• Asian-Australasian Journal of Animal Sciences
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• 제23권7호
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• pp.916-923
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• 2010

We report nutritional physiology and non-specific immune responses of vitamin E in parrot fish for the first time. This study aimed to investigate the essentiality and requirements in diets based on growth performances, non-specific immune responses and a challenge test against Vibrio angullarum. Six casein-gelatin based semi-purified diets were formulated to contain six graded levels of DL-${\alpha}$-tocopheryl acetate (${\alpha}$-TA) at 0, 25, 50, 75, 100 and 500 mg/kg diet (designated as E0, E25, E50, E75, E100 and E500, respectively) and fed to triplicate groups of juvenile parrot fish for 12 weeks. The analyzed dietary concentrations of vitamin E were 0, 38, 53, 87, 119 and 538 mg/kg diet for E0, E25, E50, E75, E100 and E500, respectively. At the end of the feeding trial, growth performance and feed utilization of fish fed the E25 were significantly higher compared to that of fish fed the other diets. Liver ${\alpha}$-tocopherol concentration was significantly increased with an increase in dietary ${\alpha}$-TA in a dose dependent manner. No apparent clinical signs of vitamin E deficiency and mortality were observed in fish fed the basal diet for 12 weeks. Among the immune responses assayed, phagocytic (NBT assay) and myeloperoxidase activities were significantly increased with increment of dietary ${\alpha}$-TA levels. During the challenge test with V. anguillarum, E75, E100, and E500 diets resulted in higher survivals than E0, E25 and E50 diets. The findings of this study suggest that parrot fish require exogenous vitamin E and the optimum dietary level could be approximately 38 mg ${\alpha}$-TA/kg diet for normal growth and physiology. Dietary ${\alpha}$-TA concentration over 500 mg/kg could be required to enhance the nonspecific immune responses and improve the resistance of juvenile parrot fish against V. anguillarum.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2005년도 춘계학술대회 논문집
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• pp.399-404
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• 2005

본 논문은 생체시스템의 인공면역시스템을 이용한 Immunized PID 제어기를 구성하였으며, 상층부위에 제동시스템이 부착된 다층 건축물의 진동제어에 적용하였다. 인공면역시스템은 인체가 외부로부터 침투하는 바이러스, 병원균 등으로부터 보호하기 위하여 내부의 항체들이 이를 극복하기 위하여 행동하는 현상을 모델링한 것으로써 외란입력에 대한 적응성 및 강인한 응답특성을 가지고 있다. 본 논문에서 설계된 제어시스템은 항만의 건축물에 능동제어기로 적용하였으며, 바람이나 지진과 같은 환경적 부하로 인해 발생되는 건축물의 응답변위를 컴퓨터 시뮬레이션을 통해 나타내었다. 그리고, 기존의 진동제어에 널리 이용되는 제어기도 함께 적용하여 제안한 제어기 성능의 우수성을 입증하고자 함과 동시에 인공면역시스템을 응용한 제어기 설계에 대한 비젼도 제시하고자 한다.

• Asian-Australasian Journal of Animal Sciences
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• 제17권8호
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• pp.1145-1149
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• 2004

Immunomodulatory feed additives might offer alternatives to antimicrobial growth promoters in poultry production. This experiment was carried out to test the effect of $\beta$-glucan supplementation on the growth performance and immune response in broilers. Total of 160 day-old broilers were randomly assigned to 4 treatment groups fed corn-soybean diets containing 0, 0.012, 0.025 or 0.05% of $\beta$-glucan supplement in a 6 week feeding experiment. Growth performance, antibody titer against New Castle vaccine, lymphocyte blastogensis, and peritoneal macrophage chemotaxis activity of broilers were evaluated. Results showed that there were no significant differences in weight gain and feed efficiency among the treatments, and no differences in antibody titer was observed. Supplementation of $\beta$-glucan did not elevate the lymphocyte blastogensis among treatments, following stimulation with different mitogens. However, supplementation with 0.025 and 0.05% $\beta$-glucan enhanced the macrophage chemotaxis activity of broilers. These results suggest that $\beta$-glucan may enhance some cell-mediated immune responses of chickens by modulate macrophages ability.

• Asian-Australasian Journal of Animal Sciences
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• 제14권1호
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• pp.70-76
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• 2001

This experiment was conducted to investigate the effects of crystalline isoleucine supplementation of a low protein, corn-soybean meal diet on the performance and immune function of weanling pigs. Forty-five crossbred ($Duroc{\times}Landrace{\times}Large\;White$) piglets, weighing an average of $11.00{\pm}0.07kg$, were assigned to either a control diet containing 20% crude protein (0.64% isoleucine), a 16% crude protein diet without isoleucine supplementation (0.41% isoleucine) or a 16% crude protein diet supplemented with isoleucine (0.64% isoleucine). Reducing the crude protein content of the diet from 20 to 16% significantly (p<0.05) reduced both average daily gain and feed intake. Feed conversion also tended (p=0.07) to be poorer for a low protein diet without isoleucine supplementation. Isoleucine supplementation of the 16% crude protein diet increased both gain and feed intake to a level similar to that obtained by pigs fed the 20% crude protein diet (p>0.05). Blood urea nitrogen, serum total protein and serum globulin were significantly (p<0.05) higher for pigs fed the unsupplemented 16% crude protein diet than for pigs fed the isoleucine-supplemented diet or the control. Egg albumin antibody titre decreased significantly (p<0.05) in pigs fed the diet with isoleucine supplementation, whereas the antibody titre of pigs fed the low protein and low isoleucine diet was similar to that of pigs fed the diet containing 20% crude protein and 0.64% isoleucine. It was suggested that crystalline isoleucine supplementation of a low protein and low isoleucine diet improved pig performance but suppressed humoral immune function.

• Asian-Australasian Journal of Animal Sciences
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• 제25권3호
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• pp.393-400
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• 2012

The study was conducted to examine the effects of partially replacing soybean meal (SBM) by solid-state fermented cottonseed meal (FCSM) on growth performance, serum biochemical parameters and immune function of broilers. After inoculated with Bacillus subtilis BJ-1 for 48 h, the content of free gossypol in cottonseed meal was decreased from 0.82 to 0.21 g/kg. A total of 600, day-old male yellow-feathered broilers were randomly divided into four groups with three replicates of 50 chicks each. A corn-SBM based control diet was formulated and the experimental diets included 4, 8 or 12% FCSM, replacing SBM. Throughout the experiment, broilers fed 8% FCSM had higher (p<0.05) body weight gain than those fed 0, 4 and 12% FCSM. The feed intake in 8% FCSM group was superior (p<0.05) to other treatments from d 21 to 42. On d 21, the concentration of serum immunoglobin M in the 4% and 8% FCSM groups, as well as the content of complements (C3, C4) in 8% FCSM group were greater (p<0.05) than those in the SBM group. Besides, birds fed 8% FCSM had increased (p<0.05) serum immunoglobin M, immunoglobulin G and complement C4 levels on d 42 compared with bird fed control diet. No differences (p>0.05) were found between treatments regarding the serum biochemical parameters and the relative weights of immune organs. In conclusion, FCSM can be used in broiler diets at up to 12% of the total diet and an appropriate replacement of SBM with FCSM may improve growth performance and immunity in broilers.

• 한국수산과학회지
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• 제45권6호
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• pp.648-653
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• 2012

The present study examined the effects of dietary supplementation with nucleotide (inosine monophosphate product, IMP) on the growth performance, feed utilization, and non-specific immune responses of juvenile tilapia Oreochromis niloticus. Triplicate groups of tilapia (initial body weight, $7.4{\pm}0.04$ g) were fed experimental diets containing 0%, 0.05%, 0.1%, and 0.2% IMP. Fish were fed six times a day until apparent satiation for 13 weeks. At the end of the feeding trial, final body weight and food utilization of fish fed 0.1% IMP were significantly higher than those of fish fed the control diet. Results of hematological parameters were not affected by dietary IMP. However, blood protein level was significantly higher in the 0.05% treatment, as compared to that of the control and 0.2% IMP diets. Myeloperoxidase activity was higher in fish fed 0.1% IMP than in fish fed the control and 0.2% IMP diets. These results suggest that dietary supplementation with IMP can enhance the growth performance, feed utilization, and innate immune response of juvenile tilapia. The optimal IMP supplementation level appears to be 0.1% in practical feed formulations for tilapia.

• 한국정밀공학회지
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• 제21권10호
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• pp.65-77
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• 2004

In this paper, we propose an adaptive mechanism based on immune algorithm and neural network identifier technique. It is also applied fur an autonomous guided vehicle (AGV) system. When the immune algorithm is applied to the PID controller, there exists the case that the plant is damaged due to the abrupt change of PID parameters since the parameters are almost adjusted randomly. To solve this problem, we use the neural network identifier (NNI) technique fur modeling the plant and humoral immune algorithm (HIA) which performs the parameter tuning of the considered model, respectively. After the PID parameters are determined in this off-line manner, these gains are then applied to the plant for the on-line control using an immune adaptive algorithm. Moreover, even though the neural network model may not be accurate enough initially, the weighting parameters are adjusted to be accurate through the on-line fine tuning. Finally, the simulation and experimental result fur the control of steering and speed of AGV system illustrate the validity of the proposed control scheme. These results for the proposed method also show that it has better performance than other conventional controller design methods.

• 한국지능시스템학회논문지
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• 제12권4호
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• pp.353-360
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• 2002

PID 제어기의 자동 동조 방법이 제어분야에서 많은 연구가 되어 왔으며, 제안된 제어기 또한 PID 제어기 자동동조에 관한 연구이다. 제안된 면역 알고리즘은 인간의 면역 체계를 모방한 최적화 알고리즘으로 기억 세포 메카니즘과 다른 면역 알고리즘에 비하여 덜 복잡한 구조를 가지고 있다. 이렇게 제안된 면역 알고리즘을 PID 제어기의 파라메터를 최적화하는데 사용하고자 한다. 현재까지 면역 알고리즘은 주로 시스템 파라메터의 변동이 없는 최적화 문제에 적용되어왔다. 그러므로 면역 알고리즘에서의 기억세포 메카니즘에 대한 유용성이 없으며, 또한 그에 대한 연구가 미진한 상태이다. 본 연구에서는 비선형 가변 시스템에 기억세포를 사용한 면역 알고리즘을 적용하고자 한다. 제안된 면역 알고리즘의 성능 평가를 위하여 비선형 직류 모터의 속도 제어에 적용하고, 그 결과를 컴퓨터 모의실험을 통하여 제안된 면역 알고리즘이 가변 시스템 파리메에 대하여 빠른 수렴 성능과 좋은 제어 성능을 보임을 보이고자 한다.

• Journal of Ginseng Research
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• 제44권2호
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• pp.179-193
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• 2020

Ginseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health-care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product that is essential for the evaluation of effectiveness and safety. This review focuses on the well-characterized and standardized ginseng extract, G115, which represents an excellent example of an herbal drug preparation with constant safety and efficacy within the herbal medicinal products. Over the many decades, extensive preclinical and clinical research has been conducted to evaluate the efficacy and safety of G115. In vitro and in vivo studies of G115 have shown pharmacological effects on physical performance, cognitive function, metabolism, and the immune system. Furthermore, a significant number of G115 clinical studies, most of them double-blind placebo-controlled, have reinforced the findings of preclinical evidence and proved the efficacy of this extract on blood glucose and lipid regulation, chronic obstructive pulmonary disease, energy, physical performance, and immune and cognitive functions. Clinical trials and 50 years of presence on the market are proof of a good safety profile of G115.

• 한국지능시스템학회논문지
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• 제12권3호
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• pp.246-254
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• 2002

In this paper auto-tuning scheme of PID controller based on the reference model has been studied for a Process control system by immune algorithm. Up to this time, many sophisticated tuning algorithms have been tried in order to improve the PID controller performance under such difficult conditions. Also, a number of approaches have been proposed to implement mixed control structures that combine a PID controller with fuzzy logic. However, in the actual plant, they are manually tuned through a trial and error procedure, and the derivative action is switched off. Therefore, it is difficult to tune. Since the immune system possesses a self organizing and distributed memory, it is thus adaptive to its external environment and allows a PDP (Parallel Distributed Processing) network to complete patterns against the environmental situation. Simulation results reveal that reference model basd tuning by immune network suggested in this paper is an effective approach to search for optimal or near optimal process control.