• Ocean and Polar Research
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• v.40 no.1
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• pp.23-35
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• 2018

A small cyclopoid copepod M. subtilis (Giesbrecht, 1893 ["1892"]) belonging to the genus Monothula $B{\ddot{o}}ttger-Schnack$ and Huys, 2001 was collected by using $60{\mu}m$ mesh net and firstly recorded in the epipelagic layer of the equatorial Pacific Ocean. We redescribed its morphological characteristics for both female and male, comparing with those of previous studies. Specimens of M. subtilis from the equatorial Pacific Ocean differ from those previously reported by others in terms of the length of the seta G on antenna, being much shorter than setae E and F; in the distal spine on the swimming leg 4, being longer than the length of the third segment on P4. The outer spine of the P3 enp-3 in male is slightly over the tip of conical process. The spine lengths of the distal endopods of P2-P4 for both sexes showed variations among individuals, and the proportions of spine lengths in female are higher than those in male.

• Journal of Korea Multimedia Society
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• v.25 no.1
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• pp.10-28
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• 2022

In this paper, we present an entry-level COVID-19 stand-alone digitial signage player (CoSiP) which performs not only conventional digital signage functionalities but also fever detection, face mask wearing detection, and KI-pass QR code checking. The overall design of CoSiP is proposed, and implementation of a temperature checking algorithm using a low cost thermal sensor is elaborately presented. Through experiments over datasets and against a developed CoSiP device, it is shown that the fever detection, face mask wearing detection, KI-pass QR code checking as well as signage functionalities of the proposed CoSiP work properly and reliably.

• Korean Chemical Engineering Research
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• v.61 no.4
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• pp.570-575
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• 2023

Targeted anticancer drug delivery systems are needed to enhance therapeutic efficacy by selectively delivering drugs to tumor cells while minimizing off-target effects, improving treatment outcomes and reducing toxicity. In this study, a silica-based nanocarrier capable of targeting drug delivery to cancer cells was developed. First, silica nanoparticles were synthesized by the Stöber method using the surfactant cetyltrimethylammonium bromide (CTAB). Increasing the ratio of EtOH in the solvent produced uniformly spherical silica nanoparticles. Washing the nanoparticles removed unreacted residues, resulting in a non-toxic carrier for drug delivery in cells. Upon surface modification, the pH-responsive polymer, polyethyleneimine (PEI) exhibited slow doxorubicin release at pH 7.4 and accelerated release at pH 5.5. By exploiting this feature, we developed a system capable of targeted drug release in the acidic tumor microenvironment.

• Korean Journal of Poultry Science
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• v.42 no.4
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• pp.291-297
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• 2015

We investigated the effects of dietary pearlzyme (mudflat-bacteria origin protease) on growth performance and development of digestive organs in broilers. Two hundred forty, 4 day-old female Ross broiler chicks were divided into 2 groups (control vs. pearlzyme) which were randomly housed in 8 pens with 15 chicks/pen. They were fed one of two diets containing pearlzyme at 0 or 0.1% for 4 weeks. Dietary pearlzyme resulted in significant increase in body weight during the first week of the experiment (p<0.05). With age, weight gain and feed efficiency continued to decrease reaching significant level during the last week. Mortality was 3.3% in control but not in pearlzyme during the entire period of the experiment. Dietary pearlzyme resulted in increased weight (p<0.05) in the ceca and rectum, and increased length in the ceca (p<0.05). However, there were tendencies to increase the weight of the gizzard (p<0.071) but to decrease the length of the small intestine (p<0.068). The results of the current study show that dietary pearlzyme affects weight gain and the development of digestive organs.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.1
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• pp.67-73
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• 2015

Purpose: This study was investigated the relationship between the male and female of near stereoacuity and phoria, and was examined the correlations between near stereoacuity and phoria and refractive error. Methods: Adult 83 (male 36, female 47, mean age $21.09{\pm}1.74$(19~29) years old) target was examined after full correction of refractive error. Near stereoacuity was measured by using Titmus-fly Stereotest(Stereo Optical Co., Inc., Chicago, IL, USA), and RANDOT Stereotest (Stereo Optical Co., Inc., Chicago, IL, USA), phoria was measured by using modified torrington method, at distance 40 cm. Results: In near stereoacuity, male was better good than female, and there was no difference between male and female (p>0.05). In near phoria, female was more higher than male, and there was a significant difference between male and female (p<0.05). Near stereoacuity by Titmus-fly test and Randot test result respectively was $262.17{\pm}562.43$ sec (second of arc) $243.08{\pm}68.04$ sec in esophoria, $148.42{\pm}269.54$ sec, $107.40{\pm}263.74$ sec in orthophoria, $113.94{\pm}152.46$ sec, $79.70{\pm}136.83$ sec in exophoria, there was a no difference between three phoria groups (p>0.05), and was a high correlation between phoria and near stereoacity(r=0.68). In addition, near stereoacuity in the refractive error respectively was $80.00{\pm}571.43$ sec, $68.75{\pm}36.82$ sec in myopia, $133.57{\pm}224.15$ sec, $93.14{\pm}214.95$ sec in hyperopia, $511.20{\pm}855.00$ sec, $511.4{\pm}855.60$ sec, there was a significant difference between three phoria groups (p<0.05). when was classfiied near stersoacuity into degree of refractive error, near stersoacuity was best in emmetropia, and was reduced when refractive error was highest in high degree myopia, and hyperopia. Conclusions: Titmus-fly Stereotest and RANDOT Stereotest result, near stereoacuity of adults, when esophoria and high degree refractive error, was reduced, there was a relationship between near stereoacuity with phoria, and refractive error. In this both stereotests if was bad when near stereoacuity can expect a phoria and refractive error.

• Journal of Microbiology and Biotechnology
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• v.13 no.3
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• pp.444-450
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• 2003

In order to develop an effective means to treat P. aeruginosa infections, we have purified P. aeruginosa outer membrane proteins (OMPs)-specific human IgG antibody. In this study, we investigated the protective activity of the purified anti-OMPs IgC against P. aeruginosa infection in a rabbit endophthalmitis model. Rabbits were inoculated by an intravitreal injection with P. aeruginosa, and treated with a single dose of 1 mg anti-P. aeruginosa OMPs IgG. All the control rabbits predominantly developed edematous responses and opacity in the eyes, but the rabbits treated with the antibody showed only very limited degree of edema. Aliquots of the vitreous humor were extracted and analyzed for the number of viable bacteria and endotoxin level. The results showed that the anti-OMPs IgC significantly reduced the bacterial count compared with the control group, and that the endotoxin level of the vitreous from the IgG-treated rabbits was more than 70-fold lower 6 h after the administration than the control animals. These data suggested that the anti-P. aeruginosa OMPs IgG is effective in inhibiting the bacterial growth and thereby in reducing endotoxin levels in the vitreous, warranting further development of the anti-P. aeruginosa OMPs IgG as a therapeutic means for treating Pseudomonas endophthalmitis.

• Journal of Microbiology and Biotechnology
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• v.12 no.5
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• pp.844-848
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• 2002

In more than half of human tumors, the p53 tumor suppressor gene is mutated. Thus, restoration of wild-type p53 activity by repair of mutant RNA could be a potentially promissing approach to cancer treatment. To explore the potential use of RNA repair for cancer therapy, trans-splicing group I ribozymes were developed that could replace mutant p53 RNA with RNA sequence attached to the 3'end of ribozymes. By employing a mapping library of ribozymes, we first determined which regions of the p53 RNA are accessible to ribozymes, and found that the leader sequences upstream of the AUG start codon appeared to be particularly accessible. Next, trans-splicing ribozymes were generated that specifically recognized the sequences around these accessible regions. Subsequently, the ribozymes reacted with and altered the p53 transcripts by transferring a 3'exon tag sequence onto the targeted p53 RNA with high fidelity. Thus, these ribozymes could be utilized to repair mutant p53 in tumors, which would revert the neoplastic phenotype.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.06a
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• pp.55-56
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• 2007

The p-type ZnO thin film, fabricated by means of the ampoule-tube method, was used to make the ZnO p-n junction, and its characteristics was analyzed. The ampoule-tube method was used to make the p-type ZnO based on the As diffusion, and the hall measurement was used to confirm that the p-type is formed. the current-voltage characteristics of the ZnO p-n junction were measured to confirm the rectification characteristics of a typical p-n junction and the low leakage voltage characteristics. Using the ampoule-tube to fabricate the p-type ZnO will provide a very useful technology for producing the UV ZnO LED and ZnO-based devices.

• Journal of Microbiology and Biotechnology
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• v.12 no.4
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• pp.657-663
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• 2002

Probiotics have been suggested to improve gastrointestinal health in humans. To investigate the effects of Bacillus polyfermenticus SCD administration on fecal microflora and putrefactive metabolites in humans, Bacillus polyfermenticus SCD (4.00${\times}$10$\sub$5/ CFU/mg) was administrated to ten healthy subjects (5 men and 5 women, average age 24 years) three times a day for 2 weeks. Fecal samples were collected before (1st and 2nd weeks, control), during (3rd and 4th weeks), and 2 weeks after the administration. The fo11owing microbial groups were evaluated in the feces: aerobic and anaerobic bacteria, Bacillus polyfermenticus SCD, Lactobacillus, Bifidobacterium, total lactic acid bacteria, Salmonella, Clostridium, Clostridium perfringens, Eubacterium, Staphylococcus, Coliform bacteria, Pseudomunas, and Yeast. Fecal concentrations of total aerobic bacteria (p<0.05, p<0.01, 3rd and 4th weeks), total lactic acid bacteria (p<0.01, 3rd, 4th and 5th weeks), and Bifidobacteria (p<0.05, 4th and 5th weeks) were significantly increased in all subjects, compared to the control, from the 3rd week after the administration of the products. Clostridium (p<0.01, 4th week), Clostridium perfringens (p<0.05, p<0.01, 3rd and 4th weeks), and coliform (p<0.01,5th week) were significantly reduced from the 3rd week of administration. No significant changes in the fecal concentrations of Pseudomonas, Lactobacillus, Eubacterium, Staphylococcus, yeast, and total anaerobes were observed. Six weeks after the administration, the concentration of all rnicroorganlsrns returned to the basal level. Bacillus polyfermenticus SCD was significantly maintained from the 3rd week to 6th week of the study. Despite the absence of a statistical significance, the putrefactive metabolites (ammonia, indole, skatole, and $\rho$-cresol) and the pH value tended to be lower during and after the test periods than the base line. These results show that this probiotic preparation is able to colonize the intestine, and suggest that it may be useful as a beneficial probiotic in humans.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.1
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• pp.61-69
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• 2001

A total of 120 pigs were used to investigate the effects of yucca extracts on the growth performance, nutrient digestibility and excretion of growing pigs fed different levels of dietary protein. Pigs were allotted into $2{\times}3$ factorial design by the supplementation with yucca extract (YE, 0 and 120 mg/kg) and 3 levels of dietary protein (16, 18, 20%). During the whole experimental period (18 to 52 kg body weight), there were no significant differences in ADG, ADFI or F/G by YE addition or different protein levels among treatments (p>0.05). Overall, although addition of YE to the diet and elevation of protein level showed better ADG, there were no significant differences in growth performance among treatments. Pigs fed diets with YE showed significantly (p<0.05) higher dry matter (DM), crude ash (CA) and crude protein (CP) digestibility than did the others during the growing period. Concerning the levels of dietary protein, only the CP digestibility was significantly higher in pigs fed high protein diet. Pig fed the low protein diet without YE showed a significantly low CP digestibility (p<0.05). No significant differences were found in crude fat (CF), calcium (Ca) and phosphorus (P) digestibilities regardless of YE supplementation or dietary protein levels. Pigs fed YE supplemented diets showed significantly (p<0.05) higher amino acid digestibility. Also, high CP level diets showed a higher amino acid digestibility than low CP diets (p<0.05). DM and N excretion did not show any significant differences among treatments, there was a slightly lower excretion with increase in dietary protein level. Supplementation with YE significantly decreased the DM and N excretion. Interaction (YE$\times$protein) was found in P excretion. Pigs fed a medium protein diet without YE showed the lowest P excretion during the growing period. The NH3-N content in the feces tended to be increased by the increased dietary protein levels and with YE supplementation. During the whole experimental period, the cost for YE supplementation was similar to value of the improvements of performance obtained. The cost of feeding high level protein was significantly higher than that of medium level protein by 10% and low level protein by 9% (p<0.05). It could be concluded that the effects of dietary protein level and yucca extract on growth performance, nutrient digestibility and excretion might play a role to some extent in growing pigs from the aspect of pollution control.