• Biomedical Science Letters
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• v.3 no.1
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• pp.29-35
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• 1997

Cardiovascular disease has been the leading cause of death among patients with chronic renal failure. Many reports have been described that homocysteine is one of the independent risk factor to the occulsive vascular disease. In this study, HPLC/FLD (high performance liquid chromatography-fluorescence detector) technique was used to measure homocysteine level in patients with chronic renal failure and normal control group. The detection limit and recovery of total plasma homocysteine using HPLC/FLD were 98.6$\pm$5.8% and 0.2 nmol/ml, respectively. The linearity of this method was established in concentration range of 2~50 nmol/ml (correlation coefficient=0.9997). The concentrations of total plasma homocysteine were 6.81$\pm$1.54 nmol/ml and 27.28$\pm$14.94 nmol/ml in normal control (n=20) and patient group (n=90), respectively (p<0.05). In this study, the HPLC/FLD method showed high sensitivity and reproducibility for a routine clinical laboratory testing. Moreover determination of homocysteine level in plasma might be useful for a biochemical marker for predicting the cardiovascular diseases and for monitoring of therapeutic effect of lowering homocysteine in patients with chronic renal failure.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.31 no.1
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• pp.19-26
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• 2020

Background and Objective Endoscopic airway dilation is the primary treatment for pediatric subglottic stenosis (SGS) due to its feasibility and non-invasiveness. The aim of this study is to evaluate the risk factors for the failure of endoscopic airway dilation in pediatric patients with SGS. Materials and Methods This study reviewed medical records of 38 pediatric patients had endoscopic dilation from a single and tertiary referral center, retrospectively. The success of the endoscopic dilation procedure was defined as no dyspneic symptom without tracheostomy or laryngotracheal reconstruction. Demographic profiles, underlying disease, and Myer-Cotton SGS severity grade were recorded. Success rates and risk factors for the failure of treatment were analyzed. Results The SGS patients with severity grade I was most common. After mean 1.8 numbers of procedures, there were 23 patients (60.5%) in the success group and 15 patients (39.5%) in the failure group. Age, sex, underlying diseases, and SGS severity grade were not significantly different between two groups. In patients who had multiple endoscopic procedures, the failure group showed SGS deteriorated after procedures in 66.7%, compared to 11.1% of the success group. In multivariable analysis, a long-term intubation (≥1 month) was identified as an independent risk factor for failure of endoscopic dilation procedure. Conclusion Although endoscopic dilation procedure is safe and effective for the management, repetitive endoscopic dilation may not give clinical benefit in patient with long-term intubation. Other airway procedures must be considered in those group of patients.

• Korea Trade Review
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• v.41 no.2
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• pp.61-96
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• 2016

This study investigates the effects of M&A experience of Chinese firms and characteristics of deal partners in cross border M&A deal failures. 1,610 firms that participated in 1,558 cross border M&As from 2000 to November 2015 are used as samples. The dependent variable is the M&A transaction failures, which were cases of deal pending or withdrawal of Chinese firms. Major independent variables are the nationality diversity of transaction partner firm, the partner firm belonging to a developed country, domestic M&A experience of the Chinese firms, M&A experience in a particular target country, etc. After conducting a probit model analysis, we find that deal partner firm's nationality diversity increases the failure rate of M&A. While prior domestic M&A experience in China has no influence on deal failure, prior M&A experience of Chinese and focal firms in a particular country have a negative effect on the probability of deal failure. This study has academic implication on figuring out why firms are likely to fail in the process of strategic activities based on the inter-organizational learning through partnerships perspective.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.18 no.5
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• pp.141-157
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• 2023

Start-ups are the driving force of economic development and play an important role in improving national competitiveness. The country's start-up support policies are increasing every year, but indicators that do not challenge them and do not consider future start-ups can predict employment reduction and unemployment can increase further. You can. The increase in the number of young people doing nothing is causing economic hardship and neglect of future precious human resources, which calls for a more realistic national entrepreneurship policy. Accordingly, this study sought to identify bias and environmental factors in order to reveal factors that influence the will to start a business among potential entrepreneurs in Korea. For this purpose, descriptive statistical analysis was performed using SPSS on a sample of 227 responses from the general public who are potential entrepreneurs interested in starting a business. As a result, prejudice decreased the will to start a business and increased fear of failure. On the other hand, the entrepreneur's environmental factors reduced the fear of failure and increased the will to start a business. Lastly, fear of failure was found to play a mediating role between the two independent variables and the will to start a business. The results of this study showed that prejudice was a negative factor in the will to start a business, and the environment was a positive factor. These research results suggest that in order to revitalize entrepreneurship, positive environmental factors that can provide entrepreneurs' correct recognition and support for entrepreneurship are necessary.

• Proceedings of the KIEE Conference
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• 2004.07c
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• pp.1802-1804
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• 2004

In seashore, outdoor insulators are polluted due to salty wind and the pollution causes the flashover and failure of electric equipments. As well known, the pollution has a close relation with meteorological factors such as wind velocity, precipitation, wind direction, relative humidity, dew point, etc. In this paper we statistically analyzed the correlation between the pollution and the meteorological factors including snowfall and freezing. The multiple regression analysis was used for the statistical analysis; daily measured equivalent salt deposit density(dependent variable) and the meteorological data(independent variable) were used. From the results of this investigation, we verified the influence of snowfall and freezing on the ESDD, which has been overlooked in the preceding investigation.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.8
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• pp.3455-3473
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• 2016

Cloud computing is a paradigm in which information is permanently stored in servers on the Internet and cached temporarily on clients. Virtual private network (VPN) is the most widely used technology for secure cloud access. Unfortunately, VPN-based cloud services become unavailable when a VPN failure occurs. In this paper, we propose a new scheme to improve the availability of VPN connections against such failures, called high-availability virtual communication (HAVC). Unlike most of the multipath transmission schemes in the literature, the proposed scheme is implemented by using a virtualization technique, and its protocol functions are independent of existing networks - potential clients are not required to modify their applications or operating systems. Simulation results show that the HAVC can not only tolerate VPN failures but also achieve high transmission performance.

• Communications for Statistical Applications and Methods
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• v.5 no.2
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• pp.459-475
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• 1998

In many clinical trials, we are interested in comparing the failure time distribution of different treatment groups. Because of ethical and economic reasons, clinical trials need to be monitored for early dramatic benefits or potential harmful effects. Prior knowledge, evolving knowledge, statistical considerations, medical judgment and ethical principles are all involved in the decision to terminate a trial early, and thus the monitoring is usually carried out by an independent scientific committee. This paper reviews the recently proposed group sequential testing procedures for clinical trials with survival data. Design considerations of such clinical trials are also discussed. This paper compares the characteristics of each of these methods and provides the biostatisticians with the guidelines for choosing the appropriate group sequential methods in a given situation.

• Journal of the Korean Data and Information Science Society
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• v.7 no.1
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• pp.21-35
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• 1996

In this paper, estimation and prediction procedures are discussed for grneral situation in which the failure time follows the independent density $f_{i}({\varepsilon}_{i})$ for the accelerated life testing under Type II censoring. In the context of accelerated life test experiment, procedures are given for estimating the parameters in the Eyring model, and for estimating mean life at a given future stress level. The procedures given are conditional confidence interval procedures, obtained by conditioning on ancillary statistics. A comparison is made of these procedures and procedures based on asymptotic properties of the maximum, likelihood estimates.

• Biomedical Science Letters
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• v.11 no.4
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• pp.421-427
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• 2005

To evaluate the diagnostic significance of p16 overexpression in human hepatocellular carcinoma (HCC), we analyzed p16 status and growth inhibitory patterns by p16 overexpression in HCC cell lines having different pRE status. SKHep1 and SNU449 cells show homozygous deletion of p16. The p16 gene in SNU398 cell is inactivated at posttranscription level. Adenovira1-p16 (Ad-p16) infection inhibits the cell growth in Hep3B, SNU398, and SNU449. Failure of growth inhibition in SKHepl results from the low transduction efficiency of adenovirus. The p16-mediated growth inhibition shows G 1 phase arrest in pRE-positive SNU449 but not in pRE-negative Hep3B. These results suggest that therapeutic efficacy of p16 gene might be considered on the transduction efficiency and the toxicity of adenoviral vector. Beside, growth inhibitory effect of p16 could be exerted through either pRE-dependent or -independent pathway.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.34 no.1
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• pp.42-51
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• 2011

Poisson model and Gamma-Poisson model are popularly used to analyze statistical behavior from defective data. The methods are based on binary criteria, that is, good or failure. However, manufacturing industries prefer polytomous criteria for classifying manufactured products due to flexibility of marketing. In this paper, I introduce two multivariate Gamma-Poisson(MGP) models and estimation methods of the parameters in the models, which are able to handle polytomous data. The models and estimators are verified on defective pixels of LCD manufacturing. Experimental results show that both the independent MGP model and the multinomial MGP model have excellent performance in terms of mean absolute deviation and the choice of method depends on the purpose of use.