• Journal of Pharmaceutical Investigation
• /
• v.16 no.1
• /
• pp.31-35
• /
• 1986

Effect of ethanol on the absorption rate, blood level and bioavailability of sulfamethazine (SM) in rats was determined. Absorption rate of SM was determined both by the in vitro and in situ experiment. In vitro, absorption rate of SM in rat small intestine was increased by 0.3, 1.0 and 3.0% ethanol. In situ, absorption rate of SM was increased by 0.3 and 1.0% ethanol but not by 3.0% ethanol. After oral administration, blood level of SM was elevated and relative bioavailability was significantly increased to 114.8% at the dose of 0.6g/kg ethanol but not significantly at the dose of 3.0g/kg ethanol. The time for attainment of peak blood level was changed from 2.5 to 1.5hr. Ethanol enhanced absorption rate constant of SM significantly and reduced elimination rate constant of SM administered orally at the dose of 0.6g/kg ethanol.

• Journal of the Semiconductor & Display Technology
• /
• v.20 no.3
• /
• pp.27-31
• /
• 2021

VI probe, which is one of various in-situ plasma monitoring sensor, is frequently used for in-situ process monitoring in mass production environment. In this paper, we correlated the plasma etch results with VI probe data with the small amount of gas flow rate changes to propose usefulness of the VI probe in real-time process monitoring. Several different sized contact holes were employed for the etch experiment, and the etched profiles were measured by scanning electron microscope (SEM). Although the shape of etched hole did not show satisfactory relationship with VI probe data, the chamber status changed along the incremental/decremental modification of the amount of gas flow was successfully observed in terms of impedance monitoring.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.12 no.2
• /
• pp.107-119
• /
• 2014

The worldwide Status-of-Art survey for the in-situ experiments of the engineered barrier system for HLW underground disposal was performed as a preliminary action for the design of the in-situ demonstration at KURT. Some nations, which have executed or is ongoing the in-situ experiments at their underground research facilities, were summarized in this review. The demonstration projects reviewed were TBT/Sweden-France, LOT/Sweden, HE-E/Switzerland, PRACLAY/Belgium, FEBEX/Spain, HORONOBE/Japan, and BCE/Canada. The investigated items for the projects were mainly their purposes, constitutional structures, test conditions, monitoring parameters and the measuring tools, and test results. In this review, the hardware design and the assembling of the test system were more concentrated rather than their experimental results, because the purpose of this review is to achieve the necessary information for the practical design of the in-situ experiment to be installed at KURT. A mid scale in-situ demonstration of EBS at KURT, that is called IN-DBES, will be launched right after the completion the expanding project of KURT in 2015. It is hoped that the structural design, installing methods, hardware equipments required in the establishment of IN-DEBS will be referred on this review.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.14 no.3
• /
• pp.221-230
• /
• 2002

In this study, in-situ performance test of an air source heat pump which has a arted capacity of 10 RT is carried out. Since test conditions, such as indoor and outdoor air conditions cannot be controlled to satisfy the standard test conditions, experiments are done with the inlet air conditions as they exist. To estimate the performance for other conditions, he heat pump is modeled with a small number of selected parameters. The values of the parameters are determined from the few measurements measured on-site during normal operation. A simulation program is developed to calculate cooling capacity and power consumption t any other operating conditions. The simulation results are in good agreement with the experiment. This study provides a method of an on-site performance diagnosis of an air source heat pump.

• Korea-Australia Rheology Journal
• /
• v.16 no.3
• /
• pp.147-152
• /
• 2004

Ultrasound-assisted melt mixing was applied to blending polystyrene (PS) and low density polyethylene(LDPE). The influence of the ultrasonic irradiation on the morphology and mechanical properties of the blends was investigated. It was observed that the domain sizes of the blend were significantly reduced and phase stability was well sustained even after a thermal treatment. Such morphological feature was consistent with the improvements in mechanical performance of the blends. The desirable results of ultrasonic compatibilization are mainly attributed to the in-situ formation of PS-LDPE copolymers as confirmed by a proper separation experiment. An important relationship between ultrasonic irradiation time and mechanical properties is revealed and an issue on the thermal stability of the blend is discussed.

• Proceedings of the Polymer Society of Korea Conference
• /
• 2006.10a
• /
• pp.71-72
• /
• 2006

We investigated a simultaneous living anionic polymerization process of isoprene (I) and 4styrene-d_8$ (S) in $benzene-d_6$ as a solvent with sec-buthyllithium as an initiator into polyisoprene(PI)-block-poly($styrene-d_8$)(PS) and the polymerization-induced molecular self-assembling process. This process was observed in-situ by time-resolved small-angle neutron scattering (SANS) experiment. The SANS profiles measured exhibited three time regions, where (i) the selective growth of PI chains occurs; (ii) the living chain ends switch from isoprenyllithium to styryllithium, and (iii) the SANS exhibited the polymerization induced disorder-to-order transition and order-to-order transition.

• Journal of Environmental Science International
• /
• v.11 no.12
• /
• pp.1333-1337
• /
• 2002

A significant fraction of nutrients, such as nitrogen and phosphorus released from sediment are utilized by primary production in the shallow water of coast and lake. The purpose of this study is to introduce the mechanism of nutrients release from sediment and to introduce the methods of the measurement of nutrient released from sediment. One approach is to calculate nutrients released from sediment by a concentration gradient between sediment pore waters and overlying water based on the Fick's law. The other approaches of measurement are the undisturbed sediment core experiments and measurement of nutrient released from sediment by the in situ chamber equipment.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2012.02a
• /
• pp.523-523
• /
• 2012

As the wafer geometric requirements continuously complicated and minutes in tens of nanometers, the expectation of real-time add-on sensors for in-situ plasma process monitoring is rapidly increasing. Various industry applications, utilizing plasma impedance monitor (PIM) and optical emission spectroscopy (OES), on etch end point detection, etch chemistry investigation, health monitoring, fault detection and classification, and advanced process control are good examples. However, process monitoring in semiconductor manufacturing industry requires non-invasiveness. The hypothesis behind the optical monitoring of plasma induced ion current is for the monitoring of plasma induced charging damage in non-invasive optical way. In plasma dielectric via etching, the bombardment of reactive ions on exposed conductor patterns may induce electrical current. Induced electrical charge can further flow down to device level, and accumulated charges in the consecutive plasma processes during back-end metallization can create plasma induced charging damage to shift the threshold voltage of device. As a preliminary research for the hypothesis, we performed two phases experiment to measure the plasma induced current in etch environmental condition. We fabricated electrical test circuits to convert induced current to flickering frequency of LED output, and the flickering frequency was measured by high speed optical plasma monitoring system (OPMS) in 10 kHz. Current-frequency calibration was done in offline by applying stepwise current increase while LED flickering was measured. Once the performance of the test circuits was evaluated, a metal pad for collecting ion bombardment during plasma etch condition was placed inside etch chamber, and the LED output frequency was measured in real-time. It was successful to acquire high speed optical emission data acquisition in 10 kHz. Offline measurement with the test circuitry was satisfactory, and we are continuously investigating the potential of real-time in-situ plasma induce current measurement via OPMS.

• Atmosphere
• /
• v.29 no.4
• /
• pp.355-365
• /
• 2019

Based on in-situ monitoring data produced by National Institute of Meteorological Sciences, we evaluated the performance of Joint UK Land Environment Simulator (JULES) on the surface energy balance for rice-paddy and cropland in Korea with the operational ancillary data used for Unified Model (UM) Local Data Assimilation and Prediction System (LDAPS) (CTL) and the high-resolution ancillary data from external sources (EXP). For these experiments, we employed the one-year (March 2015~February 2016) observations of eddy-covariance fluxes and soil moisture contents from a double-cropping rice-paddy in BoSeong and a cropland in AnDong. On the rice-paddy site the model performed better in the CTL experiment except for the sensible heat flux, and the latent heat flux was underestimated in both of experiments which can be inferred that the model represents flood-irrigated surface poorly. On the cropland site the model performance of the EXP experiment was worse than that of CTL experiment related to unrealistic surface type fractions. The pattern of the modeled soil moisture was similar to the observation but more variable in time. Our results shed a light on that 1) the improvement of land scheme for the flood-irrigated rice-paddy and 2) the construction of appropriate high-resolution ancillary data should be considered in the future research.

• Korean Journal of Veterinary Research
• /
• v.37 no.4
• /
• pp.793-807
• /
• 1997

We tried to develop detection system of porcine reproductive and respiratory syndrome virus(PRRSV) by in situ hybridization(ISH) in the piglets experimentally infected with KPRRS-2, the Korean isolate(12 piglets) or Mn-1b, the American isolate(4 piglets), and in the natural infection suspected 6 piglets. Twelve 30-days-old piglets(two pigs per each inoculated group) were inoculated by nasal instillation of KPRRS-2 virus(total dose $10^{4.5}TCID_{50}$), Six piglets(one pig per each group) were induced contact infection with inoculated piglets, during the experiment, and two piglets were used as control. Inoculated or contacted piglets were euthanized at 1, 3, 5, 7, 14 and 21 days postinoculation(DPI). The respiratory signs such as coughing and nasal discharge were observed on day 3 DPI, and ear cyanosis were on day 5 DPI, including contacted piglets. Through the necropsy, purple discolorization of dorsal part of lung, and hypertrophy of local lymph nodes were observed. The histopathological lesions of lung were interstitial pneumonia characterized by type 2 pneumocyte hyperplasia. We prepared the probe for ISH by RNA isolation from KPRRS-2, RT-PCR, and biotin labeling. We performed the ISH within only 1~2 hours using $Microprobe^{TM}$ capillary action system. As the results, the strong red specific positive signals, means PRRSV distribution, was mainly observed in the cytoplasm of alveolar macrophages. And also signals were detected in some type 2 pneumocytes and bronchiolar epithelium of lung, myocardium, liver, kidney, tonsil, spleen, gastrointestinal mucosa, testis and lymph nodes.