• 제목/요약/키워드: In folic acid

검색결과 262건 처리시간 0.031초

Evaluation of 8-week body weight control program including sea tangle (Laminaria japonica) supplementation in Korean female college students

  • You, Jeong-Soon;Sung, Min-Jung;Chang, Kyung-Ja
    • Nutrition Research and Practice
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    • 제3권4호
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    • pp.307-314
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    • 2009
  • This study was conducted to evaluate the effects of a body weight control program with supplementation of sea tangle (20 g/day) on 22 female college students. The contents of the program for 8 weeks contained diet therapy, exercise and behavioral modification through nutrition education. Body composition, dietary habit scores, serum lipid profiles, daily nutrient intakes and the quality of life were assessed at the beginning and at the end of the program. Average age of subjects and height were 20.8 years and 161.9 cm, respectively. After 8 weeks, there were significant reductions in body weight, body fat mass, percent body fat, waist-hip ratio and BMI. The dietary habit score such as a balanced diet, regularity of mealtime, overeating, eating while watching TV or using the computer and eating salty food were increased significantly. Serum lipid levels such as total cholesterol level, LDL-cholesterol level and triglyceride level were decreased but not significantly. There were decreases in intake of energy, protein and fat and increases in intakes of dietary fiber, folic acid, calcium and potassium from the beginning to the end of the program. There were significant improvements on subcomponents of quality of life; physical functioning, general-health and vitality. The limitation of this study was the fact that there was no control group, but an overall evaluation suggests the 8-week body weight control program consisting of diet therapy, exercise and behavioral modification with supplementation of sea tangle would be helpful to improve the body composition, dietary habits, daily nutrient intakes and quality of life in Korean female college students.

비타민 무기질 임의영양강화 최대허용수준 추정 (Estimation of Safe Maximum Levels of Vitamins and Minerals to Foods)

  • 정해랑;오세영
    • Journal of Nutrition and Health
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    • 제39권7호
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    • pp.692-698
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    • 2006
  • The voluntary addition of vitamins and minerals to the appropriate foods may help reduce the risks associated with low intakes of these micronutrients, yet the potential of excessive intake, particularly for persons consuming very large amount of foods needs to be addressed. Using the Flynn's model to estimate the level of each vitamins and minerals that can be added safely to foods, maximum levels of fortification to conventional foods per 100 kcal portion were estimated. Critical factors in the Flynn's model included tolerable upper intake level (UL), each micronutrient intake at the $95^{th}$ percentile, the proportion of fortified foods in the diets of individuals, the proportion of foods to which micronutrients could be practically added, and a range of estimates for fractions of foods which might be actually fortified in each nutrient. Food vehicles included all foods except for fresh foods and alcoholic beverages, in general. With fortification of 50% of all potentially fortifiable foods, micrornutrients could be added safely to foods at levels per 100 kcal 1) > 100% Recommended Intake (RI) for vitamin $B_12$, 2) 1,200% RI for vitamin $B_1$ and niacin, 3) 1,000% $B_1$ for vitamins $B_2$ and $B_6$, 4) 400% RI for vitamin E, 5) 30% RI for calcium, 6) 20% RI for folic acid, iron and zinc, 7) 10% RI for manganese, 8) no fortification for magnesium, phosphorous and vitamin A, and 8) further consideration of vitamin D, copper and selenium due to insufficient evidence. Results of this study suggests a wide range of vitamins and minerals that can be added safely to foods in current diets of Koreans.

Recombinant Human Erythropoietin Therapy for a Jehovah's Witness Child With Severe Anemia due to Hemolytic-Uremic Syndrome

  • Woo, Da Eun;Lee, Jae Min;Kim, Yu Kyung;Park, Yong Hoon
    • Clinical and Experimental Pediatrics
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    • 제59권2호
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    • pp.100-103
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    • 2016
  • Patients with hemolytic-uremic syndrome (HUS) can rapidly develop profound anemia as the disease progresses, as a consequence of red blood cell (RBC) hemolysis and inadequate erythropoietin synthesis. Therefore, RBC transfusion should be considered in HUS patients with severe anemia to avoid cardiac or pulmonary complications. Most patients who are Jehovah's Witnesses refuse blood transfusion, even in the face of life-threatening medical conditions due to their religious convictions. These patients require management alternatives to blood transfusions. Erythropoietin is a glycopeptide that enhances endogenous erythropoiesis in the bone marrow. With the availability of recombinant human erythropoietin (rHuEPO), several authors have reported its successful use in patients refusing blood transfusion. However, the optimal dose and duration of treatment with rHuEPO are not established. We report a case of a 2-year-old boy with diarrhea-associated HUS whose family members are Jehovah's Witnesses. He had severe anemia with acute kidney injury. His lowest hemoglobin level was 3.6 g/dL, but his parents refused treatment with packed RBC transfusion due to their religious beliefs. Therefore, we treated him with high-dose rHuEPO (300 IU/kg/day) as well as folic acid, vitamin B12, and intravenous iron. The hemoglobin level increased steadily to 7.4 g/dL after 10 days of treatment and his renal function improved without any complications. To our knowledge, this is the first case of successful rHuEPO treatment in a Jehovah's Witness child with severe anemia due to HUS.

식사도구 사용능력에 따른 뇌성마비아동의 식생활 (Eating Patterns of Children with Cerebral Palsy by Table Utensil-Handling Skills)

  • 김잔듸;배윤경;조미숙
    • 대한영양사협회학술지
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    • 제15권2호
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    • pp.139-151
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    • 2009
  • The purpose of this study was to investigate the eating patterns of children with cerebral palsy having motor disturbances as well as stiffness. The food habits, nutritional status, and snack intakes of 1 to 7 year-old children with cerebral palsy were examined. The subjects were grouped into three categories according to their table-utensil handling skills: superior, normal, and inferior. The children in the superior group were significantly taller and heavier compared to children in the other two groups. The %EARs of folic acid and total calorie intake were insufficient in all three groups; however, their %EARs of other nutrients were fully sufficient. When comparing the children's intake frequencies and preferences for snacks, the superior group showed a greater likelihood to consume various kinds of snacks than the inferior group. And the inferior group disliked more kinds of snacks than the other two groups. It was also shown that the inferior group had a significantly higher tendency for problems in chewing and swallowing. These results indicate that the development of table utensil-handling skills is very important for the food intake and growth of children with cerebral palsy, and the better their table utensil-handling skills the greater their physical development. Thus, considering their preference and intake frequency, it seems necessary that children in the inferior group be provided a greater variety of snacks and foods to receive more calories.

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체중조절 프로그램을 통한 비만 아동의 비만도, 혈중지질 및 영양소섭취량의 변화 (Changes of Obesity Index, Serum Lipid Profiles and Nutrient Intakes in Obese Children after the Weight Control Program of Nutrition Education)

  • 이은주;김경희
    • 대한지역사회영양학회지
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    • 제15권1호
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    • pp.61-72
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    • 2010
  • The purpose of this study was to evaluate the effect of a weight control program on anthropometric values, serum lipid profiles and nutrient intakes. The subjects of this study were 38 obese children (boy : 17, girl : 21) with obesity index over 120%. The weight control program for obese children included nutritional education (50 min) and exercise (50 min) for 10 weeks. The nutrition intakes of the children were surveyed before and after the weight control program by 24hr recall test. The BMI, R$\ddot{o}$hrer Index, Obesity Index, WHR (Waist - Hip ratio) and body fat(%) were significantly decreased after completion of the weight control program. The total cholesterol and HDL-cholesterol of subjects were significantly increased after the weight control program. Distribution of serum lipid profiles was slightly changed. The energy intakes were significantly decreased (p < 0.001). from 1760.8 kcal to 1435.2 kcal. In addition, the intakes of P, Zn, retinol, vitamin $B_1$, vitamin $B_2$, vitamin E and niacin were significantly decreased. while intakes of vitamin C and folate were increased. Calcium and folic acid were upper 25% of subjects, under EAR(Estimated Average Requirements) intake before the weight control program. The distribution of energy intakes was significantly changed into positive status; fat percentage was decreased 26.3% to 22.1% (p < 0.01). Carbohydrate was increased 58.6% to 61.2% (p < 0.05). Meal distribution of energy intakes was changed; calorie percentage from lunch significantly increased from 32.2% to 38.3%. Calorie percentage from snack significantly decreased from 17.7% to 13.5%. In conclusion, weight control program for 10 weeks is effective in obesity index and nutrient intakes although serum lipid values were a little changed.

식생활교육이 저나트륨식 적응에 미치는 영향 (Effects of Dietary Education on Low-sodium Diet Adaptation)

  • 김혜영;김주현
    • 한국식생활문화학회지
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    • 제29권2호
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    • pp.212-221
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    • 2014
  • Korean style DASH (Dietary Approaches to Stop Hypertension) and a dietary education program for sodium reduction were developed. Reduced sodium diets (15 and 30% reductions) were developed from general diets for 3 consecutive weeks from Monday through Saturday. Subjects (19 total) were classified into two groups according to dietary education. Experimental period was from June 24 to July 23, 2012. Total sum of adaptation scores for low sodium diets significantly increased in the group that underwent dietary education compared to that without (p<0.05). After the experiment, both groups showed significantly increased values in terms of food group balance, sodium-related nutrition knowledge, attitude, and practice by paired t-test. Especially, group that underwent dietary education showed significantly higher values for attitudes by ANCOVA pre-test as a variation (p<0.01). For the results of the nutrient intake survey, group that underwent dietary education showed significantly increased values for dietary fiber (p<0.01), vitamin A (p<0.001), vitamin K (p<0.001), vitamin C (p<0.01), Folic acid (p<0.001), vitamin B12 (p<0.01), calcium (p<0.01), iron (p<0.05), and zinc (p<0.05) and significantly decreased values for sodium (p<0.05) and chloride (p<0.005). Subjects adapted to reduced sodium diets showed apparent improvements in sodium-related knowledge, attitude, practice and intake of nutrient, and these improvements were even higher in the group that underwent dietary education compared to that without. Thus, adaptation to low sodium diet combined with dietary education can improve dietary habits.

The relationship of sperm DNA integrity with serum vitamin levels (folate and cobalamin) and food consumption in infertile men

  • Sara Boushaba;Yassine Helis;Rachida Lebaal;Sabah Beldjebel;Ayache Benhamza;Chafia Ziti;Ghania Belaaloui
    • Clinical and Experimental Reproductive Medicine
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    • 제50권1호
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    • pp.53-62
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    • 2023
  • Objective: The aim of this study was to investigate the relationships of serum folate (vitamin B9), cobalamin (vitamin B12) levels and diet with semen parameters (semen standard parameters [SSP] and DNA fragmentation index [DFI]) in infertile men. Methods: Sperm samples were assessed for SSP and DFI (using the sperm chromatin dispersion test). Serum vitamin concentrations were measured with an immuno-electrochemiluminescence assay, and men completed a semi-quantitative food frequency questionnaire (FFQ). Results: Serum folate levels were positively correlated with sperm progressive motility and DFI. A comparison of SSP between two groups of patients according to serum folate concentration (B9 <4.840 ng/mL and B9 ≥4.840 ng/mL) showed significantly higher sperm concentration and sperm progressive motility in the latter group. However, there was no difference between these groups regarding DFI. Interestingly, serum folate levels were significantly higher in patients with a high DFI (using the cut-offs of 30% or 18%). FFQ data showed that the consumption of fruits and egg yolk correlated positively with sperm concentration and sperm motility, respectively. Conclusion: Serum folate levels showed significant associations with sperm concentration and sperm progressive motility. However, the positive association of serum folate with DFI raises the need for careful prescription of folate supplements.

Nutritional Intervention for a Patient With Sleeve Gastrectomy

  • Seonhye Park;Sohye Kim;Soyoun Kim;Ah-Reum Shin;Youngmi Park
    • Clinical Nutrition Research
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    • 제12권3호
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    • pp.177-183
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    • 2023
  • Bariatric surgery is the most effective treatment for sustained weight reduction, and it can result in substantial improvements in the severity of type 2 diabetes, metabolic syndrome, nonalcoholic fatty liver disease, and quality of life. However, sleeve gastrectomy, a weight loss surgery that removes two-thirds of the stomach, reduces appetite and nutrient absorption, impairing digestion and the absorption of nutrients like iron, vitamin B12, and protein-bound nutrients. This case study aims to demonstrate that patients undergoing sleeve gastrectomy require long-term and periodic monitoring of biochemical data, weight changes, and caloric and protein intake by a professional nutritionist to prevent malnutrition and nutritional deficiencies. In this case study, a 48-year-old woman was diagnosed with morbid obesity, hypertension, sleep apnea syndrome, and chronic gastritis. At initial evaluation, she was 160 cm tall and weighed 89 kg, with a body mass index of 34.8 kg/m2. At 1 postoperative year, she consumed 650 kcal and 25 g of protein per day, the percentage of excess weight loss was 141.1%, and body mass index was 21 kg/m2. Compared to preoperative levels, calcium and folic acid levels did not decrease after 1 postoperative year, but hemoglobin, ferritin, and vitamin B12 levels decreased. In conclusion, when patients experience rapid weight loss after sleeve gastrectomy, follow-up should be frequent and long. Dietary education should be conducted according to digestive symptoms, and oral nutritional supplements, including vitamins and minerals.

In vitro에서 1-β-D-arabinofuranosyl-cytosine의 염색체 파열 유도 (1-β-D-Arabinofuranosyl-cytosine Induces Chromosomal Breaks in vitro)

  • 전인상
    • Clinical and Experimental Pediatrics
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    • 제46권12호
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    • pp.1186-1193
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    • 2003
  • 목 적 : 염색체 취약부위는 세포를 특정의 화학물질에 노출시키거나 특수한 배양조건에서 배양 할 때 쉽게 파열되는 염색체상의 특정구역이다. 취약부위는 유전성질환 및 악성종양과 관련이 있으며, 현재에는 분자생물학적 실험기법의 개발로 분자수준에서 이해가 되고 있다. 새로운 취약부위 및 취약부위의 발현을 높이거나 쉽게 관찰할 수 있는 실험실적 조건을 알아보기 위하여 항암제로 사용되는 Ara-C를 이용하여 염색체파열을 조사하여 보았다. 한편 염색체 취약부위가 종양형성과 관련이 있다는 사실에 기초하여 Ara-C에 의해 발열되는 취약부위와 암유전자가 위치하는 부위 및 종양에서 일정하게 염색체변이가 관찰되는 특정의 염색체 부위와의 상관관계도 알아보고자 하였다. 방 법 : 정상 성인 남녀 각각 3명의 말초혈액 내 T-림프구를 세포배양 후 Ara-C를 첨가하고 다시 caffeine을 처리한 뒤 종전에 시행했던 방법과 동일하게 검체 처리하여 염색체파열 부위를 관찰하였다. 염색체 취약부위는 염색체상의 일정부위에서 100개의 염색체파열 당 2회 이상의 염색체파열이 6명 중 4명 이상에서 관찰되는 경우로 정의하였다. 결 과 : 1) T-림프구를 엽산이 부족한 MEN-FA 배지에서 배양 시 Ara-C는 100개의 분열세포 당 252.1개의 염색체파열을 유도하였으며, Ara-C를 처리하지 않은 대조군에서 25.2개가 관찰되어 Ara-C를 처리한 경우에 염색체파열이 의미 있게 많았다(P<0.05). 2) Ara-C에 의한 염색체파열은 엽산이 부족한 MEM-FA 배지에서 엽산이 충분한 RPMI 1640 배지에서 보다 많이 되었다(P<0.05). 한편, 2.0 mM 농도의 caffeine은 엽산만 부족한 배양 배지에서는 염색체파열을 상승시키지 못했으나, Ara-C와 병행사용 시 상승시켰다. 3) Ara-C에 의해 가장 많이 파열된 부위는 3p14.2.이었으며, 발현된 취약부위는 20부위였다. 4) 발현된 취약부위 중 7 부위는 JUN, SKI, REL, N-MYC, FHIT, MET, ETS-1, FOS의 암유전자가 위치하는 부위와 일치하였으며, 15부위는 급성림프구성백혈병, 급성골수성백혈병, 만성림프구성백혈병, 골수이형성성증, 악성흑색종, 신경모세포종, 소세포성폐암, 난소암, 유전성 신장암, 혼합성 지방육종시 염색체상에 이상이 있는 부위와 일치하였다. 결 론 : S기 특이성 항암제인 Ara-C는 정상성인의 T-림프구를 엽산이 부족한 MEM-FA배지에서 배양시 염색체 파열을 대조군에 비해 의미 있게 유도하였다. 한편으로 Ara-C 특이성 염색체 취약부위는 암유전자가 위치하는 부위 및 특정 종양에서 관찰되는 특이한 염색체변이가 있는 부위와 상당 예에서 일치하여 아직 알려지지 않은 암유전자를 찾거나 분석하는데 기초적인 자료를 제공할 뿐 아니라 염색체변화와 종양형성과정의 상관관계를 이해하는데 도움이 될 것으로 사료된다.

칼슘강화 메뉴 첨가에 의한 학교급식 식단 조정이 여고생의 영양소 섭취 개선에 미치는 효과 (Effect of School Lunch Menu Intervention through Calcium Enriched Menus on Nutrient Intakes of High School Girls)

  • 이언경;최영선;배복선
    • 대한지역사회영양학회지
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    • 제16권2호
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    • pp.265-277
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    • 2011
  • This study was conducted to improve the nutritional status of high school girls via lunch menu intervention. Surveys were carried out twice to evaluate basal status and status after lunch menu intervention. In the first survey nutrient intakes of 24-hour and school lunch were each estimated by 24-hour recall dietary survey and self-recording, respectively. Calcium intake was the lowest among nutrients, and stir-frying was the most preferred cooking method. Five dishes of school lunch menus which were included in the first survey were replaced with recipes containing foods with higher calcium level; anchovy stir-fried with red pepper paste, anchovy stir-fried with almond, pork stir-fried with shredded kelp, crab meat soup, and tteokbokki with cheese. In the second survey calcium intake from school lunch was significantly (p < 0.001) increased from 45.5% to 50.2% of one thirds of recommended intake (RI) after calcium enriched lunch menu intervention. Intakes of vitamin A and E were also significantly increased, whereas those of energy, thiamin, and vitamin C were decreased. Index of nutritional quality values of nutrients of 24-hour intakes (except thiamin, vitamin B6, vitamin C) is increased by intervention; however, those of calcium, folic acid, iron are still very low. Even though this study shows a possibility of improving nutrient intakes of students through school lunch menu intervention, lunch intervention by itself is not enough action to improve nutritional status of micronutrient for adolescents.