• Journal of Korean Neurosurgical Society
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• 제63권4호
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• pp.463-469
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• 2020

Objective : This study aimed to investigate the changes and significance of microRNA155 levels in serum of patients with cerebral small vessel disease (CSVD). Methods : Thirty patients with CSVD who met the inclusion criteria were selected and divided into eight patients with lacunar infarction (LI) group and 22 patients with multiple lacunar infarction (MLI) combined with white matter lesions (WML) group according to the results of head magnetic resonance imaging (MRI). Thirty samples from healthy volunteers without abnormalities after head MRI examination were selected as the control group. The levels of serum microRNA155 in each group were determined by real-time polymerase chain reaction, and the correlation between microRNA155 in the serum of patients with CSVD and the increase of imaging lesions was analyzed by Spearman correlation analysis. Results : Compared with the control group, the serum microRNA155 level in the LI group, MLI combined with WML group increased, the difference was statistically significant (p<0.05); serum microRNA155 level was positively correlated with the increase of imaging lesions (p<0.05). Conclusion : The change of serum microRNA155 level in patients with CSVD may be one of its self-protection mechanisms, and the intensity of this self-protection mechanism is positively correlated with the number of CSVD lesions.

• Asian-Australasian Journal of Animal Sciences
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• 제30권3호
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• pp.363-369
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• 2017

Objective: The current study compared the effects of dietary levels of two phase stoned olive cake (OC) in form of silage (OCS) on milk production and quality of Saanen goats. Methods: The OCS included in total mixed ration (TMR) at dry matter proportions of 0.0 (OC0), 0.10 (OC10), and 0.20 (OC20). The TMR were fed to a total of 18 goats in a completely randomized design for a period of 5 weeks. Results: Dietary treatments had no effect on the milk yield of Saanen goats, but the daily milk fat production was greater (p<0.05) at feeding OC20. The total phenolic (TP) compounds contents increased (p<0.01) in each increment of OCS in TMR and this was also reflected in the TP contents of milk. The C8:0, C10:0, C12:0, and C14:0 saturated fatty acids (FAs) in milk fat decreased (p<0.01) with increasing dietary level of OCS, but the decrease (p<0.001) in C16:0 and the increase (p<0.01) in C18:0 in milk fat occurred similarly at each inclusion level of OCS. Only OC20 reduced (p<0.05) the total saturated FA, yet the reduction (p<0.01) in n6/n3 ratio and atherogenicity index occurred in both OC10 and OC20. Conclusion: Two phase stoned OCS increases milk quality not only through modifying the milk FA composition, but also by increasing the milk TP content. These favorable changes in milk quality are closely associated with the dietary level of OCS.

• Clinical and Experimental Reproductive Medicine
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• 제41권1호
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• pp.33-36
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• 2014

Objective: To estimate the failure rate of medical treatment and to identify variables associated with treatment failure in patients with tubal pregnancy and an initial serum level of human chorionic gonadotropin (HCG) over 10,000 IU/L. Methods: The inclusion criteria were tubal pregnancy diagnosed using ultrasonography, primary treatment of intramuscular methotrexate injection at one of the four institutions between January 2003 and December 2011, a serum HCG level within two days before treatment >10,000 IU/L, and follow-up data to determine treatment success or failure. Exclusion criteria were other primary treatments besides intramuscular methotrexate injection. The clinicopathologic data of 36 patients were collected and analyzed. Results: Medical treatment failed and surgery was performed in 19 (53%) patients. In univariable analysis, age, parity, and size of the gestational sac were associated with treatment failure, but none of the variables were associated with treatment failure in multivariable analysis. The failure rate in the subgroup with age<33 years and size of gestational sac ${\geq}1.1cm$ was significantly higher than those of the other subgroups (82% vs. 41% [mean of the other subgroups], respectively). Conclusion: Patients with a serum HCG level >10,000 IU/L who received medical treatment had a high failure rate. Among them, patients aged<33 year and with a gestational sac ${\geq}1.1cm$ had an extremely high failure rate.

• Journal of Power Electronics
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• 제18권6호
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• pp.1791-1804
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• 2018

To achieve a fast dynamic response and to solve the multi-objective control problems of the output currents, capacitor voltages and system constraints, this paper proposes a deadbeat and hierarchical predictive control with space-vector modulation (DB-HPC-SVM) for five-level nested neutral point piloted (NNPP) converters. First, deadbeat control (DBC) is adopted to track the reference currents by calculating the deadbeat reference voltage vector (DB-RVV). After that, all of the candidate switching sequences that synthesize the DB-RVV are obtained by using the fast SVM principle. Furthermore, according to the redundancies of the switch combination and switching sequence, a hierarchical model predictive control (MPC) is presented to select the optimal switch combination (OSC) and optimal switching sequence (OSS). The proposed DB-HPC-SVM maintains the advantages of DBC and SVM, such as fast dynamic response, zero steady-state error and fixed switching frequency, and combines the characteristics of MPC, such as multi-objective control and simple inclusion of constraints. Finally, comparative simulation and experimental results of a five-level NNPP converter verify the correctness of the proposed DB-HPC-SVM.

• Physical Therapy Rehabilitation Science
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• 제7권2호
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• pp.49-53
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• 2018

Objective: This study was performed to examine differences in the association between straight and curved walking abilities of inpatients in the subacute phase and walking independence level. Design: Cross-sectional study. Methods: Subjects were divided into an independent group and a supervised group (n=10 each) by walking independence level within the ward decided by physical therapists. Inclusion criteria comprised the ability to ambulate independently within the ward, regardless of the use of walking aids. Straight walking abilities (walking velocity, stride length, and cadence) were evaluated using the 5-meter walk test. Curved walking abilities were evaluated using the Figure-of-8 Walk Test (F8W) and the 3-meter zigzag walk test (3ZW). Differences in associations between straight and curved walking abilities of inpatients were examined by calculating correlation coefficients between straight and curved walking abilities. Results: Age, walking velocity, stride length, F8W and 3ZW varied markedly between independent and supervised groups. In the independent group, F8W and 3ZW correlated significantly with walking velocity and cadence (p<0.05). In the supervised group, F8W correlated significantly with walking velocity and stride length (p<0.05), but 3ZW did not correlate significantly with straight walking abilities. Conclusions: The association between straight and curved walking abilities varied between inpatients who could ambulate independently and inpatients requiring supervision for ambulating. These differences may depend on skill on straight and curved walking abilities. There is a possibility that curved walking exercise is necessary for supervised group.

• Neurospine
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• 제15권4호
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• pp.368-375
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• 2018

Objective: To evaluate the results of operative management of subaxial spine injuries managed with 2-level anterior cervical corpectomy and fusion with a cervical locking plate and autologous bone-filled titanium mesh cage. Methods: This study included 23 patients with a subaxial spine injury who matched the inclusion criteria, underwent 2-level anterior cervical corpectomy and fusion at our institution between 2013 and 2016, and were followed up for neurological recovery, axial pain, fusion, pseudarthrosis, and implant failure. Results: According to Allen and Ferguson classification, there were 9 cases of distractive extension; 4 of compressive extension; 3 each of compressive flexion, vertical compression, and distractive flexion; and 1 of lateral flexion. Sixteen patients had a score of 6 on the Subaxial Injury Classification system, and the rest had a score of more than 6. The mean follow-up period was 19 months (range, 12-48 months). Neurological recovery was observed in most of the patients (78.21%). All patients experienced relief of axial pain. None of the patients received a blood transfusion. Twenty-one patients (91.3%) showed solid fusion and 2 (8.69%) showed possible pseudarthrosis, with no complications related to the cage or plate. Conclusion: Two-level anterior cervical corpectomy and fusion, along with stabilization with a cervical locking plate and autologous bone graft-filled titanium mesh cage, can be considered a feasible and safe method for treating specific subaxial spine injuries, with the benefits of high primary stability, anatomical reduction, and direct decompression of the spinal cord.

• 한국의학물리학회지:의학물리
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• 제32권4호
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• pp.92-98
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• 2021

Purpose: This study automatically discriminates homogeneous and structure edge regions on computed tomography (CT) images, and it evaluates the noise level and edge preservation ratio (EPR) according to the different types of iterative reconstruction (IR). Methods: The dataset consisted of CT scans of 10 patients reconstructed with filtered back projection (FBP), statistical IR (iDose⁴), and iterative model-based reconstruction (IMR). Using the 10th and 85th percentiles of the structure coherence feature, homogeneous and structure edge regions were localized. The noise level was estimated using the averages of the standard deviations for five regions of interests (ROIs), and the EPR was calculated as the ratio of standard deviations between homogeneous and structural edge regions on subtraction CT between the FBP and IR. Results: The noise levels were 20.86±1.77 Hounsfield unit (HU), 13.50±1.14 HU, and 7.70±0.46 HU for FBP, iDose⁴, and IMR, respectively, which indicates that iDose⁴ and IMR could achieve noise reductions of approximately 35.17% and 62.97%, respectively. The EPR had values of 1.14±0.48 and 1.22±0.51 for iDose⁴ and IMR, respectively. Conclusions: The iDose⁴ and IMR algorithms can effectively reduce noise levels while maintaining the anatomical structure. This study suggested automated evaluation measurements of noise levels and EPRs, which are important aspects in CT image quality with patients' cases of FBP, iDose⁴, and IMR. We expect that the inclusion of other important image quality indices with a greater number of patients' cases will enable the establishment of integrated platforms for monitoring both CT image quality and radiation dose.

• 지식경영연구
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• 제23권4호
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• pp.1-19
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• 2022

언택트 문화가 확산되면서 취약계층의 디지털 정보의 접근성 문제인 디지털정보격차가 사회·문화 분야를 비롯한 다양한 분야에서 정보의 불평등을 초래할 수 있다. 이에 본 연구는 취약대층을 대상으로 디지털 정보격차수준을 파악하고 정보의 접근성, 인구사회학적특성, 신체 및 정신건강 특성이 정보수준에 미치는 영향을 분석하였다. 그 결과, 정보접근성이 높을수록 정보격차는 감소하고 디지털활용능력수준은 증가하는 것으로 나타나고 있어 정보기기의 접근성을 높이고 활용할 수 있는 역량을 갖출 수 있는 기회를 제공해야 할 것이다. 또한 연령이 높을수록, 남성보다는 여성이, 소득수준이 낮을수록 정보격차가 커지는 것으로 나타나고 있어 취약계층에 대한 세부적인 계층별 프로그램을 통해 디지털 역량을 높일 수 있는 방안이 필요하다. 마지막으로 정보격차와 디지털활용능력수준은 취약계층의 삶의 만족도와 일상생활의 만족도에 유의한 영향을 미치고 있어 디지털 포용정책으로 패러다임을 전환하여 정보 활용 역량을 높이기 위한 역량강화 교육프로그램 확대가 지속적으로 운영되어야 할 것이다.

• 한국가금학회지
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• 제42권2호
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• pp.139-145
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• 2015

본 실험은 감초와 구기자 복합제 수준별 급여가 육계의 생산성, 혈액성상, 면역성상 및 장내 미생물 균총에 미치는 영향을 조사하기 위하여 실시하였다. 육계(ROSS 308) 750수를 공시하여 3처리 5반복으로 반복당 50수씩 완전 임의 배치하여 자유 섭식하게 하였으며, 35일간 전기(0~21일), 후기(22~35일)로 나누어 실시하였다. 처리구는 HM 0.0, 0.5 및 1.0% 첨가구 총 3처리구로 구성하였다. 35일 시험결과, Stater 급여기간(0 to 21d) 동안에는 증체량은 사료 내 LF and GU mixture 수준이 증가할수록 유의하게 증가하였으며(quadratic, P<0.05), 사료 요구율 역시 유의하게 감소하였다(quadratic, P<0.05). 전 기간(0 to 35 d)에서는 증체량은 사료 내 HM 수준이 증가할수록 유의하게 증가하였으며(linear and quadraric, P<0.05), 사료 섭취량과 사료 요구율은 처리 간에 유의적인 차이는 나타나지 않았다. 반면, 혈액 성상 중 leukocytes 함량들은 모든 항목에서 유의적인 차이가 나타나지 않았으며, 혈장 IgG 함량은 사료 내 LF and GU mixture 수준이 증가함에 따라(quadratic, P<0.05) 증가하였다. 또한 유익균인 Lactobacillus 함량은 사료 내 LF and GU mixture 수준이 증가함에 따라(linear, P<0.05) 증가하였으며, 유해균인 Escherichia coli 함량은 감소하였다(quadratic, P<0.01). 결론적으로 LF and GU mixture은 육계의 성장 개선에 효과적이었으며, 면역성상 중 IgG를 향상시키는 효과와 장내 미생물 균총 환경 개선이 효과적이었다.

• Asian-Australasian Journal of Animal Sciences
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• 제28권7호
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• pp.958-965
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• 2015

Lycopene, a red non-provitamin A carotenoid, mainly presenting in tomato and tomato byproducts, has the highest antioxidant activity among carotenoids because of its high number of conjugated double bonds. The objective of this study was to investigate the effect of lycopene supplementation in the diet on plasma lipid profile, lipid peroxidation and antioxidant defense system in feedlot lamb. Twenty-eight Bamei male lambs (90 days old) were divided into four groups and fed a basal diet (LP0, 40:60 roughage: concentrate) or the basal diet supplemented with 50, 100, and 200 mg/kg lycopene. After 120 days of feeding, all lambs were slaughtered and sampled. Dietary lycopene supplementation significantly reduced the levels of plasma total cholesterol (p<0.05, linearly), total triglycerides (TG, p<0.05) and low-density lipoprotein cholesterol (LDL-C, p<0.05), as well as atherogenic index (p<0.001), whereas no change was observed in high-density lipoprotein cholesterol (p>0.05). The levels of TG (p<0.001) and LDL-C (p<0.001) were decreased with the feeding time extension, and both showed a linear trend (p<0.01). Malondialdehyde level in plasma and liver decreased linearly with the increase of lycopene inclusion levels (p<0.01). Dietary lycopene intake linearly increased the plasma antioxidant vitamin E level (p<0.001), total antioxidant capacity (T-AOC, p<0.05), and activities of catalase (CAT, p<0.01), glutathione peroxidase (GSH-Px, p<0.05) and superoxide dismutase (SOD, p<0.05). The plasma T-AOC and activities of GSH-Px and SOD decreased with the extension of the feeding time. In liver, dietary lycopene inclusion showed similar antioxidant effects with respect to activities of CAT (p<0.05, linearly) and SOD (p<0.001, linearly). Therefore, it was concluded that lycopene supplementation improved the antioxidant status of the lamb and optimized the plasma lipid profile, the dosage of 200 mg lycopene/kg feed might be desirable for growing lambs to prevent environment stress and maintain normal physiological metabolism.