• 대한한방소아과학회지
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• 제19권1호
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• pp.67-82
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• 2005

Objectives : This study was conducted to find out the effect of Yukmijiwhangtanggamibang (YM) on growth, learning and memory of rats. Methods : It was divided SD rats into Sham group, 192 Saporin injection(SA+Saline) group and Injection of 192 Saporin with YM(SA+YM) group. Growth measure length of bone and tail. Memory performance was used aquisition test and learning retention of morris water maze. It was detected acetylcholinesterase(AChE), cholineacetyltransferase(ChAT) at medial septum and hippocampus by immunohistochemistry Results : Body Weight of the SA+YM Group increased effectively, as compared with SA Saline group. Growth of bone in the SA+YM Group increased effectively, as compared with SA+Saline group. Growth of Tail in the SA+YM Group increased effectively, as compared with SA_Saline group. The SA+YM Group in Aquisition Test improved effectively, as compared with SA+Saline group. The SA+YM Group in Learning Test improved effectively, as compared with SA+Saline group. The numbers of ChAT cells in Medial septum increased effectively, as compared with SA+Saline group. The numbers of ChAT cells in CA1 of Hippocampus increased, but was not effective. Conclusion : These results suggest that YM has an improving effect on the impaired learning through the effects on memory registration and retrieval.

• 동의생리병리학회지
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• 제16권6호
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• pp.1236-1242
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• 2002

In order to make an efficient prescription and cope with dementia, learning and memory functions of Sprague-Dawley model rats were tested with Morris water maze. And to evaluate the effect of the sample drug(CHM) on choline acetyltranferase and acetylcholine esterase, immunoreactive measurement and enzymatic activity measuring were carried out. Rats were injected with ibotenic acid through hippocampus CA1 and CA3 area. The results are as following. CHM improves the learning ability in the acquisition test and memory function in the retention test significantly. And CHM increases the level of AChE which is resolving acetylcholine. Though it doesn't increase the level of ChAT significantly which is synthesizing acetylcholine, but it shows the tendency of increase. So these results show that CHM improve the cholinergic catabolism and anabolism, and the increment of metabolic activity of cholinergic system. Thus it can be concluded that CHM will be helpful to cholinergic brain disease induced by primary or senile reduction of acetylcholine secretive activity.

• 한국컴퓨터산업학회논문지
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• 제7권3호
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• pp.145-154
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• 2006

본 논문에서는 프로그램 최적화를 위해 개선된 추론적 부분 중복 제거(SPRE) 알고리즘을 제안했다. 본 논문에서 제안한 SPRE 기법은 컴파일러의 프로필링 기법 등을 통해 얻어진 실행 빈도에 대한 정보를 이용하여 실행 속도 최적화를 수행한다. 제안하는 알고리즘의 첫 번째 목적은 프로그램 실행 시 요구되는 메모리의 감소이며 두 번째는 실행 시간을 감소시키는 것이다. 단지 프로그램의 실행 속도만을 고려하는 경우에는 메모리 요구가 크게 증가하기 때문에 메모리 감소에 대한 고려도 중요하다. 이것은 프로그램을 실행하는데 요구되는 메모리의 크기가 실행 속도 보다 더 중요한 임베디드 시스템에 적합한 최적화 기법이다. 본 논문에서는 제어흐름그래프를 네트워크로 구성하여 분할하는데 사용하는 Min-Cut 알고리즘을 구현한다.

• 대한본초학회지
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• 제27권5호
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• pp.27-35
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• 2012

Objectives : The purpose of this study was to characterize the effect of the fraction of Taraxacum officinale and T.coreanum on the learning and memory impairments induced by scopolamine. Methods : The cognition-enhancing effect of Taraxacum officinale and T.coreanum was investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : The results showed that the Aug harvested T.offiicinale extract-treated group (200 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Passive avoidance Y-maze test and Watermaze test. And these results are same manner in DPPH radical scavenger effect and Acetylcholineseterase inhibition effect. Conclusions : These results suggest that Taraxacum officinale extract maybe a useful cognitive impairment treatment, and its beneficial effects are depending on the collecting time and origin plants. As a result, Taraxacum officinale harvested in August improve memory most.

• 한국전기전자재료학회논문지
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• 제29권6호
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• pp.327-331
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• 2016

Resistive random access memory (ReRAM) of metallic conduction channel mechanism is based on the electrochemical control of metal in solid electrolyte thin film. Amorphous chalcogenide materials have the solid electrolyte characteristic and optical reactivity at the same time. The optical reactivity has been used to improve the memory switching characteristics of the amorphous $As_2Se_3$-based ReRAM. This study focuses on the formation of holographic lattices patterns in the amorphous $As_2Se_3$ thin film for straight conductive channel. The optical parameters of amorphous $As_2Se_3$ thin film which is a refractive index and extinction coefficient was taken by n&k thin film analyzer. He-Cd laser (wavelength: 325 nm) was selected based on these basic optical parameters. The straighten conduction channel was formed by holographic lithography method using He-Cd laser.$ Ag^+$ ions that photo-diffused periodically by holographic lithography method will be the role of straight channel patterns. The fabricated ReRAM operated more less voltage and indicated better reliability.

• 정보처리학회논문지A
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• 제8A권4호
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• pp.439-446
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• 2001

현재 대부분의 병렬 알고리즘은 동기 알고리즘으로 올바른 계산을 위해서는 프로세서들의 동기화와 부하균형이 필수적이다. 만일 부하균형이 불가능하거나 이질적 클러스터처럼 각 프로세서의 성능이 다른 경우, 연산은 가장 느린 프로세서의 성능에 의해 결정된다. 비동기 반복법은 이런 문제를 해결하는 하나의 방안으로 각광받고 있으나, 현재까지의 연구는 비교적 구현이 쉬운 공유 메모리 시스템을 사용한 것이었다. 본 논문에서는 분산 메모리 환경에서 초대형 선형 시스템 문제를 풀기 위해, 빠른 프로세서의 유휴 시간을 최대한 줄임으로써 전체적으로 성능을 향상시키는 비동기 병렬 알고리즘을 제안하고 이를 클러스터에 구현하였다.

• 생약학회지
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• 제51권4호
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• pp.310-316
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• 2020

Kyung-Ok-Go (KOK) is a traditional prescription used for debilitating natural aging and post-illness debilitation. KOK has been used in a variety of ways because it strengthens immunity, prevents illness, and helps recovery in case of illness. In particular, recent research has revealed that KOK helps improve memory and cognition. Therefore, in this study, we investigated whether KOK was effective in improving memory decline and depression-state observed during menopause. In the present study, we employed ovariectomized mouse as an animal model for measuring menopausal syndrome. The administration of KOK for 8 weeks, the object recognition memory and working memory were improved in novel object recognition test and Y-maze test. And in the forced swimming test, the immobility time were decreased. Additionally, the expression level of mature brain derived neurotropic factor (mBDNF) was increased by KOK administration in ovariectomized mouse hippocampus. These results suggested that KOK could improve cognitive decline and depression during menopausal period, and it might be come from enhancing expression level of mBDNF in hippocampus.

• 한국정보과학회논문지:시스템및이론
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• 제37권3호
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• pp.147-160
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• 2010

최근 서버의 통합을 통해 시스템 자원의 효율적인 활용을 제공할 수 있는 시스템 가상화가 많은 주목을 받고 있다. 이 시스템 가상화 기술을 통하여 보다 효과적으로 시스템 자원을 활용하고 가상화 소프트웨어의 성능을 향상시킬 수 있는 방안이 다양하게 연구되고 있다. 이러한 연구들은 CPU 측면에서 동적으로 가상머신에 할당된 양을 조절하거나 마이그레이션 기능을 활용하여 머신 간 자원 관리 등의 다양한 측면에서 활발하게 진행되고 있으나 메모리 측면에서는 그 연구가 매우 부족한 실정이다. 따라서 서버 통합에서의 메모리 자원의 이용은 가상머신 탑재 시에 정적으로 할당된 메모리를 사용하는 수준에서 머물고 있다. 하지만 본 논문의 성능 비교 환경인 Xen 가상화에서 가상머신에 정적으로 메모리를 할당하는 방식은 유휴메모리를 다량 발생시켜 메모리 이용률을 낮추게 된다. 메모리 이용률을 높이기 위하여 가상머신에 할당하는 메모리양을 줄일 경우 다른 시스템 자원에도 영향을 미치게 되며 가상머신에서 운영되는 서비스의 성능 저하를 유발하게 된다. 본 논문에서는 가상머신 사이의 메모리 할당량을 조절하여 가상머신의 서비스에 성능저하가 없으면서 이용률을 향상시킬 수 있는 메모리의 동적 할당을 제안한다. 메모리 사용량 예측을 위한 AR 모델과 메모리 이용률 최적화를 위한 개미 군집 알고리즘을 사용하여 구현한 메모리의 동적 할당 시스템을 통하여 정적 할당의 경우에 비하여 더 많은 수의 가상머신을 운영할 수 있게 되고 서버로 운영되는 가상머신의 서비스 성능 저하 없이 약 1.4배의 이용률 향상을 얻을 수 있었다.

• Biomolecules & Therapeutics
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• 제21권5호
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• pp.381-390
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• 2013

The purpose of this study was to examine whether ginsenoside Rg3 (GRg3) could improve learning and memory impairments and inflammatory reactions induced by injecting lipopolysaccharide (LPS) into the brains of rats. The effects of GRg3 on proinflammatory mediators in the hippocampus and the underlying mechanisms of these effects were also investigated. Injection of LPS into the lateral ventricle caused chronic inflammation and produced deficits in learning in a memory-impairment animal model. Daily administration of GRg3 (10, 20, and 50 mg/kg, i.p.) for 21 consecutive days markedly improved the LPS-induced learning and memory disabilities demonstrated on the step-through passive avoidance test and Morris water maze test. GRg3 administration significantly decreased expression of pro-inflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-1${\beta}$, and cyclooxygenase-2 in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. Together, these findings suggest that GRg3 significantly attenuated LPS-induced cognitive impairment by inhibiting the expression of pro-inflammatory mediators in the rat brain. These results suggest that GRg3 may be effective for preventing or slowing the development of neurological disorders, including Alzheimer's disease, by improving cognitive and memory functions due to its anti-inflammatory activity in the brain.

• The Korean Journal of Physiology and Pharmacology
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• 제16권2호
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• pp.79-89
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• 2012

We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic system and pro-inflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses for 14 days of PA (100 and 200 mg/kg, i.p.) and BER (20 mg/kg, i.p.) 30 min before scopolamine injection (2 mg/kg, i.p.). Daily administration of PA and BER improved memory impairment as measured by the passive avoidance test and reduced the escape latency for finding the platform in the Morris water maze test. Administration of PA and BER significantly alleviated memory-associated decreases in cholinergic immunoreactivity and restored brain-derived neurotrophic factor and cAMP-response element-binding protein mRNA expression in the hippocampus. PA and BER also decreased significantly the expression of proinflammatory cytokines such as interleukin-$1{\beta}$, tumor necrosis factor-${\alpha}$ and cyclooxygenase-2 mRNA in the hippocampus. These results demonstrated that PA and BER had significant neuroprotective effects against neuronal impairment and memory dysfunction caused by scopolamine in rats. These results suggest that PA and BER may be useful as therapeutic agents for improving cognitive functioning by stimulating cholinergic enzyme activity and alleviating inflammatory responses.