Phases}$ (p = 0.016). Conclusion: The $ITV_{4Phases}$ may be an efficient approach alternative to optimal $ITV_{10Phases}$ in SBRT for early-stage NSCLC with less tumor motion.

• 대한교통학회지
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• 제33권1호
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• pp.61-69
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• 2015

이 연구에서는 국내 총 화물물동량에 대한 5개 계량경제모형들의 예측정확도를 비교한다. 적용된 5개 모형은 통상최소자승모형, 부분조정모형, 축소된 자기회귀분포시차모형, 벡터자기회귀 모형, 시간변동계수모형이다. 모형의 추정과 예측은 1970-2011년 동안의 연간 국내 화물물동량 자료와 광공업생산지수를 이용하여 수행되었다. 5개 모형은 반복적인 예측방법을 이용하여 1년 후, 3년 후, 5년 후 예측성능이 비교되었다. 추가적으로 장래변동성의 크기에 따라 두 예측기간으로 나누어 예측정확도를 비교하였고, 결과적으로 시간변동계수모형은 변동을 갖는 예측기간에 대해서 가장 높은 정확도를, 반면에 벡터자기회귀 모형은 점진적인 변화를 갖는 예측기간에 대해서 다른 모형에 비해 우수한 성능을 보여주는 것으로 분석되었다.

• 한국항만경제학회지
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• 제38권3호
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• pp.1-13
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• 2022

부울경 메가시티는 동남권지역의 성장과 연계성을 강화하여 제2수도권으로 성장하는 것을 목표로 설정하였다. 이 목표를 달성하기 위해 4가지 공동체 구성을 정책수단으로 설정하고 있다. 본 연구는 부울경 경제공동체에 초점을 맞추어 항만물류와 지역경제발전 간의 연계성을 분석하기 위해 VAR 모형, Granger 인과관계분석, 충격반응함수, 분산분해 등의 연구방법을 사용하였다. 실증분석 결과는 다음과 같다. 첫째, 선박입출항은 화물수송량에 정(+)의 유의미한 영향을 미치는 것으로 나타났다. 분산분해 결과에 의하면 선박입출항은 화물수송량에 대하여 0.84%~9.94%의 영향을 주는 것으로 나타났다. 둘째, 화물수송량은 선박출입항과 경기종합지수에 대하여 선행적으로 영향을 미치는 것으로 나타났다. 분산분해 결과에 따르면 화물수송량은 선박입출항에 대하여 32.73%~36.48%, 경기종합지수에 대하여 0.07%~3.65%의 영향을 주는 것으로 나타났다. 경기종합지수는 화물수송량에 정(+)의 유의미한 영향을 미치는 것으로 나타났다. 충격반응분석과 분산분해 결과를 통해 경기종합지수가 선박입출항과 화물수송량에 약한 충격을 주고 있음을 확인할 수 있었다. 본 논문의 정책적 시사점은 다음과 같다. 첫째, 부울경 지역 정부는 해양항만 인프라 확충, 투자장려 등 해양경제 활성화를 위한 인센티브를 제공해야 한다. 둘째, 부울경 지역과 연계된 주요 국가 항만의 화물수송량 증가는 부울경 지역 경제에 대하여 정(+)의 영형을 미치기 때문에 부울경 메가시티 항만화물 증가를 위해 이들 국가 및 항만을 대상으로 적극적인 항만마케팅 및 정기항로 서비스를 확대해 나가야 한다. 셋째, 글로벌 선박사의 초대형 선박 및 크루즈가 부울경 메가시티 항만에 지속 기항할 수 있도록, 시설확충 등 해양항만 인프라 확대를 위한 투자가 지속적으로 이루어져야 한다.

• Archives of Plastic Surgery
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• 제47권1호
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• pp.33-41
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• 2020

Background Closed-suction drains are widely used in expander-based breast reconstruction. These drains are typically removed using a volume-based criterion. The drainage volume affects the hospital stay length and the recovery time. However, few studies have analyzed the factors that influence drainage volume after expander-based breast reconstruction. Methods We retrospectively analyzed data regarding daily drainage from patients who underwent expander-based breast reconstruction between April 2014 and January 2018 (159 patients, 176 expanders). Patient and operative factors were analyzed regarding their influence on total drainage volume and drain placement duration using univariate and multivariate analyses and analysis of variance. Results The mean total drainage volume was 1,210.77±611.44 mL. Univariate analysis showed correlations between total drainage volume and age (B=19.825, P<0.001), body weight (B=17.758, P<0.001), body mass index (B=51.817, P<0.001), and specimen weight (B=1.590, P<0.001). Diabetes history (P<0.001), expander type (P<0.001), and the surgical instrument used (P<0.001) also strongly influenced total drainage. The acellular dermal matrix type used did not affect total drainage (P=0.626). In the multivariate analysis, age (B=11.907, P=0.004), specimen weight (B=0.927, P<0.001), and expander type (B=593.728, P<0.001) were significant predictors of total drainage. Conclusions Our findings suggest that the total drainage and the duration of drain placement needed after expander-based breast reconstruction can be predicted using preoperative and intraoperative data. Patient age, specimen weight, and expander type are important predictors of drainage volume. Older patients, heavier specimens, and use of the Mentor rather than the Allergan expander corresponded to a greater total drainage volume and a longer duration of drain placement.

• 대한핵의학회지
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• 제21권2호
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• pp.175-182
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• 1987

For measurement of ventricular performance, ejection fraction (EF) has gained wide acceptance. But EF is influenced not only by changes in muscle function but also by changes in cardiac loading conditions. In case of valvular heart disease which is variable in loading conditions, EF cannot be reliable as an index of myocardial contractility. The end systolic pressure (ESP)-end systolic volume (ESV) relation, howver, is known to represent myocardial contractility, independent of changes in loading conditions. Similar results can be obtained by using peak-systolic pressure (PSP) instead of ESP. To evaluate the utility of the peak systolic pressure-end systolic volume index (PSP-ESVI) relation as an index of myocardial function, we measured $PSP&ESVI$ in 19 partents with coronary artery disease before $(PSP_1\;&\;ESVI_1)$ and after $(PSP_2\;&\;ESVI_2)$ sublingual administration of nitroglycerin. PSP was measured with standard mercury sphygmomanometer during gated blood pool scintigraphic study. ESVI was measured by count derived method after attenuation correction. $PSP_2\;&\;ESVI_2$ measurement was started when the fall of PSP was greater than 5 mmHg after 7-14 minutes post-administration of nitroglycerin. Mean values $({\pm}S.D.)$ of $PSP_1\;&\;ESVI_1$ was $124.9({\pm}20.7)mmHg\;&\;59.4({\pm}39.9)ml/M^2$. Mean values $({\pm}S.D)$ of $PSP_2\;&\;ESVI_2$, was $113.2({\pm}19.9)mmHg\;&\;37.5({\pm}26.1)ml/M^2$. There was a significant difference between mean values of $PSP_1\;&\;PSP_2$, (p<0.01), and mean values of $ESVI_1\;&\;ESVI_2$, (p<0.01). $PSP_1-PSP_2/ESV_1-ESVI_2,\;PSP_1/ESVI_1$ and EF were in the range of 0.14-5.19 mmHg/ml/$M^2$, 0.67-7.68 mmHg/ml/$M^2$ and 10.8%-74.5% respectively. $PSP_1-PSP_2/ESVI_1-ESVI_2$, and EF showed exponential correlation (r=0.85, P<0.01). The correlation coefficient between $PSP_1/ESVI_1$ and EF was 0.73(p<0.01). With the above results, we suggest that $PSP_1-PSP_2/ESVI_1-ESVI_2$, and $PSP_1/ESVI_1$, can be used as an index of myocardial function.