• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10057-10059
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• 2015

Positron emission tomography (PET) as the functional component of current hybrid imaging (like PET/CT or PET/MRI) seems to dominate the horizon of medical imaging in coming decades. $^{18}$Flourodeoxyglucose ($^{18}FDG$) is the most commonly used probe in oncology and also in cardiology and neurology around the globe. However, the major capital cost and exorbitant running expenditure of low to medium energy cyclotrons (about 20 MeV) and radiochemistry units are the seminal reasons of low number of cyclotrons but mushroom growth pattern of PET scanners. This fact and longer half-life of $^{18}F$ (110 minutes) have paved the path of a centralized model in which $^{18}FDG$ is produced by commercial PET radiopharmacies and the finished product (multi-dose vial with tungsten shielding) is dispensed to customers having only PET scanners. This indeed reduced the cost but has limitations of dependence upon timely arrival of daily shipments as delay caused by any reason results in cancellation or rescheduling of the PET procedures. In recent years, industry and academia have taken a step forward by producing low energy, table top cyclotrons with compact and automated radiochemistry units (Lab-on-Chip). This decentralized strategy enables the users to produce on-demand doses of PET probe themselves at reasonably low cost using an automated and user-friendly technology. This technological development would indeed provide a real impetus to the availability of complete set up of PET based molecular imaging at an affordable cost to the developing countries.

• 한국잠사곤충학회지
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• 제51권2호
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• pp.114-118
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• 2013

본 연구에서는 소리곤충인 왕귀뚜라미를 이용한 체험학습프로그램을 개발하여 초등학생에게 적용함으로써 학습성취도의 변화를 알아보고자 하였다. 연구의 대상은 서대문자연사박물관에서 운영 중인 교육프로그램을 신청한 초등학교 2-3학년생 123명이었다. 총 7회에 걸쳐 동일한 검사지를 통해 사전 및 사후 학습 성취도 검사를 실시하였다. 그 결과 학습 성취도는 사전검사보다 사후검사결과에서 평균점수가 높게 나왔으며, 대응표본 t-test 결과 통계적으로도 유의한 것으로 나타났다. 따라서 소리곤충을 이용한 체험학습프로그램의 적용은 학생들의 학습 성취도를 향상 시키는데 매우 효과적임을 확인할 수 있었다. 이를 통해 교육현장에서는 다양한 형태의 체험학습프로그램의 개발과 적용이 가능해져 보다 체계적인 프로그램이 적극적으로 활용될 수 있을 것으로 기대된다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 제4회 추계심포지움
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• pp.153-159
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• 1996

${\alpha}$-Melanotropin (Ac-Ser-Tyr- Ser-Met-Glu$\^$5/-His-Phe-Arg-Trp-Gly$\^$10/-Lys-Pro-Val-NH$_2$) is one of the first peptide hormones to be isolated and have its structure determined. It was early recognized to have essentially the same N-terminal tridecapeptide sequence as adrenocorticotropic hormone (ACTH) except that the N-terminal was acetylated in the case of ${\alpha}$-MSH but not in the case of ACTH, indicating that their biosyntheses were different (Figure 1). Subsequently it was discovered that ${\alpha}$-MSH and ACTH were derived from the same gene, currently referred to as proopiomelanocortin (POMC). Its original bioactivity was pigmentation, but it also was recognized that it may have activity in the central nervous system, though the precise nature of these central activities have been controversial. The recent cloning and expression of five melanocortin receptors, with the MC3 and MC4 receptors found primarily in the brain and the MC5 receptor (MC5-R) found throughout the body, has provided new impetus to understand the structure-activity relationships of ${\alpha}$-MSH at these receptors. The effects of ${\alpha}$-MSH on pigmentation are mediated by the MC1-R expressed specifically on the surface of melanocytes. Similarly the MC2-R is involved in the regulation of adrenal steroidogenesis by ACTH. However, given the complexity of expression of the MC3, MC4, and MC5 receptors, it has not been possible to identify any simple correlations between these receptors and the reported biological activities of the melanocortin peptides. Consequently, potent and receptor specific agonists and especially antagonists would be extremely valuable tools for the determination of the physiological roles of the MC3, MC4, and MC5 receptors. Though the extensive structure-activity relationships have provided much information on agonist activity related to pigmentary effects, only recently has it been possible to begin to systematically develop potent and selective antagonists.

• 한국농공학회지
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• 제43권4호
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• pp.57-68
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• 2001

It is matter of common knowledge to give impetus to the water resources development to cope with increasing demand and supply for the water utilization project including agricultural living and industrial water owing to the economic and civilization development in recent years. Regional design rainfall is necessary or the design of the dam reservoir levee and drainage facilities for the development of various kinds of essential waters including agricultural water. For the estimation of the regional design rainfall classification of the climatologically an geographically homogeneous regions should be preceded preferentially This study was mainly conducted to derive the optimal regionalization of the precipitation data which can be classified by the climatologically and geographically homogeneous regions all over the regions except Cheju and Wulreung islands in Korea. A total of 65 rain gauges were used to regional analysis of precipitation. Annual maximum series for the consecutive durations of 1, 3, 6, 12, 24, 36, 48 and 72hr were used for various statistical analysis. Both K-means clustering and mean annual precipitation methods are used to identify homogeneous regions all over the regions. Nine and five homogeneous regions for the precipitation were classified by the K-means clustering and mean annual methods, respectively. Finally, Five homogeneous regions were established by the trial and error method with homogeneity test using statistics of $\chi$$^2$ distribution.

• 정보관리연구
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• 제39권4호
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• pp.1-20
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• 2008

최근 학술커뮤니케이션에 나타난 변화 중 괄목할 만한 것이 '오픈액세스(Open Access)인데, 세계적으로 정보공유를 위한 연구자들의 참여와 학계와 정부에서의 지원 정책 발표가 이어면서 서구를 중심으로 급속히 확산되고 있다. 정보공유에 있어서 가장 중요한 것은 정보의 생산자이면서 소비자인 연구자들의 참여의지와 인식이다. 따라서 연구성과 정보의 공유에 대한 인식 조사는 대단히 긴요하다. 본 조사는 특정 주제 분야의 연구자들을 대상으로 오픈액세스 환경에 대한 인식도를 조사하였다. 이 조사를 바탕으로 오픈액세스 환경에서 이슈가 되고 있는 저작권 문제를 조명하였다. 결과적으로 국내 연구자들에게 있어서 '오픈액세스'에 대한 인식은 아직은 미비한 것으로 나타난 반면, 저작권이 침해되지 않는 범위 내에서 명확한 출처를 밝히고 합법적인 목적으로 연구물을 사용한다면 오픈액세스 활동에 참여할 의사를 가지고 있는 것으로 조사되었다. 이러한 결과를 바탕으로 이 논문에서는 저작권과 라이선스의 마련, 그리고 산재한 연구성과물의 원활한 관리와 접근 및 활용을 극대화시킬 수 있는 연구정보관리 체제의 구축이 필요함을 밝혔다.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2018년도 춘계학술대회 및 임시총회
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• pp.41-41
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• 2018

There has been an impetus in the development of biocontrol agents (BCAs) with the removal of a number of chemical compounds in the market, especially in the European Union. This has been a major driver in the development of Integrated Pest Management systems (IPM) for both pest and disease control. For control of mycotoxigenic fungi, there is interest in both control of colonization and more importantly toxin contamination of staple food commodities. Thus the relative inoculum potential of biocontrol agent vs the toxigenic specie sis important. The major bottlenecks in the production and development of formulations of biocontrol agents are the resilience of the strains, inoculum quality and formulation with effective field efficacy. It was recently been shown for mycotoxigenic fungi such as Aspergillus flavus, under extreme climate change conditions, growth is not affected although there may be a stimulation of aflatoxin production. Thus, the development of resilient biocontrol strains which can may have conserved control efficacy but have the necessary resilience becomes critical form a food security point of view. Indeed, under predicted climate change scenarios the diversity of pests and fungal diseases are expected to have profound impacts on food security. Thus, when examining the identification of potential biocontrol strains, production and formulation it is critical that the resilience to CC environmental factors are included and quantified. The problems in relation to the physiological competence and the relative humidity range over which efficacy can occur, especially pre-harvest may be increase under climate change conditions. We have examined the efficacy of atoxigenic strains of A. flavus and Clanostachys rosea and other candidates for control of A. flavus and aflatoxin contamination of maize, and for Fusarium verticillioides and fumonisin toxin control. We have also examined the potential use of fluidized-bed drying, nanoparticles/nanospheres and encapsulation approaches to enhance the potential for the production of resilient biocontrol formulations. The objective being the delivery of biocontrol efficacy under extreme interacting climatic conditions. The potential impact of climate change factors on the efficacy of biocontrol of fungal diseases and mycotoxins are discussed.

• Carbon letters
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• 제8권3호
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• pp.184-190
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• 2007

Carbon Nano Tubes could be either metallic or semi-conducting in nature, depending on their diameter. Its photocatalytic behavior has given an impetus to use it as an anti-microbial agent. More than 95% Escherichia coli and Staphylococcus aureus bacteria got killed when exposed to Carbon Nano Tubes for 30 minutes in presence of sunlight. Carbon Nano Tubes are supposed to have smooth surface on to which it accumulates positive charges when exposed to light. The surface that is non illuminated has negative charge. At the cellular level microorganisms produce negative charges on the cell membrane, Therefore damaging effect of multi walled carbon nano tubes (exposed to light) on the microorganisms is possible. In this paper, photo catalytic killing of microbes by multi walled carbon nano tubes is reported. Killing was due to damage in the cell membrane, as seen in SEM micrographs. Moreover biochemical analysis of membrane as well as total cellular proteins by SDS PAGE showed that there was denaturation of membrane proteins as well as total proteins of both the microbes studied. The killed microbes that showed a decrease in number of protein bands (i.e. due to breaking down of proteins) also showed an increase in level of free amino acids in microbes. This further confirmed that proteins got denatured or broken down into shorter units of amino acids. Increased level of free amino acids was recorded in both the microbes treated with multi walled carbon nano tubes and sunlight.

• 한국항해항만학회지
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• 제37권6호
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• pp.655-662
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• 2013

최근 화석 연료의 사용에 따른 문제들로 인해 다양한 그린 에너지들이 주목 받고 있다. 그린 에너지의 한 종류로써 풍력 발전의 원동력인 바람은 육상에서 보다 해상에서 양질의 값이 관측된다. 또한, 부지확보, 소음, 전자파와 같은 육상 풍력 발전의 문제점을 해결할 대안으로써, 또한 더 효율적인 풍력 발전을 위해 해상 풍력 발전의 개발이 주목받고 있다. 이에 따라 해상 풍력에 대한 많은 연구들이 수행되고 있다. 풍력 타워가 해상으로 진출함에 따라 해상 풍력 타워는 점차 거대해지고 있다. 따라서 풍력과 파력을 견뎌내기 위한 안정성이 요구되고 있다. 본 연구에서는 p-y 관계를 이용해 다층 지반의 기초에 작용하는 외력을 계산하였다.

• Journal of the Korean Wood Science and Technology
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• 제26권4호
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• pp.43-49
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• 1998

The availability of large quantities of waste woods provides an impetus for investigating woody biomass potential uses. Polyurethane (PU) foams are prepared with reacting isocyanates and polyols, and are used. in various industry fields. Thus, lignocellulosic waste raw-materials are proposed as replacement for synthetic polyol to PU foam formulation. In this study PU foams were manufactured from liquefied woods, methanediisocyanate(MDI), catalyst, foaming stabilizer, and viscosity aids. The polyol content, isocyanate.hydroxyl group (NCO/OH) ratio, and water content were varied to evaluate their effects on the foaming and water absorption of the PU foams. Less than 400 Molecular weight. of polyethylene glycol(PEG) and 1 to 3 solvent to woody raw-material ratio were desirable for liquefying woody materials. Liquefying rate was increased with more than 3 % addition of inorganic and organic catalysts and raising reaction temperature more than $150^{\circ}C$. Addition of starch enhanced liquefying of woody materials. Fourty percents of starch resulted in about 90% liquefying rates. Foaming rates were increased with increasing moisture contents of liquefied wood. Moisture contents of 0.6% resulted in 5 time-foaming rates, and seven percents of moisture contents more than 30 time-foaming rates. But, an increase in water content may result in a decrease in cross-links between wood polyol and isocyanate, because the NCO/OH ratio is constant. Increasing moisture contents have significantly decreased density of PU foams. The optimum water content should be about 2.5% or less in this adopted condition.

• Journal of Power Electronics
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• 제19권6호
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• pp.1366-1379
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• 2019

High-gain DC/DC converters have become one of the key technologies for the grid-connected operation of new energy power generation, and its research provides a significant impetus for the rapid development of new energy power generation. Inspired by the transformer effect and the ripple-suppressed ability of a coupled inductor, a double-coupled inductor high gain DC/DC converter with a ripple absorption circuit is proposed in this paper. By integrating the diode-capacitor voltage multiplying unit into the quadratic Boost converter and assembling the independent inductor into the magnetic core of structure coupled inductors, the adjustable range of the voltage gain can be effectively extended and the limit on duty ratio can be avoided. In addition, the volume of the magnetic element can be reduced. Very small ripples of input current can be obtained by the ripple absorption circuit, which is composed of an auxiliary inductor and a capacitor. The leakage inductance loss can be recovered to the load in a switching period, and the switching-off voltage spikes caused by leakage inductance can be suppressed by absorption in the diode-capacitor voltage multiplying unit. On the basis of the theoretical analysis, the feasibility of the proposed converter is verified by test results obtained by simulations and an experimental prototype.