• 한국식품저장유통학회지
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• 제16권3호
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• pp.392-399
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• 2009

녹차는 생리활성의 촉진작용뿐아니라 항암, 항산화, 고혈압 억제효과, 체중조절 등 다방면의 약리효과를 보이는 것으로 보고되고 있다. 아울러, 녹차의 항균 및 항진균 작용에 관한 연구결과도 발표되고 있으나, 항균작용 기작에 접근한 기초 연구는 별로 많지 않다. 본 연구는 식품변패미생물에 대한 녹차추출물의 항균작용을 구명하는 기초자료를 획득하는데 그 목적이 있다. 녹차추출물의 항균력을 조사한 결과, $500{\mu}g/mL$ 이상의 농도에서 뚜렷한 항균활성을 보였고, 광역의 병원성 및 부패성 미생물들에 대하여 항균활성을 나타내었다. 또한, 녹차추출물의 항균물질은 넓은 범위의 온도($40{\sim}150^{\circ}C$) 및 pH($3{\sim}11$)에서 안정성을 나타냈다. 따라서 녹차추출물의 항균물질은 항균활성이 높고, 항균 대상 미생물의 분야가 광범위할 뿐아니라, 넓은 범위의 온도 및 pH에 안정하여 이상적인 천연 항균제로서의 개발가능성을 제시하였다. 아울러, 녹차추출물의 항균작용을 알기 위하여, 녹차추출물 처리가 미생물 세포막 기능에 미치는 영향을 조사한 결과, 녹차추출물의 주요 작용기작은 세포막 perturbation에 기인한 것으로 사료되었다.

• 대한소아치과학회지
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• 제35권4호
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• pp.731-736
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• 2008

치성각화성낭종(Odontogenic keratocyst, OKC)은 치체(dental lamina)로부터 발생하는데, 모든 악골 낭의 $5{\sim}17$% 정도를 차지하며 낭의 내부는 이장상피로부터 유래한 점액성이나 치즈양 물질인 케라틴(keratin)으로 채워져 있다. 치성낭 중 가장 높은 재발률을 보인다는 것이 이 낭의 중요한 특징이다. 간혹 기저층에서 인접 결체조직 벽으로 돌기가 증식하기도 하며 결체조직 벽 내에 존재하는 치성 상피조직 섬의 증식이 위성 소낭을 발생시키기도 한다. 이들 소낭들이 치성각화성낭종의 높은 재발률의 원인으로 여겨진다. 치성각화성낭종은 다양한 연령층에서 발견되나, 20대와 30대에서 호발한다. 남성에서 다소 호발하며 하악, 특히 제3대구 치와 하악지 부위에서 자주 발생한다. 대개 피질골의 팽융에 의해 처음 발견되며 매복치와 관련되어 있고 일반적으로는 증상이 없지만 동통과 감염이 나타날 수도 있다. 흡인시 걸쭉한 노란 치즈양 물질인 케라틴이 관찰되며 특히 재발이 잘 된다. 치성 각화낭의 중요한 특징 중의 하나는 병소가 피질골의 팽창을 많이 유발시키지 않으면서 악골의 내면을 따라 성장한다 는 것이다. 치성각화성낭종화낭은 인접 치아를 변위시키고 흡수시킬 수 있으나 함치성낭보다는 정도가 심하지 않다. 하악관을 하방으로 변위시키기도 하며 상악 병소의 경우는 상악동을 침범해서 상악동 전체를 차지하기도 한다. 본 증례는 7세 10개월 된 여아의 하악 우측 제2유구치 부위에 발생한 치성각화성낭종에 대한 증례로써 전신마취하 낭종적 출술을 시행하였다. 낭종에 포함된 제1,2유구치, 유견치 및 제1소구치 치배를 발거하였으며, 현재 공간유지장치를 장착후 주기적으로 내원중이다.

• Tuberculosis and Respiratory Diseases
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• 제75권2호
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• pp.52-58
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• 2013

Background: More than half of cases for advanced non-small-cell lung cancer (NSCLC) occur in elderly patients with a median age at diagnosis of 70 years. The aim of our study was to examine the clinical features and prognostic factors contributing to mortality in elderly patients with advanced NSCLC. Methods: Following a retrospective review of clinical data, 122 patients aged 70 years and over with a histopathological diagnosis of locally advanced (stage IIIB, n=32) and metastatic (stage IV, n=90) NSCLC between 2005 and 2011 were enrolled. Results: The median age was 76 years (interquartile range, [IQR], 72-80 years), and 85 (70%) patients were male. Fifty-seven (46%) patients had never smoked, and 17 (19%) were in a malnourished state with a body mass index (BMI) of <$18.5kg/m^2$. The initial treatments included chemotherapy (40%) and radiotherapy (7%), but 57% of the patients received supportive care only. The 1-year survival rate was 32%, and the 3-year survival rate was 4%, with a median survival duration of 6.2 months (IQR, 2.5-15.3 months). Male gender (hazard ratio [HR], 2.2; 95% confidence interval [CI], 1.3-3.9; p=0.005), low BMI (HR, 2.3; 95% CI, 1.3-3.9; p=0.004), and supportive care only (HR, 1.9; 95% CI, 1.2-2.9; p=0.007) were independent predictors of shorter survival based on a Cox proportional hazards model. Conclusion: Elderly patients with advanced NSCLC had a poor prognosis, particularly male patients, those with a low BMI, and those who received supportive care only.

• 대한인간공학회지
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• 제34권4호
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• pp.313-326
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• 2015

Objective: The objective of this research is to quantitatively analyze muscle activities of arm and shoulder, according to direction in various types of one-handed manual material handling, based on surface electromyography. Background: Workers in industrial sites frequently carry out one-handed manual material handling using arm and shoulder muscles. Therefore, chronic load and accumulated fatigue occur to arm and shoulder muscles, which becomes a main cause of upper arm and shoulder musculoskeletal disorders. The shoulder muscles have widely range of motion, and complex interactions take place among various muscles including rotator cuff muscles. In this regard, research on interactions among should muscles, according to such various dynamic motions, is required. Method: Ten male subjects in their 20s participated in this research. This research considered upward, downward, leftward, rightward, forward and backward directions and fourteen muscles around arm and shoulder (biceps brachii and trapezius, etc.) as independent variables. The mean muscle activity was set as the dependent variable. This research extracted $4^{th}{\sim}7^{th}$ repetition signals according to ten times of repetitive muscle contraction, and analyzed the muscle activity concerned using the envelope detection technique. Results: The mean muscle activity of upward direction was analyzed highly statistically significant. The reason is that the effect of gravity works to arm and shoulder muscles. Also, it is conjectured that deformation of coracoacromial ligament was caused, and its contact pressure increased, due mainly to the shoulder flexion, and therefore load was analyzed high. Muscle activity was analyzed significantly low, according to concentric ballistic motion used in the concentric contraction phase by storing elastic energy in the eccentric contraction phase with a motion to bring the weight to the front of subject's body as to downward, leftward and backward directions. Because, elbow joint's flexion-extension motions mainly occurred, biceps brachii was analyzed high muscle activity as the prime mover. Conclusion: The information on the quantitative load of muscles can be applied to ergonomic work design for one-handed manual material handling to minimize muscle load. Application: This research has effectively identified muscle activity according to dynamic contraction by applying an envelope detection technique. The results can be used for ergonomic work design to minimize muscle load during the one-handed manual material handling, according to each direction. The research results are expected to be used for musculoskeletal disorder prevention and physiotherapy in the rehabilitation medical field, based on the muscle load of arm and shoulder in various directions.

• 한국사회복지학
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• 제57권1호
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• pp.147-167
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• 2005

서구사회에서의 장애인복지 서비스패러다임의 변천은 개별적 모델에서 사회적 모델로 방향이 이동하는 추세에 있으며, 또한 유물적 접근에서 관념적 접근으로 이동하는 현상을 보여주고 있다. 이 같은 패러다임의 변화를 토대로, 본 논문에서는 우리나라 공동모금 재정지원을 바탕으로 장애인복지 서비스 패러다임의 현상을 파악하고 이를 법 제도, 장애운동의 패러다임과도 비교했다. Priestly의 장애학의 다중패러다임 모형을 응용한 분석틀에 따라 공동모금회의 2003년도 장애인복지 분야의 신청사업 프로포절을 분류하였다. 분석결과 공동모금지원 서비스는 개별적 관념론에 지원이 집중되고 있으며, 상대적으로 접근권, 자립생활, 차별금지 등 최근에 이슈가 되고 있는 사회적 모델에 입각한 서비스 지원은 부족한 것으로 나타났다. 이 같은 상황에서 공동모금 재정지원은 현행 실천서비스에 기초를 두면서도 사회적 모델로의 비중을 확대해 가는 적절한 재정지원 포트폴리오(portfolio)를 구성해야 할 것이다. 본 연구는 다중 패러다임의 각 입장에서 장애라는 사회 현상을 바라보고, 장애에 대한 대처 방법을 모색하면서 장애학 연구의 이론적 논의와 실천서비스의 방향성을 제공하였다는데 의의가 있다.

• Tuberculosis and Respiratory Diseases
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• 제68권5호
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• pp.259-266
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• 2010

Background: Pulmonary tuberculosis (TB), requiring the intensive care unit (ICU) care, has been a high-mortality condition until now. In the present study, we aimed to investigate clinical features and parameters associated with TB mortality. Methods: From August 2003 to December 2008, patients with microbiologically or histologically confirmed pulmonary TB then admitted to the ICU, were retrospectively enrolled into the study. Upon enrollment, their medical records were reviewed. Results: Forty three patients (30 males, 13 females) were included and their mean age was 63.8 years (range: 17~87 years). Twelve patients died, an overall in-hospital mortality of 27.8%. The main reason for the ICU care was dyspnea or hypoxemia requiring mechanical ventilation (n=17). Other diagnoses for ICU care were hemoptysis, monitoring after procedures, neurologic dysfunction, shock, and gastrointestinal bleeding. On univariate analysis, the factors affecting the mortality were malnutrition-related parameters including low body mass index, hypoalbuminemia, lymphocytopenia, and hypocholersterolemia, as well as severity-related variables such as high acute physiology and chronic health evaluation (APACHE) score, number of involved lobes, and high C-reactive protein. In addition, respiratory failure requiring mechanical ventilation and acute respiratory distress syndrome contributed to patient fatality. It was shown on multivariate analysis that respiratory failure and hypoalbuminemia were significantly independent variables associated with the mortality. Conclusion: Acute respiratory failure is the most common reason for the ICU care and also the most important factor in predicting poor outcome. In addition, our data suggest that the parameters associated with malnutrition could be possible factors contributing to mortality.

• Journal of Preventive Medicine and Public Health
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• 제40권1호
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• pp.23-28
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• 2007

Objectives : Chronic infections with hepatitis B or C and alcoholic cirrhosis are three well-known major risk factors for liver cancer. Diabetes has also been suggested as a potential risk factor. However, the findings of previous studies have been controversial in terms of the causal association. Therefore, the aim of this study was to evaluate the association between serum glucose levels and liver cancer development in a Korean cohort. Methods : Thirty-six liver cancer cases were identified in the Korean Multi-Center Cancer Cohort (KMCC). Baseline information on lifestyle characteristics was obtained via questionnaire. Serum glucose levels were measured at the study's enrollment. Relative risks (RRs) were estimated using a Cox proportional hazard regression model. The adjusting variables included age, gender, smoking history, alcohol consumption, body mass index, and hepatitis B surface antigen (HBsAg) seropositivity. Results : The RRs of serum glucose for liver caner were 1.20 (95% CI = 0.48-2.99) for the category of 100 to 125 mg/dL of serum glucose and 2.77 (95% CI = 1.24-6.18) for the >126 mg/dL serum glucose category (both compared to the <100 mg/dL category). In a subgroup analysis, the RR of serum glucose among those who were both HBsAg seronegative and non-drinkers was 4.46 (95% CI = 1.09-18.28) for those with glucose levels >100 mg/dL. Conclusions : The results of this study suggest that a high level of serum glucose can increase liver cancer risk independently of hepatitis infection and drinking history in Koreans. This study implies that glucose intolerance may be an independent risk factor for liver cancer.

• 한국항만경제학회지
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• 제24권3호
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• pp.101-123
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• 2008

광양만권 경제자유구역은 2003년 함께 지정되었던 인천, 부산 경제자유구역 등에 비해서 지리적, 인지도, 사회간접자본 등의 측면에서 불리한 여건에 있다. 물론 정부, 지자체, 광양만권 경제자유구역청 등은 변화시키기 어려운 우리사회의 여건 속에서 외국인투자 유치를 위한 최선의 방안을 모색하고, 이를 실행하기 위한 각종 제도의 정비, 환경조성, 운영전략 등 외국인 투자유치를 위해 노력하고 있지만 이에 대한 실적은 부족한 실정이다. 광양만권 경제자유구역이 성공하기 위해서는 경제자유구역을 거점으로 아시아와 세계를 상대로 하는 비즈니스를 구상하고, 수행하는 많은 외국인투자기업을 유치하기 위한 운영전략이 필요하다. 그러나 아직까지 광양만권 경제자유구역 내 이러한 양질의 외국인투자기업을 유치하기 위한 광양만권 경제자유구역만의 차별화 된 운영전략이 부족한 것으로 평가되고 있다. 광양만권 경제자유구역의 외국인 투자유치 활성화를 위한 마케팅 믹스 전략을 제시하면 다음과 같다. 첫째, 제품(product)전략으로 주변 특성과 연계된 클러스터를 구축해야 한다. 둘째, 가격(price)전략 측면에서는 탄력적인 인센티브와 맞춤형 인센티브, 현물 및 현금보조금 제도의 비중을 높여야 한다. 셋째, 촉진(promotion)전략 측면에서는 전문능력 및 외국어능력을 겸비한 인력양성과 수요자 위주의 환경을 조성해야 한다. 넷째, 유통(place) 전략 측면에서는 광양만권 경제자유구역청의 독립화 및 전문화가 구축되어야 한다.

• 한국의류학회지
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• 제26권2호
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• pp.303-314
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• 2002

The colors of apparel have become an important element to be used strategically in order to give differentiated character at the level of fiber and fabric production. The colors of apparel have a close relationship with the skin colors of consumers and their preference colors. This study was carried out to classify the skin colors of Korean elderly women into several similar skin colors and to analyse their preference colors. Sample size was 471 Korean elderly women. With color spectrometer, JX-777, we measured 4 points of the body; cheek with removing cosmetics off, forehead, rear neck and arm on the interior part near elbow. All subjects had been shown with 40 color chips and answered the preference colors of apparel and the preference colors. Data weirs analysed to classify skin colors using K-means Cluster Analysis and Duncan test. Independent variables for Cluster Analysis were 12 variables out of L value, a value and b value of 4 points. In doing so, we used SPSS WIN 10 statistical package. Findings were as follows: 1) The skin colors of the Korean elderly women were composed of skin colors of YR, R, and Y. 2) 355 subjects were classified into 4 kinds of skin color groups. 3) The average face color of type 1 was 6.7YR 5.1/4.3 and 56 observations out of 355 subjects were composed of Type 1 and of Type 2 was 6.1YR 6.1/4.5 and 166 observations out of 355 and of 3 Type 6. YR 4.8/4.2 and 75 observations out of 355 and of Type was 6.17 YR 5.7/4.7 and 58 observations out of 355. 4) The average skin color of Type 1 was 7.0YR 5.9/4.4 and of Type 2 was 7.2YR 6.3/4.2 and of Type 3 was 7.0YR 6.2/4.2 and of Type 4 was 7.6YR 5.4/4.2 respectively. 5) The mean values of 12 variables between the 4 classified face color and skin color groups showed significantly different except H value of skin color. 6) All 4 groups showed that the most preference color of apparel and the most preference color were 2.5R 5/14 respectively.

• Asian-Australasian Journal of Animal Sciences
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• 제25권3호
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• pp.335-340
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• 2012

The data used came from two trials undertaken under the same climatic conditions (spring-summer). In both trials pluriparious buffaloes were utilized similar in weight, body condition score, and milk production from the previous year. From the first trial the data used was from the sub-period 23-88 DIM provided by seven animals fed ad libitum with diet A (6.69 MJ/kg DM; 158.30 g/kg of crude protein) with a forage/concentrate ratio of 48/52. From the second trial the data used was from the sub-period 33-90 DIM provided by seven animals fed ad libitum with diet B (6.63 MJ/kg DM; 179.50 g/kg of crude protein) and by seven animals fed ad libitum with diet C (5.99 MJ/kg DM; 155.40 g/kg of crude protein), each of the diets had the same forage/concentrate ratio (53/47). A significant difference was found in milk production between group B and C (13.08 vs. 11.56 kg/d, p<0.05), an intermediate production (12.10 kg/d) was noted in group A. A significant difference was found between fat (76.58 vs. 69.24 g/kg, p<0.05), protein (46.14 vs. 43.16 g/kg, p<0.05) and casein (39.94 vs. 34.98 g/kg, p<0.05) of the milk of group B with respect to group A. The milk of group C gave fat values (71.80 g/kg), protein (45.52 g/kg) and casein (39.06 g/kg) statistically equal to those of group B. The milk of groups B and C, in respect to the milk of group A, gave values of $K_{20}$ (1.77, 1.82 vs. 3.68 min, p<0.05), statistically lower and values of $A_{30}$ (48.28, 47.27 vs. 40.64 mm, p<0.05) statistically higher. Two simple linear regressions were calculated where the independent variable (x) was the daily standardized milk production, the dependent variable (y) or the daily intake of net energy or crude protein. Equation 1) NE (MJ/d) = 74.4049+2.8308${\times}$kg of normalized milk; equation 2) CP (kg/d) = 1.4507+0.1085${\times}$kg of normalized milk, both the equations were significant (p<0.05) with determination coefficients of 0.58 and 0.50 respectively. For a production of normalized milk that varies from 9 to 13 kg, the respective energy-protein concentrations fluctuate from 6.09 to 6.78 MJ/kg DM and from 148.00 to 174.46 g/kg DM.