• 한국철도학회논문집
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• 제12권2호
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• pp.291-301
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• 2009

열차 증수선 시설은 편성, 차량, 차체, 대차 등으로 구분하여 프로세스를 수행하게 되는데 각각의 수선 방법 및 프로세스가 상이하여 일반적인 수리적 기법으로 분석하는 것은 한계를 가지게 된다. 따라서 본 논문에서는 열차중수선 시설의 시뮬레이션 모델링 및 분석에 관한 체계적인 방법을 제시하였다. 시뮬레이션 분석은 종속 변수와 설계 변수를 구분하여 시뮬레이션 모델링에 반영 한 후 다 기준 의사결정 기법을 사용하여 설계 대안을 선정하게 된다. 그리고 선정 된 대안에 관한 최적화를 수행하여 실제 설계에 적용하게 된다. 이 분석 방법에 관한 예로 전기기관차 중수선 시설에 관한 시뮬레이션 설계 및 분석 방법을 제시하였다. 시뮬레이션에 기반 한 분석은 실제 시스템의 설계 전에 설계변수의 최적화를 위하여 꼭 수행하여야 하며, 최적의 설계를 구축하는 하나의 중요한 단계로 고려되어져야 하고, 본 논문에서 제시된 방법은 시뮬레이션의 체계적인 접근에 활용이 될 수 있다.

• Archives of Pharmacal Research
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• 제29권5호
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• pp.354-362
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• 2006

Dietary flavonoids have attracted a great deal of attention as agents for preventing estrogen-related diseases, such as postmenopausal symptoms, and for reducing the risk of estrogen-dependent cancer. Kaempferol is one of the most commonly found dietary phytoestrogen. The aim of this study was to investigate the estrogenic and/or antiestrogenic effect of kaempferol, which can confirm its potency as a preventive agent against estrogen-related diseases. Kaempferol has both estrogenic and antiestrogenic activity, which are biphasic response on estrogen receptor. The estrogenic activity of kaempferol induced via ER-mediated pathway depending on $E_2$ concentration $(\leq\;10^{-12}M)$. Kaempferol $(10^{-5}\;M)$ also caused antiproliferative effect on MCF-7 cell in the presence of $E_2\;(10^{-11}\;M)$ and restored to the addition of excess $E_2\;(10^{-7}\;M)$, which confirms that antiproliferation of kaempferol was induced via ER-dependent pathway. However, at $10^{-4}\;M$, concentration higher than the concentrations at which the estrogenic effects of kaempferol are detected $(10^{-5}\;M)$, kaempferol induced strong antiproliferative effect, but were unaffected by the addition of excess $E_2\;(10^{-7}\;M)$ indicating that kaempferol exerts antiproliferation via ER-independent pathway. In particular, kaempferol blocked the focus formation induced by $E_2$, which confirms that kaempferol might inhibit the malignant transformation caused by estrogens. Therefore, we suggested that kaempferol might regulate a suitable level of estrogenic activity in the body and is expected to have potential beneficial effects in preventing estrogen imbalance diseases (breast cancer, osteoporosis, cardiovascular disease and etc.).

• 한국추진공학회지
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• 제4권3호
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• pp.55-63
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• 2000

튜브 스피닝 성형에 대한 연구는 전통적 스피닝 공정에 비해 본질적으로 변형의 메카니즘이 보다 복잡한데 기인하여 이론 덴 해석 연구가 국한적으로 이루어져 왔다. 특히, 상계법을 이용한 해석의 제한성을 극복하기 위한 유한요소법을 이용한 연구는 아직 소수에 그치고 있는 실정이다. 본 연구에서는 티타늄 합금을 재료로 사용한 용기의 튜브 스피닝 공정을 상계법과 유한요소법을 이용하여 조사하였다. 해석에 있어 티타늄합금의 성형특성을 고려하여 상계법을 통해 공정변수가 설정되었으며, 유한요소해석 code인 ABAQUS를 사용하여 티타늄 합금재의 신장량과 편평도를 얻었다. 해석에 사용된 독립변수들은 로울러의 전 ·후방각도와 가공깊이, Feed rate이며 이 변수들은 유한요소법과 상계 해법을 통하여 최적화된다. 이 해석법에서 우리는 스피닝 가공의 가공동력과 힘 그리고 지름의 감소 율윽 얻을 수 있고, 또한 유한요소해석에 의해서 가공재의 편평도와 신장량도 구할 수 있다. 그 결과로부터 정해진 변수들이 티타늄 합금의 스피닝 공정에 있어서 중요한 요소임을 알 수 있으며, 그 변수들의 최적값을 얻을 수 있다.

• 한국의상디자인학회지
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• 제10권2호
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• pp.39-56
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• 2008

It is a remarkable phenomenon that tattoos has been rapidly spreading among women of modern years. The extremism of feminine ornaments, and pricking and piercing of the skin seem to have deep connection with women's consciousness changing to being independent, active and aggressive. The objective of this study is to analyze the potential quality of today's women, who appears emblematically through tattoo, and to search out the whole aspect and keynote of female tattoos. The methods of research are by examining the general characteristics including concept and history, considering the type and significance of ethnic female tattoos, and then comparing with the symbolism of today's female tattoos. The sphere is limited to women's tattoos from ancient times to today's modern lift, examined from large portions of Africa, Asia, Australasia, the Americas, and Arctic regions. As a result, the following had been reflected in female tattoos in the past. First, incantation, tribe, adult age, adornment, marital status, domestic ability and sex distinction, where among others, the incantatory, ornamental symbol, and domestic sign were representatives. Second, the most popular body parts for having a tattoo were around the lips, hands and abdominal region. Third, the more harsh the environment becomes such as tropical forests, isolated islands, and polar regions, the more number of females have tatoos. Fourth, women's tattoos were much less glamorous and smaller compared to those of men, distinguishing one's sex. On the other hand, today's female tattoos can be classified as five symbols: masculinity, independence, voluptuousness, affection, and purity. These symbols contain women's mentality to pass the limit, and to overcome social inferiority. In modern society, where women must compete with met it has become necessary for women to educe their potential masculine qualities. Being violent accessories for them, tattoos became a mark of such potential. Therefore, in the future, women's interest and demand for tattoos are expected to rise in proportion to the social demand of women's force.

• Journal of Gastric Cancer
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• 제15권1호
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• pp.19-28
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• 2015

Purpose: To compare the clinicopathological data and long-term survival of gastric cancer patients in China and Korea. Materials and Methods: Patients who had undergone gastrectomy for gastric cancer between 1998 and 2009 in 2 high-volume institutions in both China (n=1,637) and Korea (n=2,231) were retrospectively evaluated. Clinicopathological variables, overall survival (OS), progression-free survival (PFS), and surgery-related complications were assessed for all patients and compared between the 2 institutions. Results: Chinese patients included in the study were significantly older and had a significantly lower body mass index (BMI) than the Korean patients. Esophagogastric junction tumors were more frequent in Chinese patients. However, the number of patients with stage I gastric cancer, the number of harvested lymph nodes, and the number of total gastrectomies were significantly higher in the Korean population. Korean patients also presented with fewer undifferentiated tumors than Chinese patients. Furthermore, Korean patients had prolonged OS and PFS for stage III cancers only. BMI, tumor-node-metastasis (TNM) stage, tumor invasion, number of positive lymph nodes, and distant metastases were all independent factors affecting OS and PFS. Conclusions: Although China and Korea are neighboring Asian countries, the clinicopathological characteristics of Chinese patients are significantly different from those of Korean patients. Korean gastric cancer patients had longer OS and PFS than Chinese patients. Influencing factors included TNM stage, tumor invasion, and lymph node metastasis.

• Journal of Gastric Cancer
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• 제16권2호
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• pp.98-104
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• 2016

Purpose: The incidence of gallstones after gastrectomy for gastric cancer is higher than in the general population. However, the causes and mechanisms of post-gastrectomy gallstones are unclear. The aim of this study was to evaluate the incidence of gallstone formation and the risk factors for their development after gastrectomy for gastric cancer. Materials and Methods: Of 1,744 gastric cancer patients who underwent gastrectomy at Seoul National University Bundang Hospital between January 2010 and December 2012, 1,284 were included in this study and retrospectively reviewed. Patients' age, sex, body mass index (BMI), tumor location, stage, type of gastrectomy, type of reconstruction, and extent of node dissection were evaluated. Results: The incidence of gallstones after gastrectomy for gastric cancer was significantly higher in men than in women (P=0.019). Exclusion of the duodenum during reconstruction was associated with a significantly higher incidence of gallstones (P=0.003). Overweight and obese patients with BMI ${\geq}23kg/m^2$ had significantly higher incidence of gallstones than those with a lower BMI (P=0.006). Multivariate analysis showed that obesity (hazard ratio, HR=1.614; 95% confidence interval, CI: 1.135~2.296; P=0.008), male sex (HR=1.515, 95% CI: 1.029~2.231, P=0.033), and exclusion of the duodenum (HR=1.648, 95% CI: 1.192~2.280, P=0.003) were significant, independent risk factors for gallstones after gastrectomy. Conclusions: The cumulative incidence of gallstones for 5 years after gastrectomy was 15.3%. Male sex, obesity, and exclusion of the duodenum were risk factors for gallstone formation after gastrectomy. Careful surveillance will be required for these patient groups after gastrectomy.

• 대한지역사회영양학회지
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• 제8권1호
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• pp.102-111
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• 2003

The purpose of this study was to investigate the relationship among serum leptin, nutritional status, and the obesity indices of 55 obese children in Daegu and Kyungpook area. Obesity was defined as fat percentage that exceed 25% of body fat mass. Energy and nutritional status were tended to be low, and dietary intake of calcium and iron were less than any other nutrients in all the subjects. Especially, beverage intake of obese group was more than non-obese group. The leptin level were significantly correlated with %RDA of energy (0.41, p < 0.001), protein (0.44, p < 0.001), phosphate (0.40, p < 0.001), iron (0.37, p < 0.001), vitamin A (0.31, p < 0.01), thiamin (0.40, p < 0.001), riboflavin (0.26, p < 0.05), niacin (0.51, p < 0.001), and vitamin C (0.24, p < 0.05). The leptin level were significantly correlated with MAR (mean adequacy ratio, r : 0.43, p <0.001) and INQ (index of nutrient quality) of thiamin (r : 0.22, p <0.05). Multiple regression analysis showed that %RDA of niacin in obese group ($R^2$: 0.208, p : 0.001) and total subjects ($R^2$ : 0.257, p : 0.000), MAR (p : 0.003) and INQ (p : 0.048) of niacin in obese group ($R^2$ : 0.255) and MAR (p : 0.000) and rNQ ofca (p : 0.024) in total subjects ($R^2$ : 0.231) may be important independent predictors to leptin level. MAR showed a significantly positive correlation with %fat (r = 0.42, p < 0.01), BMI (r = 0.46, p < 0.01), RW (r : 0.44, p < 0.01), WHR (r : 0.39, p < 0.01) and, "ieRnA (p < 0.05, p < 0.01). These data indicated relationships among leptin level, nutrient intake, %RDA, MAh, and INQ in children.dren.

• 한국발생생물학회지:발생과생식
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• 제10권4호
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• pp.215-225
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• 2006

사춘기 조숙증은 여아에서 8세 이전에 유방 발육이 있거나 남아에서 9세 이전에 고환이 4 mL 이상 커지는 것으로 정의되는데 최근 사춘기 발현 연령이 점차 낮아지고 있다. 사춘기를 시작하는 gonadotrophin releasing hormone(GnRH)의 활성화에는 흥분성 및 억제성 아미노산, 성장인자, 전사조절인자, 아디포카인 등 많은 인자들이 복합적으로 작용한다. 특발성 사춘기 조숙증의 원인으로서 유전인자, 영양상태(특히 체지방 증가), 환경호르몬 노출 등 여러 가지 원인이 추정되고 있다. 사춘기 조숙증은 정서적 스트레스뿐 아니라 성장판의 조기폐쇄로 인한 저신장을 초래할 수 있다. 사춘기 조숙증은 진성 성조숙증과 가성 성조숙증으로 분류할 수 있으며 gonadotrophin이 활성화되는 진성 성조숙증에서는 적절한 시기에 GnRH 길항제를 치료하였을 때 사춘기 지연 및 최종 성인 신장을 호전시키는 것으로 보고되고 있으나 그 효과 및 장기적 부작용에 대해서는 좀더 연구가 필요하리라 사료된다.

• 대한한의진단학회지
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• 제11권2호
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• pp.27-44
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• 2007

Background: Eight-Constitution Medicine (ECM) classifies the human body into eight constitutions. Diagnosis of discrimination of the eight constitutions depends on a unique pulse diagnosis. However, pulse diagnosis is subjective and requires vigorous training. Objectives: This study aims to analyze the validity and reliability of the Eight-Constitution Questionnaire as a diagnostic method. Methods: Participants of this study were outpatients in six ECM clinics located in Seoul. The resources were collected from 409 patients who were classified into one of the eightconstitutions according to their pulse types and their responses to constitution-acupuncture therapy. SPSS 13.0 for Windows was used for statistical analysis: factor analysis, reliability analysis, independent sample t-test, and multinomial logistic regression were used to verify the results. Results and Conclusions: 1. The proportion of participants' constitutions is in the order of Pancreotonia (23.7%), Colonotonia (19.8%), Pulmotonia (18.1%), Hepatonia (16.9%), Vesicotonia (8.1%), Cholecystotonia (7.3%), Renotonia (5.3%) and Gastrotonia (0.7%). 2. Sevencomponents and 74 items were selected through factor factor and relaibility analysis performed on about 251 items. 3. The firstcomponent's mean is significantly higher in Pancreotonia than that in other constitutions (p<0.05). The second is in Pulmotonia and Colonotonia, whereas the third is in Hepatonia and Cholecystotonia. Fifth is in Vesicotonia, the sixth is in Colonotonia, and the fourth and seventh are not significant in specific constitutions. 4. The percentage that Pancreotonia is correctly predicted is 96.9%, Pulmotonia is 91.9%, Colonotonia is 91.4%, Hepatonia is 88.4%, Vesicotonia is 81.8%, Gastrotonia is 66.7%, Renotonia is 66.7%, Choleeystotonia is 30.0%, and the total percentage is 85.3%.

• Archives of Plastic Surgery
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• 제38권5호
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• pp.621-626
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• 2011

Purpose: Implant-based breast reconstruction has multiple advantages such as decreased morbidity, shorter operative time and faster recovery. However, postoperative infection with tissue expander increases medical cost and causes a delay in concurrent antineoplastic treatment. To reduce tissue expander infection, it is important to identify related risk factors and minimize them when possible. Methods: A retrospective review of patient records in a single breast cancer center was performed. Eighty-six tissue expanders were placed in 80 women for postmastectomy breast reconstruction. Variables including patients'age, body mass index (BMI), preoperative breast volume, operation time, drain indwelling time, postoperative seroma/hematoma formation, chemotherapy, and radiation therapy were evaluated. Infection was defined as the status that shows any symptom of local inflammation and identification of pathogens. Representative values were compared through Student's t-test and univariate and multivariate analyses. Results: We examined 86 postmastectomy tissueexpanders which were placed between June 2004 and April 2010. Seven cases of tissue expander infection (8.1%) were identified. The infected tissue expander was removed in three of the cases. The relationship between BMI, and preoperative breast volume and that between infection and non-infection groups were significant ($p$ <0.05). Univariate analysis showed significant association between BMI ($p$=0.023) and preoperative breast volume ($p$=0.037). Multivariate analysis revealed that BMI and preoperative breast volume were independent variables regarding tissue expander infection. Conclusion: Certain characteristics of implant-based breast reconstruction patients increase infection rate of tissue expander. These risk factors should be monitored and evaluated before surgeries for more successful outcome.