• Radiation Oncology Journal
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• v.11 no.2
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• pp.267-275
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• 1993

Eighty five patients of oral cavity cancer, treated with radiation at the Department of Therapeutic Radiology, Korea Cancer Center Hospital, during the period from March 1985 to September 1990 were analyzed retrospectively. Among 85 patients, 37 patients were treated with radiation only and 48 patients were treated with radiation following surgery. And 70 patients received external irradiation only by $^{60}Co$ with or without electron, the others were 7 patients for external irradiation plus interstitial implantation and 8 patients for external irradiation plus oral cone electron therapy. Primary sites were mobile tongue for 40 patients, mouth floor for 17 patients, palate for 12 patients, gingiva including retromolar trigone for 10 patients, buccal mucosa for 5 patients, and lip for 1 patient. According to pathologic classification, squamous cell carcinoma was the most common (77 patients). According to AJC TNM stage, stage I + II were 28 patients and stage III+IV were 57 patients. Acturial overall survival rate at 3 years was $43.9\%,$ 3 year survival rates were $60.9\%$ for stage I + II, and $23.1\%$ for stage III+IV, respectively. As a prognostic factor, primary T stage was a significant factor (p<0.01). The others, age, location, lymph node metastasis, surgery, radiation dose, and cell differentiation were not statistically significant. Among those factors, radiation plus surgery was more effective than radiation only in T3+T4 or in any N stage although it was not statistically sufficient (p<0.1). From those results, it was conclusive that definitive radiotherapy was more effective than surgery especially In the view of pertainig of anatomical integrity and function in early stage, and radiation plus surgery was considered to be better therapeutic tool in advanced stage.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.04a
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• pp.28-28
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• 2018

본 연구는 강원도 인제군 매봉 지역 일대를 중심으로 식물상 조사를 수행하였다. 관속식물은 73과 173속 228종 3아종 28변종 6품종으로 총 265분류군으로 조사되었다. 분류군별로는 양치식물이 5과 14분류군, 나자식물 1과 3분류군, 쌍자엽식물 60과 182분류군, 단자엽식물 7과 29분류군으로 확인되었다. 주요 식물로는 특산식물 고려엉겅퀴(Cirsium setidens), 무늬족도리풀(Asarum versicolor), 병꽃나무(Weigela subsessilis) 등 8과 9분류군, 희귀식물은 멸종위기종(CR) 긴개별꽃(Pseudostellaria japonica), 애기가물고사리(Woodsia glabella) 2분류군, 위기종(EN) 댕강나무(Abelia mosanensis) 1분류군, 취약종(VU) 멱쇠채(Scorzonera austriaca subsp. glabra) 1분류군, 약관심종(LC)인 과남풀(Gentiana triflora var. japonica), 금강제비꽃(Viola diamantiaca), 너도바람꽃(Eranthis stellata) 등 9분류군으로 총 13분류군이 확인되었다. 환경부지정 특정식물종은 V등급 1분류군, IV등급 2분류군, III등급 13분류군이 확인되었다. 귀화식물은 단풍잎돼지풀(Ambrosia trifida), 달맞이꽃(Oenothera biennis), 닭의덩굴(Fallopia dumetorum) 등 6과 11분류군이 확인되었다. 산림청에서 지정한 특별산림보호대상종은 댕강나무(Abelia mosanensis), 참배암차즈기(Salvia chanryoenica)가 확인되었다. 유용식물로는 용도를 모르는 96분류군(36.2%)를 제외하면 169분류군(63.8%)이 자원식물로 이용가치가 있는 것으로 나타났다. 이들을 용도에 따라 구분해보면 식용 114분류군(33.2%), 섬유용 5분류군(1.5%), 약용 82분류군(23.9%), 관상용 33분류군(9.6%), 사료용 94분류군(27.4%), 산업용 1분류군(0.3%), 염료용 3분류군(0.9%), 목재용 11분류군(3.2%)으로 확인되었다.

• Journal of Preventive Medicine and Public Health
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• v.5 no.1
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• pp.97-104
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• 1972

For the purpose of ascertaining the status of physical growth and health status of the University Students, an intensive survey was conducted by the authors towards a total of 1,250 (Male 792, Female 458) who passed the written entrance examination at the Kyung Hee University in 1972. The items included the measurements on physical growth, various physical and nutritional indices, status of visual distourbance, dental status and tuberculosis. The findings and results cad be summarized as follows; 1. Physical Growth and Develspment. i) The average of body height by anthropometric was $169.39{\pm}5.05cm$ in male and $157.45{\pm}4.43cm$ in female. ii) The averages of body weight by sex were $59.42{\pm}6.47Kg\;and\;51.81{\pm}5.21Kg$, respectively. iii) The averages of chest-girth were $87.18{\pm}5.30cm\;and\;80.51{\pm}4.53cm$. iv) The averages of sitting-height were $92.21{\pm}2.79cm\;and\;86.28{\pm}2.57cm$. In all cases the male measurements were higher than female. 2. Various ludices about Physical Growth and Development; i) Relative body weights by sex were 35.08 and 32.91, relative chestgirth 51.47 and 51.13, and relative sitting-height 54.43, 54.79, respectively. ii) Rohrer index was 1.222 in males and 1.327 in females, Kaup index 2.071 and 2.089, Verveck index 86.54 and 84.04, and Pelidisi index 91.15 and 93.08, respectively 3. Status of visual distourbance The vision of the students under 0.8 with Landolt's testing chart was 45.4% in left eye and 46.6% in right eye(male: 44.4% and 45.7%, female: 47.2% and 48.0%), while under 0.6 in both visions was 41.0% and 40.5% (male: 40.8% and 40.7%, female: 41.5% and 40.2%), respectively. 4. Dental Status Out of total 19.4% (male 19.2%, female 19.6%) had gingivitis, the female incidence rate of gingivitis was higher than male. Average number of teeth in each subject was 29.6 teeth: male had 29.9 teeth and female had 29.1 teeth. The caries rate was 78.9%(male 75.6%, female 84.5%), the female caries rate was higher than male. Total filing per subject was 35.6% (male 34.0%, female 37.1%), female incidence was higher shan male. The average number of i) Caries per tooth rate was 8.5% in male and 9.2% in female, ii) Missing per tooth rate was 0.3% and 0.2%, iii) Filling per tooth rate was 3.9% and 4.2%. in all cases, the female incidences were higher than the male. The average number of D.M.F. was 3.8 teeth in male and 4.0 teeth in female, female was higher than male. The average rate of D.M.F. was 12.7% in male and 13.7% in female, female was higher than male. 5. Pulmonary infiltration Among the total, 53 students were diagnosed as pulmonary infiltration (tuberculosis), of whom 51 were minimal cases, one were moderately advanced case and one were far advanced case.

• Journal of Chest Surgery
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• v.23 no.2
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• pp.213-221
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• 1990

We have experienced 62 cases of modified Fontan operations in Seoul Nat’l University Hospital from Apr. 1986 to Jul. 1989, They were 38 males and 24 females, and their age was ranged from 16 months to 15.5 years of age. [mean age : 5.73$\pm$2.99 years] There were 16 operative deaths and 2 late deaths, therefore 29% of overall mortality. Their diagnoses were as follows; 28 single ventricle, 11 tricuspid atresia, 6 DORV with LV hypoplasia, 3 pulmonary atresia with hypoplastic RV, 3 TGA with hypoplastic RV, 3 cor\ulcornerGA with hypoplastic LV and PA, 6 AV canal defects with PA, and 2 others. Low cardiac output and pleural effusion were developed frequently, so we divide 40 patients into some groups to analyze the physiologic and anatomic causes of them. By the degree of the LCO, group A was no LCO[mean amount of inotropics used: 0-5 \ulcornerg/kg/min] with 17 cases, B mild LCO [5-10] with 11, C moderate to severe LCO but alive[>10] with 8, D severe LCO to death with 4 cases. For the pleural effusion, group 1 was to be removed the chest tube within 1 week with 8 cases, group II within 3 weeks with 21 cases, group III beyond 3 weeks with 12 cases. We considered their age, diagnosis, pulmonary artery size[PA index], pulmonary artery abnormality, palliative shunt, systemic ventricular type, pulmonary artery wedge pressure, as preoperative factors, and operative methods, and as postoperative factors, CVP, LAP, arrhythmia, thrombosis, atrioventricular valvular insufficiency, etc. In the view of LCO, pulmonary artery size and PCWP were statistically significant [P<0.05], and arrhythmia, A-V valve insufficiency were inclined to the group C and D Pleural effusion was influenced by the pulmonary artery size, pulmonary artery resistance, PCWP, and CVP significantly. [P<0.05] And arrhythmia, residual shunt, and A-V valvular insufficiency were inclined to group II and III, too. As a results, the followings are to be reminded as the important factors at the care of post-Fontan LCO, and persistent pleural effusion [1] pulmonary artery size, [2] pulmonary artery resistance, [3] PCWP, [4] CVP, [5] arrhythmia, [6] residual shunt, [7]A-V valvular insufficiency.

• Korean Journal of Medicinal Crop Science
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• v.13 no.1
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• pp.30-34
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• 2005

Polygonatum species are a useful medical crop in Korea but basic study in the species was not well conducted. The study was carried out to analyse genetic diversity and intraspecific relationship of 47 Polygonatum species collected from Gyeongnam province. Their analysis was done through principle component analysis and average linkage cluster analysis with their twelve morphological traits. The result of principle component analysis showed the Prin 1, Prin 2 and Prin 3 represented 79% of total variation. By the 0.7 average distance of the cluster analysis and the calculated Euclidian distance, the 47 collected species were grouped into five groups. Group I included 22 collected species representing P. ordoratum var. pluriflorum, group II did 5 ones representing P. involucratum, group III was divided into two subclasses, 2 species including P. inflatum and 7 species including P. thunbergii, group IV also consisted of 2 subclasses, a species similar to P. thunbergii and P.involucratum, respectively, and finally group V included 8 species representing P.lasianthum var. coreanum. meaning that the useful germplasms can be collected from relatively small area.

• Journal of environmental and Sanitary engineering
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• v.13 no.1
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• pp.123-134
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• 1998

The study was performed to investigate the differences among various evaluation criteria for noise-induced hearing loss(NIHL). The subjects were 100 workers who had received detailed audiometric examinations after the periodic annual examination for hearing loss. The evaluation criteria included were as follows: The criterion I was NIHL of 50dB or greater at 4,000Hz in either ear which is one of the legal requirements for determining occupational hearing loss in Korea. The criterion II was NIHL of 40dB or greater by 4-divided classification(a+b+c+d/4 at 500Hz(a), 1,000Hz(b), 2,000Hz(c), 4,000Hz(d)) which is also one of the legal requirements for determining occupational hearing loss in Korea. The criterion III was NIHL of 31dB of greater by 6-divided classification(a+2b+2c+d/6) which is the workers' compensation standard. The criterion IV was NIHL of 40dB or greater by 6-divided classification(a+2b+2c+d/6), the criterion used to prohibite workers to be employed in the noisy workplace. The criterion V was NIHL of 40dB or greater by 3-divided classification(a+b+c/3) which is the guideline of the Japanes Labour Department. The results were as follows; 1. The percentage of workers with NIHL by the criterion I was the highest(96%) and covered all workers with NIHL diagnosed by other criteria. Therefore, this criterion was the most sensitive one for early detection of NIHL among various evaluation criteria. 2. The percentage of workers with NIHL by the criterion II was 29% of the subjects, but all of them could be diagnosed as having NIHL by the criterion I and 33.1% of the NIHL by the criterion III could not be covered by the criterion II. Thus, this criterion was not considered suitable as an initial step for determining occupational hearing loss. 3. The percentage of workers with NIHL by the criterion III was 45% of the subjects. This percentage was 46.9% of the NIHL by the criterion I and was estimated to cover 3.6% of all noise exposed workers. 4. The percentage of workers with NIHL by the criterion IV was 28% of the subjects, but 37.8% of the NIHL by the criterion III and 70.8% of the NIHL by the criterion I were not covered by the criterion. Therefore, these workers could have been employed in the noisy workplaces. 5. Employed relocation which was one of the post management methods was an option in the criterion I in Korea and in the criterion V in Japan. The number of NIHL by the criterion I was 6.7times greater than that by the criterion V. Thus, although employee relocation was not used exclusively, many more workers with NIHL could have been relocated. In conclusion, this study revealed that the criteria being used for managing occupational hearing loss showed a lack uniformity among them. In addition, since these criteria are all relied on the total threshold shifts caused by the noise exposure at the time of hearing test with no consideration given to the past noise exposure history nor age, it can be said that they are not an effective tool for occupational hearing loss management. Since legal requirements are usually followed after being diagnosed as having NIHL, it is recommended that a uniform diagnostic criterion should be used to minimize confusion. Pre-employment hearing tests should also be utilized so as to managing occupational hearing loss after employment rather than being used as a legal roadblock of prohibiting workers with mild hearing loss from being employed. Thus, what is needed is an establishment of a rational criterion for occupational hearing loss management rather than for legal requirements.

• Journal of Chest Surgery
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• v.20 no.1
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• pp.112-127
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• 1987

Myasthenia gravis is a neuromuscular transmission function disorder characterized by fatigue and weakness of voluntary muscles. This muscular weakness is intensified by activity and stress, and improved by the use of anticholinesterase compounds. It was initially described by Erb in 1879 and later named myasthenia gravis by Jolly in 1895. Although the pathogenesis is Known to be an autoimmune related reduction in the number of available acetylcholine receptors at neuromuscular junctions, the role of thymus in myasthenia gravis is still unclear and under investigation. Thymectomy in the management of myasthenia gravis has become increasingly important since Dr. Blalock observed in 1939 that some patients with thymic tumors and myasthenia gravis improved following thymectomy. A clinical study of 102 cases of myasthenia gravis was performed at Yonsei University College of Medicine. Seoul, Korea from Jan. 1976 to Jun. 1986. In order to determine which factors are of prognostic significance, attention is focused upon pre-operative patient evaluation, problems in operative and post-operative care, and long-term follow-up observations. The results were as follows: 1. The sex distribution was 67 females and 35 males, the mean age of onset was 28.95*1.69 years, and the maximal incidence occurred between 21 and 40 years of age [56 cases: 54.9%]. 2. Clinical manifestations of ocular symptoms were seen to 70 patients [68.6%] extremities weakness in 33 [32.3%], bulbar weakness in 29 [28.4%], and dyspnea in 13 [12.7%]. 3. Study cases more than two thirds were classified as mild types [MG 1 and MG 11A] and 6 cases as grave [MG 1V] based on the modified Osserman`s classification system, 4. Thymectomy was performed in 19 cases which presented in severe myasthenia symptoms and showed no improvement with cholinergic drugs. Histologic examination of the excised thymus glands revealed no abnormalities in 4 cases, thymic hyperplasia in 5, benign thymoma in 5, and malignant thymoma in 5. 5. Immediate post-operative complications included 2 cases of pneumothorax which were treated by tube thoracostomies, there was no operative mortality. 6. The response to cholinergic drugs in 36 cases younger than 20 years old and in 27 cases older than 40 years was relatively poor, while that in 35 cases between the ages of 21 and 40 years old was good. 7. Thirty of 39 cases in groups IIB, III & IV improved markedly with medical or surgical management while only 16 of 59 cases in the mild groups [I and IIA] improved, almost all surgical cases improved in all categories. 8. There were 5 deaths. occurring between 7 months and 3 years 3 months of treatment of myasthenia gravis. The causes of death were myasthenic crisis in 2 cases, respiratory failure due to candidiasis & radiation pneumonitis in one case, cerebral hemorrhage due to high blood pressure in two case.

• Journal of Veterinary Science
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• v.22 no.3
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• pp.39.18-39.18
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• 2021

Background: Interferon lambda receptor 1 (IFNLR1) is a type II cytokine receptor that clings to interleukins IL-28A, IL29B, and IL-29 referred to as type III IFNs (IFN-λs). IFN-λs act through the JAK-STAT signaling pathway to exert antiviral effects related to preventing and curing an infection. Although the immune function of IFN-λs in virus invasion has been described, the molecular mechanism of IFNLR1 in that process is unclear. Objectives: The purpose of this study was to elucidate the role of IFNLR1 in the pathogenesis and treatment of porcine reproductive and respiratory syndrome virus (PRRSV). Methods: The effects of IFNLR1 on the proliferation of porcine alveolar macrophages (PAMs) during PRRSV infection were investigated using interference and overexpression methods. Results: In this study, the expressions of the IFNLR1 gene in the liver, large intestine, small intestine, kidney, and lung tissues of Dapulian pigs were significantly higher than those in Landrace pigs. It was determined that porcine IFNLR1 overexpression suppresses PRRSV replication. The qRT-PCR results revealed that overexpression of IFNLR1 upregulated antiviral and IFN-stimulated genes. IFNLR1 overexpression inhibits the proliferation of PAMs and upregulation of p-STAT1. By contrast, knockdown of IFNLR1 expression promotes PAMs proliferation. The G0/G1 phase proportion in IFNLR1-overexpressing cells increased, and the opposite change was observed in IFNLR1-underexpressing cells. After inhibition of the JAK/STAT signaling pathway, the G2/M phase proportion in the IFNLR1-overexpressing cells showed a significant increasing trend. In conclusion, overexpression of IFNLR1 induces activation of the JAK/STAT pathway, thereby inhibiting the proliferation of PAMs infected with PRRSV. Conclusion: Expression of the IFNLR1 gene has an important regulatory role in PRRSV-infected PAMs, indicating it has potential as a molecular target in developing a new strategy for the treatment of PRRSV.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.53 no.spc
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• pp.89-95
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• 2008

This study was carried out to examine growth characteristics and seed qualities of 1,296 Korean soybean landraces. The range of days to flowering, and days to maturity was 38 to 83 days and 47 to 102 days, respectively. The range of growth days were 105 to 160 days, and 38% was belonged to maturity group III. The 100 seed weight was 19.5g, showing the range of 2.4 g to 40.4 g, and 19.5 g in mean. 35.3% was in the range from 13.1 g to 20.0 g, and 29.4% in the range from 20.1 g to 25.0 g. Mean contents of crude protein was 41.8%, showing the range from 32.7% to 49.2%. Mean contents of crude oil was 18.0%, showing the range from 11.8% to 22.2%. The composition of unsaturated fatty acids were from 81.8% to 94.2%, and 85.4% in mean. Sucrose contents were in the range from 1.24% to 7.91% with the mean 5.21%, and oligo-saccharide contents from 2.45% to 11.13% with the mean 8.01%. Total isoflavone contents were in the range from $278.4\;{\mu}g/g$ to $2,736.9\;{\mu}g/g$ with the mean $1,066.8\;{\mu}g/g$. Among isoflavone contents, daidzein, glycitein, and genistein contents were in the range from $48.8\;{\mu}g/g$ to $1,709.6\;{\mu}g/g$ with the mean $483.2\;{\mu}g/g$, from $0.98\;{\mu}g/g$ to $892.3\;{\mu}g/g$ with the mean $111.6\;{\mu}g/g$, and from $79.8\;{\mu}g/g$ to $1242.3\;{\mu}g/g$ with the mean $472.0\;{\mu}g/g$, respectively.

• Journal of Gastric Cancer
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• v.5 no.1
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• pp.23-28
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• 2005

Purpose: Bone metastasis is not a common event in patients with gastric cancer. Therefore, most studies of bone metastasis in such patients have been in the form of case reports, so the clinical features of the bone metastasis are not well understood. To clarify metastatic patterns, the efficacy of radiation or chemotherapy, and the prognosis, we analyzed 29 cases of patients with bone metastases after curative surgery for gastric cancer. Materials and Methods: Twenty-nine (29) gastric cancer patients with bone metastasis who underwent curative resection from January 1989 to December 2002 at the Departments of Surgery, Kangnam St. Mary's Hospital and Our Lady of Mercy's Hospital, The Catholic University of Korea, were analyzed. Results: Nineteen (19) patients were males and, 10 patients were females. The mean age of the patients was $53\pm12$ years. There were more Borrmann type-3 and type-4 cancers and more undifferentiated histologic types. Most of the original cancers were stage III or IV. The most frequently involved bone was the spine. Treatment after recurrence was done in 16 patients ($55.2\%$). The median survival time after recurrence of the patients who received treatment was seven (7) months ($0\∼75$ months in range), which was significantly longer than that of the patients who did not received treatment (P=0.019). However, there was no difference according to the treatment modality (P=0.388). Conclusion: Bone metastasis after a curative resection of gastric cancer tends to occur in Borrmann type-3 and type-4 cancers, cancers with undifferentiated histology and, in stage III/IV disease. The prognosis of bone metastasis is dismal, and aggressive treatment is the only way to prolong survival.