• Toxicological Research
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• v.30 no.3
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• pp.211-220
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• 2014

Resveratrol has received considerable attention as a polyphenol with various biological effects such as anti-inflammatory, anti-oxidant, anti-mutagenic, anti-carcinogenic, and cardioprotective properties. As part of the overall safety assessment of HS-1793, a novel resveratrol analogue free from the restriction of metabolic instability and the high dose requirement of resveratrol, we assessed genotoxicity in three in vitro assays: a bacterial mutation assay, a comet assay, and a chromosomal aberration assay. In the bacterial reverse mutation assay, HS-1793 did not increase revertant colony numbers in S. typhimurium strains (TA98, TA100, TA1535 and TA1537) or an E. coli strain (WP2 uvrA) regardless of metabolic activation. HS-1793 showed no evidence of genotoxic activity such as DNA damage on L5178Y $Tk^{+/-}$ mouse lymphoma cells with or without the S9 mix in the in vitro comet assay. No statistically significant differences in the incidence of chromosomal aberrations following HS-1793 treatment was observed on Chinese hamster lung cells exposed with or without the S9 mix. These results provide additional evidence that HS-1793 is non-genotoxic at the dose tested in three standard tests and further supports the generally recognized as safe determination of HS-1793 during early drug development.

• (The)Study of the Eastern Classic
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• no.49
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• pp.261-295
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• 2012

In the past, 'Samcheong-Dong'(三淸洞) was the most beautiful place in Seoul. So this place appealed to everyone. Regardless of their position, people of all age and both sexes wanted to go Samcheong-Dong. And in Samcheong-Dong, the temple of Taoism(道敎) that named Sokeokseou(昭格署) hold ritual to Heaven. Many poets wrote poem about this temple. As a result, Samcheong-Dong has the aura of the sacred mood. Because of the breathtaking landscapes, many people meet in Samcheong-Dong, and hold the poetry club. Not only the upper ten, but also the middle class people composed poems and published many books of poem. The image of Samcheng-Dong that our contemporaries must remember is the next three distinctive qualities. In the first, the Korean unique temple of Taoism was located in Samcheong-Dong. Secondly, the house of royal family and the upper ten was adjacent to Samcheong-Dong, so this place has the aura of high culture. Thirdly, many poem was created in Samcheong-Dong, so this place leave a masterpiece of middle class that will go down in literary history.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2002.05a
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• pp.269-271
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• 2002

In this paper, we consider the fuzzy linear regression line for fuzzy number data.

• Radiation Oncology Journal
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• v.37 no.3
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• pp.207-214
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• 2019

Purpose: To identify the prognostic factors that could influence survival and to compare prognoses of the patients with the number of the risk factors that might assist in the adequate management of hepatocellular carcinoma (HCC) patients with bone metastases that showed a heterogeneous range of survival. Materials and Methods: A total of 41 patients, treated with radiotherapy (RT) for bone metastases from HCC from 2014 to 2017, were enrolled retrospectively. Survival was determined by the Kaplan-Meier method from the start of the RT for metastatic bone lesions. Pre-RT clinical features were evaluated and their influences on survival were analyzed. The significant factors were considered to compare survivals according to the number of prognostic factors. Results: Median follow-up was 6.0 months (range, 0.5 to 47.0 months). The median overall survival was 6.5 months, and the 1-year and 2-year survival rates were 35.5% and 13.5%, respectively. Multivariate analysis revealed that the Child-Pugh class A group, alpha-fetoprotein increased more than 30 ng/mL, and HCC size of more than 5 cm were associated with worse overall survival. The median survivals in HCC with none, 1, 2, and 3 of the aforementioned risk factors were 19.5, 9.0, 2.5, and 1.0 months, respectively (p < 0.05). Conclusion: Our results show that the overall survivals were significantly different according to the number of the risk factors among HCC patients with bone metastases who showed various lengths of survival.

• The Journal of Internal Korean Medicine
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• v.28 no.4
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• pp.733-740
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• 2007

Objective : This study investigated the relationship between warning signs and Sasang constitution (SC) in acute stroke patients. Methods : From October in 2005 to March in 2007, 629 acute stroke patients were studied. Patients were hospitalized within 14 days after the onset ofstroke at one of 3 oriental medical hospitals in Seoul and Kyong-gi province. We assessed the type of SC of acute stroke patients by Questionnaire for Sasang Constitution Classification II (QSCC II). We investigated warning signs (motor weakness, blindness, dysarthria, sensory disturbance, finger dullness, facial & eyelid spasm, neck stiffness), general characteristics, etc. Results : This study showed a higher proportion of Tae-eum & So-eum experience upper extremity sensory disturbance but So-yangexperience lower extremity sensory disturbance. Smoker So-eumexperience 1st & 2nd finger dullness more than non-smoker So-eum. So-eum women experience motor weakness more than So-eum men. Conclusion : Besides these results, we could observe almost no relationship between warning signs and Sasang constitution (SC) in acute stroke patients. More data from prospective cohort studies will help people better understand the relationship between warning signs and Sasang constitution (SC) in acute stroke patients.

• Journal of Acupuncture Research
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• v.20 no.2
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• pp.11-17
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• 2003

Objective : The aim of this research was to investigate the depressive effect of depletion of B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patients. Methods : Depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patient who were admitted in Dong-Seo Oriental Medical Hospital every other day form 4 weeks, without western antihypertensive drug. Results : After treatment in 2nd week, depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) without western antihypertensive drug increased the systolic and diastolic blood pressure. After treatment in 4th week, depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) without western antihypertensive drug decreased the systolic and diastolic blood pressure. After treatment in 4th week, values of RBC and hemoglobine were not significantly changed. Conclusions : Continous depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patient without western antihypertensive drug implies decreasement of blood pressure, without change of values of RBC and hemoglobine.

• Current Research on Agriculture and Life Sciences
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• v.20
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• pp.33-38
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• 2002

The purpose of this study is to analysis of disposition distance of city park for the plan of suitable arrangement of city park based on the date examining Daegu Metropolitan City. The results of this study are as follows. 1) The result of analysis of population density as the case of districts, it appeared highly in city center area which Seo-Gu district and Nam-Gu district besides Jung-Gu district. However, it apperared in a low Buk-Gu district, Dong-Gu district and Salseong-Gun. 2) The result of analysis of population density as the case of regions, it appeared very highly Joukjun-Dong of Dalseo-Gu district($31,554per/km^2$), Naedang-Dong of Seo-Gu district($29,922per/km^2$). However it appeared in a low Yeuga-Maen($85per/km^2$) and Gachang-Maen($94per/km^2$) of Dalseong-Gun. The regions where the population density is high have very low green space and live a lot of low income layer. 3) The result of analysis of disposition distance, in the case of children park, it appeared an intensive distribution in Dongcheon-Dong and Guam-Dong of Buk-Gu district, Whanggm-Dong and Dusan-Dong of Suseong-Gu district, Sangin-Dong and Yeongsan-Dong and Walsung-Dong of Dalseo-Gu district. however, it appeared in a low in Jung-Gu district. The case of urban park of the neighboring area, it appeared the most in Dalseo-Gu district except 2 parks in Jung-Gu district, the case of urban park of the walking area, it appeared in equality in city. 4) In conclusion, the area have high population density and lots of low income layer, is in out of disposition distance should be considered in first for city park plan.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2002.07a
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• pp.211-211
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• 2002

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.135.2-136
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• 2001

• Journal of Haehwa Medicine
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• v.16 no.2
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• pp.7-12
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• 2007

This paper is study on Dong-Eue-Bo-Gam(東醫寶鑑) Dong-Eue-Bo-Gam(單方門)that is written by Heo-Joon. When Heo-Joon worte Dong-Eue-Bo-Gam(東醫寶鑑) between 1596 and 1610, it was the time for the people's healthy to be threatened by all kinds of infections and malnutrition. Dong-Eue-Bo-Gam(東醫寶鑑) compiled Chinese medical books and our medical books that still exists systematically. Especially there was Dan-Bang-Mun(單方門), medical art that is to use only one herb, at the end of each chapter for the people to treat disease. There was Tang-Aek-Pyun the end of Dong-Eue-Bo-Gam(東醫寶鑑). In this part, as it says herbs in rural areas were written in details, it was easy for everyone to get herbs to prevent any disease and to treat their sickness. That's why I'd like to succeed to our senior doctors' spirit for the medicine. So I decided to study Tang-Aek-Pyun that is based on Dan-Bang-Mun in Dong-Eue-Bo-Gam(東醫寶鑑) and many herbs that refer to the 4th of Gang-Je-By-Geup(廣濟秘笈). Medicine that was introduced in Dan-Bang-Mun(單方門) was 860 kinds of medicine. Among them, I choose about 3 kinds of medicine that was used the most frequently.