• 미생물학회지
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• 제37권4호
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• pp.245-252
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• 2001

MLS (macrolide-lincosamide-streptogramin B) 항생제 내성인자 단백질인 Erm 단백질들은 아미노산 서열 중 그 동일성과 유사성이 높아 구조적으로도 동등한 단백질의 한 집단을 형성한다. 최근 X-ray crystallography에 의해 구조가 결정된 ErmC\` 및 ErmAM 단백질의 구조에 근거하여 ErmSF 단백질도 catalytic domain과 substrate binding domain으로 구분하였고 N-terminal end에 존재하는 catalytic domain의 대량생산을 다양한 pET 발현 vector를 사용하여 시도하였다. 그리고 catalytic domain을 coding하는 DNA 절편은 세 종류를 사용하였다: DNA 절편 1은 Met 1부터 Glu 186까지를 coding하고 DNA 절편 2는 Arg 60부터 Glu 186까지의 정보를 가진 DNA이고 DNA 절편 3은 Arg 60부터 Arg 240까지를 encoding하는 DNA이다. 사용된 다양한 발현 vector중에서 pET19b는 DNA 절편 3, pET23b는 DNA 절편 1과 2를 성공적으로 대량생산하였다. 그러나 대량생산된 catalytic domain들은 불용성 단백질 집합체인 inclusion body를 형성하였다. ErmSF catalytic domain들의 용해성 단백질의 생산을 위하여 chaperone GroESL과 Thioredoxin의 동시 발현 및 배양온도를 $22^{\circ}C$로 낮추어 시도했으나 대량 발현된 단백질의 용해에는 도움을 얻지 못하였다.

• 자원환경지질
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• 제21권2호
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• pp.149-164
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• 1988

청양지역 광화대 금-은 광상들은 화강편마암내의 단층대를 충진한 수개조의 함 금-은 열수맥상 광체로 구성된다. 광화작용의 시기는 $127.1{\pm}2.8\;Ma$이고, 열수광화작용은 구조운동에 시기적으로 2회에 걸쳐 진행되었다. 공생광물의 유체포유물 및 안정동위원소 연구에 의하면, 초기 약 $340^{\circ}$의 고온에서 $180^{\circ}$에 이르는 제 I 광화시기에는 일렉트럼 (42.2-66.8mole % Au), 농홍은석, 함은사면동석, 휘은석, 유비철서, 방연석, 황동석 및 섬아연석 $X_{FeS}{\fallingdotseq}0.13$)등이, ${\delta}^{34}S_{{\sum}S}$=2-5%, $fs_2$ < $10^{-9.8}atm$., 1-8wt. % NaCl상당염농도를 갖는 유체로부터 비등현상과 함께 침전되었다. 광화작용시의 압력은 <200-700기압이고, 광화작용의 심도는 약 1.5km였다. 열수 광화유체내 물의 수소(-90~-130‰), 산소(-5.9~+0.1‰)동위원소 값은 광화유체의 기원이 천수임을 뜻하고, 광화유체의 비등현상과 냉각작용은 $340^{\circ}C$이하에서 유체내 금-은 복합체 ($Au\;(HS)^-_2$, $AgCl^-_2$)의 파괴를 초래하여 금-은 광물의 침전을 유도하였다.

• 지능정보연구
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• 제24권2호
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• pp.171-193
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• 2018

본 연구는 시멘틱 웹의 실질적 구현체인 LOD 클라우드에서 연결정책을 활용함으로써 LOD들간 연결을 효과적으로 제공하고 LOD의 변경된 내용을 검색결과에 빠짐없이 반영할 수 있는 방안을 제시한다. 현재 LOD 클라우드에서는 개체간 연결은 를 이용하여 개체들이 동일함을 명시적으로 기술하는 방식으로 이루어져 있다. 하지만, 이러한 명시적 연결방식은 LOD 클라우드 규모의 방대함에도 불구하고 개체간 동일성을 개체단위에서 파악하여야 하는 어려움이 있으며 주기적으로 LOD에 추가하여야 함에 따라 검색 시 개체들이 누락되는 한계가 있다. 이를 극복하기 위하여 본 연구에서는 명시적 연결을 생성하는 대신 LOD별로 연결하고자 하는 LOD와의 연결정책을 수립하여 LOD와 함께 공개하는 방식을 제안한다. 연결정책을 활용함으로써 연결하여야 할 동일개체를 검색시점에서 파악할 수 있으므로 추가되었던 개체들을 누락됨 없이 검색결과에 포함시킬 수 있고 LOD 클라우드에서의 연결성도 효과적으로 확충할 수 있다. 확충된 연결성은 정보의 지능적 처리의 선행과정인 지식확장의 근간이 된다. 연결정책은 연결하고자 하는 소스와 타겟 LOD의 주어 개체들간의 동일성을 평가하는데 도움이 되는 술어 쌍을 명세하는 방식으로 수립하며 검색 시 이러한 술어쌍에 대응하는 RDF 트리플을 검색하고 이들의 목적어들이 충분히 동일한 것인가를 평가하여 주어개체들의 동일수준을 판단한다. 본 연구에서는 이러한 연결정책을 이용하여 여러 LOD들을 심층적으로 검색하는 시스템을 구현하였다. 검색과정에서는 기존 명시적 연결들도 함께 활용하도록 구현하였다. 검색시스템에 대한 실험은 DBpedia의 주요 LOD들을 대상으로 진행하였다. 실험결과 연결대상 개체들의 목적어들이 0.8 ~ 0.9의 유사수준을 가지는 경우 적정한 확장성을 가지고 충분히 신뢰적인 개체들을 적절하게 포함하는 것으로 확인하였다. 또한, 개체들은 8개 이상의 동일연결을 제공하여야 검색결과가 신뢰적으로 활용될 수 있을 것으로 파악되었다.

• 자원환경지질
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• 제28권6호
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• pp.541-551
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• 1995

The Yeongdeog gold-silver deposits at Jipum, Gyeongsangbugdo, is of a middle Paleogene $(45.52{\pm}1.02Ma)$ vein type, and is hosted in shale and sandstone of Cretaceous age. Based on mineral paragenesis, vein structure and mineral assemblages, the ore mineralization can be divided into two distinct depositional stages. The early stage is associated with base-metals such as pyrite, arsenopyrite (27.99~30.99 at%), hematite, rutile, pyrrhotite, sphalerite (10.53~18.42 FeS mole%), chalcopyrite and galena with wallrock alteration such as chlorite, sericite and pyrite. The late stage is characterized by the Au-Ag mineralization such as electrum, Ag-bearing tetrahedrite, freibergite, pyrargyrite, unidentified mineral, pyrite, sphalerite (1.08~5.57 FeS mole%), chalcopyrite and galena. Fluid inclusion data indicate that fluid temperatures and salinities range from 343 to $227^{\circ}C$ and from 8.3 to 5.7 wt% eq. NaCl in early stage, respectively. Temperatures and salinities of NaCl eq. wt% range from 299 to $225^{\circ}C$ and from 12.9 to 4.3 in late stage, respectively. They suggest that complex cooling histories were occured by the mixing of the fluids. Sulfur fugacity $(-logfs_2)$ deduced by mineral assemblages and composition ranges from 8.3 to 14.7 atm. in early stage, and from 8.8 to 14.5 atm. in late stage. It suggests that the mineralization was related to decrease of temperature in early stage and fluctuations of $fS_2$ with decrease of temperature in late stage. Sulfur and oxygen isotope compositions are 4.48~5.60‰ and 9.25~10.8% in early stage, and late stage is 4.84~7.00‰ and 5.7‰, respectively. It indicated that hydrothermal fluids may be magmatic origin with some degree of mixing of another water during paragenetic time.

• 한국구조물진단유지관리공학회 논문집
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• 제10권1호
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• pp.131-138
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• 2006

일정한 크기의 마찰력을 도입한 가새(FSB)는 에너지를 소산시키는 효과적인 구조 부재이며, 가새의 축력이 마찰력을 넘지 않을 때까지만 탄성 거동을 한다. 본 연구에서는 FSB 개념을 보다 확장시켜서 가새를 죄는 마찰력의 크기를 능동적으로 변화시킬 수 있는 능동 조임 마찰 가새(AFSB)를 착상하여 단자유도 구조물에 적용하고 조화 하중으로 기진시켜 그 거동을 시뮬레이션 하여 FSB와 비교 분석해본다. 이를 위해 간단하고 효과적인 알고리즘을 개발해보았다. 연구 결과, 지반 가속도 값이 그다지 크지 않은 경우, AFSB는 초기에 오우버슈팅이 발생하는 문제만 제외하고 FSB에 비해 효과적으로 진폭과 밑면 전단력을 감소시켰다.

• 여성건강간호학회지
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• 제19권2호
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• pp.67-74
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• 2013

Purpose: Dysmenorrhea is a menstrual condition characterized by severe and frequent cramps and pain. Effective treatment methods for dysmenorrhea are not yet fully understood. This research compares the effects of pain killers and heated red bean pillows. Methods: Data were got on demographic data, menstrual cycle status, and activities of daily living (ADLs) limitations, dysmenorrhea severity and menstrual pain scores. Following a 10% drop-out rate, 44 young women satisfied the inclusion criteria. To prevent any bias, the experimental and control groups were selected from different campuses. We used two sizes of red bean pillows: $13{\times}11.5cm$, weighing 400g; and $15{\times}18cm$, weighing 220g. For analysis, we used IBM SPSS statistics 19.0. Results: Ninety-nine point seven percentage of total subjects reported moderate to severe dysmenorrhea and 63.6% reported as moderate to severe daily activities limitations. The mean pain score with visual analogue scale was $80.2{\pm}9.42$ of 100 and 86.4% used pain killers to alleviate menstrual discomfort in all the subjects. In both groups, all three variables showed significant improvement and the Moos's Menstrual Distress Questionnaire (MDQ) scores changed significantly between menstrual and post-menstrual time point at within groups and not significantly different at premenstrual and menstrual time point at between groups. However, the MDQ score was significantly higher in experimental group than control group at post-menstruation time point and the degree of satisfaction was higher in the control group. Conclusion: This research shows that red-bean pillows on the abdomen are effective in assisting the ADL and diminishing pain severity. With regard to its safety the study indicates it can be a convenient and safe option for female students with menstrual discomfort in schoolas a non-pharmacological self-help.

• Imaging Science in Dentistry
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• 제35권3호
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• pp.167-173
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• 2005

Purpose : To investigate the relationship between three-dimensional (3D) bone imaging parameters and trabecular strength in the mandible. Materials and Methods : Bone specimens were obtained from the mandibles of five male pigs weighing around 110 kg each. Of those, 43 samples were selected for 3D analysis and measured by micro-computed tomography. The five morphometric parameters were trabecular thickness (Tb.Th), bone specific surface (BS/BV), percent bone volume (BV/TV), structure model index (SMI) and degree of anisotropy (DA). Through destructive mechanical testing, strength parameters were obtained. Results : BV/TV, SMI, BS/BV, and Tb.Th showed significant correlations with strength parameters. DA did not show any correlation with the other parameters. In multiple linear regression analysis, BV/TV alone explained $43\%$ of the variance in Young's modulus. By stepwise inclusion of SMI, the variance in the Young's modulus was better explained up to $52\%$. Conclusions : Predicting trabecular strength in the mandible through architectural analysis would be possible. Further study is needed to establish the tendency and variety of trabecular architecture and strength according to the locations within the mandible.

• Archives of Plastic Surgery
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• 제37권5호
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• pp.717-720
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• 2010

Purpose: Absorbable plate and screw fixation is widely used technique for internal rigid fixation in craniomaxillofacial surgery. However, there are some potential problems associated with the use of plate. The purpose of this study is to evaluate the feasibility of bone fixation in facial fracture using absorbable mesh in place of absorbable plate. Methods: The records of 55 patients with zygomaticomaxilla fractures treated by open reduction, performed by the author from February 2008 to May 2009, were retrospectively reviewed. Patients were selected to receive absorbable mesh fixation. The incidence of all complications including infection, hypoesthesia, and deformity was examined. Analysis with postoperative computed tomography follow-up demonstrates degree of reduction. Results: Forty-six patients met criteria for inclusion in the study. All patients went on to satisfactory healing without complication. Postoperative computed tomography revealed good bony alignment similarly non affected side. Conclusion: This study demonstrates that the rigid internal fixation of fractured bone fragments using absorbable mesh is more effective than absorbable plate, especially in comminuted fracture of maxilla.

• Transactions on Electrical and Electronic Materials
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• 제17권5호
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• pp.280-288
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• 2016

Microelectronic product consumers may already be expecting another paradigm shift with smarter phones over smart phones, but the current status of microelectronic manufacturing engineering education (MMEE) in universities hardly makes up the pace for such a fast moving technology paradigm shift. The purpose of MMEE is to educate four-year university graduates to work in the microelectronics industry with up-to-date knowledge and self-motivation. In this paper, we present a comprehensive curriculum for a four-year university degree program in the area of microelectronics manufacturing. Three hands-on experienced-based courses are proposed, along with a methodology for undergraduate students to acquire hands-on experience, towards integrated circuits (ICs) design, fabrication and packaging, are presented in consideration of manufacturing engineering education. Semiconductor device and circuit design course for junior level is designed to cover how designed circuits progress to micro-fabrication by practicing full customization of the layout of digital circuits. Hands-on experienced-based semiconductor fabrication courses are composed to enhance students’ motivation to participate in self-motivated semiconductor fab activities by performing a series of collaborations. Finally, the Microelectronics Packaging course provides greater possibilities of mastered skillsets in the area of microelectronics manufacturing with the fabrication of printed circuit boards (PCBs) and board level assembly for microprocessor applications. The evaluation of the presented comprehensive curriculum was performed with a students’ survey. All the students responded with “Strongly Agree” or “Agree” for the manufacturing related courses. Through the development and application of the presented curriculum for the past six years, we are convinced that students’ confidence in obtaining their desired jobs or choosing higher degrees in the area of microelectronics manufacturing was increased. We confirmed that the hypothesis on the inclusion of handson experience-based courses for MMEE is beneficial to enhancing the motivation for learning.

• 무역상무연구
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• 제57권
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• pp.243-282
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• 2013

This study aims to develop the research model about the factors that have impact on uTradeHub users' acceptance and resistance to innovation. The followings show the research hypotheses and the results of test. i) The result of H1 empirical analysis confirmed that relative advantage and task adaptedness of e-Trade have more impact on acceptance of innovation than on resistance to it. And also perceived risk and complicity of e-Trade have more impact on resistance of innovation than on acceptance to it. ii) The result of H2 analysis confirmed that the characteristics of foreign trading companies (support by CEO and IT infra maturity) has more impact on acceptance of innovation than on resistance to it. iii) The result of H3 analysis confirmed that characteristics of uTradeHub user' resistance has more impact on resistance of innovation than on acceptance to it. And also, it was confirmed that acceptance of innovation has more impact on the diffusion of e-Trade than resistance to innovation. iv) The result of H4 analysis confirmed that the difference of the degree and factors that has impact on the user's resistance and acceptance by adoption stage of e-Trade. This study has significance in that it arranges the concept and stages of e-Trade systematically and, unlike other studies, it goes beyond the acceptance and diffusion of e-Trade to the inclusion of resistance together in the model.