• 한국물환경학회지
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• 제24권5호
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• pp.556-562
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• 2008

We divided the downstream of South-Han River into three water zones, such as river zone, transition zone and lacustrine zone depending on the flow rate, and elucidated the major effect factors on the growth of phytoplankton and the sources of organic matters in each water zone. The difference of chlorophyll-a concentration which represents the standing crop of phytoplankton was statistically significant among the water zones. From the results of bivariate correlation analysis between chlorophyll-a concentration and water quality parameters in each water zone, the outflow of Chungju dam and hydraulic retention time of Lake Paldang which are directly related with the flow rate seemed to have obvious impact on phytoplankton growth in the downstream of South-Han River. The concentration of nutrients such as phosphorus and nitrogen exceeded the criterion of eutrophication and did not showed significant relationship with chlorophyll-a concentration. There were strong correlations between $BOD_5$ and chlorophyll-a concentrations in transition and lacustrine zone showing autochthonous production of phytoplankton was dominant source of organic matters in these zones especially in dry seasons. The results of this study show that the control of abundance of phytoplankton is the key target for reduction of the organic pollution in the downstream of South-Han River.

• Journal of Pharmaceutical Investigation
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• 제34권3호
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• pp.229-254
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• 2004

The objective of this study was to scrutinize the rationale of SUPAC-MR and its application in processing postapproval changes to modified release solid oral dosage forms. The types of postapproval changes that were primarily covered with SUPAC-MR included variations in the components and composition, the site of manufacturing, batch size, manufacturing equipment, and manufacturing process. SUPAC-MR defined levels of postapproval changes that the industry might make. Classification of such categories was based on the likelihood of risk occurrence and potential impact of changes upon the safety and efficacy of approved drug products. In most cases, the changes could be classified into 3 levels. It described what chemistry, manufacturing, and control tests should be conducted for each change level. The important tests specified in SUPAC-MR were batch release, stability, in vitro dissolution, and in vivo bioequivalence tests. It then suggested what type of a filing report should be submitted to the FDA for each change level. In general, level 1 changes could be reported in an annual report, whereas level 2 and/or 3 changes could be submitted in changes-being-effected or prior approval supplements. It could be understood that the purpose of SUPAC-MR was to maintain the safety and quality of approved modified release solid oral dosage forms undergoing certain changes. At the same time, it contributed to providing a less burdensome regulatory process with the manufacturers when they wanted to make postapproval changes. European regulatory agencies also implemented SUPAC-like regulations in handling such changes to drug products. Therefore, in this study a recommendation was made for KFDA and the Korean industry to evaluate thoroughly the usefulness of these guidances and regulations in dealing with postapproval changes to modified release solid oral dosage forms.

• 한국통신학회논문지
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• 제37권4B호
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• pp.219-226
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• 2012

무선 센서 네트워크에서 위치기반 멀티캐스트 라우팅은 중복되어 전송되는 메시지 전송 횟수를 줄임으로써 무선 센서 네트워크망의 채널 용량과 수명을 증가시킬 수 있다. 하지만 기존의 위치기반 멀티캐스트 알고리즘들은 센서 노드의 위치만을 고려하여 패킷을 전송하기 때문에 장애물이나 다른 무선기기의 간섭영향이 존재하는 실제환경에서는 네트워크 성능이 저하될 수 있다. 이를 해결하기 위하여 본 논문에서는 간섭의 영향을 고려한 위치기반 멀티캐스트 알고리즘을 제안한다. 제안한 알고리즘에서 각 센서 노드는 간섭영향을 고려하여 각 링크에 패킷전송 시 소모되는 에너지를 계산하고 이를 바탕으로 간섭영향이 가장 적은 링크를 통해 멀티캐스트 패킷을 전송한다. 시뮬레이션 결과, 제안한 알고리즘은 기존 연구들에 비하여 패킷전송률과 에너지 소비 측면에서 향상된 성능을 보였다.

• 융합보안논문지
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• 제13권6호
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• pp.35-41
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• 2013

의료정보 보안에 대한 대안은 무엇보다 의료정보의 안전한 보존과 각종의 보안 위협으로부터 안전성을 강구하는 소프트웨어 설계로부터 시작되어야 한다. 의료정보시스템은 산재된 의료정보를 실시간으로 통합할 수 있어야 하고 의료정보의 교환은 신뢰할 수 있는 데이터 통신이어야 한다. 의료정보시스템의 소프트웨어 아키텍처 설계는 의료정보 공유상 보안 문제를 파악하고 의사소통을 통해 사용자 요구사항을 파악하여 소프트웨어 설계에 반영한다. 소프트웨어 프레임워크 설계, 메시지 표준 설계, 웹기반 프로세스간 통신절차 설계, 접근제어 알고리즘 설계, 아키텍처 기술서 작성, 아키텍처 평가의 제반 절차를 정립한다. 소프트웨어 아키텍처 초기 결정은 설계, 개발, 테스트, 유지보수에 지속적인 영향을 미친다. 또한 프로젝트상의 세부적 의사결정 근거가 된다. 의료정보보안 기반 소프트웨어 아키텍처 설계방법은 오늘날 중요한 과제가 되고 있는 의료정보 보안의 기본틀을 제공할 수 있을 것이다.

• 전기전자학회논문지
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• 제21권1호
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• pp.30-38
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• 2017

사이트에 설치되어 운용 중인 능동위상배열레이다가 외부의 충격 또는 장기간 운용에 따른 성능열화가 의심될 경우, 위상배열안테나의 이상여부를 확인해야 한다. 하지만, 위상배열안테나를 측정하기 위해서는 무반향성 챔버에서 근접전계 시험이 수행되어야 하므로, 레이다 장치의 분해 및 운송을 위해 많은 시간과 비용이 투입되어야 하고 레이다 시스템의 운용 가용도가 나빠지게 된다. 따라서, 본 논문에서는 사이트에서 위상배열안테나의 이상여부를 확인할 수 있도록 이동성을 구비한 능동위상배열안테나 근접전계 스캐너를 제안하고, 무반향성 챔버에서 측정한 데이터와 비교하여 크기 ${\pm}0.5dB$와 위상 ${\pm}1.5^{\circ}$ 오차수준으로 측정유효성을 검증하였다.

• 한국결정성장학회:학술대회논문집
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• 한국결정성장학회 1996년도 제11차 KACG 학술발표회 Crystalline Particle Symposium (CPS)
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• pp.285-309
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• 1996

Non oxide ceramics such as nitrides of transition metals have shown significant potential for future economic impact, in diverse applications in ceramic, aerospace and electronic industries, as refractory products, abrasives and cutting tools, aircraft components, and semi-conductor substrates amid others. Combustion synthesis has become an attractive alternative to the conventional furnace technology to produce these materials cheaply, faster and at a higher level of purity. However he process os highly exothermic and manifests complex dynamics due to its strongly non-linear nature. In order to develop an understanding of this process and to study the effect of operational parameters on the final outcome, numerical modeling is necessary, which would generated essential knowledge to help scale-up the process. the model is based on a system of parabolic-hyperbolic partial differential equations representing the heat, mass and momentum conservation relations. The model also takes into account structural change due to sintering and volumetric expansion, and their effect on the transport properties of the system. The solutions of these equations exhibit steep moving spatial gradients in the form of reaction fronts, propagating in space with variable velocity, which gives rise to varying time scales. To cope with the possibility of extremely abrupt changes in the values of the solution over very short distances, adaptive mesh techniques can be applied to resolve the high activity regions by ordering grid points in appropriate places. To avoid a control volume formulation of the solution of partial differential equations, a simple orthogonal, adaptive-mesh technique is employed. This involves separate adaptation in the x and y directions. Through simple analysis and numerical examples, the adaptive mesh is shown to give significant increase in accuracy in the computations.

• Clinical and Experimental Reproductive Medicine
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• 제47권2호
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• pp.108-113
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• 2020

Objective: Endometrial fibrosis, the primary pathological feature of intrauterine adhesion, may lead to disruption of endometrial tissue structure, menstrual abnormalities, infertility, and recurrent pregnancy loss. At present, no ideal therapeutic strategy exists for this fibrotic disease. Eupatilin, a major pharmacologically active flavone from Artemisia, has been previously reported to act as a potent inducer of dedifferentiation of fibrotic tissue in the liver and lung. However, the effects of eupatilin on endometrial fibrosis have not yet been investigated. In this study, we present the first report on the impact of eupatilin treatment on transforming growth factor beta (TGF-β)-induced endometrial fibrosis. Methods: The efficacy of eupatilin on TGF-β-induced endometrial fibrosis was assessed by examining changes in morphology and the expression levels of fibrosis markers using immunofluorescence staining and quantitative real-time reverse-transcription polymerase chain reaction. Results: Eupatilin treatment significantly reduced the fibrotic activity of TGF-β-induced endometrial fibrosis in Ishikawa cells, which displayed more circular shapes and formed more colonies. Additionally, the effects of eupatilin on fibrotic markers including alpha-smooth muscle actin, hypoxia-inducible factor 1 alpha, collagen type I alpha 1 chain, and matrix metalloproteinase-2, were evaluated in TGF-β-induced endometrial fibrosis. The expression of these markers was highly upregulated by TGF-β pretreatment and recovered to the levels of control cells in response to eupatilin treatment. Conclusion: Our findings suggest that suppression of TGF-β-induced signaling by eupatilin might be an effective therapeutic strategy for the treatment of endometrial fibrosis.

• Journal of Ecology and Environment
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• 제41권6호
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• pp.173-181
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• 2017

Background: This study was undertaken to analyze the distribution and ecological characteristics of invasive alien plant species on Jeju Island, and to provide basic data for their management and control. Results: A field research was conducted at 436 locations on Jeju Island. The field research identified nine species of invasive alien species growing on Jeju Island. Based on the distribution pattern, Hypochaeris radicata L., Rumex acetosella, and Ambrosia artemisiifolia L. were found to be distributed horizontally throughout Jeju Island, with vertical growth in two or more vegetation zones, from warm temperate to the subalpine zone. Widely distributed species penetrate various habitats, such as grasslands, ranches, roadsides, farmlands, and empty lots, and have an immensely negative impact on the ecosystem, including declining biodiversity on Jeju Island. Paspalum distichum var. indutum Shinners, Paspalum distichum L., Solanum carolinense L., and Aster pilosus Willd. were distributed in some areas as a biased distribution species, whereas Lactuca scariola L. and Solidago altissima L. were found only in certain areas as centralized distribution species. Conclusions: The centralized distribution species and biased distribution species of the invasive plants in the ecosystem of Jeju Island should be physically eliminated, keeping in mind the short- and mid-term perspectives and monitoring, and by considering expansion of additional distribution areas. Due to limitations of physical/chemical elimination, time, and cost, widely distributed species require to be eliminated and managed, mainly to restore the integrity of the ecosystem, by planting native species to reestablish the habitat.

• 조명전기설비학회논문지
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• 제13권1호
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• pp.94-101
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• 1999

본 논문은 PWM인버터 장치의 스위칭 서지에 관한 문제를 분석한 것이다. 교류 전동기의 효율적인 속도제어를 위한 가변속 구동 장치의 적용이 증가함에 따라 전동기와 가변속 구동장치에 관련된 고장이 발생한다. 산업용 전동기 설비에 PWM 드라이브의 도입은 때때로 높은 과도전압 피크에 의한 상권선 사이 절연파괴를 낳을 수 있다. 높은 스위칭 주파수와 결합한 전동기 케이블 길이는 적?한 드라이브 동작을 위한 매우 민감한 문제가 된다. 케이블 길이와 높은 스위칭주파수의 결과는 전동기와 인버터에 영향을 미칠 수 있다. 전동기 권선 절연레벨이 낮을 때, 높은 피크전압과 빠른 전압상승시간에 의해 생겨난 고장 확률은 높다. 전압반사는 전동기 용량, 여러 가변속 구동장치와 상승시간에 대해 계산하였으며 이를 도식적으로 나타내었다. 인버터 구동 교류 전동기 시스템에서 전동기 단자 과전압과 전압상승률을 줄이기 위한 필터효과도 언급하였다. 연구결과 전동기 용량과 전동기 절연정격 레벨이 낮을수록 그리고 스위칭 시간과 케이블 길이가 짧을수록 절연파괴의 가능성이 높아짐을 알 수 있었다.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2000년도 추계학술발표회 초록집
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• pp.1-2
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• 2000

In chip plating, several parameters must be taken into consideration. Current density, solution concentration, pH, solution temperature, components volume, chip and media ratio, barrel geometrical shape were most likely found to have an effect to the process yields. The 3 types of barrels utilized in chip plating industry are the onventional rotating barrel, vibrational barrel(vibarrel), and the centrifugal type. Conventional rotating barrel is a close type and is commonly used. The components inside the barrel are circulated by the barrel's rotation at a horizontal axis. Process yield has known to have higher thickness deviation. The vibrational barrel is an open type which offers a wide exposure to electrolyte resulting to a stable thickness deviation. It rotates in a vertical axis coupled with multi-vibration action to facilitate mixed up and easy transportation of components. The centrifugal barrel has its plated work centrifugally compacted against the cathode ring for superior electrical contact with simultaneous rotary motion. This experiment has determined the effect of barrel vibration intensity to the plating thickness distribution. The procedures carried out in the experiment involved the overall plating process., cleaning, rinse, Nickel plating, Tin-Lead plating. Plating time was adjusted to meet the required specification. All other parameters were maintained constant. Two trials were performed to confirm the consistency of the result. The thickness data of the experiment conducted showed thatbthe average mean value obtained from higher vibrational intensity is nearer to the standard mean. The distribution curve shown has a narrower specification limits and it has a reduced variation around the target value. Generally, intensity control in vi-barrel facilitates mixed up and easy transportation of components. However, it is desirable to maintain an optimum vibration intensity to prevent solution intrusion into the chips' internal electrode. A cathodic reaction can occur in the interface of the external and internal electrode. 2H20 + e $\rightarrow$M/TEX> 20H + H2.. Hydrogen can penetrate into the body and create pressure which can cause cracks. At high intensity, the chip's motion becomes stronger, its contact between each other is delayed and so plating action is being controlled. However, the strong impact created by its collision can damage the external electrode's structure there by resulting to bad plating condition.