• Title/Summary/Keyword: Importance of Risk Factor

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Outcomes of 1st Remission Induction Chemotherapy in Acute Myeloid Leukemia Cytogenetic Risk Groups

  • Zehra, Samreen;Najam, Rahela;Farzana, Tasneem;Shamsi, Tahir Sultan
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.12
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    • pp.5251-5256
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    • 2016
  • Background: Diagnostic karyotyping analysis is routinely used in acute myeloid leukemia (AML) clinics. Categorization of patients into risk stratified groups (favorable, intermediate and adverse) according to cytogenetic findings can serve as a valuable independent prognostic factor. Method and Material: A retrospective descriptive study was conducted based on the patient records of newly diagnosed non-M3 AML young adult cases undergoing standard 3+7 i.e, Daunorubicin and Ara-C (DA) as remission induction chemotherapy. Diagnostic cytogenetic analysis reports were analyzed to classify the patients into risk stratified groups according to South West Oncology Group criteria and prognostic significance was measured with reference to achievement of haematological remission after 1st induction chemotherapy. Results:A normal karyotype was commonly expressed, found in 47.2% of patients, while 65% (n=39) appeared to have intermediate risk cytogenetics, and 13.3% (n=8) adverse or unclassified findings. Favourable cytogenetics was least frequent in the patient cohort, accounting for only 8.3 % (n=5).The impact of cytogenetic risk groups on achievement of haematological remission was evaluated by applying Pearson Chi-square, and was found to be non-significant (df=12, p=0.256) but when the outcomes of favourable risk groups with intermediate, adverse and unclassified findings compared, results were highly significant (df=6, p=0.000) for each comparison. In patients of the favourable cytogenetic risk group, HR?? was reported in 40% (n=2/5), as compared to 62.2% (n=23/37) in the intermediate cytogenetic risk group, 57.1% (n=4/7) in the adverse cytogenetic risk group and 28.6% (n=2/7) in hte unclassified cytogenetic risk group. Conclusion: Cytogenetic risk stratification for AML cases following criteria provided by international guidelines did not produce conclusive results in our Pakistani patients. However, we cannot preclude an importance as the literature clearly supports the use of pretreatment karyotyping analysis as a significant predictive marker for clinical outcomes. The apparent differences between Pakistani and Western studies indicate an urgent need to develop risk stratification guidelines according to the specific cytogenetic makeup of South Asian populations.

Extracting Risk Factors and Analyzing AHP Importance for Planning Phase of Real Estate Development Projects in Myanmar (미얀마 부동산 개발형사업 기획단계의 리스크 요인 추출 및 AHP 중요도 분석)

  • Kim, Sooyong;Chung, Jaihoon;Yang, Jinkook
    • Korean Journal of Construction Engineering and Management
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    • v.22 no.2
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    • pp.3-11
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    • 2021
  • Myanmar is an undeveloped country with high development value among Asian countries. Therefore, various countries including the U.S. are considering entering the market. In this respect, demand for real estate development project is forecast to grow on increased inflow of foreigners and Myanmar's economic growth. However, Myanmar is a high-risk country in terms of overseas companies, including national risk. In this study, we conducted an in-depth interview with experts (law, finance, technology, and local experts) after analyzing data on Myanmar to extract risk-causing factors. Through this, 106 risk factors were extracted, and the final risk classification system was established by conducting three-time groupings using the affinity diagramming. And the relative importance of each factor was presented using the analytic hierarchy process (AHP) technique. As a result, the country-related risk, the fund-related risk, and the pre-sale-related risk were highly important. The research results are expected to provide risk management standards to companies entering the Myanmar real estate development type project.

Risk Evaluation of the Project Finance for Overseas Independent Power Projects Using a Fuzzy Multi-Criteria Decision-Making Analysis (퍼지 다기준 의사결정분석을 통한 해외 독립발전사업 사업금융 리스크 분석)

  • Hur, Kyong-Goo;Kim, Joo-Nam
    • The Journal of the Korea Contents Association
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    • v.17 no.5
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    • pp.574-590
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    • 2017
  • The purpose of this paper is the provision of a decision-making tool for developers to identify the project risks for under-consideration overseas independent power projects (IPPs), and to analyze the priority and importance weights of the risks through the employment of a fuzzy multi-criteria decision-making (MCDM) approach. A fuzzy MCDM is the calculation method for which the imprecision of each respondent's unique opinion is considered. Through the extensive literature surveys that were conducted for this paper, eight major project finance (PF) risks have been derived credit risk, completion risk, market risk, fuel risk, operating risk, financial risk, environmental risk, and force majeure. The empirical results show that the market risk is the most important risk factor in terms of overseas IPPs, thereby confirming that the long-term power purchase agreement (PPA) guarantee of the host country is one of the most important corresponding factors for the PF.

Groundwater pollution risk mapping using modified DRASTIC model in parts of Hail region of Saudi Arabia

  • Ahmed, Izrar;Nazzal, Yousef;Zaidi, Faisal
    • Environmental Engineering Research
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    • v.23 no.1
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    • pp.84-91
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    • 2018
  • The present study deals with the management of groundwater resources of an important agriculture track of north-western part of Saudi Arabia. Due to strategic importance of the area efforts have been made to estimate aquifer proneness to attenuate contamination. This includes determining hydrodynamic behavior of the groundwater system. The important parameters of any vulnerability model are geological formations in the region, depth to water levels, soil, rainfall, topography, vadose zone, the drainage network and hydraulic conductivity, land use, hydrochemical data, water discharge, etc. All these parameters have greater control and helps determining response of groundwater system to a possible contaminant threat. A widely used DRASTIC model helps integrate these data layers to estimate vulnerability indices using GIS environment. DRASTIC parameters were assigned appropriate ratings depending upon existing data range and a constant weight factor. Further, land-use pattern map of study area was integrated with vulnerability map to produce pollution risk map. A comparison of DRASTIC model was done with GOD and AVI vulnerability models. Model validation was done with $NO_3$, $SO_4$ and Cl concentrations. These maps help to assess the zones of potential risk of contamination to the groundwater resources.

The Comparative Study on the Differences among Choice of Information Source, Risk Perception and Benefits Sought According to the Purchase Type of the Men's Suits (남성복 구매형태에 따른 정보원 선택, 위험지각, 추구혜택의 차이에 관한 비교 연구)

  • 김노호;황선진
    • Journal of the Korean Society of Costume
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    • v.51 no.7
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    • pp.123-134
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    • 2001
  • The purpose of this study to compare the purchasing behaviour of men's business suits, among custom suits, system order, and ready-made suits, centering around the choice of information source, risk perception and benefits sought. The survey of this study was collected from 450 adult male in Seoul. The data was analyzed by factor analysis and ANOVA. The result of this study were as follows : 1. Custom suits, system order, and ready-made suits consumers have a significant difference in the choice of information source. The consumer attaching most importance to the impersonal information source is the system order users, custom suits users, and ready-made suits users respectively. However there was no significant difference in the personal source among 3 different purchasing behaviour of men's suits. 2. For the risk perception, 1) the group who perceived the highest in economic risk is the system order users, followed by custom suits users, and ready-made suits users. 2) the group who perceived performance risk as being the highest concern is the ready-made suits consumers, followed by system order user, and custom suits user. 3) the group who perceived the socio-psychological risk as the highest is the ready-made suits consumers, and followed by custom suits user and system order users. 4) there is no difference among the three groups with respect to the fashionability loss risk. 5) the group of the highest perceiving the useful loss risk is the ready-made suits consumers, and the next is system order users, custom suits users. 6) the group of the highest perceiving the time and convenience loss risk is ready-made suits users, and the next is system order users, custom suits users. 3. For the benefit sought, the group of the highest perceiving the aesthetics is custom suits consumers, and the next is system order users, ready-made suits users.

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A Risk Factor Detour Multi-Path Routing Scheme in Wireless Multimedia Sensor Networks (무선 멀티미디어 센서 네트워크 환경에서 위험요소 우회 다중 경로 라우팅 기법)

  • Hwang, Donggyo;Son, In-Goog;Park, Junho;Seong, Dong-Ook;Yoo, Jaesoo
    • The Journal of the Korea Contents Association
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    • v.13 no.1
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    • pp.30-39
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    • 2013
  • In recent years, with the development of devices to collect multimedia data such as small CMOS camera sensor and micro phone, studies on wireless multimedia sensor network technologies and their applications that extend the existing wireless sensor network technologies have been actively done. In such applications, various basic schemes such as the processing, storage, and transmission of multimedia data are required. Especially, a security for real world environments is essential. In this paper, in order to defend the sniffing attack in various hacking techniques, we propose a multipath routing scheme for physically avoiding the data transmission path from the risk factors. Our proposed scheme establishes the DEFCON of the sensor nodes that are geographically close to risk factors and the priorities according to the importance of the data. Our proposed scheme performs risk factor detour multipath routing through a safe path considering the DEFCON and data priority. Our experimental results show that although our proposed scheme takes the transmission delay time by about 5% over the existing scheme, it reduces the eavesdropping rate that can attack and intercept data by the risk factor by about 18%.

An analysis on risk factor of constructor with Fuzzy-FMEA (Fuzzy-FMEA를 활용한 시공사의 리스크 요인 분석)

  • Kim, Seok Cheol
    • Journal of the Korea Safety Management & Science
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    • v.19 no.4
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    • pp.43-52
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    • 2017
  • The purposes of this study are to analyze risks of construction step BIM(Building Information Modeling) applied project and improve it. Recently, construction industry has emphasized an importance of BIM for efficient utilization of various information. In the whole life cycle of huge construction project, there are cases introducing BIM and projects applying BIM are gradually increased to the work of construction step. However, the process of communication is not established, so the contents of BIM process of construction step are just showing rough fields and concepts of working utilization, so it's restrictive to utilize BIM actively on constructions step. Through results of case study in this research, constructor risks of BIM business should be efficiently treated with Fuzzy-FMEA that is more precise than existing danger evaluation.

Rigidity Evaluation under Uncertainties for Multiple Investment Alternatives over Multiple Periods

  • Kono, Hirokazu;Mizumachi, Tadahiro
    • Industrial Engineering and Management Systems
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    • v.9 no.2
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    • pp.107-120
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    • 2010
  • In today's uncertain economic environment, the evaluation of safety for investment alternatives is of practical importance in manufacturing companies. This paper examines a method of quantitatively evaluating profitability and risk for multiple alternatives using the total-cost unit-cost domain. The paper assumes such factors as unit sales price, sales and production volume, unit variable cost, fixed cost, and yield for each alternative. The paper incorporates the relationship between production capacity and demand, distinguishing between cases of production capacity surplus and shortage for each year over the entire planning horizon. The paper investigates the case in which the values of each factor independently move in the direction of decreasing profit each year, and clarifies the procedure of comparing safety among multiple investment alternatives on a single consolidated total-cost unit-cost domain. The difficulty of the problem lies in the method of consolidating multiple total-cost unit-cost domains into a single domain since the combination of years of capacity surplus and shortage depends upon the change values in each factor under consideration. A systematic method of evaluating profitability as well as risk is presented, and the validity of the proposed method is verified using a numerical example.

Mullti-factor fusion Process for Pedestrian Risk Assesment (보행자의 위험도 산출을 위한 다중요인 융합 처리)

  • Ryu, Chang-Keun
    • The Journal of the Korea institute of electronic communication sciences
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    • v.11 no.8
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    • pp.817-826
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    • 2016
  • The importance of common life safety is getting growth with modern society progress. This paper shows the extended way of assessment of danger that outcomes better result than the previous assessment based on crime frequency assessment. The assessment of this paper involves time, illusion degree, floating population and the personal condition. The evidence theory is not beneficial when the number of component increases, the assessment is more complex than before. This research solves the problem through the fuzzy theory adoption. This paper shows more advanced result that can express better danger awareness and get the adjective expression.

Study on Prioritizing the countries for BOT nuclear power project using Analytic Hierarchy Process (시스템엔지니어링에 기반한 원자력 사업대상국가 평가방법 연구)

  • Choi, Sun Woo;Bui, Hoang Ha;Roh, Myung Sub
    • Journal of the Korean Society of Systems Engineering
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    • v.9 no.2
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    • pp.1-6
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    • 2013
  • Developing Build-Own (or Operate)-Transfer (BOT) nuclear power project carrying large capital in the long term requires initially well-made multi-decision which it prevents sorts of risks from unexpected situation of target countries. In order to analyze the feasibility of project country, the Analytic Hierarchy Process is adopted. Firstly, the factors influencing the success of BOT nuclear power project in overseas countries were investigated through the literature survey for the country risk and were evaluated by expert interview for estimating comparative weight through pairwise comparison between such factors. Finally, it is developed comparative database of alternate countries with respect to each factor. This analytic method enables the developer to select and focus on the country which has preferable circumstance so that it enhances the efficiency of the project promotion. Also, it enables the developer to quantify the qualitative factors so that it diversifies the project success strategy and policy for the target country.