• Journal of Ginseng Research
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• v.47 no.2
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• pp.199-209
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• 2023

Background: Due to the interrupted blood supply in cerebral ischemic stroke (CIS), ischemic and hypoxia results in neuronal depolarization, insufficient NAD+, excessive levels of ROS, mitochondrial damages, and energy metabolism disorders, which triggers the ischemic cascades. Currently, improvement of mitochondrial functions and energy metabolism is as a vital therapeutic target and clinical strategy. Hence, it is greatly crucial to look for neuroprotective natural agents with mitochondria protection actions and explore the mediated targets for treating CIS. In the previous study, notoginseng leaf triterpenes (PNGL) from Panax notoginseng stems and leaves was demonstrated to have neuroprotective effects against cerebral ischemia/reperfusion injury. However, the potential mechanisms have been not completely elaborate. Methods: The model of middle cerebral artery occlusion and reperfusion (MCAO/R) was adopted to verify the neuroprotective effects and potential pharmacology mechanisms of PNGL in vivo. Antioxidant markers were evaluated by kit detection. Mitochondrial function was evaluated by ATP content measurement, ATPase, NAD and NADH kits. And the transmission electron microscopy (TEM) and pathological staining (H&E and Nissl) were used to detect cerebral morphological changes and mitochondrial structural damages. Western blotting, ELISA and immunofluorescence assay were utilized to explore the mitochondrial protection effects and its related mechanisms in vivo. Results: In vivo, treatment with PNGL markedly reduced excessive oxidative stress, inhibited mitochondrial injury, alleviated energy metabolism dysfunction, decreased neuronal loss and apoptosis, and thus notedly raised neuronal survival under ischemia and hypoxia. Meanwhile, PNGL significantly increased the expression of nicotinamide phosphoribosyltransferase (NAMPT) in the ischemic regions, and regulated its related downstream SIRT1/2/3-MnSOD/PGC-1α pathways. Conclusion: The study finds that the mitochondrial protective effects of PNGL are associated with the NAMPT-SIRT1/2/3-MnSOD/PGC-1α signal pathways. PNGL, as a novel candidate drug, has great application prospects for preventing and treating ischemic stroke.

• Journal of Digital Policy
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• v.2 no.3
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• pp.17-24
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• 2023

This study identified the degree of self-worth and college life adjustment of students in the department of paramedicine, and analyzed whether there was a difference according to the presence or absence of religion and the intimacy of family members. An online survey was conducted on 183 students in department of paramedicine students attending a university, and the subject's gender, religious affiliation, and intimacy with family members were analyzed by frequency and percentage. Self-worth and adjustment to college life according to the presence or absence of religion and intimacy with family members were analyzed by mean, standard deviation, t-test, and ANOVA. As a result, there was a difference in self-worth according to religion status and family closeness. According to intimacy with family members, there was a significant difference in academic adjustment among the sub-factors of college life adjustment. Through the results of this study, it is necessary to consider the existence of religion and intimacy with family members in setting up a counseling strategy tailored to the factors of personal self-worth improvement and college life adjustment. It is proposed to develop a college life adjustment promotion program to improve various self-worth, apply it to department of paramedicine students, and verify its effectiveness.

• Korean Journal of Environmental Agriculture
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• v.42 no.1
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• pp.44-51
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• 2023

Nitrogen fertilizer is an essential macronutrient that requires repeated input for crop cultivation. Excessive use of nitrogen fertilizers can adversely affect the environment by discharging NH₃, NO, and N₂O into the air and leaching into surrounding water systems through rainfall runoff. Therefore, it is necessary to develop a technology that reduces the amount of nitrogen fertilizer used without compromising crop yields. Fertilizer deep placement could be a technology employed to increase the efficiency of nitrogen fertilizer use. In this study, a deep fertilization device that can be coupled to a tractor and used to inject fertilizer into the soil was developed. The deep fertilization device consisted of a tractor attachment part, fertilizer amount control and supply part, and an underground fertilizer input part. The fertilization depth was designed to be adjustable from the soil surface down to a depth of 40 cm in the soil. This device injected fertilizer at a speed of 2,000 m²/hr to a depth of 25 to 30 cm through an underground fertilizer injection pipe while being attached to and towed by a 62-horsepower agricultural tractor. Furthermore, it had no difficulty in employing various fertilizers currently utilized in agricultural fields, and it operated well. It could also perform fertilization and plowing work, thereby further simplifying agricultural labor. In this study, a newly developed device was used to investigate the effects of deep fertilizer placement (FDP) compared to those with urea surface broadcasting, in terms of rice and soybean grain yields. FDP increased the number of rice grains, resulting in an average improvement of 9% in rice yields across three regions. It also increased the number of soybean pods, resulting in an average increase of 23% in soybean yields across the three regions. The results of this study suggest that the newly developed deep fertilization device can efficiently and rapidly inject fertilizer into the soil at depths of 25 to 30 cm. This fertilizer deep placement strategy will be an effective fertilizer application method used to increase rice and soybean yields, in addition to reducing nitrogen fertilizer use, under conventional rice and soybean cultivation conditions.

• Journal of Service Research and Studies
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• v.12 no.4
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• pp.72-81
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• 2022

As new disasters such as COVID-19, MERS, and earthquakes appear in modern society, the nation's ability to manage uncertain risks is becoming more important. The government is promoting a disaster safety management policy closely related to daily life by reinforcing on-site response capabilities. Therefore, in order to respond more effectively to disasters that have recently been enlarged, complicated, and delocalized, there is a limit to only disaster-related organizations in the public sector. It is necessary to check it and find ways to develop it. In the event of an unpredictable national disaster or infection, the government needs disaster safety management measures closely related to daily life. Accordingly, as an efficient response and strategy such as procedures and methods for funeral support at the scene of a national disaster were needed, a designated funeral home was introduced. In the event of a major disaster, a large number of casualties that exceed the daily work level of the relevant department occur and rapid changes in relief, medical care, funeral and administrative procedures occur accordingly. The purpose of this study is to derive basic operating directions and prompt funeral support plans for funeral homes designated for national disaster preparedness.

• Journal of the Korea Institute of Building Construction
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• v.23 no.3
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• pp.305-313
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• 2023

With an increasing interest in the commercialization of research results in the present societal climate, especially in the construction industry, preliminary product analysis plays a critical role when introducing a new product to the market. It significantly influences the product's success or failure. In this context, this study aims to investigate the utility of Importance-Performance Analysis (IPA) as a management strategy tool for preliminary analysis in the commercialization of new architectural technologies. The study specifically assesses a smart ball product engineered for pipeline inspection. The evaluation is carried out based on product quality, convenience, and usability categories. Seventeen factors are recognized as sub-items, and a survey is conducted among relevant experts and consumer groups. From the survey, four key items are chosen: "Keep up the good work," "Concentrate here," "Low priority," and "Possible overkill." Suitable strategic measures are derived for each item. By conducting a correlation analysis between product importance and performance, this study offers a method to establish priority directions for future development. This analysis assists in identifying areas that necessitate improvement or additional focus to increase the product's commercial potential. On the whole, this study contributes to understanding and applying Importance-Performance Analysis as a valuable tool in the preliminary analysis and commercialization of novel technologies in the field of architecture.

• Korean Journal of Healthcare-Associated Infection Control and Prevention
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• v.21 no.2
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• pp.50-56
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• 2016

Background: Alternatives to carbapenem are increasingly needed to decrease the usage of carbapenem. We evaluated the possibility of using non-carbapenem antibiotics against urinary tract infections (UTI) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE). Methods: This retrospective study was performed at 2 university hospitals between October 2010 and December 2012. All diagnosed adult cases of ESBL-PE UTI were identified from the microbiological database. The subjects were divided into 3 groups based on the empirical antibiotic classes and susceptibility: carbapenem (C) group, susceptible non-carbapenem (SNC) group, and non-susceptible non-carbapenem (NSNC) group. Results: A total of 84 patients were eligible for analysis. For empirical therapy, 41, 23, and 20 patients were included in the NSNC, SNC, and C empirical groups, respectively. During the empirical therapy, 7 patients (17.1%) in the NSNC group, 18 patients (78.3%) in the SNC group, and 19 patients (78.3%) in the C group experienced clinical improvement. No significant difference was observed between the SNC and C empirical groups (P=0.192). Severe sepsis or shock was the predictor of empirical SNC treatment failure (P=0.048). There was a tendency to use carbapenem as a definite therapy in cases of NSNC. In contrast, empirical SNC was maintained as a definite therapy. Conclusion: SNC could be considered as an alternative to carbapenems for treating ESBL-PE UTI. This strategy might decrease the usage of carbapenem without clinical deterioration. However, it should be noted that SNC therapy may fail in the case of severe sepsis or shock.

• Journal of the Korean Society of Floral Art and Design
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• no.41
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• pp.93-114
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• 2019

The purpose of this study is to analyze the characteristics and problems of the content of flower design education videos on YouTube and to search for improvement direction. The subjects of analysis were 129 pieces of videos uploaded in the last one year including 'craftman floral design' as a search term. The result shows that contents covered were practical lectures, theory lectures, test related tips, job and character introduction, test work, educational guidance and publicity. The production format could be divided into studio lecture, classroom lecture, video feature, interview, Vlog, and television program. The hub-type programming strategy that periodically uploads the videos satisfying the target audiences' interests is mostly applied. The type of lecture covered 'practical skill test' got a good response from the users. Overall, content diversity, interaction between creators and users, and harmonious programming strategies are lacking. In order to improve this, it is necessary for emotional and expressive creators to pioneer differentiated fields and practice based on actual field. The introduction of interactive elements such as games and quizzes and the application of new media technologies such as VR and AR are worth trying. Three strategic types of 'hero', 'hub', and 'how to' should be applied complementary. As the demand for education content related to flower design is expected to expand in the future, it is required to develop content that can be used in various platforms, foster professional creators, and develop associated business models.

• Korea Trade Review
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• v.43 no.4
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• pp.155-175
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• 2018

This study estimates the technical efficiency and total factor productivity(TFP) of and analyzes the relationship between TFP and exports for Korean manufacturing companies from 2000 to 2016. Specially, TFP is decomposed into Technical Change(TC), Technical Efficiency Change (TEC), and Sale Effect(SE), and compared between large and small enterprises. First, in the case of technical efficiency, the Korean economy has been very vulnerable to external shocks, such as the sharp decline following the 2008 financial crisis. The efficiency of the electronics, automobile, and machinery sectors is low and needs to be improved. In addition, the technological efficiency of large enterprises is higher than that of SMEs in most manufacturing sub-sectors except for non-ferrous metals. In the case of TFP, most changes are due to TC, and the effective combination of labor, capital and the effect of scale have little effect, suggesting that improvement of internal structure is urgent. In addition, volatility due to the impact of the financial crisis in 2008 was much larger in SMEs than in large companies, so external economic impacts are more greater for SMEs than large enterprises. The relationship between TFP decomposition factors and exports shows that TC has a positive effect only on exports of SMEs. Therefore, in order to increase exports, in the case of SMEs, R&D support to promote technological development is needed. In the case of large companies, it is necessary to establish differentiated strategies for each export market, competitor company, and item to link efficiency and scale effect of exports.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.6D
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• pp.693-702
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• 2009

In the Seoul metropolitan area (SMA), transportation sector is the largest source of air pollutant emissions. Of the total amount of air pollutant emissions in the SMA, about 52% of the particulate matter emissions and 59% of the nitrogen oxide emissions are from superannuated heavy diesel vehicles. To lessen the air pollutant emissions from superannuated heavy vehicles in the SMA, this study devised several strategies for operating Environmental Zone (EZ) program, which requires superannuated heavy diesel vehicles to install reduction equipments as well as restricts them entering part of the SMA, and evaluated the effects of different strategies on air pollution in the SMA. By using the Korean traffic statistics, an evaluation has been made of six EZ scenarios, which were devised by different target areas and vehicles. The results showed that the EZ program with retrofitting a DPF (Diesel Particulate Filter) equipment to 7-year-old heavy diesel vehicles and early scrapping of pre-1998 heavy diesel vehicles is the most efficient alternative in terms of air pollution reduction. In addition, the results showed that the magnitude of air pollution reduction increases when implementing the EZ program to all entering superannuated heavy diesel vehicles to the SMA rather than registered ones in the SMA.

• Maritime Security
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• v.6 no.1
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• pp.37-56
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• 2023

Recently, with the rapid development of ICT(Information and Communication Technology) and AI(Artificial Intelligence) technology industries, the emergence of MASS(Maritime Autonomous Surface Ship), which were thought only in the distant future, is approaching a reality. Along with the development of these amazing technologies, changes in the private law sector, such as liability, compensation for damages, and maritime insurance, as well as in the public law sector, such as maritime safety, marine environment protection, and maintenance of maritime order, have become necessary in the field of maritime law. In particular, with the advent of a new type of ship called MASS that does not have a crew on board, the kind and type of liability, compensation for damages, and insurance contracts in the event of a marine accident will also change. In this paper, the general theory about concept, classification, effectiveness and future of MASS and the general theory about concept and various obligations and responsibilities under the maritime law for discussion of MASS are reviewed. Next, in addition, regarding the problems that may occur in the event of a marine accident from MASS, the status as a ship, the legal relationship of the chartering contract, obligation to exercise due diligence in making the vessel seaworthiness, subject of responsibility, and liability for damages and immunity are reviewed from the perspective of maritime law. In addition, in the degree four of MASS, the necessities of further research to clarify the attributable subjects and standards of responsibility in the event of a marine accident, as well as the necessities of institutional improvement such as technology development, enactment and amendment of law and funding are presented.